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    "headline": "(18)F-FDG-PET/CT findings of a rare adult T-cell leukaemia/lymphoma in the anterior mandible: case-based review.",
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    "headline": "A Monovalent SMAC Mimetic as a Potential Host-Directed Therapy for Tuberculosis.",
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    "headline": "Cell Therapy and Graft Engineering for Chronic Graft-versus-host Disease.",
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    "headline": "Cell-mediated response against heat-inactivated viral hemorrhagic septicemia virus (VHSV) IVb using Rainbow trout (Oncorhynchus mykiss) dorsal fin cells as antigen presenting cells.",
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    "headline": "CRISPR Screening Reveals SAA1-Driven Neutrophil Extracellular Traps Promote CD8⁺ T Cell Dysfunction in Renal Cell Carcinoma.",
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    "headline": "Current and future immunotherapies for NSCLC.",
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    "id": "pubmed:42069583",
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    "headline": "Longitudinal TCR repertoire profiling predicts refractory cytomegalovirus reactivation after haploidentical hematopoietic stem cell transplantation.",
    "summary": "Virology journal. Virol J. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069583/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Patient-derived TCR data: tcr repertoire",
    "journal": "Virology journal",
    "pmid": "42069583",
    "doi": "10.1186/s12985-026-03181-7",
    "preprint_id": "",
    "authors": "Yuan H; Liu L; Chen G; Xu J; Zhang K; Yang R; Han C; Hou J; Jiang M",
    "assignee": "",
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    "id": "biorxiv:10.64898/2026.04.29.721002",
    "canonical_key": "doi:10.64898/2026.04.29.721002",
    "headline": "Average local nucleosome motion remains constant during interphase in living human cells",
    "summary": "BackgroundDynamic chromatin behavior, which is related to chromatin accessibility, plays a critical role in various genome DNA functions such as RNA transcription and DNA replication/repair.",
    "url": "https://doi.org/10.64898/2026.04.29.721002",
    "source": "bioRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Clinical or translational importance: phase i",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.29.721002",
    "preprint_id": "biorxiv:10.64898/2026.04.29.721002",
    "authors": "Nagata, Y.; Iida, S.; Shimazoe, M. A.; Tamura, S.; Nakazato, K.; Shimizu, K.; Hatoyama, Y.; Kanemaki, M.; Maeshima, K.",
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    "primary_source": "bioRxiv",
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    "source_type": "papers",
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    "rank_index": 3,
    "score": 24,
    "id": "pubmed:42069790",
    "canonical_key": "pmid:42069790",
    "headline": "A TRAC-478-adjuvanted recombinant N1 neuraminidase influenza virus vaccine induces balanced and broadly protective immune responses.",
    "summary": "NPJ vaccines. NPJ Vaccines. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069790/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "NPJ vaccines",
    "pmid": "42069790",
    "doi": "10.1038/s41541-026-01456-2",
    "preprint_id": "",
    "authors": "Hoxie I; Vasilev K; Clark J; Amin H; Peña Alzua G; Bhavsar D; Puente-Massaguer E; Siram K; Short K; Tee R; Burkhart D; Evans JT; Krammer F",
    "assignee": "",
    "publication_number": "",
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    "source_type": "papers",
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    "rank_index": 4,
    "score": 24,
    "id": "pubmed:42082110",
    "canonical_key": "pmid:42082110",
    "headline": "CD34(+) cell-Derived Endothelial Cells Orchestrate Vascular and Immune Remodeling in the Transplanted Liver.",
    "summary": "Journal of hepatology. J Hepatol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42082110/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of hepatology",
    "pmid": "42082110",
    "doi": "10.1016/j.jhep.2026.04.028",
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    "authors": "Chen R; Li X; Zhu P; Yi X; Wang T; Chen H; Huang X; Ye G; Jiang J; Ong M; Jiang L; Li Y; Zhong S; He Y; Fan R; Zhang B; Li H; Cai J; Zheng S; Xu Q; Ling Q; Zhang H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "source_type": "papers",
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    "rank_index": 5,
    "score": 24,
    "id": "biorxiv:10.64898/2026.04.29.721097",
    "canonical_key": "doi:10.64898/2026.04.29.721097",
    "headline": "CD4+ T cell activation is dependent on a novel form of ULK1/2-independent autophagy",
    "summary": "Autophagy is essential for CD4+ T cell activation and immune regulation. However, during activation both autophagy and anabolic signaling must be simultaneously sustained, challenging established models of pathway antagonism.",
    "url": "https://doi.org/10.64898/2026.04.29.721097",
    "source": "bioRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
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    "doi": "10.64898/2026.04.29.721097",
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    "authors": "Coffer, P. J.; Corrigan, E.; van Beek, J.; Raud, B.; Oliverira Lima, J.; de Maziere, A.; Knol, A.; Pals, C.; Amsen, D.; Klumperman, J.; Mocholi, E.",
    "assignee": "",
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    "claims": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
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    "source_type": "papers",
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    "score": 24,
    "id": "pubmed:42068188",
    "canonical_key": "pmid:42068188",
    "headline": "Curcumin-Embedded Magnesium-Polyphenol Network Hydrogel for Dual Delivery of aPD1 and Promotion of Pleural Sealing in Lung Cancer Immunotherapy.",
    "summary": "Advanced healthcare materials. Adv Healthc Mater. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42068188/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Advanced healthcare materials",
    "pmid": "42068188",
    "doi": "10.1002/adhm.71157",
    "preprint_id": "",
    "authors": "Yang X; Hu C; Wu J; Luan H; Ji G; Liang X; Wang X; Wang M",
    "assignee": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 2,
    "score": 24,
    "id": "pubmed:42068367",
    "canonical_key": "pmid:42068367",
    "headline": "Dissecting Immune Mechanisms Underlying Sarcopenia Using Multi-omics Approaches.",
    "summary": "Calcified tissue international. Calcif Tissue Int. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42068367/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Calcified tissue international",
    "pmid": "42068367",
    "doi": "10.1007/s00223-026-01524-8",
    "preprint_id": "",
    "authors": "Ding K; Jiang W; Lei M; Gao Y",
    "assignee": "",
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    "score": 24,
    "id": "pubmed:42081990",
    "canonical_key": "pmid:42081990",
    "headline": "Elotuzumab enhances the anti-tumor activity of Vγ9Vδ2 T cells against Primary Effusion Lymphoma.",
    "summary": "European journal of pharmacology. Eur J Pharmacol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081990/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "European journal of pharmacology",
    "pmid": "42081990",
    "doi": "10.1016/j.ejphar.2026.178922",
    "preprint_id": "",
    "authors": "Maeda K; Kariya R; Panaampon J; Matsuda K; Okada S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 4,
    "score": 24,
    "id": "pubmed:42068384",
    "canonical_key": "pmid:42068384",
    "headline": "Evaluation of the predictive and prognostic potential of blood immune cell profiles in metastatic cancer patients treated with immune checkpoint inhibitors.",
    "summary": "Cancer immunology, immunotherapy : CII. Cancer Immunol Immunother. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42068384/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cancer immunology, immunotherapy : CII",
    "pmid": "42068384",
    "doi": "10.1007/s00262-026-04404-0",
    "preprint_id": "",
    "authors": "Nurmela V; Schroderus AM; Tiainen S; Kuittinen O; Tenhunen O; Jokimäki A; Suoranta S; Pasonen-Seppänen S; Sievänen T; Kinnunen T; Rönkä A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "window_start": "2026-05-01T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 5,
    "score": 24,
    "id": "pubmed:42068444",
    "canonical_key": "pmid:42068444",
    "headline": "Evidence of anti-corticotroph autoantibodies in Down syndrome with isolated adrenocorticotropic hormone deficiency: findings from a single case.",
    "summary": "Endocrine. Endocrine. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42068444/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Endocrine",
    "pmid": "42068444",
    "doi": "10.1007/s12020-026-04629-0",
    "preprint_id": "",
    "authors": "Watanabe M; Urai S; Bando H; Yamamoto M; Iguchi G; Ogawa W",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "window_start": "2026-05-01T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 6,
    "score": 24,
    "id": "medrxiv:10.64898/2026.04.30.26352160",
    "canonical_key": "doi:10.64898/2026.04.30.26352160",
    "headline": "Frequency and Medical Costs of Hypersensitivity- and Anaphylaxis-Related Adverse Events for Different Intravenous Iron Products Using the US Food and Drug Administration Adverse Event Reporting System (FAERS)",
    "summary": "BackgroundIn the United States (US), several intravenous (IV) iron products are available for treatment of iron deficiency, including low-molecular-weight iron dextran (LMWID), iron sucrose (IS), ferumoxytol (FM), ferric carboxymaltose (FCM), ferric derisomaltose (FD), and sodium ferric gluconate (FG).",
    "url": "https://doi.org/10.64898/2026.04.30.26352160",
    "source": "medRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.30.26352160",
    "preprint_id": "medrxiv:10.64898/2026.04.30.26352160",
    "authors": "Wang, Y.; Numan, S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "medRxiv",
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    "keywords": "medrxiv; epidemiology"
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    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 7,
    "score": 24,
    "id": "pubmed:42069610",
    "canonical_key": "pmid:42069610",
    "headline": "Generation and single-cell characterization of functional megakaryocytes derived from umbilical cord blood.",
    "summary": "Stem cell research & therapy. Stem Cell Res Ther. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069610/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Stem cell research & therapy",
    "pmid": "42069610",
    "doi": "10.1186/s13287-026-05047-9",
    "preprint_id": "",
    "authors": "He Y; Liang Y; He J; Shen Y; Wu Z; Pei S; Zhu F",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
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    "source_type": "papers",
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    "rank_index": 8,
    "score": 24,
    "id": "pubmed:42082118",
    "canonical_key": "pmid:42082118",
    "headline": "Genistein and the immune system: experimental evidence, key challenges, and future perspectives.",
    "summary": "Biochemical pharmacology. Biochem Pharmacol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42082118/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Biochemical pharmacology",
    "pmid": "42082118",
    "doi": "10.1016/j.bcp.2026.118024",
    "preprint_id": "",
    "authors": "Vishwa R; Aswani BS; Sajeev A; Abbas M; Alqahtani MS; Sethi G; Kunnumakkara AB",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 9,
    "score": 24,
    "id": "pubmed:42069657",
    "canonical_key": "pmid:42069657",
    "headline": "Gut microbiome modulates breast cancer risk in socially isolated mice.",
    "summary": "Breast cancer research : BCR. Breast Cancer Res. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069657/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Breast cancer research : BCR",
    "pmid": "42069657",
    "doi": "10.1186/s13058-026-02292-x",
    "preprint_id": "",
    "authors": "de Oliveira Andrade F; Staley C; Jin L; Ozgul-Onal M; McDermott M; Kenanoglu S; de Oliveira KA; Verma V; Hilakivi-Clarke L",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 10,
    "score": 24,
    "id": "pubmed:42068380",
    "canonical_key": "pmid:42068380",
    "headline": "In silico analysis of gene expression signatures and drug repurposing associated with metastatic progression in melanoma (skin cancer).",
    "summary": "Naunyn-Schmiedeberg's archives of pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42068380/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Naunyn-Schmiedeberg's archives of pharmacology",
    "pmid": "42068380",
    "doi": "10.1007/s00210-026-05403-9",
    "preprint_id": "",
    "authors": "Majeed KA; Majeed RA; Ibrahim TK; Khan NU",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 11,
    "score": 24,
    "id": "pubmed:42070314",
    "canonical_key": "pmid:42070314",
    "headline": "Knockdown of histone deacetylase 9 ameliorates immunoglobulin a nephropathy by modulating immune response.",
    "summary": "International immunopharmacology. Int Immunopharmacol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42070314/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "International immunopharmacology",
    "pmid": "42070314",
    "doi": "10.1016/j.intimp.2026.116776",
    "preprint_id": "",
    "authors": "Zhao S; Zhang B; Guo M; Ni S; Zhuang X",
    "assignee": "",
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    "primary_source": "PubMed",
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  {
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    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 12,
    "score": 24,
    "id": "biorxiv:10.64898/2026.04.29.721478",
    "canonical_key": "doi:10.64898/2026.04.29.721478",
    "headline": "LAT condensation gates PLCγ1 activation via bimodal LAT phosphorylation",
    "summary": "T cells can respond to even a single molecular binding event of antigen to a TCR. A key step in the TCR signaling pathway that definitively exhibits this single molecule response is the initiation of calcium influx by activation of PLC{gamma}1 in the LAT protein condensate.",
    "url": "https://doi.org/10.64898/2026.04.29.721478",
    "source": "bioRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
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    "doi": "10.64898/2026.04.29.721478",
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    "authors": "Ren, H.; Lee, H.-R.; Omar, Y. A. D.; DeGrandchamp, J. B.; Hung, C.-L.; Eisen, T. J.; Stamou, D.; Kuriyan, J.; Chakraborty, A. K.; Groves, J. T.",
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    "primary_source": "bioRxiv",
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    "rank_index": 13,
    "score": 24,
    "id": "pubmed:42069599",
    "canonical_key": "pmid:42069599",
    "headline": "Molecularly sculpted NIR-II nano-igniter converts local photothermal heat into systemic antitumor vaccination.",
    "summary": "Journal of nanobiotechnology. J Nanobiotechnology. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069599/",
    "source": "PubMed",
    "published_date": "2026-05-02",
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    "journal": "Journal of nanobiotechnology",
    "pmid": "42069599",
    "doi": "10.1186/s12951-026-04361-x",
    "preprint_id": "",
    "authors": "Ding Q; Liu T; Xiang C; Wang Q; Li M; Sun Y; Zhang R",
    "assignee": "",
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    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "id": "biorxiv:10.64898/2026.04.27.720974",
    "canonical_key": "doi:10.64898/2026.04.27.720974",
    "headline": "Multi-omics Characterization of Duck Embryonic Stem Cells for Cultivated Meat",
    "summary": "Industrializing cultivated meat requires cell lines with high proliferative capacity, genetic stability, and suspension adaptability. We present a comprehensive multi-omics framework, integrating genomics, transcriptomics, and proteomics, to characterize a commercial duck Embryonic Stem Cell (dESC) line.",
    "url": "https://doi.org/10.64898/2026.04.27.720974",
    "source": "bioRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.27.720974",
    "preprint_id": "biorxiv:10.64898/2026.04.27.720974",
    "authors": "Kusters, R.; Mathieu, T.; Kamgang Nzekoue, F.; Manzati, M.; Palma, J.; Chun, B.; Lester, H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
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    "keywords": "biorxiv; cell biology"
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    "source_type": "papers",
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    "score": 24,
    "id": "biorxiv:10.64898/2026.04.30.721640",
    "canonical_key": "doi:10.64898/2026.04.30.721640",
    "headline": "Myo1e/f regulate phagocytic podosomes to promote efficient cup closure in macrophages",
    "summary": "Phagocytosis requires coordinated remodeling of the actin cytoskeleton to generate protrusive and contractile forces that drive target engulfment.",
    "url": "https://doi.org/10.64898/2026.04.30.721640",
    "source": "bioRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.30.721640",
    "preprint_id": "biorxiv:10.64898/2026.04.30.721640",
    "authors": "Paul, T. C.; Loyd, Y. M.; Chase, S. E.; O'Connor, T. W.; Hobson, C. M.; Lee, R. M.; Vorselen, D.; Krendel, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
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    "source_type": "papers",
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    "rank_index": 16,
    "score": 24,
    "id": "pubmed:42065320",
    "canonical_key": "pmid:42065320",
    "headline": "Non-Engineered Physiologically Modulated Nanovesicles Augment Antitumor Immune Responses via Dual-Pathway T Cell Activation.",
    "summary": "Advanced materials (Deerfield Beach, Fla.). Adv Mater. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42065320/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Advanced materials (Deerfield Beach, Fla.)",
    "pmid": "42065320",
    "doi": "10.1002/adma.73231",
    "preprint_id": "",
    "authors": "Fan X; Liu F; You Q; Wang Y; Du L; Zou X; Sun F; Qi L; He Z; Sun J; Wang S; Sang L; Wang K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 17,
    "score": 24,
    "id": "pubmed:42067197",
    "canonical_key": "pmid:42067197",
    "headline": "Nucleotide-Derived Competitive Inhibitors of Ectonucleotidase CD39─A Promising Extracellular Target for Immunotherapy of Cancer.",
    "summary": "Journal of medicinal chemistry. J Med Chem. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42067197/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of medicinal chemistry",
    "pmid": "42067197",
    "doi": "10.1021/acs.jmedchem.6c00054",
    "preprint_id": "",
    "authors": "Bi C; Schwermer F; Schäkel L; Mirza S; Baburi H; Riziki P; Schmies CC; Winzer R; Idris R; Rolshoven G; Schilling J; Luckenbach L; Pelletier J; Brusoni LS; Al Hroub H; Al Hamwi G; Lopez V; Ahmadsay A; Raulien L; Sylvester K; Sévigny J; Tolosa E; Guse AH; Müller CE",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
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    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 18,
    "score": 24,
    "id": "pubmed:42068580",
    "canonical_key": "pmid:42068580",
    "headline": "Oleanolic acid ameliorates collagen induced arthritis in rats through the gut microbiota.",
    "summary": "The Journal of pharmacy and pharmacology. J Pharm Pharmacol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42068580/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "The Journal of pharmacy and pharmacology",
    "pmid": "42068580",
    "doi": "10.1093/jpp/rgag040",
    "preprint_id": "",
    "authors": "Liu C; Zhao Y; Su X; Sun Y; Jia Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 19,
    "score": 24,
    "id": "pubmed:42085638",
    "canonical_key": "pmid:42085638",
    "headline": "Oncolytic Herpes Virus G47∆ Potentiates ADCC-Inducing Molecular Targeted Therapy via Coordinated Activation of Innate and Adaptive Immune Responses.",
    "summary": "Molecular cancer therapeutics. Mol Cancer Ther. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42085638/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Molecular cancer therapeutics",
    "pmid": "42085638",
    "doi": "10.1158/1535-7163.MCT-25-1350",
    "preprint_id": "",
    "authors": "Nagatomo T; Iwai M; Tanaka M; Nishino H; Todo T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 24,
    "id": "pubmed:42081979",
    "canonical_key": "pmid:42081979",
    "headline": "Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in X-linked Hyper IgM Syndrome: A Multicenter Chinese Cohort Study from CCBMT.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081979/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Transplantation and cellular therapy",
    "pmid": "42081979",
    "doi": "10.1016/j.jtct.2026.04.023",
    "preprint_id": "",
    "authors": "Yu U; Zhou C; Tang X; Sun Y; Liu R; Xiong H; Zhu Y; Qian X; Dou Y; Wang P; Wang Z; Zhai X; Yu J; Chen J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
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    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 21,
    "score": 24,
    "id": "biorxiv:10.64898/2026.04.28.717272",
    "canonical_key": "doi:10.64898/2026.04.28.717272",
    "headline": "Oxidative DNA lesions destabilize centromeres and drive chromosome instability",
    "summary": "Centromeres are essential regions of the genome that ensure chromosome segregation during mitosis. Yet, they are also hotspots for chromosome breaks and rearrangements in cancer. The mechanisms underlying this fragility is not fully elucidated.",
    "url": "https://doi.org/10.64898/2026.04.28.717272",
    "source": "bioRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.28.717272",
    "preprint_id": "biorxiv:10.64898/2026.04.28.717272",
    "authors": "Thompson, L.; Nassar, R.; Angrisani, A.; Hsiu, O. O. N.; Yang, Y.; Kedziora, K. M.; Muoio, D.; Fachinetti, D.; Stallaert, w.; Fouquerel, E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
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  {
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    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 22,
    "score": 24,
    "id": "europepmc:IND609455424",
    "canonical_key": "url:https://europepmc.org/article/agr/ind609455424",
    "headline": "Paeoniae Radix Alba polysaccharides: Structural characterization, macrophage immunomodulation, and potent vaccine adjuvant activity",
    "summary": "Zhao M, Wang Y, Guan R, Qin S, Li G, Wang J, Wang Z, Shang J, Xu L, Lin Q, Ding Y, Ma X, Xu W.",
    "url": "https://europepmc.org/article/AGR/IND609455424",
    "source": "Europe PMC / AGR",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Carbohydrate polymers.",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhao M;  Wang Y;  Guan R;  Qin S;  Li G;  Wang J;  Wang Z;  Shang J;  Xu L;  Lin Q;  Ding Y;  Ma X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / AGR",
    "secondary_coverage": "",
    "keywords": "europe pmc; journal article"
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  {
    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 23,
    "score": 24,
    "id": "pubmed:42070936",
    "canonical_key": "pmid:42070936",
    "headline": "Pattern-based histologic approach in colitis without chronic architectural damage: GIPAD recommendations.",
    "summary": "Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. Dig Liver Dis. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42070936/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver",
    "pmid": "42070936",
    "doi": "10.1016/j.dld.2026.04.008",
    "preprint_id": "",
    "authors": "Panarese I; Spaggiari P; Albarello L; Arpa G; Gambella A; Grillo F; Vanoli A; Mastracci L; Giordano C; Vasuri F; Ambu R; Mescoli C; Arborea G; Bossa F; Savarino EV; Caputo A; Reggiani-Bonetti L; Rosini F; Di Sabatino A; Fassan M; Parente P",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 24,
    "score": 24,
    "id": "pubmed:42062862",
    "canonical_key": "pmid:42062862",
    "headline": "Peripheral immune signatures associated with invasive behavior in pituitary neuroendocrine tumor: a blood-based analysis.",
    "summary": "BMC immunology. BMC Immunol. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42062862/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "BMC immunology",
    "pmid": "42062862",
    "doi": "10.1186/s12865-026-00840-w",
    "preprint_id": "",
    "authors": "Liu H; Wu L; Chen C; Liu J; Li F; Chen L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 24,
    "id": "pubmed:42085861",
    "canonical_key": "pmid:42085861",
    "headline": "Persistence of Campylobacter fetus subsp. venerealis in the reproductive tract of vaccinated heifers after experimental infection: Insights into vaginal mucosal immunity in heifers.",
    "summary": "Veterinary immunology and immunopathology. Vet Immunol Immunopathol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42085861/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Veterinary immunology and immunopathology",
    "pmid": "42085861",
    "doi": "10.1016/j.vetimm.2026.111131",
    "preprint_id": "",
    "authors": "Scioli MV; Sosa E; Barale J; Azaldegui I; Méndez A; Paolicchi F; García JA",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-02",
    "window_start": "2026-05-01T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 26,
    "score": 24,
    "id": "pubmed:42069769",
    "canonical_key": "pmid:42069769",
    "headline": "Personalized tacrolimus therapy in allogeneic hematopoietic stem cell transplantation: from pharmacokinetic variability to novel control strategies.",
    "summary": "Journal of pharmaceutical health care and sciences. J Pharm Health Care Sci. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069769/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of pharmaceutical health care and sciences",
    "pmid": "42069769",
    "doi": "10.1186/s40780-026-00581-3",
    "preprint_id": "",
    "authors": "Yoshikawa N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "window_start": "2026-05-01T05:15:00.000Z",
    "window_end": "2026-05-02T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 27,
    "score": 24,
    "id": "biorxiv:10.64898/2026.04.29.721300",
    "canonical_key": "doi:10.64898/2026.04.29.721300",
    "headline": "Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies",
    "summary": "Dual-specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) modulates the cell cycle, cell fate during development, and is deregulated in cancer and metabolic syndrome. However, only a few DYRK1B substrates have been defined, so we undertook a phosphoproteomics screen in cells that exhibit inducible DYRK1B expression.",
    "url": "https://doi.org/10.64898/2026.04.29.721300",
    "source": "bioRxiv",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.29.721300",
    "preprint_id": "biorxiv:10.64898/2026.04.29.721300",
    "authors": "Ashford, A. L.; Ber, S.; Ems, M. S.; Duncan, E.; Balmanno, K.; Reeves, H.; Huntly, R.; Cassidy, M. A.; Johnston, H. E.; Oxley, D.; Nthiga, T. M.; Johansen, T.; Kluge, M.; Jacob, R.; Lauth, M.; Cook, S. J.",
    "assignee": "",
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    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
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    "source_type": "papers",
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    "rank_index": 28,
    "score": 24,
    "id": "pubmed:42069714",
    "canonical_key": "pmid:42069714",
    "headline": "Preexisting IgG forms immune complexes and links local thermal reactogenicity with immunogenicity in influenza vaccination.",
    "summary": "NPJ vaccines. NPJ Vaccines. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069714/",
    "source": "PubMed",
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    "headline": "Individualized Mechanistic Modeling Reveals Viral Infectivity and CD8+ T cell Expansion as Drivers of Heterogeneous Influenza Dynamics",
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    "headline": "Nuclear mTOR-Polycomb synergism at developmental gene promoters prone to activation",
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    "headline": "Palbociclib Enhances Radiotherapy Efficacy by Promoting Apoptosis and Immune Modulation in Oral Squamous Cell Carcinoma.",
    "summary": "International journal of radiation oncology, biology, physics. Int J Radiat Oncol Biol Phys. 2026-05-03",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42086124/",
    "source": "PubMed",
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    "authors": "Lee PY; Lee PH; Tu HF; Liao TL; Chung YH; Chiang IT; Hsu FT",
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    "headline": "Placental CD4⁺ T cells from women with gestational diabetes recapitulate disease features in a pregnant rat model, improved by metformin or mitotempo.",
    "summary": "Hypertension in pregnancy. Hypertens Pregnancy. 2026-05-03",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42070109/",
    "source": "PubMed",
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    "journal": "Hypertension in pregnancy",
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    "doi": "10.1080/10641955.2026.2665113",
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    "authors": "Frieson D; Vel J; Johnson T; Campbell N; Zheng B; Belk S; Dodd C; Butler K; Lamarca B; Deer E",
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    "headline": "Potential association of HLA and KIR genetic profiles with resistance to HIV infection in high-risk men who have sex with men",
    "summary": "ABSTRACT Understanding the immune response against HIV-1 and the natural resistance exhibited by HIV-exposed Seronegative Individuals (HESN) offers the possibility of proposing new control strategies. Several studies suggest an important role of HLA and KIR genes in protecting against HIV-1 infection.",
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    "authors": "Ossa-Giraldo, A. C.; Blanquiceth, Y.; Florez-Alvarez, L.; Penata, A.; Bustamante, J.; Marin, N. D.; Rojas, W.; Hernandez, J. C.; Zapata, W.",
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    "primary_source": "medRxiv",
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    "headline": "Targeting ZC3H12C improves T cell persistence and antitumor function in adoptive T cell therapy",
    "summary": "Adoptive T cell therapy (ACT) has achieved remarkable clinical responses in hematologic malignancies but remains limited by progressive T cell dysfunction under chronic antigen stimulation.",
    "url": "https://doi.org/10.64898/2026.04.30.721618",
    "source": "bioRxiv",
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    "journal": "bioRxiv",
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    "doi": "10.64898/2026.04.30.721618",
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    "authors": "Kavishwar, G.; Perl, M.; Heuser-Loy, C.; Knoedler, L.; Shah, D.; Mastrogiovanni, F.; Herfeld, K.; Noronha, P.; Kovacs-Sautter, M.; Krieger, M.; Loipfinger, S.; Silveira, C. R. F.; Goettert, S.; Schelker, R.; Becker, L.-M.; Vadasz, T.; Gerlach, C.; Lutzny-Geier, G.; Gattinoni, L.; Poeck, H.; Schmidl, C.",
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    "headline": "The autophagy-inhibitory tissue hormone DBI/ACBP is essential for glucocorticoid-induced immunosuppression.",
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    "source": "PubMed",
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    "journal": "Autophagy",
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    "authors": "Shen Z; Pan H; Zhao L; Liu P; Kepp O; Maiuri MC; Ma Y; Martins I; Kroemer G",
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    "headline": "The TET-dependent DNA demethylation pathway is the driving force of hematopoiesis",
    "summary": "A complex network of signaling cascades regulates the differentiation of hematopoietic stem and progenitor cells (HSPCs) into mature blood cells during hematopoiesis. We demonstrated that DNA demethylation driven by Ten-Eleven Translocation (TET) enzymes controls the activity of multiple of these signaling cascades.",
    "url": "https://doi.org/10.64898/2026.04.29.721744",
    "source": "bioRxiv",
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    "doi": "10.64898/2026.04.29.721744",
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    "authors": "Dvoriantchikova, G.; Fleishaker, M.; Barreras, H.; Levy, R. B.; Ivanov, D.",
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    "headline": "The value of preoperative CD4(+) T-cell count in predicting infectious complications after endoscopic lithotripsy for upper urinary tract calculi among human immunodeficiency virus-infected patients.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42071191/",
    "source": "PubMed",
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    "authors": "Lai P; Shao E; Zhu Z; Ma J; Chen K; Wang W",
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    "headline": "Third-Party Viral Specific T cells for Immunocompromised Hosts and Access Barriers: A Review and Commentary by an Expert Panel from ASTCT.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081980/",
    "source": "PubMed",
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    "journal": "Transplantation and cellular therapy",
    "pmid": "42081980",
    "doi": "10.1016/j.jtct.2026.04.027",
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    "authors": "Davies SM; Blyth E; Bollard CM; Craddock J; Dahi PB; Gottlieb D; Grimley MB; Keller MD; Khoury R; Olson AL; Rezvani K; Rubinstein JD; Sampson ME; Shpall EJ; Spivey SM; Vasileiou S; Heslop HE",
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    "canonical_key": "pmid:42070504",
    "headline": "TMEM72 Inhibits the proliferation by promoting cellular senescence through the activation of the P38/MAPK signaling pathway in renal cell carcinoma.",
    "summary": "Translational oncology. Transl Oncol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42070504/",
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    "journal": "Translational oncology",
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    "doi": "10.1016/j.tranon.2026.102789",
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    "authors": "Dai F; Wang H; Chu W; Lin Y; He J; Wen H; Feng X; Liu X; Xu Z; Bi L; Lyu Z",
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    "score": 24,
    "id": "pubmed:42069521",
    "canonical_key": "pmid:42069521",
    "headline": "Urobiome composition after renal transplantation: an exploratory study.",
    "summary": "BMC microbiology. BMC Microbiol. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069521/",
    "source": "PubMed",
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    "journal": "BMC microbiology",
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    "doi": "10.1186/s12866-026-05106-4",
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    "authors": "Harriman D; Ng A; Bronowski M; Yang R; Dang T; Sherwood K; Nguan C; Miller A; Lange D",
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    "headline": "Valemetostat is efficacious against recurrent adult T-cell leukemia/lymphoma skin lesions and cutaneous GVHD.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081978/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "doi": "10.1016/j.jtct.2026.04.008",
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    "authors": "Matsuoka Y; Fuji S; Hosoya M; Amemiya Y; Nakahara W; Tada Y; Shingai Y; Yuda S; Satomi H; Honma K; Ishikawa J; Yokota T",
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    "headline": "Impaired suppressive effect of FoxP3 regulatory T cells on B cells in multiple sclerosis.",
    "summary": "Journal of neuroinflammation. J Neuroinflammation. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42069653/",
    "source": "PubMed",
    "published_date": "2026-05-02",
    "match_reason": "Downranked for Non-therapeutic broad immunology: inflammation",
    "journal": "Journal of neuroinflammation",
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    "authors": "Greeck VB; Würthwein C; Mimura K; Mattes K; Kutza M; Schirmer L; Fairless R; Williams SK; Jarius S; Haas J; Ruprecht K; Wildemann B",
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    "id": "pubmed:42069634",
    "canonical_key": "pmid:42069634",
    "headline": "Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation.",
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    "authors": "Shi G; Tan R; Cao Y; Zheng X; Zhan R",
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    "headline": "Development of Chimeric Antigen Receptor-Modified NK Cells for the Immunotherapy of Adult T-Cell Leukemia/Lymphoma.",
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    "match_reason": "Downranked for Generic T cell biology without antigen specificity: nk cell",
    "journal": "European journal of haematology",
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    "authors": "Uchida Y; Tateo S; Wakao M; Shinchi H; Sawayama H; Fukumoto A; Yoshimitsu M; Suda Y",
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    "headline": "Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42068336/",
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    "journal": "Cancer immunology, immunotherapy : CII",
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    "doi": "10.1007/s00262-026-04403-1",
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    "authors": "Li C; Zhang P; Zhao X; Feng R; Xian N; Huang G; Jiang W; Hu Z; Zhang Y; Ji N",
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    "headline": "Immune landscape characterization of neurofibromas with atypical features in Neurofibromatosis1 reveals PD-1 and the Tim-3/Galectin-9 pathway as potential therapeutic targets.",
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    "authors": "Brunet A; Coulpier F; Onfroy A; Sako N; Radomska KJ; Aftimos V; Lacroix L; Briand-Suleau A; Maille P; Hermeziu O; Laurendeau I; Pasmant E; Wolkenstein P; Topilko P; Ortonne N",
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    "headline": "In vivo CRISPR-based screen identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors",
    "summary": "CAR-T cell therapy has shown limited efficacy in solid tumors, largely due to T cell dysfunction driven by chronic antigen exposure. To uncover mediators of this dysfunction, we developed an in vivo screening platform using an ovarian xenograft tumor model in which CD28-based CAR-T cells undergo exhaustion leading to tumor escape.",
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    "authors": "Barbao, P.; Rodriguez-Garcia, A.; Galindo-Albarran, A.; Gimenez-Alejandre, M.; Clavero, P.; Lobo-Jarne, T.; Botas, M.; Colell, G.; Castellsague, J.; Cascallo, G.; Andreu-Saumell, I.; Soria-Castellano, M.; Colell, S.; Marzal, B.; Martin-Mur, B.; Esteve-Codina, A.; Urbano-Ispizua, A.; Prat, A.; Gattinoni, L.; Mendoza-Parra, M.; Guedan, S.",
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    "headline": "Constitutive STAT3 Signaling, in Comparison with STAT5, Enhances CAR T-cell Efficacy and Lowers Systemic Toxicity.",
    "summary": "Cancer immunology research. Cancer Immunol Res. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41758968/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Clinical or translational importance: toxicity",
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    "pmid": "41758968",
    "doi": "10.1158/2326-6066.CIR-25-0611",
    "preprint_id": "",
    "authors": "Zhang H; Ito Y; Kasuya H; Hayakawa T; Li Y; Inoue S; Ouchida T; Kagoya Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "id": "pubmed:42082201",
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    "headline": "Efficacy and Safety of T Cell-Targeted Immunotherapy in Newly Diagnosed Type 1 Diabetes: A Systematic Review and Meta-Analysis.",
    "summary": "Diabetes, obesity & metabolism. Diabetes Obes Metab. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42082201/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Clinical or translational importance: safety",
    "journal": "Diabetes, obesity & metabolism",
    "pmid": "42082201",
    "doi": "10.1111/dom.70829",
    "preprint_id": "",
    "authors": "Wang Y; Zhou Y; Zhu M; Wang X; Shi X; Li X; Huang G; Li L; Xie Z; Zhou Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "headline": "Engineered CCR7 Overexpression Enhances Nodal CAR T-cell Homing and Cytotoxicity toward B-cell Lymphoma.",
    "summary": "Cancer immunology research. Cancer Immunol Res. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41733597/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Clinical or translational importance: toxicity",
    "journal": "Cancer immunology research",
    "pmid": "41733597",
    "doi": "10.1158/2326-6066.CIR-25-1381",
    "preprint_id": "",
    "authors": "Zschummel M; Bunse M; Spierling AL; Li A; Joedicke JJ; Margineanu A; Blachut S; Lindberg EL; Ruiz-Orera J; Hübner N; Rehm A; Höpken UE",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "id": "pubmed:42082272",
    "canonical_key": "pmid:42082272",
    "headline": "Phase 2 study of palbociclib plus retifanlimab in patients with advanced dedifferentiated liposarcoma.",
    "summary": "Journal for immunotherapy of cancer. J Immunother Cancer. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42082272/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Clinical or translational importance: phase 2",
    "journal": "Journal for immunotherapy of cancer",
    "pmid": "42082272",
    "doi": "10.1136/jitc-2025-014346",
    "preprint_id": "",
    "authors": "Rosenbaum E; Seier K; Gularte-Mérida R; Seffar E; Dickson MA; Avutu V; Banks LB; Chan JE; Chi P; Gounder MM; Kelly CM; Keohan ML; Maki RG; Movva S; Reed D; Desir R; Biniakewitz M; Cho JM; Duchemin M; Erinjeri JP; Lefkowitz RA; Koff A; Singer S; Tap W; Qin LX; D'Angelo S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed"
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    "source_type": "papers",
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    "rank_index": 5,
    "score": 42,
    "id": "pubmed:42082270",
    "canonical_key": "pmid:42082270",
    "headline": "Safety and immunogenicity of a tri-antigen vaccine targeting IGFBP-2, HER2, and IGF-IR in participants with non-metastatic breast cancer.",
    "summary": "Journal for immunotherapy of cancer. J Immunother Cancer. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42082270/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Clinical or translational importance: safety",
    "journal": "Journal for immunotherapy of cancer",
    "pmid": "42082270",
    "doi": "10.1136/jitc-2025-014314",
    "preprint_id": "",
    "authors": "Stanton SE; Cecil DL; Bailey HH; Liu Y; Gwin WR; Colveler AL; Liao JB; Wisinski KB; Barroilhet L; Kim K; Havighurst TC; DeShong K; Twaroski K; Childs JS; Dimond E; Wojtowicz M; Heckman-Stoddard BM; Disis ML",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed"
  },
  {
    "digest_date": "2026-05-04",
    "window_start": "2026-05-03T05:15:00.000Z",
    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 1,
    "score": 42,
    "id": "pubmed:42071008",
    "canonical_key": "pmid:42071008",
    "headline": "Total neoadjuvant chemotherapy combined with PD‑1 blockade and IL‑2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II study.",
    "summary": "Signal transduction and targeted therapy. Signal Transduct Target Ther. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42071008/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Clinical or translational importance: phase i",
    "journal": "Signal transduction and targeted therapy",
    "pmid": "42071008",
    "doi": "10.1038/s41392-026-02683-8",
    "preprint_id": "",
    "authors": "Tang J; Wang L; Yang S; Peng W; Zhang Y; Zhang Y; Jin K; Wang X; Feng Y; Sun Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  },
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    "window_start": "2026-05-03T05:15:00.000Z",
    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 2,
    "score": 42,
    "id": "pubmed:41416402",
    "canonical_key": "pmid:41416402",
    "headline": "Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.",
    "summary": "Molecular cancer therapeutics. Mol Cancer Ther. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41416402/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Clinical or translational importance: toxicity",
    "journal": "Molecular cancer therapeutics",
    "pmid": "41416402",
    "doi": "10.1158/1535-7163.MCT-25-0005",
    "preprint_id": "",
    "authors": "Rahmati P; Bonifacius A; Dragon AC; Malinconico C; Floegel F; Halenius A; Blasczyk R; Maecker-Kolhoff B; Hudecek M; Floess S; Huehn J; Eiz-Vesper B",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 3,
    "score": 24,
    "id": "pubmed:42080285",
    "canonical_key": "pmid:42080285",
    "headline": "A Colloidal Quantum Dot Thermistor and Bolometer.",
    "summary": "Advanced materials (Deerfield Beach, Fla.). Adv Mater. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42080285/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Advanced materials (Deerfield Beach, Fla.)",
    "pmid": "42080285",
    "doi": "10.1002/adma.202519385",
    "preprint_id": "",
    "authors": "Kumar G; Dalmases M; Taghipour N; Bera R; Whitworth GL; Torres Perez G; Dosil M; Konstantatos G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "window_start": "2026-05-03T05:15:00.000Z",
    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 4,
    "score": 24,
    "id": "pubmed:42080357",
    "canonical_key": "pmid:42080357",
    "headline": "A Nanobody-LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy.",
    "summary": "Advanced science (Weinheim, Baden-Wurttemberg, Germany). Adv Sci (Weinh). 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42080357/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
    "pmid": "42080357",
    "doi": "10.1002/advs.202523024",
    "preprint_id": "",
    "authors": "Qin S; Huang Z; Huang H; Zhang Y; Chen Y; He X; Niu Z; Xiang Z; Zou C; Song X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "rank_index": 5,
    "score": 24,
    "id": "pubmed:42081292",
    "canonical_key": "pmid:42081292",
    "headline": "A systematic analysis of the inherent dose uncertainty in autologous CAR T-cell products.",
    "summary": "Journal of biopharmaceutical statistics. J Biopharm Stat. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081292/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of biopharmaceutical statistics",
    "pmid": "42081292",
    "doi": "10.1080/10543406.2026.2664711",
    "preprint_id": "",
    "authors": "Choi S; Dave K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "rank_index": 6,
    "score": 24,
    "id": "europepmc:PPR1184958",
    "canonical_key": "doi:10.21203/rs.3.rs-9461073/v1",
    "headline": "Ancestry-Stratified Transcriptome-Wide Association Study Reveals Tissue-Specific Mechanisms of Type 2 Diabetes Heterogeneity",
    "summary": "Cheung N.",
    "url": "https://doi.org/10.21203/rs.3.rs-9461073/v1",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "",
    "pmid": "",
    "doi": "10.21203/rs.3.rs-9461073/v1",
    "preprint_id": "",
    "authors": "Cheung N.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
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  {
    "digest_date": "2026-05-04",
    "window_start": "2026-05-03T05:15:00.000Z",
    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 7,
    "score": 24,
    "id": "pubmed:41661680",
    "canonical_key": "pmid:41661680",
    "headline": "Androgen Receptor Signaling Induces CD8+ T-cell Dysfunction That Is Reversed by Androgen Deprivation Therapy in Male Head and Neck Squamous Cell Carcinoma.",
    "summary": "Cancer research. Cancer Res. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41661680/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cancer research",
    "pmid": "41661680",
    "doi": "10.1158/0008-5472.CAN-25-2384",
    "preprint_id": "",
    "authors": "Wang Q; Tan Z; Zheng C; Xu J; Li Q; Hong S; Yu D; Hu X; Wang J; Jiang L; Huang P; Zhang Y; Ge M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "window_start": "2026-05-03T05:15:00.000Z",
    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 8,
    "score": 24,
    "id": "pubmed:42085930",
    "canonical_key": "pmid:42085930",
    "headline": "Antibody-mediated targeting of SOSIP HIV-1 Env to skin Langerhans cells potentiates humoral responses.",
    "summary": "EBioMedicine. EBioMedicine. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42085930/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "EBioMedicine",
    "pmid": "42085930",
    "doi": "10.1016/j.ebiom.2026.106269",
    "preprint_id": "",
    "authors": "Hammoudi A; Surenaud M; Legros J; Picard F; Hypolite G; Manso J; Agyar T; Kembou A; Esposito M; Sicherre E; Flor G; Pedenko B; Guilligay D; Bouceba T; Fenwick C; Moog C; Zurawski S; Zurawski G; Pantaleo G; Weissenhorn W; Centlivre M; Godot V; Lévy Y; Cardinaud S",
    "assignee": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 9,
    "score": 24,
    "id": "pubmed:42082707",
    "canonical_key": "pmid:42082707",
    "headline": "Artificial intelligence-powered H&E-based quantification of spatial tumor-infiltrating lymphocyte distribution identifies prognostic immune niches in colorectal cancer.",
    "summary": "Cancer immunology, immunotherapy : CII. Cancer Immunol Immunother. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42082707/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cancer immunology, immunotherapy : CII",
    "pmid": "42082707",
    "doi": "10.1007/s00262-026-04409-9",
    "preprint_id": "",
    "authors": "Koh HH; Lee S; Oum C; Song S; Cho SI; Pereira S; Ahn CH; Kim JY; Kim M; Jung M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "window_start": "2026-05-03T05:15:00.000Z",
    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 10,
    "score": 24,
    "id": "pubmed:41263056",
    "canonical_key": "pmid:41263056",
    "headline": "AXL Kinase Inhibition Promotes Cytosolic DNA Sensor cGAS Activity and Sensitizes Poorly Immunogenic Tumors to Chemo-Immunotherapy.",
    "summary": "Molecular cancer therapeutics. Mol Cancer Ther. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41263056/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Molecular cancer therapeutics",
    "pmid": "41263056",
    "doi": "10.1158/1535-7163.MCT-24-0440",
    "preprint_id": "",
    "authors": "Dhakal S; Siraji MI; Grøndal SM; Skarsten GN; Moutoussamy EE; Gausdal G; Lorens JB; Bougnaud S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "window_start": "2026-05-03T05:15:00.000Z",
    "window_end": "2026-05-04T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 11,
    "score": 24,
    "id": "pubmed:41914851",
    "canonical_key": "pmid:41914851",
    "headline": "B Cells and Tertiary Lymphoid Structures as Integral Components of the Cancer Immunity Cycle.",
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    "headline": "Harnessing pre-existing measles immunity: mRNA-Lipid nanoparticle-mediated measles hemagglutinin expression boosts antitumor CD8⁺ T cell responses.",
    "summary": "Signal transduction and targeted therapy. Signal Transduct Target Ther. 2026-05-04",
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    "authors": "Martínez-Latorre J; Soriano-Teruel PM; Candela-Noguera V; Acúrcio RC; Florindo HF; García-Fernández A; Martínez-Máñez R",
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    "headline": "High frequency of CD95(+)/CD45RA(-) regulatory T cells defines an immunosuppressive profile associated with MDS progression.",
    "summary": "British journal of haematology. Br J Haematol. 2026-05-04",
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    "source": "PubMed",
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    "journal": "British journal of haematology",
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    "authors": "Vazquez R; Deredec N; Boussaid I; Boncoeur P; Knosp C; Houvert A; Zalmai L; Friedrich C; Almire C; Dussiau C; Willems L; Birsen R; Decroocq J; Bouscary D; Kosmider O; Kordasti S; Fontenay M; Simoni Y; Chapuis N",
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    "headline": "High-Temperature Transparent Polymer Heater Based on n-Doped Poly(benzodifurandione).",
    "summary": "ACS applied materials & interfaces. ACS Appl Mater Interfaces. 2026-05-04",
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    "source": "PubMed",
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    "authors": "Romo JA; Lee WJ; Gaitonde A; You L; Cerjan B; Flagg LQ; Sunday D; Snyder CR; DeLongchamp DM; Marconnet AM; Mei J",
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    "headline": "Hippocampal ripple-mediated convergence of spatial codes drives the emergence of cortical contextual representations",
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    "headline": "IgG2a-formatted 4-1BB agonism combined with S100A9 inhibition enhances T cell activation and tumor control in a preclinical model of multiple myeloma.",
    "summary": "Journal of experimental & clinical cancer research : CR. J Exp Clin Cancer Res. 2026-05-04",
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    "journal": "Journal of experimental & clinical cancer research : CR",
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    "doi": "10.1186/s13046-026-03716-4",
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    "authors": "Satilmis H; Denis A; Verheye E; Van der Vreken A; Zhan D; Calliauw E; Törngren M; Eriksson H; Faict S; De Bruyne E; Menu E; Vanderkerken K; De Veirman K",
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    "id": "pubmed:41499552",
    "canonical_key": "pmid:41499552",
    "headline": "IL10R Inhibition Induces Neutrophil Tumoricidal Activity.",
    "summary": "Cancer immunology research. Cancer Immunol Res. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41499552/",
    "source": "PubMed",
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    "journal": "Cancer immunology research",
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    "doi": "10.1158/2326-6066.CIR-25-0834",
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    "authors": "Khalil DN; Gomez R; Regev A; Samaan F; Marouf Y; Budhu S; Hirschhorn D; Schulze I; Lavery JA; Ceglia N; Freeman SS; Maltez VI; Garcia JM; Suek N; Weng CH; Cabanski CR; Monette S; Romin Y; Li Y; Chaligne R; Yellin MJ; Keler T; Maurer DM; Flamar AL; Morgado-Palacin L; Mangarin LM; Harding JJ; Park W; Lyman JP; Maddock S; O'Hara MH; Abou-Alfa GK; Vonderheide RH; O'Reilly EM; Germain RN; Wolchok JD; Merghoub T",
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    "id": "pubmed:41824510",
    "canonical_key": "pmid:41824510",
    "headline": "IL1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma.",
    "summary": "Cancer immunology research. Cancer Immunol Res. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41824510/",
    "source": "PubMed",
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    "journal": "Cancer immunology research",
    "pmid": "41824510",
    "doi": "10.1158/2326-6066.CIR-25-0651",
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    "authors": "Mariancini A; Supino D; Mapelli SN; Meral A; Carnevale S; Di Ceglie I; Pezone G; Ventura M; Dambra M; Swatler J; Di Donato R; Albano F; Bonecchi R; Rigatelli A; Scavello F; Grieco G; Riva F; Gabay C; Mantovani A; Jaillon S; Magrini E; Garlanda C",
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    "canonical_key": "pmid:42082178",
    "headline": "Immunohistochemical Evaluation of GATA3 Expression in Patch-Stage Mycosis Fungoides (MF) Compared With Benign Inflammatory Dermatoses (BID).",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42082178/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of cutaneous pathology",
    "pmid": "42082178",
    "doi": "10.1111/cup.70117",
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    "authors": "Montazer F; Malekan M; Abedi H",
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    "id": "pubmed:42081143",
    "canonical_key": "pmid:42081143",
    "headline": "In silico design and immunogenicity evaluation of a multi-epitope vaccine against EV-A71.",
    "summary": "Journal of computer-aided molecular design. J Comput Aided Mol Des. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081143/",
    "source": "PubMed",
    "published_date": "2026-05-04",
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    "journal": "Journal of computer-aided molecular design",
    "pmid": "42081143",
    "doi": "10.1007/s10822-026-00822-5",
    "preprint_id": "",
    "authors": "Wang X; Chen X",
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    "score": 24,
    "id": "pubmed:42030029",
    "canonical_key": "pmid:42030029",
    "headline": "In vitro prediction of the immunogenicity of therapeutic proteins: state of the art and current challenges and perspectives.",
    "summary": "Expert opinion on drug discovery. Expert Opin Drug Discov. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42030029/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Expert opinion on drug discovery",
    "pmid": "42030029",
    "doi": "10.1080/17460441.2026.2665791",
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    "authors": "Fardel O; Mahfoudhi E; Launay L; Moreau A; Denizot C; Malnoë D; Parmentier Y",
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    "score": 24,
    "id": "pubmed:42081290",
    "canonical_key": "pmid:42081290",
    "headline": "Inhibitors of Ectonucleotidase CD39 for Immunotherapy of Cancer and Infections─Recent Developments and Future Perspectives.",
    "summary": "Journal of medicinal chemistry. J Med Chem. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081290/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of medicinal chemistry",
    "pmid": "42081290",
    "doi": "10.1021/acs.jmedchem.6c00078",
    "preprint_id": "",
    "authors": "Bi C; Schwermer F; Tang L; Müller CE; Liu W",
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    "rank_index": 39,
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    "id": "pubmed:42085844",
    "canonical_key": "pmid:42085844",
    "headline": "iNOS deficiency aggravates DNFB-induced atopic dermatitis in mice.",
    "summary": "International immunopharmacology. Int Immunopharmacol. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42085844/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "International immunopharmacology",
    "pmid": "42085844",
    "doi": "10.1016/j.intimp.2026.116750",
    "preprint_id": "",
    "authors": "Guo P; Cui H; Wang B; Shi L; Li F; Di Y; Wang S; Zhang B; Li X; Hu L",
    "assignee": "",
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    "id": "pubmed:42071248",
    "canonical_key": "pmid:42071248",
    "headline": "ISX-TWIST1 reprograms CD47-inflammasome signaling to reshape the immune microenvironment in liver cancer.",
    "summary": "Experimental hematology & oncology. Exp Hematol Oncol. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42071248/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Experimental hematology & oncology",
    "pmid": "42071248",
    "doi": "10.1186/s40164-026-00777-1",
    "preprint_id": "",
    "authors": "Wang LT; Lin MH; Li YC; Wang SN; Chai CY; Hsu JM; Chiou SS; Chiou HC; Huang SK; Hung MC; Hsu SH",
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    "rank_index": 41,
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    "id": "pubmed:42081084",
    "canonical_key": "pmid:42081084",
    "headline": "Large Vessel Vasculitis: Recent Advances in Pathophysiology and Targeted Therapies.",
    "summary": "Drugs. Drugs. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42081084/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Drugs",
    "pmid": "42081084",
    "doi": "10.1007/s40265-026-02323-z",
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    "authors": "Reisch M; Thiel J; Bosch P",
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    "id": "pubmed:42082949",
    "canonical_key": "pmid:42082949",
    "headline": "Local insights into hepatitis B Virus: genotype distribution and clinical profiles among HIV/HBV co-infected patients in Maputo, Mozambique.",
    "summary": "BMC infectious diseases. BMC Infect Dis. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42082949/",
    "source": "PubMed",
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    "journal": "BMC infectious diseases",
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    "doi": "10.1186/s12879-026-13454-9",
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    "authors": "Chambal LM; Sevene E; Nilsson C; Tchavana C; Augusto O; João JL; Manjate E; Manjate A; Piedade J; Parreira R",
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    "score": 24,
    "id": "europepmc:PPR1185259",
    "canonical_key": "doi:10.21203/rs.3.rs-8141059/v1",
    "headline": "Long-term outcomes and neutralising antibody kinetics after Tixagevimab/Cilgavimab prophylaxis in haematological patients: a real-world cohort study in Japan",
    "summary": "Ara T, Ichikawa T, Hashimoto D, Kamiyama A, Tamura T, Suzuki R, Suzuki S, Miyajima T, Hasegawa Y, Ohigashi H, Matsukawa T, Shiratori S, Goto H, Onozawa M, Nakagawa M, Kahata K, Endo T, Fukuhara T, Teshima T.",
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    "headline": "Multi-omics reveals CXCR4 drives immune escape in colorectal cancer via metabolic reprogramming and immune microenvironment remodeling.",
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    "headline": "A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8(+) T Cells.",
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    "headline": "A retrospective pharmacovigilance analysis based on the FAERS database reveals sex-associated differences in toxicities of CAR T-cell therapy.",
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    "source": "PubMed",
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    "journal": "Nature communications",
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    "authors": "Liu Y; Yang J; Iqbal M; Uyanik M; Luo M; Yang L; Lou Y; Diao L; Oluwole OO; Moslehi JJ; Johnson DB; Han L",
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    "headline": "A study to investigate HLA-G targeted exosome (SOB100) in healthy subjects.",
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    "journal": "Nanomedicine (London, England)",
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    "authors": "Yang KJ; Yu NY; Goldwater R; Chang CH; Liu CM; Kan KW; Chen YW; Cho DY; Melville D; Ho JH",
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    "headline": "Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients.",
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    "authors": "Wang X; Huang Q; Zuo Z; Wang Z; Zhang L; Qian Z",
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    "headline": "Ancestry-specific immune signatures in Parkinson's disease: a rare variant burden analysis in Montreal and Guadeloupe cohorts",
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    "url": "https://doi.org/10.64898/2026.04.24.26351405",
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    "authors": "Andriamboavonjy, L.; Labrecque, M.; Al Idrissi, L. Y.; Tressieres, B.; Veilleux Carpentier, A.; Chaumont, J.; Chaumont, H.; Gaete, S.; Ravion, S.; Duquette, A.; Chouinard, S.; Panisset, M.; Lannuzel, A.; Tetreault, M.",
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    "headline": "Author Correction: An emerging human eye disease is associated with aquatic virus zoonotic infection.",
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    "headline": "Blocking mitochondrial leucine transamination enhances T-cell activation and improves T-cell immunity against OVA-producing EL4 lymphoma.",
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    "score": 24,
    "id": "pubmed:42088926",
    "canonical_key": "pmid:42088926",
    "headline": "Acute T-cell leukemia/lymphoma presenting with leukemia cutis mimicking prurigo nodularis.",
    "summary": "JAAD case reports. JAAD Case Rep. 2026-03-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42088926/",
    "source": "PubMed",
    "published_date": "2026-03-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "JAAD case reports",
    "pmid": "42088926",
    "doi": "10.1016/j.jdcr.2026.03.014",
    "preprint_id": "",
    "authors": "Elghannam M; Osto M; Strong J; Driscoll M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 1,
    "score": 24,
    "id": "pubmed:42083322",
    "canonical_key": "pmid:42083322",
    "headline": "Adapted Live SARS-CoV-2 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5.",
    "summary": "European journal of immunology. Eur J Immunol",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42083322/",
    "source": "PubMed",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "European journal of immunology",
    "pmid": "42083322",
    "doi": "10.1002/eji.70196",
    "preprint_id": "",
    "authors": "Kochmann J; Britzke T; Halwe NJ; Ulrich L; Breithaupt A; Barut GT; Ebert N; Trüeb BS; Thiel V; Dorhoi A; Beer M; Hoffmann D; Corleis B; Schön J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 2,
    "score": 24,
    "id": "pubmed:42084518",
    "canonical_key": "pmid:42084518",
    "headline": "Adult T-Cell Leukemia/Lymphoma and Epstein-Barr Virus-Positive DLBCL: A Rare Concomitant Association.",
    "summary": "Oncology (Williston Park, N.Y.). Oncology (Williston Park). 2026-04-20",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42084518/",
    "source": "PubMed",
    "published_date": "2026-04-20",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Oncology (Williston Park, N.Y.)",
    "pmid": "42084518",
    "doi": "10.46883/2026.25921072",
    "preprint_id": "",
    "authors": "Popov VM; Grasu D; Bumbea H; Dobrea C; Mastalier B; Dumitru I; Voicu M; Andreescu M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 3,
    "score": 24,
    "id": "pubmed:42088496",
    "canonical_key": "pmid:42088496",
    "headline": "Advances in immunotherapy for renal cell carcinoma: a comprehensive review.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-20",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42088496/",
    "source": "PubMed",
    "published_date": "2026-04-20",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42088496",
    "doi": "10.3389/fimmu.2026.1715874",
    "preprint_id": "",
    "authors": "Rajih E; Bakhsh A; Borhan WM; Alqahtani SAM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 4,
    "score": 24,
    "id": "pubmed:42086354",
    "canonical_key": "pmid:42086354",
    "headline": "Analysis of risk factors for MRI-invisible prostate cancer-the significance of AGGF1 immunohistochemical detection and PSAD.",
    "summary": "The Canadian journal of urology. Can J Urol. 2026-04-15",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42086354/",
    "source": "PubMed",
    "published_date": "2026-04-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "The Canadian journal of urology",
    "pmid": "42086354",
    "doi": "10.32604/cju.2026.074814",
    "preprint_id": "",
    "authors": "Lyu J; Yue R; Tian Y; Yang B",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 5,
    "score": 24,
    "id": "pubmed:42089905",
    "canonical_key": "pmid:42089905",
    "headline": "Apremilast therapy increases CD39(+)CD4(+) T cells in peripheral blood of patients with psoriatic disease: a retrospective observational pilot study.",
    "summary": "Rheumatology international. Rheumatol Int. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42089905/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Rheumatology international",
    "pmid": "42089905",
    "doi": "10.1007/s00296-026-06114-3",
    "preprint_id": "",
    "authors": "Mavropoulos A; Tsiogkas SG; Simopoulou T; Dardiotis E; Zafiriou E; Sakkas LI; Bogdanos DP",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 6,
    "score": 24,
    "id": "pubmed:42088621",
    "canonical_key": "pmid:42088621",
    "headline": "BDKRB1 Links Copy Number-Defined Genomic Instability to Inflammatory and Immunosuppressive Tumor Ecosystems in Ovarian Cancer: An Integrative Multiomics Analysis.",
    "summary": "International journal of genomics. Int J Genomics. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42088621/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "International journal of genomics",
    "pmid": "42088621",
    "doi": "10.1155/ijog/2966274",
    "preprint_id": "",
    "authors": "Pu D; Chen H; Wang X; He S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 7,
    "score": 24,
    "id": "pubmed:42089255",
    "canonical_key": "pmid:42089255",
    "headline": "Blockade of Complement Cell Lysis and C3d Fixation by Patient HLA-A1 Antibodies: Towards a New Therapy for Prevention of Antibody-Mediated Rejection.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42089255/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "HLA",
    "pmid": "42089255",
    "doi": "10.1111/tan.70745",
    "preprint_id": "",
    "authors": "Kardol-Hoefnagel T; Akharman-Oztoprak D; van der Meijden E; Claas FH; Beurskens FJ; Otten HG",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 8,
    "score": 24,
    "id": "pubmed:42083310",
    "canonical_key": "pmid:42083310",
    "headline": "Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System.",
    "summary": "European journal of immunology. Eur J Immunol",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42083310/",
    "source": "PubMed",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "European journal of immunology",
    "pmid": "42083310",
    "doi": "10.1002/eji.70195",
    "preprint_id": "",
    "authors": "Karami Z; Hofstede HJMT; Joosten LAB",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 9,
    "score": 24,
    "id": "pubmed:42088503",
    "canonical_key": "pmid:42088503",
    "headline": "Caffeine-mediated CD39(+) Treg activation via the CD39-adenosine receptor pathway is a novel risk factor for pulmonary tuberculosis.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-20",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42088503/",
    "source": "PubMed",
    "published_date": "2026-04-20",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42088503",
    "doi": "10.3389/fimmu.2026.1784235",
    "preprint_id": "",
    "authors": "Zhu L; Zheng Z; Huang X; Lu H; Chen Z; Wu H; Peng L; Tao L; Bai Y; Yang R; Bao R; Luo S; Ma W; Song J; Tang J; Li B; Bao F; Liu A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 10,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.01.722180",
    "canonical_key": "doi:10.64898/2026.05.01.722180",
    "headline": "Cell-type specific sensing and control of firing rate statistics via channel dynamics",
    "summary": "Neurons maintain functionality through homeostatic regulation of spiking activity over extended timescales. Calcium dependent conductance expression is known to regulate mean firing rate, but this is not sufficient to ensure dynamic range in spiking activity and sensitivity to input.",
    "url": "https://doi.org/10.64898/2026.05.01.722180",
    "source": "bioRxiv",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.01.722180",
    "preprint_id": "biorxiv:10.64898/2026.05.01.722180",
    "authors": "Ramirez-Hincapie, A.; O'Leary, T.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 11,
    "score": 24,
    "id": "medrxiv:10.1101/2025.06.24.25330216",
    "canonical_key": "doi:10.1101/2025.06.24.25330216",
    "headline": "Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk",
    "summary": "Most genetic variants associated with complex diseases lie in non-coding regions, complicating efforts to identify effector genes and relevant cell types. Here, we map cis-eQTLs across 2.2 million single cells from blood and intestinal biopsies of 421 individuals, including 125 with inflammatory bowel disease (IBD).",
    "url": "https://doi.org/10.1101/2025.06.24.25330216",
    "source": "medRxiv",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.1101/2025.06.24.25330216",
    "preprint_id": "medrxiv:10.1101/2025.06.24.25330216",
    "authors": "Alegbe, T.; Harris, B. T.; Fachal, L.; Ramirez Navarro, L.; Tutert, M.; Krzak, M.; Ghouraba, M.; Strickland, M.; Ozols, M.; Cohen, C. E.; Khullar, S.; Khabirova, E.; Panousis, N. I.; Ochoa, D.; Wana, N.; Hu, M. X.; Skelton, J.; Ostermayer, J.; Cheam, K. A. X.; Taylor, D. L.; Gu, Y.; Dawson, C.; Thompson, T.; Arestang, K.; Nishad, N.; Brezina, B.; Caballes, C. Q.; Garri, W.; Leonard, S.; Iyer, V.; Parkes, M.; Wallace, C.; McIntyre, R. E.; Cotobal Martin, C.; Jones, G.-R.; Raine, T.; Anderson, C. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; genetic and genomic medicine"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 12,
    "score": 24,
    "id": "pubmed:42087070",
    "canonical_key": "pmid:42087070",
    "headline": "Comparison of Labscan 200 and FlexMap 3D Luminex for Anti-HLA Antibodies Monitoring.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42087070/",
    "source": "PubMed",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "HLA",
    "pmid": "42087070",
    "doi": "10.1111/tan.70731",
    "preprint_id": "",
    "authors": "Milhès J; Duclercq L; Blavy S; Del Bello A; Kamar N; Bouthemy C; Congy-Jolivet N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 13,
    "score": 24,
    "id": "pubmed:42087217",
    "canonical_key": "pmid:42087217",
    "headline": "Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma.",
    "summary": "Genome medicine. Genome Med. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42087217/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Genome medicine",
    "pmid": "42087217",
    "doi": "10.1186/s13073-026-01663-5",
    "preprint_id": "",
    "authors": "Wu Y; Guo X; Wang T; Zhao T; Chen S; Su Y; Li Q; Zhu J; Xia L; Ju X; Wu X; Huang S; Hu Z; Chen X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 14,
    "score": 24,
    "id": "pubmed:42090074",
    "canonical_key": "pmid:42090074",
    "headline": "Comprehensive Profiling of T- and B-Cell Receptor Repertoires Demonstrates Impaired Developmental and Activation of Adaptive Immunity in DOCK8 Deficiency.",
    "summary": "Journal of clinical immunology. J Clin Immunol. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42090074/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of clinical immunology",
    "pmid": "42090074",
    "doi": "10.1007/s10875-026-02031-z",
    "preprint_id": "",
    "authors": "Beit-Halevi T; Broides A; Lev A; Simon AJ; Nahum A; Somech R; Lee YN",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 15,
    "score": 24,
    "id": "pubmed:42087055",
    "canonical_key": "pmid:42087055",
    "headline": "Computational Design of an mRNA Vaccine Targeting LRP6 for Triple-Negative Breast Cancer Therapy.",
    "summary": "Cancer reports (Hoboken, N.J.). Cancer Rep (Hoboken)",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42087055/",
    "source": "PubMed",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cancer reports (Hoboken, N.J.)",
    "pmid": "42087055",
    "doi": "10.1002/cnr2.70567",
    "preprint_id": "",
    "authors": "Teimoori P; Heidari M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-06",
    "window_start": "2026-05-05T05:15:00.000Z",
    "window_end": "2026-05-06T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 16,
    "score": 24,
    "id": "pubmed:42089351",
    "canonical_key": "pmid:42089351",
    "headline": "Discovery of the Novel HLA-DQB1*06:552 Allele in a Taiwanese Individual.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42089351/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "HLA",
    "pmid": "42089351",
    "doi": "10.1111/tan.70744",
    "preprint_id": "",
    "authors": "Yang KL; Lin PY",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "authors": "Singchat W; Wongloet W; Budi T; Panthum T; Chaiyes A; Jangtarwan K; Duengkae P; Payungporn S; Meesawat S; Kemthong T; Hamada Y; Malaivijitnond S; Srikulnath K",
    "assignee": "",
    "publication_number": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
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    "source_type": "papers",
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    "score": 66,
    "id": "biorxiv:10.64898/2026.05.03.722528",
    "canonical_key": "doi:10.64898/2026.05.03.722528",
    "headline": "Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity",
    "summary": "Engineered MAGE-A3 A3A TCR variants were stepped back toward wild type to preserve tumor cytotoxicity while removing Titin/off-target cross-reactivity, a useful specificity-rescue case study.",
    "url": "https://doi.org/10.64898/2026.05.03.722528",
    "source": "bioRxiv",
    "published_date": "2026-05-06",
    "match_reason": "LLM rank exception: user-rated 60/100 engineered TCR specificity/cross-reactivity paper; MAGE-A3/Titin safety lesson is relevant but not a discovery dataset.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.03.722528",
    "preprint_id": "biorxiv:10.64898/2026.05.03.722528",
    "authors": "McCarthy, J. V.; Heroven, A. C.; Ifashe, K.; Fellermeyer, M.; Hudson, D.; Cioaca, R.; Quastel, M. N.; Yang, Y.; Cagiada, M.; Dragonov, S. D.; Thorpe, C. J.; Pinto-Fernandez, A.; Greenshields-Watson, A.; Gillespie, G. M.; Deane, C. M.; Fernandes, R. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 2,
    "score": 58,
    "id": "pubmed:42095629",
    "canonical_key": "pmid:42095629",
    "headline": "The Phase Ib IMPACT Trial of Intramuscular Personalized Neoantigen Synthetic Long Peptide Vaccines in Patients with Advanced Melanoma and Renal Cell Carcinoma.",
    "summary": "Phase Ib personalized neoantigen long-peptide vaccine trial in advanced melanoma and renal cell carcinoma; relevant clinical neoantigen translation, but not direct TCR/pMHC discovery.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42095629/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "LLM rank exception: neoantigen clinical translation is relevant to antigen-targeting strategy.",
    "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
    "pmid": "42095629",
    "doi": "10.1158/1078-0432.CCR-25-4271",
    "preprint_id": "",
    "authors": "Pakvisal N; Wongkongkathep P; Bunrasmee W; Sodsai P; Siriluksana J; Boonnak N; Sangcharoen T; Trakarnsanga B; Sukprakun S; Wantanasiri P; Chotirosniramit K; Phanichkrivalkosil M; Nanthawong S; Chanchaem P; Mankhong S; Kumpunya S; Supabphol S; Sirijun N; Kongtragulsub K; Pearngam P; Somparn P; Payne DM; Zhao B; Praphanphoj V; Pornputtapong N; Sriswasdi S; Wichadakul D; Uttamapinan S; Angspatt P; Wongchanapat P; Teeyapun N; Luangdilok S; Sitthideatphaiboon P; Susiriwatananont T; Zungsontiporn N; Parinyanitikul N; Tanasanvimon S; Vinayanuwattikun C; Salazar A; Hirankarn N; Sriuranpong V; Pisitkun T",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 3,
    "score": 52,
    "id": "pubmed:42091580",
    "canonical_key": "pmid:42091580",
    "headline": "Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition.",
    "summary": "Mechanistic MR1 antigen-presentation paper linking riboflavin transporter delivery of bacterial metabolites to MAIT recognition; pMHC-adjacent antigen-presentation biology.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42091580/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "LLM rank exception: antigen-presentation mechanism with MR1/MAIT relevance, adjacent to pMHC discovery interests.",
    "journal": "Immunology and cell biology",
    "pmid": "42091580",
    "doi": "10.1111/imcb.70130",
    "preprint_id": "",
    "authors": "Cruz-Gomez S; Lim HJ; Nijagal B; Yang Y; Lau N; Mak JY; Fairlie DP; Newton H; Salio M; Villadangos JA; McWilliam HE",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 4,
    "score": 48,
    "id": "pubmed:42093013",
    "canonical_key": "pmid:42093013",
    "headline": "Germline HLA-I genotypes predict pathologic response and survival outcomes in esophageal cancer patients undergoing neoadjuvant immunochemotherapy: a retrospective cohort study.",
    "summary": "Retrospective esophageal cancer cohort associating germline HLA-I genotype with pathologic response and survival after neoadjuvant immunochemotherapy.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42093013/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "LLM rank exception: HLA-I genotype/clinical-response association is field-relevant though not a TCR mapping paper.",
    "journal": "World journal of surgical oncology",
    "pmid": "42093013",
    "doi": "10.1186/s12957-026-04374-8",
    "preprint_id": "",
    "authors": "Omindo WW; Wang Q; Deng S; Zhang R; Sun W; Zhang L; Zhang N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 5,
    "score": 44,
    "id": "biorxiv:10.64898/2026.05.04.722749",
    "canonical_key": "doi:10.64898/2026.05.04.722749",
    "headline": "Pre-transplant TCR Network Topology Predicts Kidney Allograft Rejection Independent of HLA Mismatch",
    "summary": "Pre-transplant TCR network topology is proposed as a rejection predictor independent of HLA mismatch, making this a lower-but-real patient TCR repertoire signal.",
    "url": "https://doi.org/10.64898/2026.05.04.722749",
    "source": "bioRxiv",
    "published_date": "2026-05-07",
    "match_reason": "LLM rank exception: patient TCR repertoire/network feature with HLA context; transplant setting lowers direct oncology relevance.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.04.722749",
    "preprint_id": "biorxiv:10.64898/2026.05.04.722749",
    "authors": "Borcherding, N.; Sanders, J. M.; Martens, G. R.; Murakami, N.; Doilicho, N.; Banbury, B. L.; He, J.; Leventhal, J. R.; Mathew, J. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 1,
    "score": 28,
    "id": "pubmed:41592291",
    "canonical_key": "pmid:41592291",
    "headline": "Ruxolitinib for ciltacabtagene autoleucel-associated refractory diarrhea.",
    "summary": "Blood. Blood. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41592291/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "Watchlist hits: Roche",
    "journal": "Blood",
    "pmid": "41592291",
    "doi": "10.1182/blood.2025032347",
    "preprint_id": "",
    "authors": "Blumenberg V; Birocchi F; Shih A; Escobar G; Mucci A; Armstrong A; Cirstea D; Harris DL; Bozym DJ; Puliafito BR; Newcomb R; Dhawale TM; Johnson PC; El-Jawahri A; Jeffrey R 3rd; Barselau AL; Li A; Emmanuel-Alejandro E; Cook D; Lindell K; Luk SO; Chaffee R; Yee AJ; Branagan A; Raje N; Graham CE; Hammond SP; Bushman FD; Roche AM; Reddy S; McFarland AG; Chen YB; Choi BD; Mount CW; Dougan M; Nardi V; Sohani AR; Gallagher KME; Maus MV; Frigault MJ; Leick MB",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 2,
    "score": 24,
    "id": "pubmed:42091471",
    "canonical_key": "pmid:42091471",
    "headline": "[Strategic evolution of drug discovery modalities: Tanabe Pharma's approach to immunology and oncology].",
    "summary": "Nihon yakurigaku zasshi. Folia pharmacologica Japonica. Nihon Yakurigaku Zasshi",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42091471/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Nihon yakurigaku zasshi. Folia pharmacologica Japonica",
    "pmid": "42091471",
    "doi": "10.1254/fpj.25100",
    "preprint_id": "",
    "authors": "Totsuka R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 3,
    "score": 24,
    "id": "pubmed:42096023",
    "canonical_key": "pmid:42096023",
    "headline": "A Bloody Mimic of Crohn's Disease: Primary Intestinal EBV-Positive NK/T-Cell Lymphoma.",
    "summary": "Digestive diseases and sciences. Dig Dis Sci. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42096023/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Digestive diseases and sciences",
    "pmid": "42096023",
    "doi": "10.1007/s10620-026-09900-y",
    "preprint_id": "",
    "authors": "Iacobucci A; Norman J; Ennin E; Fernandez-Pol S; Triadafilopoulos G; Barber G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 4,
    "score": 24,
    "id": "medrxiv:10.64898/2026.05.05.26352430",
    "canonical_key": "doi:10.64898/2026.05.05.26352430",
    "headline": "A Pragmatic Trial of Antibiotics and Supportive Care for Severe Pneumonia in Hospitalized Children.",
    "summary": "Background Evidence to guide the choice of injectable antibiotics and supportive care for children with severe pneumonia is limited and may not reflect changes in epidemiology associated with vaccination and antimicrobial resistance.",
    "url": "https://doi.org/10.64898/2026.05.05.26352430",
    "source": "medRxiv",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.05.26352430",
    "preprint_id": "medrxiv:10.64898/2026.05.05.26352430",
    "authors": "Isaaka, L.; Opondo, C.; Mumelo, L.; Njoroge, T.; Shangala, J.; Kimego, D.; Njuguna, R.; Wanyama, C.; Saisi, M.; Isinde, E.; Jowi, E.; Adem, A.; Barasa, J.; Ikol, M.; Inginia, R.; Ithondeka, A.; Lubanga, D.; Makokha, F.; Malangachi, R.; Marete, C.; Modi, J.; Muchela, M.; Kariuki, C. W.; Mwangi, P.; Namulala, E.; Njoroge, M.; Nzioki, C.; Ocharo, S.; Ombito, L.; Thuranira, L.; Kuria, M.; Mwangi, N.; Njiru, E.; Nokes, J.; Irimu, G.; Were, F.; Akech, S.; Barasa, E.; Obimbo, E. M.; English, M.; Allen, E.; Agweyu, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; pediatrics"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 5,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.04.722801",
    "canonical_key": "doi:10.64898/2026.05.04.722801",
    "headline": "A Single-Cell Peripheral Immune Atlas Spanning High-Risk Lesions to Invasive Breast Cancer in Black and White Women",
    "summary": "Black women are at risk for breast cancer nearly a decade before women of other racial groups for unclear reasons. Because immune responses influence cancer initiation and progression, we performed single-cell RNA sequencing of peripheral blood mononuclear cells from non-Hispanic Black (NHB) and non-Hispanic White (NHW) women with high-r...",
    "url": "https://doi.org/10.64898/2026.05.04.722801",
    "source": "bioRxiv",
    "published_date": "2026-05-07",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.04.722801",
    "preprint_id": "biorxiv:10.64898/2026.05.04.722801",
    "authors": "Chen, F.; Ogayo, E. R.; Rahman, T.; Recko, A.; Starobinets, H.; Spasic, M.; Parsons, A. M.; Van Galen, P.; Mittendorf, E.; McAllister, S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 6,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.05.722909",
    "canonical_key": "doi:10.64898/2026.05.05.722909",
    "headline": "A suture-specific oocyst wall protein COWP4 is essential for excystation and infectivity, while COWP6 links wall architecture to host interaction in Cryptosporidium parvum",
    "summary": "The oocyst of Cryptosporidium is a highly resilient transmission stage that protects sporozoites in the environment and mediates infection through a specialized opening known as the suture.",
    "url": "https://doi.org/10.64898/2026.05.05.722909",
    "source": "bioRxiv",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.05.722909",
    "preprint_id": "biorxiv:10.64898/2026.05.05.722909",
    "authors": "Wu, X.; Yin, J.; Qi, W.; Jiang, P.; Zhang, Y.; Zhang, D.; Wang, D.; Zhu, G.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 7,
    "score": 24,
    "id": "pubmed:42094356",
    "canonical_key": "pmid:42094356",
    "headline": "A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidney.",
    "summary": "bioRxiv : the preprint server for biology. bioRxiv. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42094356/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv : the preprint server for biology",
    "pmid": "42094356",
    "doi": "10.64898/2026.04.28.721379",
    "preprint_id": "",
    "authors": "Liñares-Blanco J; Schäfer PSL; Zimmermann L; Melo Ferreira R; Toro-Dominguez D; Carmona-Saez P; Tanevski J; Alarcón Riquelme ME; Eadon MT; Ramirez Flores RO; Saez-Rodriguez J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 8,
    "score": 24,
    "id": "pubmed:42090697",
    "canonical_key": "pmid:42090697",
    "headline": "Aedes aegypti salivary gland extract enhances Zika virus replication through immune modulation.",
    "summary": "Memorias do Instituto Oswaldo Cruz. Mem Inst Oswaldo Cruz. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42090697/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Memorias do Instituto Oswaldo Cruz",
    "pmid": "42090697",
    "doi": "10.1590/0074-02760250272",
    "preprint_id": "",
    "authors": "Hilario G; Dorneles GP; Freitas DN; Silva OSD; Prophiro JS; Fazolo T; Machado RRG; Bonorino C; Oliveira DBL; Fonseca SGD; Romão PRT; Rodrigues LC Jr",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-07",
    "window_start": "2026-05-06T05:15:00.000Z",
    "window_end": "2026-05-07T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 9,
    "score": 24,
    "id": "pubmed:41632522",
    "canonical_key": "pmid:41632522",
    "headline": "Age-stratified clinical outcomes and adverse events in patients with metastatic castration-sensitive prostate cancer receiving triplet therapy with darolutamide, androgen deprivation therapy, and docetaxel.",
    "summary": "Japanese journal of clinical oncology. Jpn J Clin Oncol. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41632522/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Japanese journal of clinical oncology",
    "pmid": "41632522",
    "doi": "10.1093/jjco/hyag011",
    "preprint_id": "",
    "authors": "Uchimoto T; Hirosuna K; Niigawa H; Jo T; Morinaka H; Fukuokaya W; Yoshizawa A; Saruta M; Morita T; Fujimoto S; Yamamoto Y; Sakamoto M; Nishimura K; Maenosono R; Tsujino T; Nishio K; Yoshikawa Y; Ichihashi A; Urabe F; Mori K; Yanagisawa T; Tsuzuki S; Takahara K; Inamoto T; Fujita K; Azuma H; Kimura T; Komura K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
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    "headline": "Altered immune and treatment response gene expression signatures among povertyexposed children with B-cell acute lymphoblastic leukemia.",
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    "headline": "An update on drug-induced liver injury-What's new?",
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    "headline": "Androgen loss accelerates brain tumour growth via HPA axis activation.",
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    "authors": "Lee J; Chung YM; Silver DJ; Hao Y; Harwood DSL; Ealy A; Serapiglia AM; Curtin L; Benedetti JR; Ballard CAP; Lapsley K; Alvarez-Vazquez A; Goldberg J; Li C; Kaur S; Neal R; Wang SZ; Kay KE; Volovetz J; Hong ES; Fodor R; Jarmula J; Nicosia M; Rubin JB; Swanson KR; Ostrom QT; Panicker N; Kristensen BW; Berens M; Sharifi N; Lathia JD",
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    "headline": "Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production.",
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    "headline": "AtGPP2 encodes a 3-deoxy-manno-octulosonate-8-phosphatase required for the synthesis of KDO in rhamnogalacturonan II",
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    "authors": "Kielbik A; Bahlinger V; Schürch CM; Barcena ML; Vakhrusheva O; Thomas A; Tsaur I; Heitmann JS; Salih HR; Hagelstein I",
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    "headline": "Bifidobacterium animalis suppresses melanoma progression and activates anti-tumor immunity by inhibiting YAP1 expression in CD8+ T cells.",
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    "authors": "Li C; Zhang X; Yang Y; Zeng H; Shi Y; Zhang J; Liu L; Zhu C; Zhang Z; Li C; Wang X; Bai X; Deng H; Li Q",
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    "headline": "Bioinspired Nanoplatform Potentiates Sonodynamic Immunotherapy by Remodeling the Antioxidant Tumor Microenvironment and Activating STING pathway.",
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    "headline": "Biological Sex Influences Immune Response to Influenza Infection in Juvenile Outbred Mice.",
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    "headline": "CAR T cell therapy shows promise for treatment of stiff person syndrome.",
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    "authors": "Wood H",
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    "authors": "Moya-Guzmán MJ; de Solminihac J; Carrasco-Loncharic T; Kaehne T; Pino-Lagos K",
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    "headline": "CD8 T Cell Sensing of Type I Interferon Impacts Anergy.",
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    "authors": "Haefke AS; Gröber H; Sandu I; Skipness V; Pantouloufos N; Gräbnitz F; Tuchel ME; Zangger N; Stark D; Kříž M; Cristinzio C; Pircher H; Spörri R; Quast I; Oxenius A",
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    "headline": "CDK4/6 inhibitor ribociclib and doxorubicin combination treatment inhibits breast cancer bone metastasis and enhances T-cell targeted therapy.",
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    "headline": "Cell Growth and Division Shape mRNA-Protein Correlations",
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    "headline": "Decoding Condition-Specific Cellular Crosstalk in Spatial Omics via Bilinear Edge Classification",
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    "headline": "Defining the rules of engagement: B cells, antibodies and cancer control.",
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    "headline": "DENV-Specific IL-10-Producing Regulatory T Cells Are Associated With Mild Clinical Outcomes in Dengue.",
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    "authors": "Gonçalves-Pereira MH; Queiroz-Glauss C; Figueiredo MM; Quintino-de-Carvalho IL; Ramos MF; Bento GA; Magalhães TVB; Mafra AA; Diniz LMO; Costa ÚLD; Gollob KJ; Nogueira ML; Antonelli LRDV; Santiago HDC",
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    "headline": "Design and in silico evaluation of an mRNA vaccine against HTLV-1 using AI-driven reverse vaccinology approaches.",
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    "headline": "Development and Evaluation of a Bispecific Single-Chain Antibody Targeting PSMA and CD3 to Enhance T-Cell-Mediated Lysis.",
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    "headline": "Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1",
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    "url": "https://doi.org/10.64898/2026.05.03.722513",
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    "headline": "Do transfusion-related HLA antibodies always indicate clinically relevant sensitisation?",
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    "authors": "Liu S; Han D; Li J",
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    "headline": "Dual-antigen-targeting T-cell immunotherapies in MM: circumventing tumor heterogeneity and preventing antigen escape.",
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    "headline": "Elevated target expression by dual PD-L1 and 4-1BB engagement is associated with (89)Zr-PD-L1x4-1BB bispecific Mabcalin tumor uptake.",
    "summary": "Theranostics. Theranostics. 2026-04-22",
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    "source": "PubMed",
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    "journal": "Theranostics",
    "pmid": "42094613",
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    "authors": "van Winkel CAJ; Fan X; Giesen D; Gauderat G; de Jong S; Jaquin T; Timens W; Lepissier A; Richter M; Grüner S; Andersen N; Laboureur L; Pattarini L; Lelièvre H; de Vries EGE; Morales-Kastresana A; Hooge MNL",
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    "headline": "Emergent directional persistence in fibrous granular scaffolds guides myotube organization",
    "summary": "Granular scaffolds have emerged as promising platforms for tissue regeneration, offering injectability and cell-scale porosity that support robust cell infiltration and tissue formation. However, the isotropic pore structure of spherical building blocks does not provide the directional cues needed to guide organized tissue formation.",
    "url": "https://doi.org/10.64898/2026.05.01.721636",
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    "headline": "Endothelial-derived PANoptosis factor IL33 is a potential immunotherapy in breast cancer.",
    "summary": "iScience. iScience. 2026-04-15",
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    "source": "PubMed",
    "published_date": "2026-04-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "iScience",
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    "authors": "Qi Y; Li Z; Jia L; Yang S; Li Z; Li Y; Zhang S",
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    "headline": "Epigenetic Gatekeeping of Intestinal Stem Cell Transformation",
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    "url": "https://doi.org/10.64898/2026.01.31.702974",
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    "authors": "Lorzadeh, A.; Sharma, S.; Ye, G.; Rabaya, S.; Kang, Y. J.; Shivdasani, R.; Jadhav, U.",
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    "headline": "Erratum: Evolution of Therapy in Pediatric ALL From Aminopterin to Chimeric Antigen Receptor T-Cell Therapy: Global Advances, Indian Adaptations, and Lessons for Low- and Middle-Income Countries.",
    "summary": "JCO global oncology. JCO Glob Oncol. 2026-05-06",
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    "source": "PubMed",
    "published_date": "2026-05-06",
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    "journal": "JCO global oncology",
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    "doi": "10.1200/GO-26-00276",
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    "authors": "Mohapatra D; Meena JP; Gupta AK; Seth R",
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    "headline": "Establishment of Integration-Free iPSCs from Diverse Porcine Species: A Novel Resource for Conservation and African Swine Fever Research",
    "summary": "The accelerating biodiversity crisis, compounded by emerging infectious diseases like African swine fever (ASF), necessitate innovative conservation and disease management. ASF susceptibility varies wildly across species, from near-100% mortality in Asian suids to asymptomatic carriage in African forest species.",
    "url": "https://doi.org/10.64898/2026.05.02.722394",
    "source": "bioRxiv",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "doi": "10.64898/2026.05.02.722394",
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    "authors": "Bao, Q.; Yingyan LIM, C.; Yeo, H. L.; PUNYAWAI, K.; HSU, C. D.; CHONG, S. M.; XIE, S.; LOH, J. Y.-H.; NG, S. C.; pomp, O.",
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    "id": "pubmed:42094600",
    "canonical_key": "pmid:42094600",
    "headline": "Esterase-responsive albumin-binding PROTAC-mediated BRD4 degradation for cancer immunotherapy.",
    "summary": "Theranostics. Theranostics. 2026-04-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42094600/",
    "source": "PubMed",
    "published_date": "2026-04-23",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Theranostics",
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    "doi": "10.7150/thno.130510",
    "preprint_id": "",
    "authors": "Lee H; Jeong S; Park J; Son HJ; Kweon S; Lee SS; Shim N; Oh Y; Kang H; Lee C; Lee J; Kim J; Cho H; Kim K",
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    "canonical_key": "pmid:42092824",
    "headline": "Evaluation of the abscopal-like effect of radioimmunotherapy on sentinel lymph nodes in H22 hepatocellular carcinoma via dynamic lymphography.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42092824/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "BMC cancer",
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    "doi": "10.1186/s12885-026-16140-w",
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    "authors": "Wang H; Chen D; Liu Z; Zhao X; Zhang J; Zhang D",
    "assignee": "",
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    "id": "pubmed:42097835",
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    "headline": "Endogenous neoantigen-specific antibodies mediate antitumor responses and determine vaccine efficacy.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42097835/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "LLM rank exception: neoantigen-specific antitumor response and vaccine-efficacy biology is closer to antigen-discovery interests than generic checkpoint or broad T-cell items.",
    "journal": "Journal for immunotherapy of cancer",
    "pmid": "42097835",
    "doi": "10.1136/jitc-2025-014671",
    "preprint_id": "",
    "authors": "Sodhi SS; Wang JS; Severson DT; Ragusa JV; Moon N; Trotter T; Tsao LC; Lyerly HK; Hartman ZC",
    "assignee": "",
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    "id": "pubmed:42098361",
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    "headline": "αTrop2/αCD3 bispecific protein engager-armed T cells (BATs) exhibit potent antitumor activity against nasopharyngeal carcinoma.",
    "summary": "alphaTrop2/alphaCD3 bispecific protein engager-armed T cells show antitumor activity against nasopharyngeal carcinoma; CD3-engager modality is adjacent to TCR-TCE interests but not peptide-MHC targeted.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42098361/",
    "source": "PubMed",
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    "match_reason": "LLM rank exception: CD3 bispecific engager-armed T cells with a named tumor target are more relevant than broad immunotherapy trial readouts.",
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    "authors": "Suwanchiwasiri K; Somboonpatarakun C; Chaiyariti N; Suriya U; Chankhamhaengdecha S; Yenchitsomanus PT; Janvilisri T; Junking M",
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    "id": "pubmed:42096071",
    "canonical_key": "pmid:42096071",
    "headline": "Human pancreatic ductal cells from non-diabetic donors function as non-professional antigen-presenting cells upon inflammatory cytokine exposure.",
    "summary": "Human pancreatic ductal cells can act as inflammatory cytokine-induced non-professional antigen-presenting cells, a pMHC-adjacent antigen-presentation mechanism outside oncology.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42096071/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "LLM rank exception: antigen-presentation mechanism is pMHC-adjacent even though the disease context is diabetes rather than cancer.",
    "journal": "Diabetologia",
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    "authors": "Erdem N; Arribas-Layton D; Zook HN; O'Meally D; Mares J; Quijano JC; Donohue C; Ortiz JA; Jou K; Vasavada RC; Montero E; Kaddis JS; Reijonen H; Ku HT",
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    "id": "pubmed:42097493",
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    "headline": "IL-12 Augments Adoptive Cell Therapy by Reshaping CD8(+) T Dynamics and Broadening Antitumor Immunity.",
    "summary": "IL-12 is reported to improve adoptive cell therapy by reshaping CD8+ T-cell dynamics and broadening antitumor immunity; relevant ACT biology but not antigen-specific TCR work.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42097493/",
    "source": "PubMed",
    "published_date": "2026-05-05",
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    "id": "pubmed:42094336",
    "canonical_key": "pmid:42094336",
    "headline": "Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager.",
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    "id": "pubmed:42097138",
    "canonical_key": "pmid:42097138",
    "headline": "Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections.",
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    "journal": "Cell",
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    "authors": "Fournier M; Vanderkerken M; Dorgham K; Bastard P; Ahouzi O; Duquerroy S; Nguyen NK; Broutin M; Charlet M; Vandenberghe A; Van Endert P; Bizien L; Da Mata-Jardin O; Ferriño-Iriarte A; Haouz A; Belmondo T; Hüe S; Borghesi A; Rodríguez-Gallego C; Vinh DC; Andreakos E; Haerynck F; Halwani R; Pan-Hammarström Q; Björkström NK; Strunz B; Mogensen TH; COVID Human Genetic Effort; Piralla A; Varchetta S; Freixinet J; Roussel L; Trouillet Assant S; Neven B; Levy R; le Voyer T; Delmonte OM; O'Farrelly C; Rivière J; Amador Borrero B; Servettaz A; Kouyos RD; Kaufmann DE; Crickx E; Michel M; Puel A; Abel L; Luyt CE; Mathian A; Kisand K; Duffy D; Quintana-Murci L; Amoura Z; Hale BG; Weill JC; Casanova JL; Rey FA; Gorochov G; Chappert P; Mahévas M",
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    "headline": "[Current Status and Future Perspectives of Microbiome Research in Lung Cancer].",
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    "headline": "A biomimetic phase-separating hydrogel potentiates local chemo-virotherapy to eradicate recurrent glioblastoma.",
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    "headline": "A High Throughput Assay to Identify Modulators of Death Receptor 3 (DR3).",
    "summary": "SLAS discovery : advancing life sciences R & D. SLAS Discov. 2026-05-05",
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    "headline": "A novel self-amplified RNA vaccine co-expressing NA and HA1 delivered by Salmonella confers potent protection against H9N2 influenza in chickens.",
    "summary": "Poultry science. Poult Sci. 2026-05-02",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42096905/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Poultry science",
    "pmid": "42096905",
    "doi": "10.1016/j.psj.2026.107072",
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    "authors": "Wang M; Gao Y; Zhang Y; Zhang G; Xu Y; Wang T; Yang T; Zhang Y; Sun Y; Guo Q; Wang Z; Wang C; Jiang Y",
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    "headline": "A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer.",
    "summary": "Cell reports. Medicine. Cell Rep Med. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42097145/",
    "source": "PubMed",
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    "journal": "Cell reports. Medicine",
    "pmid": "42097145",
    "doi": "10.1016/j.xcrm.2026.102776",
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    "authors": "Chua J; Kaur A; Mitchell F; Korver A; Sakthivel P; Allapitan E; Uddin M; Maqsood A; Chege N; Leon-Coria A; Finney CAM; Bathe OF; Minoo P; Ayyaz A",
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    "headline": "ADCY7 dictates N-cadherin stability to inhibit HCC metastasis.",
    "summary": "JHEP reports : innovation in hepatology. JHEP Rep. 2026-02-20",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42096912/",
    "source": "PubMed",
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    "journal": "JHEP reports : innovation in hepatology",
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    "doi": "10.1016/j.jhepr.2026.101789",
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    "authors": "Chen J; Li J; Zong Y; Liu C; Wang X; Jiang Y; Liu E; Gu M; Meng Z; Liu X; Chen L; Wang H; Fu J",
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    "headline": "Assessing the Interplay Between Yeast Cell Wall Supplementation and Oral Salmonella Vaccines in Poultry Immunity",
    "summary": "Bobe E, Maupin C, Verhaeghe L, Marquis V, Pineau L, Schulthess J.",
    "url": "https://doi.org/10.21203/rs.3.rs-9315497/v1",
    "source": "Europe PMC / PPR",
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    "headline": "B-cell Maturation Antigen Targeted Chimeric Antigen Receptor T-cell Therapy for Refractory Systemic Lupus Erythematosus and Systemic Sclerosis.",
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    "doi": "10.1002/art.70211",
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    "authors": "Kfir-Erenfeld S; Elias S; Asherie N; Chen HP; Karger E; Assayag M; Bohbot E; Elmikawy R; Alaa S; Bazbaz A; Friedman-Korn T; Molho-Pessach V; Vaknin A; Grisariu S; Avni B; Zimran E; Zalcman N; Shehadeh A; Ishtay A; Dubnikob T; Regev S; Alexander-Shani R; Schlossberg M; Herr S; Ben-Shahan S; Zorde-Khevalevsky E; Krizhevskaya M; Paran D; Ravkaie L; Cohen CJ; Peleg H; Mevorach D; Stepensky P; Gur C",
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    "id": "biorxiv:10.64898/2026.05.04.722653",
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    "headline": "BGC-QUAST: a quality assessment tool for genome mining software",
    "summary": "Summary: Biosynthetic gene clusters (BGCs) encode microbial natural products, many of which have important ecological and biomedical roles. Genome mining tools enable large-scale BGC prediction, but their outputs differ substantially, complicating comparison and interpretation.",
    "url": "https://doi.org/10.64898/2026.05.04.722653",
    "source": "bioRxiv",
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    "doi": "10.64898/2026.05.04.722653",
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    "authors": "Kushnareva, A.; Tupikina, D.; Almessady, H.; McHardy, A.; Gurevich, A.",
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    "id": "pubmed:42098408",
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    "headline": "CAR T-cells targeting CD117 effectively eliminate mast cells in preclinical models of advanced systemic mastocytosis.",
    "summary": "Leukemia. Leukemia. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42098408/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Leukemia",
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    "doi": "10.1038/s41375-026-02968-5",
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    "authors": "Kaiser A; Lysenko V; Myburgh R; Volta L; Pellegrino C; Theocharides APA; Christen D; Panse J; Bühler MM; Arock M; Butterfield J; de Toledo MAS; Valent P; Zenke M; Brümmendorf TH; Manz MG",
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    "canonical_key": "pmid:42096379",
    "headline": "CD8+ T Cells in Hashimoto's Thyroiditis-Associated Papillary Thyroid Carcinoma.",
    "summary": "European thyroid journal. Eur Thyroid J. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42096379/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "European thyroid journal",
    "pmid": "42096379",
    "doi": "10.1530/ETJ-25-0365",
    "preprint_id": "",
    "authors": "Wang L; Zhang L; Chen J; Wang D; Zhang Y; Sun L; Su W; Li M; Zhou Q; Wang J; Jiang J",
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    "rank_index": 13,
    "score": 24,
    "id": "pubmed:42097179",
    "canonical_key": "pmid:42097179",
    "headline": "Chemokine dynamics after mRNA vaccination.",
    "summary": "Immunology letters. Immunol Lett. 2026-05-05",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42097179/",
    "source": "PubMed",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Immunology letters",
    "pmid": "42097179",
    "doi": "10.1016/j.imlet.2026.107183",
    "preprint_id": "",
    "authors": "Palma LM; Schlaweck S; Flores C; Aslan H; Kurts C; Brossart P; Becker-Gotot J; Heine A",
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    "id": "pubmed:42096330",
    "canonical_key": "pmid:42096330",
    "headline": "Cohesin complex cooperates with PU.1 at super-enhancers to regulate the differentiation and identity of conventional dendritic cells.",
    "summary": "Cell reports. Cell Rep. 2026-05-05",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42096330/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cell reports",
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    "doi": "10.1016/j.celrep.2026.117331",
    "preprint_id": "",
    "authors": "Choubey P; Kumar A; Podder S; Raghav SK; Bansal K",
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    "id": "biorxiv:10.64898/2026.05.04.722786",
    "canonical_key": "doi:10.64898/2026.05.04.722786",
    "headline": "Creatine kinase regulates energy metabolism and growth of trophoblasts",
    "summary": "Study question: Does the human placenta utilize the creatine phosphagen system for energy homeostasis during development? Summary answer: Components of the creatine (Cr)-creatine kinase (CK)-phosphocreatine (PCr) system are dynamically expressed by the trophoblast and mesenchymal compartments throughout gestation wherein creatine kinase...",
    "url": "https://doi.org/10.64898/2026.05.04.722786",
    "source": "bioRxiv",
    "published_date": "2026-05-07",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "doi": "10.64898/2026.05.04.722786",
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    "authors": "Sah, N.; Zheng, C.; Shaik, W.; Stein, F. H.; Rajupalem, R.; Meads, M.; Pizzo, D.; Soncin, F.",
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    "headline": "CXCL13-CXCR5 Signaling in CD8⁺ T Cell Recruitment and Lymphoid Immune Organization in Clear Cell Renal Cell Carcinoma",
    "summary": "Clear cell renal cell carcinoma (ccRCC) exhibits heterogeneity in immune infiltration and clinical outcomes, but the mechanisms governing recruitment and organization of tumor-reactive CD8+ T cells remain incompletely defined.",
    "url": "https://doi.org/10.64898/2026.05.04.722710",
    "source": "bioRxiv",
    "published_date": "2026-05-07",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "doi": "10.64898/2026.05.04.722710",
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    "authors": "Shapiro, D. D.; Nichols, K. D.; Lee, M. H.; Msaouel, P.; Li, Y.; Zong, Y.; Hu, R.; Huang, W.; Esbona, K.; Kinoshita, T.; Lotan, P.; Roadman, D. F.; Nkadori, E.; McGregor, S. M.; Beebe, D. J.; Kerr, S. C.; Capitini, C. M.; Abel, E. J.",
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    "id": "pubmed:42096962",
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    "headline": "Cytotoxic CD4(+) T cells and their implication in oral diseases and systemic diseases with oral manifestations.",
    "summary": "International immunopharmacology. Int Immunopharmacol. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42096962/",
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    "journal": "International immunopharmacology",
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    "doi": "10.1016/j.intimp.2026.116790",
    "preprint_id": "",
    "authors": "Huang XX; Hu ST; Zhou G; Zhang J",
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    "id": "biorxiv:10.64898/2026.05.05.722945",
    "canonical_key": "doi:10.64898/2026.05.05.722945",
    "headline": "Decoding translational control by cis-regulatory elements and RNA binding proteins in human effector T cells",
    "summary": "T cells are central players in killing virally infected and malignant cells. To achieve this, T cells depend on dynamic, tightly regulated alterations of the proteome. To decipher the rules instructing translation in T cells, we performed transcriptome and proteome analysis of polysome fractions from human effector CD8+ T cells.",
    "url": "https://doi.org/10.64898/2026.05.05.722945",
    "source": "bioRxiv",
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    "authors": "Popovic, B.; Sostaric, N.; Bresser, k.; Kanagasabesan, N.; Bradaric, A.; Engels, s.; Guislain, A.; Rettel, M.; Stein, F.; Perri, j.; Nicolet, B.; Wolkers, M.",
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    "headline": "Delivery of a ZBP1 agonist enhances radiotherapy-induced antitumour immunity in hepatocellular carcinoma.",
    "summary": "Journal of controlled release : official journal of the Controlled Release Society. J Control Release. 2026-05-05",
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    "source": "PubMed",
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    "headline": "Electrical stimulation precisely reproduces naturalistic spiking activity in complete and intermixed neural populations in the primate retina",
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    "headline": "Fine-scale population structure within and among Malagasy societies",
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    "headline": "Gcn1 inhibits initiation of ribosome-associated quality control",
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    "authors": "Zhou S; Jiang Y; Fan J; Guo M; Wen Y; Dai C",
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    "headline": "Improve the Efficacy of B7-H3-Targeting Antibody-Drug Conjugate DS-7300a in TP53-deficient Tumors by Inducing Ferroptosis",
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    "authors": "Sesques P; Manson G; Cartron G; Gros FX; Morschhauser F; Castilla-Llorente C; Brisou G; Bories P; Thieblemont C; Drieu La Rochelle L; Tessoulin B; André A; Rossi C; Paillassa J; Guidez S; Capes A; Herbreteau L; Choquet S; Bay JO; Chauchet A; Lebras L; Claves F; Abraham J; Malfuson JV; Rubio MT; Decroocq J; Fornecker LM; Damaj G; Fouillet L; Joris M; Loschi M; Hermine O; Hafirassou H; Zele EV; Dupont V; Gouill SL; Houot R; Camus V",
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    "headline": "A ferroptosis-based intelligent nanoplatform with chemo-sonodynamic therapy carrying oxygen for improving tumor suppression and antitumor immunity.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42104396/",
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    "headline": "A fungal hemophore relay mediates heme transfer via transient protein interactions",
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    "headline": "A Fungal Natural Product that Inhibits Plant Cellulose Biosynthesis by disrupting Cellulose Synthase Complexes",
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    "headline": "A natural COX-2 inhibitor-integrated nanoplatform for TNBC immunotherapy: Mn-PC-PTX synergizes chemotherapy and immune activation.",
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    "doi": "10.1016/j.colsurfb.2026.115763",
    "preprint_id": "",
    "authors": "Wang H; Lin S; Zhou J; Bi J; Wang Y; Li X; Yang Q; Wu S; Qi X; Shen S; Cao J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "window_start": "2026-05-08T05:15:00.000Z",
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    "rank_bucket": "lower_priority",
    "rank_index": 14,
    "score": 24,
    "id": "pubmed:42104273",
    "canonical_key": "pmid:42104273",
    "headline": "A novel Chimeric Antigen Receptor (CAR) - strategy to target EGFR(VIII)-mutated glioblastoma cells via macrophages.",
    "summary": "BMC cancer. BMC Cancer. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42104273/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "BMC cancer",
    "pmid": "42104273",
    "doi": "10.1186/s12885-026-16080-5",
    "preprint_id": "",
    "authors": "Vera K; Esken G; Hwang JW; Elbaz C; Chaker D; Oudrhiri N; Desterke C; Griscelli F; Bennaceur-Griscelli A; Turhan AG",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 15,
    "score": 24,
    "id": "pubmed:42102806",
    "canonical_key": "pmid:42102806",
    "headline": "A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma.",
    "summary": "Neuron. Neuron. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42102806/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Neuron",
    "pmid": "42102806",
    "doi": "10.1016/j.neuron.2026.03.039",
    "preprint_id": "",
    "authors": "Zhang S; Dong FY; Cai S; Zhou B; Jiang L; Hu LP; Zhu YH; Li H; Yang XM; Cai Z; Yao LL; Wang H; Yao HF; Li J; Li Q; Zhu L; Yang Q; Liu LM; Yu YQ; Zhang JF; Hua R; Zhang XL; Zhu HH; Niu N; Xue J; Jiang C; Sun YW; Han Q; Li DX; Liu DJ; Zhang ZG; Jiang SH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 16,
    "score": 24,
    "id": "pubmed:42099984",
    "canonical_key": "pmid:42099984",
    "headline": "A Self-Amplifying RNA Lipid Nanoparticle (saRNA-LNP) Vaccine Provides Effective Protection Against Porcine Epidemic Diarrhea.",
    "summary": "Transboundary and emerging diseases. Transbound Emerg Dis. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42099984/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Transboundary and emerging diseases",
    "pmid": "42099984",
    "doi": "10.1155/tbed/3115893",
    "preprint_id": "",
    "authors": "Shu J; Zhang H; Wang F; Zhang H; Liu X; Liu K; Zha Y; Chai W; Yao J; Lin Y; Wu C; Zhao X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 24,
    "id": "pubmed:42099654",
    "canonical_key": "pmid:42099654",
    "headline": "Adapter-based allogeneic CAR T cells to overcome antigen escape in solid tumors.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42099654/",
    "source": "PubMed",
    "published_date": "2026-04-22",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42099654",
    "doi": "10.3389/fimmu.2026.1822583",
    "preprint_id": "",
    "authors": "Pham PQ; Sodji QH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 18,
    "score": 24,
    "id": "pubmed:42099603",
    "canonical_key": "pmid:42099603",
    "headline": "Adaptive restoration of T-cell motility by cold acclimation through metabolic and transcriptional remodeling.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-10",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42099603/",
    "source": "PubMed",
    "published_date": "2026-04-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42099603",
    "doi": "10.3389/fimmu.2026.1789182",
    "preprint_id": "",
    "authors": "Hattori M; Onishi N; Sato T; Nakakura T; Suzuki T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  },
  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 24,
    "id": "pubmed:42099873",
    "canonical_key": "pmid:42099873",
    "headline": "Advances in cell therapy for solid tumours: European perspective and future directions.",
    "summary": "The Lancet regional health. Europe. Lancet Reg Health Eur. 2026-03-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42099873/",
    "source": "PubMed",
    "published_date": "2026-03-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "The Lancet regional health. Europe",
    "pmid": "42099873",
    "doi": "10.1016/j.lanepe.2026.101590",
    "preprint_id": "",
    "authors": "Moreno V; Thistlethwaite F; Yarza R; Tak WS; Lim KHJ; Haanen JBAG",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  },
  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 24,
    "id": "pubmed:42103815",
    "canonical_key": "pmid:42103815",
    "headline": "Amplifying immune responses via a parenteral prime-intranasal boost strategy using a lipidated chitosan nanoparticle-based multi-epitope COVID-19 vaccine.",
    "summary": "Scientific reports. Sci Rep. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42103815/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Scientific reports",
    "pmid": "42103815",
    "doi": "10.1038/s41598-026-51737-y",
    "preprint_id": "",
    "authors": "Yi CJ; Fuaad AAA; Azami NAM; Rosli SNZ; Low CF; Amin MCIM; Jamal R; Azmi F",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 21,
    "score": 24,
    "id": "biorxiv:10.1101/2024.09.12.612678",
    "canonical_key": "doi:10.1101/2024.09.12.612678",
    "headline": "An archaeal CBASS shows protective activity against both chronic and lytic viruses",
    "summary": "Many cyclic-oligonucleotide-based anti-phage signalling systems (CBASS) defend against viral infections by depleting cellular NAD+ levels, eventually leading to dormancy or death. This abortive infection strategy is beneficial in stopping fast lytic infections, as cells die before spreading the virus to neighbouring cells.",
    "url": "https://doi.org/10.1101/2024.09.12.612678",
    "source": "bioRxiv",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2024.09.12.612678",
    "preprint_id": "biorxiv:10.1101/2024.09.12.612678",
    "authors": "Choudhary, D. K.; Singla, H.; Vassover, D.; Golan, N.; Reshef, L.; Shukrun, H.; Igiraneza, A. I. B.; Pohlschroeder, M.; Gophna, U.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 22,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.05.721149",
    "canonical_key": "doi:10.64898/2026.05.05.721149",
    "headline": "An autologous cell-based therapeutic vaccine expressing IL6/1 fusokine drives robust anti-tumor response against ovarian cancer.",
    "summary": "Background Cytokines are immunomodulatory proteins that play central roles in regulating immune responses and represent attractive targets for cancer therapy. However, as single agents, cytokines have shown limited clinical benefit due to systemic toxicities and a short in vivo half-life.",
    "url": "https://doi.org/10.64898/2026.05.05.721149",
    "source": "bioRxiv",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.05.721149",
    "preprint_id": "biorxiv:10.64898/2026.05.05.721149",
    "authors": "Sharma, S.; Das, R.; Pennati, A.; Hedican, C.; Barroilhet, L.; Patankar, M. S.; Galipeau, J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 23,
    "score": 24,
    "id": "pubmed:42103518",
    "canonical_key": "pmid:42103518",
    "headline": "An online singing-based breathing and wellbeing programme (ENO Breathe) in people with long COVID breathlessness in the UK: a cohort study.",
    "summary": "The Lancet. Digital health. Lancet Digit Health. 2027-03-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42103518/",
    "source": "PubMed",
    "published_date": "2027-03-24",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "The Lancet. Digital health",
    "pmid": "42103518",
    "doi": "10.1016/j.landig.2026.100988",
    "preprint_id": "",
    "authors": "Philip KEJ; Owles H; McVey S; Pagnuco T; Bruce K; Warnock B; Chomacki A; Brunjes H; Mollica J; Lound A; Zumpe S; Abrahams AM; Padmanaban V; Hardy TH; Lewis A; Lalvani A; Elkin SL; Hopkinson NS",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 24,
    "score": 24,
    "id": "europepmc:PPR1187175",
    "canonical_key": "doi:10.21203/rs.3.rs-8946667/v1",
    "headline": "Anti-SLC7A11 monoclonal antibody Inhibits Tumor Progression through a Janus-faced Effect on CD4 + and CD8 + T Cells in Colorectal Cancer",
    "summary": "Li J, Yin Y, Hong H, Pan X, Meng CA, Zhu J, Wang X, Liu Y, Wang P, Chen S.",
    "url": "https://doi.org/10.21203/rs.3.rs-8946667/v1",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "",
    "pmid": "",
    "doi": "10.21203/rs.3.rs-8946667/v1",
    "preprint_id": "",
    "authors": "Li J;  Yin Y;  Hong H;  Pan X;  Meng CA;  Zhu J;  Wang X;  Liu Y;  Wang P;  Chen S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 24,
    "id": "pubmed:42102207",
    "canonical_key": "pmid:42102207",
    "headline": "Antigen spreading mediates heterogeneous solid tumor eradication by DNA demethylating agent-programmed CAR T cells.",
    "summary": "Science advances. Sci Adv. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42102207/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Science advances",
    "pmid": "42102207",
    "doi": "10.1126/sciadv.adz4088",
    "preprint_id": "",
    "authors": "Guo Y; Tong C; Wei J; Wu Z; Lu Y; Han F; Zhang Y; Wang C; Shi J; Shi F; Wang Y; Han W",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 24,
    "id": "pubmed:42104468",
    "canonical_key": "pmid:42104468",
    "headline": "Autophagy-enhanced hybrid pyroptotic vesicles as personalized vaccines for cancer immunotherapy.",
    "summary": "Journal of nanobiotechnology. J Nanobiotechnology. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42104468/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of nanobiotechnology",
    "pmid": "42104468",
    "doi": "10.1186/s12951-026-04496-x",
    "preprint_id": "",
    "authors": "Yan H; Wu L; Liu J; Wang R; Lu J; Miao F; Li Y; Zhu Q; Tai Z; Chen Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 27,
    "score": 24,
    "id": "pubmed:42102528",
    "canonical_key": "pmid:42102528",
    "headline": "Bioinformatics and immunoinformatic approaches for structural modeling and vaccine design of the CCHFV whole genome to develop a novel broad-spectrum multiepitope vaccine candidate.",
    "summary": "Computational biology and chemistry. Comput Biol Chem. 2026-03-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42102528/",
    "source": "PubMed",
    "published_date": "2026-03-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Computational biology and chemistry",
    "pmid": "42102528",
    "doi": "10.1016/j.compbiolchem.2026.109019",
    "preprint_id": "",
    "authors": "Hashempour A; Hassanzadeh F; Hassanzadeh Z; Karbalaee-Alinazari MM; Honari Jahromi A; Ghasemi H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 28,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.07.723151",
    "canonical_key": "doi:10.64898/2026.05.07.723151",
    "headline": "Bisphenol-A mediated ubiquitinome alteration triggers PPAR-alpha ubiquitination, affecting trophoblast cell migration",
    "summary": "Pregnant women are frequently exposed to various endocrine-disrupting chemicals (EDCs), such as bisphenol A (BPA), causing harm to both the developing placenta and fetus. BPA can promote placental dysfunction by altering key cellular processes such as differentiation, invasion, and migration in trophoblast cells.",
    "url": "https://doi.org/10.64898/2026.05.07.723151",
    "source": "bioRxiv",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.07.723151",
    "preprint_id": "biorxiv:10.64898/2026.05.07.723151",
    "authors": "Biswas, A.; Saha, S.; Sarmadhikari, D.; Bisht, K. S.; Asthana, S.; Maiti, T. K.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; biochemistry"
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 29,
    "score": 24,
    "id": "pubmed:42100144",
    "canonical_key": "pmid:42100144",
    "headline": "Boosting CAR T cell functionality with oncolytic viruses for the treatment of pediatric diffuse midline gliomas.",
    "summary": "Molecular therapy. Oncology. Mol Ther Oncol. 2026-03-30",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42100144/",
    "source": "PubMed",
    "published_date": "2026-03-30",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Molecular therapy. Oncology",
    "pmid": "42100144",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42099327/",
    "source": "PubMed",
    "published_date": "2026-04-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cureus",
    "pmid": "42099327",
    "doi": "10.7759/cureus.106549",
    "preprint_id": "",
    "authors": "Remmers CR; Sanchez DE; Ajayi FA",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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    "id": "biorxiv:10.64898/2026.05.06.723330",
    "canonical_key": "doi:10.64898/2026.05.06.723330",
    "headline": "CSLB4-mediated cell wall remodeling decouples phloem access from aphid performance in Arabidopsis thaliana",
    "summary": "The plant cell wall (CW) is a key determinant of plant defense; however, the extent to which natural variation in CW architecture contributes to resistance against phloem-feeding insects remains unclear.",
    "url": "https://doi.org/10.64898/2026.05.06.723330",
    "source": "bioRxiv",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.06.723330",
    "preprint_id": "biorxiv:10.64898/2026.05.06.723330",
    "authors": "Moraga, F.; Arias-G, D.; Sanhueza, D.; Delgado-Rioseco, J.; Fuenzalida-Valdivia, I.; Inostroza-Aguirre, C.; Peppino-Margutti, M.; Ramos, M.; Zavala-Torres, D.; Ormeno, F.; Sepulveda-, R. V.; Fusari, C. M.; Herrera-Vasquez, A.; Saez, S.; Blanco-Herrera, F.",
    "assignee": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
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  {
    "digest_date": "2026-05-09",
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    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 48,
    "score": 24,
    "id": "medrxiv:10.64898/2026.05.06.26352582",
    "canonical_key": "doi:10.64898/2026.05.06.26352582",
    "headline": "Current practices, challenges, and future directions in subcutaneous oncology monoclonal antibody delivery: A qualitative study",
    "summary": "Background: Subcutaneous oncology monoclonal antibodies (SCOmAbs) offer significant benefits compared to intravenous formulations, including reduced administration time and potential for self-administration. However, little has been published on real-world preparation and administration practices with these novel formulations.",
    "url": "https://doi.org/10.64898/2026.05.06.26352582",
    "source": "medRxiv",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.06.26352582",
    "preprint_id": "medrxiv:10.64898/2026.05.06.26352582",
    "authors": "Franzese, C.; Anderson, M.; Wu, J.; Raj, A.; Coyne, M.; Biondi, S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
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  {
    "digest_date": "2026-05-09",
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    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 49,
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    "id": "pubmed:42101520",
    "canonical_key": "pmid:42101520",
    "headline": "Deciphering the immunological landscape of HR + metastatic breast cancer: insights from single-cell transcriptomics.",
    "summary": "Human cell. Hum Cell. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42101520/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Human cell",
    "pmid": "42101520",
    "doi": "10.1007/s13577-026-01384-2",
    "preprint_id": "",
    "authors": "He L; Zhao Q; Chen Z; He L; Qi Z; Wu J; Zhou K; Cui Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-09",
    "window_start": "2026-05-08T05:15:00.000Z",
    "window_end": "2026-05-09T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 50,
    "score": 24,
    "id": "pubmed:42101566",
    "canonical_key": "pmid:42101566",
    "headline": "Decoding immunotherapy resistance in multiple myeloma: genetic insights and approaches to counter resistance.",
    "summary": "Science China. Life sciences. Sci China Life Sci. 2026-04-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42101566/",
    "source": "PubMed",
    "published_date": "2026-04-28",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Science China. Life sciences",
    "pmid": "42101566",
    "doi": "10.1007/s11427-025-3227-0",
    "preprint_id": "",
    "authors": "Li H; Xia Q; Yu M; Lv Y; Xiao J; Guo X; Dong K; Zhou Y; Zhong L; Wang T; Wu W; Gan C; Li M; Xiao N; Wang Q; Chang H; He Y; Gong B",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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  {
    "digest_date": "2026-05-10",
    "window_start": "2026-05-09T05:15:00.000Z",
    "window_end": "2026-05-10T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 1,
    "score": 84,
    "id": "biorxiv:10.64898/2026.05.05.722287",
    "canonical_key": "doi:10.64898/2026.05.05.722287",
    "headline": "AI-enabled virtual immunopeptidomics links quantitative neoantigen presentation to immunogenicity",
    "summary": "bioRxiv. Models peptide abundance for neoantigen presentation and links quantitative immunopeptidomics to immunogenicity, making it directly relevant to antigen prioritization and pMHC target discovery.",
    "url": "https://doi.org/10.64898/2026.05.05.722287",
    "source": "bioRxiv",
    "published_date": "2026-05-10",
    "match_reason": "LLM promoted: quantitative immunopeptidomics, neoantigen presentation, pMHC target discovery.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.05.722287",
    "preprint_id": "biorxiv:10.64898/2026.05.05.722287",
    "authors": "Tan, Y.; Yang, Z.; Wang, T.; Hu, H.; Fleming, J.; Pan, M.; Eisenlohr, L. C.; Li, B.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
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    "keywords": "biorxiv; bioinformatics"
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  {
    "digest_date": "2026-05-10",
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    "source_type": "papers",
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    "rank_index": 2,
    "score": 80,
    "id": "pubmed:42108342",
    "canonical_key": "pmid:42108342",
    "headline": "ImmTAC: A Novel Platform of T-Cell Receptor-Based Soluble Bispecifics.",
    "summary": "Methods in Molecular Biology. Overview of an ImmTAC-style soluble TCR bispecific platform, directly relevant to TCR-based pMHC-targeting therapeutics.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42108342/",
    "source": "PubMed",
    "published_date": "2026-05-10",
    "match_reason": "LLM promoted: ImmTAC/TCR-based soluble bispecific platform directly matches pMHC-targeting therapy interests.",
    "journal": "Methods in molecular biology (Clifton, N.J.)",
    "pmid": "42108342",
    "doi": "10.1007/978-1-0716-5037-0_4",
    "preprint_id": "",
    "authors": "Oestringer BP; Vuidepot A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-10",
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    "source_type": "papers",
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    "rank_index": 3,
    "score": 76,
    "id": "pubmed:42106149",
    "canonical_key": "pmid:42106149",
    "headline": "Non-canonical transcription and splicing shape the colorectal cancer immunopeptidome in MSI and MSS tumors.",
    "summary": "Molecular & Cellular Proteomics. Maps how non-canonical transcription and splicing shape MSI and MSS colorectal cancer immunopeptidomes, useful for tumor antigen discovery.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42106149/",
    "source": "PubMed",
    "published_date": "2026-05-07",
    "match_reason": "LLM promoted: cancer immunopeptidome paper with direct antigen-discovery relevance.",
    "journal": "Molecular & cellular proteomics : MCP",
    "pmid": "42106149",
    "doi": "10.1016/j.mcpro.2026.101581",
    "preprint_id": "",
    "authors": "Courcelles M; Hardy MP; Durette C; Lanoix J; Minati R; Laverdure JP; Vincent K; Perreault C; Thibault P",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-10",
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    "source_type": "papers",
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    "rank_index": 4,
    "score": 64,
    "id": "biorxiv:10.64898/2026.05.05.723095",
    "canonical_key": "doi:10.64898/2026.05.05.723095",
    "headline": "CD1a-Mediated Presentation of Canonical Microbial Peptides to T Cells",
    "summary": "bioRxiv. Reports canonical microbial peptide presentation by CD1a to T cells; adjacent to antigen-presentation biology and T-cell ligand discovery though not classical HLA pMHC.",
    "url": "https://doi.org/10.64898/2026.05.05.723095",
    "source": "bioRxiv",
    "published_date": "2026-05-09",
    "match_reason": "LLM promoted: peptide presentation to T cells, adjacent but lower than classical HLA/pMHC work.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.05.723095",
    "preprint_id": "biorxiv:10.64898/2026.05.05.723095",
    "authors": "De Andrade Silva, B. J.; de Jong, A.; Fischbacher, L. A.; Marques, M. A. M.; Legaspi, A.; Shahine, A.; Kollmorgen, J.; Sieling, P. A.; Choi, A.; Kim, H. J.; Matos e Silva, C. A.; Webb, K. J.; Bradshaw, J.; Brennan, P. J.; Marusina, A.; Tran, K. A.; Sarno, E. N.; Pinheiro, R. O.; Zajonc, D. M.; Moody, D. B.; Niazi, K. R.; Maverakis, E.; Sette, A.; Rossjohn, J.; Ochoa, M. T.; Belisle, J. T.; Modlin, R. L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
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    "digest_date": "2026-05-10",
    "window_start": "2026-05-09T05:15:00.000Z",
    "window_end": "2026-05-10T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 5,
    "score": 54,
    "id": "pubmed:42108354",
    "canonical_key": "pmid:42108354",
    "headline": "Clinical Development of T-Cell Bispecific Antibodies: Review, Challenges, and Prospective Solutions in Solid Tumor.",
    "summary": "Methods in Molecular Biology. Reviews T-cell bispecific antibody development in solid tumors; relevant to TCE strategy but less specific than TCR/pMHC-targeted platforms.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42108354/",
    "source": "PubMed",
    "published_date": "2026-05-10",
    "match_reason": "LLM promoted: solid-tumor T-cell bispecific review, therapeutically relevant but not pMHC-specific.",
    "journal": "Methods in molecular biology (Clifton, N.J.)",
    "pmid": "42108354",
    "doi": "10.1007/978-1-0716-5037-0_16",
    "preprint_id": "",
    "authors": "Ogami C; Ishiguro T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-10",
    "window_start": "2026-05-09T05:15:00.000Z",
    "window_end": "2026-05-10T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 1,
    "score": 34,
    "id": "pubmed:42108795",
    "canonical_key": "pmid:42108795",
    "headline": "Real-World Efficacy and Safety of Glofitamab-Based Salvage Therapy in Chinese Patients With Relapsed or Refractory Aggressive B-Cell Lymphomas.",
    "summary": "American Journal of Hematology. Real-world glofitamab salvage data in aggressive B-cell lymphoma; useful TCE context but not pMHC or TCR-directed.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42108795/",
    "source": "PubMed",
    "published_date": "2026-05-10",
    "match_reason": "LLM demoted: clinically relevant T-cell engager context, but CD20/glofitamab is outside pMHC/TCR-targeting core interest.",
    "journal": "American journal of hematology",
    "pmid": "42108795",
    "doi": "10.1002/ajh.70359",
    "preprint_id": "",
    "authors": "Zhou J; Wang C; You T; Wang Y; Zong X; Wang Q; Chen W; Sheng K; Ma X; Chen J; Wu D; Huang H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-10",
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    "rank_index": 2,
    "score": 28,
    "id": "pubmed:42106360",
    "canonical_key": "pmid:42106360",
    "headline": "Comparing UV-enhanced and direct reduction strategies for CD8⁺ T-cell electrochemical detection.",
    "summary": "Scientific reports. Sci Rep. 2026-05-09",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42106360/",
    "source": "PubMed",
    "published_date": "2026-05-09",
    "match_reason": "Watchlist hits: Roche",
    "journal": "Scientific reports",
    "pmid": "42106360",
    "doi": "10.1038/s41598-026-44056-9",
    "preprint_id": "",
    "authors": "Amoo M; Salimijazi H; Labbaf S; Karimzadeh F",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-10",
    "window_start": "2026-05-09T05:15:00.000Z",
    "window_end": "2026-05-10T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 3,
    "score": 28,
    "id": "biorxiv:10.64898/2026.05.08.723607",
    "canonical_key": "doi:10.64898/2026.05.08.723607",
    "headline": "Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding",
    "summary": "Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ~40-50% of cases1,2.",
    "url": "https://doi.org/10.64898/2026.05.08.723607",
    "source": "bioRxiv",
    "published_date": "2026-05-09",
    "match_reason": "Watchlist hits: TP53",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.08.723607",
    "preprint_id": "biorxiv:10.64898/2026.05.08.723607",
    "authors": "Zeng, J.; Cheng, Z.; Chen, H.; Thompson, J.; Crosby, K. T.; Hang, H.; Ngo, W.; Xia, C.; Rosas-Rivera, D.; Kang, M. H.; Mao, Y.; Lee, G.; Diffley, J. F. X.; Song, Y.; Qiu, L.; Krah, N. M.; Murthy, N.; Jackson, R. N.; Liu, Y.; Ashworth, A.; Doudna, J. A.",
    "assignee": "",
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    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
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    "digest_date": "2026-05-10",
    "window_start": "2026-05-09T05:15:00.000Z",
    "window_end": "2026-05-10T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 4,
    "score": 24,
    "id": "pubmed:42106230",
    "canonical_key": "pmid:42106230",
    "headline": "[Resistance to immunotherapy in non-small cell lung cancer: State of the art].",
    "summary": "Revue des maladies respiratoires. Rev Mal Respir. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42106230/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Revue des maladies respiratoires",
    "pmid": "42106230",
    "doi": "10.1016/j.rmr.2026.04.002",
    "preprint_id": "",
    "authors": "Ancel J; Dewolf M; Nawrocki-Raby B; Durlach A; Dalstein V; Cortot A; Dormoy V; Gilles C; Polette M; Deslée G",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "rank_index": 5,
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    "id": "pubmed:42107039",
    "canonical_key": "pmid:42107039",
    "headline": "[Tumor-infiltrating lymphocyte preparations have been in the fight against cancer for 40 years].",
    "summary": "Orvosi hetilap. Orv Hetil. 2026-05-10",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42107039/",
    "source": "PubMed",
    "published_date": "2026-05-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Orvosi hetilap",
    "pmid": "42107039",
    "doi": "10.1556/650.2026.33557",
    "preprint_id": "",
    "authors": "Balázs S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-10",
    "window_start": "2026-05-09T05:15:00.000Z",
    "window_end": "2026-05-10T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 6,
    "score": 24,
    "id": "pubmed:42106834",
    "canonical_key": "pmid:42106834",
    "headline": "A multi species autophagy-inducing nano-vaccine platform: uncovering immunoenhancement properties of PCV2 cap nanoparticles.",
    "summary": "Journal of nanobiotechnology. J Nanobiotechnology. 2026-05-09",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42106834/",
    "source": "PubMed",
    "published_date": "2026-05-09",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of nanobiotechnology",
    "pmid": "42106834",
    "doi": "10.1186/s12951-026-04527-7",
    "preprint_id": "",
    "authors": "Deng Z; Qiu H; Yin X; Xu H; Zhang S; Sun M; Yang H; Gu H; Fang W; Li X; He F",
    "assignee": "",
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    "headline": "CD25(+) cell depletion enhances protective immunity of PR8 inactivated influenza vaccine in aged mice.",
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    "headline": "Chimeric virus-like particles of nodavirus displaying human and avian influenza A M2e induce conserved anamnestic protective immunity against human and avian influenza A viruses.",
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    "headline": "Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress",
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    "headline": "Clinical Development of Bispecific Antibodies: Review, Advances, and Challenges in Hematological Malignancies.",
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    "headline": "Clinical features and prognostic factors of adult systemic chronic active EBV disease: A retrospective analysis in Japan.",
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    "headline": "Clinical Significance of B7-H4 in Peripheral Blood of Patients With Myasthenia Gravis.",
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    "headline": "Combined targeting of VISTA and sorafenib activates T cell-mediated anti-tumor immunity via the NF-κB/TNF axis in hepatocellular carcinoma.",
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    "headline": "Compartment-specific phase compensation between pulmonary T-Cell immunity and waning systemic responses in BA.5 breakthrough infection.",
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    "headline": "Computational analysis reveals the requirement for cell-cell interaction in liver repopulation by transplanted hepatocytes",
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    "headline": "Computationally inspired glycoengineering to maximise mAb β4-galactosylation",
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    "source": "bioRxiv",
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    "headline": "Context-Dependent Rewiring of the cGAS-STING Pathway in Cancer: Implications for Immunotherapy and Therapeutic Resistance.",
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    "headline": "Coordinated cell and chloroplast growth and its perturbation by chloroplast DNA replication inhibition in green algae",
    "summary": "Coordination among cell growth, chloroplast expansion, and organelle genome dynamics is fundamental to algal physiology, yet its regulation remains unclear.",
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    "headline": "Covalently photosensitized probiotic bacteria for light-triggered tumor clearance and self-limiting immunotherapy.",
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    "authors": "Yin Y; Cheng X; Fang Y; Zhou X; Guo H; Zhong S; Wegner SV; Sun W; Hou C; Chen F; Zeng W",
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    "headline": "dCas9 metabolic enzyme fusions modulate global and locus specific gene expression",
    "summary": "Central metabolites function as essential co substrates for chromatin modifying enzymes, directly linking cellular metabolism to chromatin regulation. Accordingly, whole cell fluctuations in co substrate availabilities have been shown to promote diverse phenotypes through chromatin dependent mechanisms.",
    "url": "https://doi.org/10.64898/2026.05.10.724078",
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    "headline": "Deciphering the Molecular Structure of the Type III Secretion System in Chlamydia trachomatis for Structure-Based Therapeutic Targeting",
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    "headline": "Dengue viruses serotypes 2 and 4 exhibit distinct infection kinetics and modulation of anti-viral immune responses in human tonsil histocultures",
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    "headline": "Ecological determinants of disease and immunity in myelodysplastic syndromes",
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    "url": "https://doi.org/10.64898/2026.05.05.720208",
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    "authors": "Stanley, R. F.; Zhang, B. D.; Argyropoulos, K. V.; Zhang, P.; Maron, M.; Gipson, B.; Park, C.; Weis, K.; Lewis, A. M.; Katsamakis, Z.; Wishnack, C.; Cuibus, M. A.; Fan, N.; Zhao, K.; Wu, K.; Snopkowski, C.; Weinreb, J.; Biswas, J.; Zatzman, M. J.; Aleynick, N.; Boiocchi, L.; Lim, M. S.; Tamari, R.; Peled, J.; Shah, G.; Moorman, A.; Elhanati, Y.; Rosiek, E.; Roshal, M.; Dogan, A.; Bhanot, U. K.; Stein, E. M.; Samorodnitsky, S.; Chaligne, R.; van den Brink, M. R. M.; Martis, S.; Greenbaum, B. D.; Abdel-Wahab, O.; DeWolf, S.",
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    "headline": "EFFICIENT EXPANSION OF NK-92 CELL LINE USING A NOVEL LOW-SHEAR STRESS BIOREACTOR",
    "summary": "Background: The use of autologous or allogeneic cell therapies has now entered to the clinical practice in several fields of medicine, especially in oncology and hematology.",
    "url": "https://doi.org/10.64898/2026.05.06.723052",
    "source": "bioRxiv",
    "published_date": "2026-05-09",
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    "doi": "10.64898/2026.05.06.723052",
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    "authors": "Bergmann, M.; Belliard, N.; Meunier, P.; Roumezi, B.; Detournay, O.; Turhan, A. G.; Bennaceur Griscelli, A.",
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    "id": "biorxiv:10.64898/2026.05.07.723170",
    "canonical_key": "doi:10.64898/2026.05.07.723170",
    "headline": "Environment-responsive individual cell growth behavior shapes stochastic and deterministic population establishment in ammonia-oxidizing bacteria",
    "summary": "Many environmental bacteria do not readily grow under laboratory conditions and population establishment often occurs stochastically.",
    "url": "https://doi.org/10.64898/2026.05.07.723170",
    "source": "bioRxiv",
    "published_date": "2026-05-09",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.07.723170",
    "preprint_id": "biorxiv:10.64898/2026.05.07.723170",
    "authors": "Ikeda, S.; Fujitani, H.; Tsuneda, S.",
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    "id": "pubmed:42107533",
    "canonical_key": "pmid:42107533",
    "headline": "Epithelial MLCK deficiency alleviates alcohol-associated liver disease via dendritic-Th17 cell axis.",
    "summary": "JHEP reports : innovation in hepatology. JHEP Rep. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42107533/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "JHEP reports : innovation in hepatology",
    "pmid": "42107533",
    "doi": "10.1016/j.jhepr.2026.101849",
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    "authors": "Wang X; Wang J; Xiong L; Tang S; Wu S; Zhao J; Wang Z; Zhu J; Li Y; Zhuang J; Wu J; Zhang J; Zhou Z; Huang J; Shen H; Wu M; Qi L; He W; Hu R; Turner JR; Huang Y; Wang H; Zuo L",
    "assignee": "",
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    "id": "biorxiv:10.64898/2026.05.06.723215",
    "canonical_key": "doi:10.64898/2026.05.06.723215",
    "headline": "Failure of Bacillus Calmette-Guerin Therapy in Patients with Bladder Cancer is Characterized by Immune Dysfunction Associated with Activator Protein 1",
    "summary": "The standard-of-care for patients with higher-risk non-muscle invasive bladder cancer (NMIBC) after tumour resection is intravesical administration of Bacillus Calmette-Guerin (BCG).",
    "url": "https://doi.org/10.64898/2026.05.06.723215",
    "source": "bioRxiv",
    "published_date": "2026-05-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.06.723215",
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    "authors": "Garven, A.; Pare, J.-F.; Robins, A.; Vera-Rodriguez, A.; Sampy, R.; Bennett, A.; Nauman, R. W.; Craig, A. W.; Greer, P. A.; Koti, M.; Cotechini, T.; Berman, D. M.; Simpson, A.; Postovit, L.-M.; Siemens, D. R.; Graham, C. H.",
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    "headline": "From Immune Activation to Cell Death: Investigating the Pro-inflammatory Phenotype of PBMCs in Major Depressive Disorder",
    "summary": "Pietruczuk K, Rückemann-Dziurdzińska K, Bierzanowski S, Grabowski K, Bryl E, Witkowski JM.",
    "url": "https://doi.org/10.21203/rs.3.rs-9336198/v1",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-09",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "pmid": "",
    "doi": "10.21203/rs.3.rs-9336198/v1",
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    "authors": "Pietruczuk K;  Rückemann-Dziurdzińska K;  Bierzanowski S;  Grabowski K;  Bryl E;  Witkowski JM.",
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    "primary_source": "Europe PMC / PPR",
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    "keywords": "europe pmc; preprint"
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    "id": "pubmed:42108515",
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    "headline": "Genomic ancestry and diversity in individuals with type 1 diabetes from Brazil and Portugal: a descriptive analysis.",
    "summary": "Diabetology & metabolic syndrome. Diabetol Metab Syndr. 2026-05-10",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42108515/",
    "source": "PubMed",
    "published_date": "2026-05-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Diabetology & metabolic syndrome",
    "pmid": "42108515",
    "doi": "10.1186/s13098-026-02144-w",
    "preprint_id": "",
    "authors": "Ferreira LL; do Vale S; Duarte MA; Silva AL; Porto LC; Turchetto-Zolet AC; Silva DA; Gomes MB",
    "assignee": "",
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    "source_type": "papers",
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    "id": "biorxiv:10.1101/2025.11.26.690754",
    "canonical_key": "doi:10.1101/2025.11.26.690754",
    "headline": "Haplotype-resolved diploid genome inference on pangenome graphs",
    "summary": "Recent algorithmic advancements have shown how to utilize pangenome graphs in combination with the haplotype reconstruction framework of Li and Stephens to accurately reconstruct a haplotype from a reference pangenome graph and a set of input reads.",
    "url": "https://doi.org/10.1101/2025.11.26.690754",
    "source": "bioRxiv",
    "published_date": "2026-05-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.11.26.690754",
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    "authors": "Chandra, G.; Doan, W. T.; Gibney, D.",
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    "id": "pubmed:42105693",
    "canonical_key": "pmid:42105693",
    "headline": "Heparanase blockade sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy and unleashes antitumor immunity.",
    "summary": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. Biomed Pharmacother. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42105693/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
    "pmid": "42105693",
    "doi": "10.1016/j.biopha.2026.119442",
    "preprint_id": "",
    "authors": "Chen CJ; Wang HC; Huang WY; Chang SS; Chang A; Lin CL; Yang CY; Shan YS",
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    "id": "pubmed:42106020",
    "canonical_key": "pmid:42106020",
    "headline": "HRD-Driven Reprogramming of Macrophage Function and Spatial Architecture in High-Grade Serous Ovarian Cancer.",
    "summary": "Genetics research. Genet Res (Camb)",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42106020/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Genetics research",
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    "doi": "10.1155/genr/7364793",
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    "authors": "Lan H; Xu F; Li L; Wei X; Li M",
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    "canonical_key": "doi:10.64898/2026.05.10.724106",
    "headline": "Human placental trophoblasts support sustained Treponema pallidum replication and reveal new candidate host pathways implicated in congenital syphilis",
    "summary": "Congenital syphilis is a leading cause of preventable stillbirth, yet the mechanisms that enable Treponema pallidum subsp. pallidum, the etiological agent of syphilis, to traverse and persist within the human placenta are virtually unknown. This knowledge gap reflects, in part, the fastidious nature of T.",
    "url": "https://doi.org/10.64898/2026.05.10.724106",
    "source": "bioRxiv",
    "published_date": "2026-05-10",
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    "authors": "McColl, E.; Edmondson, D. G.; DeLay, B. D.; Kaval, K.; Bark, S. J.; Norris, S. J.; Mysorekar, I. U.",
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    "headline": "Integrated in silico-in vitro identification of high-affinity TCR-Like antibodies targeting HPV18 E6/E7 for cervical cancer detection.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42113290/",
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    "match_reason": "High relevance: TCR-like antibody discovery against viral peptide-HLA targets with experimental affinity validation.",
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    "authors": "Sachit BA; Dass S; Rajan RS; Tye GJ; Balakrishnan V",
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    "id": "pubmed:42109827",
    "canonical_key": "pmid:42109827",
    "headline": "Rapid identification of antigen-specific TCRs for cancer immunotherapy.",
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    "source": "PubMed",
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    "headline": "Computational design of class II MHC binding peptide with sequence-based evolution information.",
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    "source": "PubMed",
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    "authors": "Cao Y; Li Y; Ren W; Li W; Yan Z",
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    "id": "pubmed:42112363",
    "canonical_key": "pmid:42112363",
    "headline": "Stable global repertoire architecture masks short-term clonal remodeling in intratumoral TCR repertoires.",
    "summary": "Intratumoral TCR repertoire study showing stable global repertoire architecture despite short-term clonal remodeling; useful as disease-context TCR repertoire data.",
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    "source": "PubMed",
    "published_date": "2026-04-23",
    "match_reason": "Relevant: tumor TCR repertoire architecture and clonal dynamics, though without direct antigen mapping.",
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    "doi": "10.3389/fimmu.2026.1819997",
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    "authors": "Pedersen PG; Gammelgaard OL; Traynor S; Ruhlmann CH; Hansen AS; Ditzel HJ; Gjerstorff MF; Terp MG",
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    "id": "pubmed:42111195",
    "canonical_key": "pmid:42111195",
    "headline": "Multiple sclerosis-associated HLA demarcates EBV-specific CD8(+) T cells with an exhausted and brain residency phenotype.",
    "summary": "HLA-associated EBV-specific CD8 T cell phenotype study in multiple sclerosis, connecting disease HLA genetics to antigen-specific T cell states.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42111195/",
    "source": "PubMed",
    "published_date": "2026-04-15",
    "match_reason": "Moderate relevance: HLA-associated antigen-specific CD8 T cell biology in disease context.",
    "journal": "iScience",
    "pmid": "42111195",
    "doi": "10.1016/j.isci.2026.115744",
    "preprint_id": "",
    "authors": "Reijm S; Marques AM; Rip J; Corsten CEA; Wierenga-Wolf AF; de Wit H; Melief MJ; van Hasselt Y; van Langelaar J; Neuteboom R; Wokke BHA; Mueller YM; Smolders J; van Luijn MM",
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    "headline": "Stress-driven remodeling of antigen presentation and chemokine signaling in pancreatic β-cells: implications for type 1 diabetes.",
    "summary": "Pancreatic beta-cell stress paper focused on antigen-presentation remodeling and chemokine signaling in type 1 diabetes.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42112402/",
    "source": "PubMed",
    "published_date": "2026-04-23",
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    "journal": "Frontiers in immunology",
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    "doi": "10.3389/fimmu.2026.1772399",
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    "authors": "Mittal R; Alipour F; Doshi J; Mittal M; Hirani K",
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    "headline": "Safety and Immunogenicity of Varicella Vaccination in Children and Adolescents Living With HIV: A Systematic Review.",
    "summary": "The Pediatric infectious disease journal. Pediatr Infect Dis J. 2026-05-11",
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    "published_date": "2026-05-11",
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    "journal": "The Pediatric infectious disease journal",
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    "authors": "Marin M; Raparti L; Leung J; Oliver SE; Levin MJ",
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    "id": "biorxiv:10.64898/2026.05.06.723371",
    "canonical_key": "doi:10.64898/2026.05.06.723371",
    "headline": "Siglec-G on B cells restrains the germinal center response by controlling T cell help during positive selection",
    "summary": "The germinal center (GC) reaction requires tight regulation of B cell and T follicular helper (Tfh) cell interactions to ensure B cell expansion and antibody affinity maturation, while preventing oncogenesis.",
    "url": "https://doi.org/10.64898/2026.05.06.723371",
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    "match_reason": "Structural or binding evidence: affinity",
    "journal": "bioRxiv",
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    "doi": "10.64898/2026.05.06.723371",
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    "authors": "Enterina, J. R.; Lin, S.-Y.; Luna-Dulcey, L.; Sarkar, S.; Schmidt, E. N.; Jame-Chenarboo, Z.; Chisholm, K.; Ul Haq, A.; Luo, S.; St. Laurent, C. D.; Ataei, T.; Giuliani, F.; Julien, O.; Macauley, M. S.",
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    "headline": "[Successful checkpoint inhibition plus extracorporeal photopheresis in patients with metastatic melanoma and advanced Sézary syndrome].",
    "summary": "Dermatologie (Heidelberg, Germany). Dermatologie (Heidelb). 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42113060/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Dermatologie (Heidelberg, Germany)",
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    "authors": "Jochims F; Ziemer M",
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    "headline": "3D cortical microtissue with innate microglia for studying real-time cell behavior across maturation and inflammatory response",
    "summary": "Microglia represent the immune component of the central nervous system (CNS) that displays dynamic responses to injury and disease. Across the developing and mature CNS, microglia emerge as immunocompetent cells that continuously survey their surroundings to maintain tissue homeostasis and respond to threats.",
    "url": "https://doi.org/10.64898/2026.05.06.723271",
    "source": "bioRxiv",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.06.723271",
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    "authors": "Del Toro, A.; Aguilar, K.; Clark, A.; Bautista, A.; Ashby, N.; Hoffman-Kim, D.",
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    "id": "pubmed:42113553",
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    "headline": "68Ga-Pentixafor PET/CT Outperforms 18F-FDG PET/CT in a Patient With Adult T-cell Leukemia/Lymphoma.",
    "summary": "Clinical nuclear medicine. Clin Nucl Med. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42113553/",
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    "journal": "Clinical nuclear medicine",
    "pmid": "42113553",
    "doi": "10.1097/RLU.0000000000006526",
    "preprint_id": "",
    "authors": "Liu H; Xiao Z; Huang Y; Wang Y; He Y",
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    "canonical_key": "pmid:42112903",
    "headline": "A cell-impermeable kinase inhibitor uncovers outside-in signaling pathways that promote HIV-1 infection.",
    "summary": "Journal of virology. J Virol. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42112903/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of virology",
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    "doi": "10.1128/jvi.00160-26",
    "preprint_id": "",
    "authors": "Vinzant K; Cheshenko N; Pan H; Cutler R; Buckler JN; Luxenburger A; Harris LD; Johnson JR; Almo SC; Herold BC",
    "assignee": "",
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    "id": "biorxiv:10.1101/2023.12.01.569475",
    "canonical_key": "doi:10.1101/2023.12.01.569475",
    "headline": "A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis",
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    "url": "https://doi.org/10.1101/2023.12.01.569475",
    "source": "bioRxiv",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2023.12.01.569475",
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    "authors": "Verma, S.; Thakur, S.; Das, M.; Sharma, R. D.; Yadav, V.; Sharma, P.; Marzuki, M.; Foo, S.; Piperno, G. M.; Khan, M. Z.; Mathew, B.; Bajpai, M.; Maras, J. S.; Howland, S.; Sarkar, S.; Benvenuti, F.; Singh, A.; Nandicoori, V.; Singhal, A.; Kumar, D.",
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    "id": "pubmed:42112346",
    "canonical_key": "pmid:42112346",
    "headline": "A molecular systems architecture of asthma.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42112346/",
    "source": "PubMed",
    "published_date": "2026-04-24",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42112346",
    "doi": "10.3389/fimmu.2026.1788984",
    "preprint_id": "",
    "authors": "Ayyadurai VAS; Deonikar P; Manoharan Y",
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    "score": 24,
    "id": "biorxiv:10.64898/2026.05.09.723998",
    "canonical_key": "doi:10.64898/2026.05.09.723998",
    "headline": "A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage",
    "summary": "DNA topoisomerase II (TOP2) generates transient DNA double-strand breaks that are trapped as TOP2-DNA covalent complexes (TOP2cc) by antibiotic and chemotherapy drugs.",
    "url": "https://doi.org/10.64898/2026.05.09.723998",
    "source": "bioRxiv",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
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    "doi": "10.64898/2026.05.09.723998",
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    "authors": "Ontoso, D.; Mehta, M.; Shabro, A.; Dittmar, J.; Reid, R. J. D.; Rothstein, R.; Nitiss, J. L.; Keeney, S.",
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    "id": "pubmed:42112412",
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    "headline": "A Rare Case of Cutaneous Lymphomatoid Granulomatosis: A Case Report and Literature Review.",
    "summary": "Cureus. Cureus. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42112412/",
    "source": "PubMed",
    "published_date": "2026-05-07",
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    "doi": "10.7759/cureus.108448",
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    "authors": "Phillips JA; Awale A; Anim-Koranteng C; Thearle M; Hatcher V",
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    "id": "biorxiv:10.64898/2026.05.06.723248",
    "canonical_key": "doi:10.64898/2026.05.06.723248",
    "headline": "Aberrant CD4+ T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease",
    "summary": "T cells modulate disease associated neuroinflammation in Parkinson's disease (PD). We report that circulating CD4+ T cells from people with PD have a dysregulated transcriptional and cytokine response to fasting and refeeding and an altered metabolic profile.",
    "url": "https://doi.org/10.64898/2026.05.06.723248",
    "source": "bioRxiv",
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    "doi": "10.64898/2026.05.06.723248",
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    "authors": "Austin-Muttitt, K.; David, B. R.; Sassi, M.; Agarwal, R.; Sabedot, T.; Jones, J. R.; Cuoco, M. S.; Jenkins, B. J.; Roberts, L. D.; Harris, L.; Kieronczyk, N.; Han, G.; Hitchings, M. D.; Donaghy, P. C.; Yarnall, A. J.; Thornton, C. A.; Mohamed, B.; Morgan, A. H.; Thomas, F.; Jones, N.; Gage, F. H.; Davies, J. S.",
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    "headline": "Ambient temperature regulates CD4(+) T cell tonic T cell receptor signaling and responsiveness.",
    "summary": "iScience. iScience. 2026-04-20",
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    "source": "PubMed",
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    "doi": "10.1016/j.isci.2026.115801",
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    "authors": "Sawada K; Eom J; Mahoney-Sutherland BA; Stankiewicz TE; Oates JR; Giles DA; Alarcon PC; Damen MSMA; Cannata A; Hargis J; McAlees JW; Ulanowicz CJ; Wayland JL; Hildeman DA; Lewkowich IP; Hogan SP; Salomonis N; Moreno-Fernandez ME; Divanovic S",
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    "headline": "An Advanced Single-Cell RNA Sequencing (scRNA-seq) Protocol Utilizing Custom-Designed Multiplexing.",
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    "doi": "10.21769/BioProtoc.5678",
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    "authors": "Gao F; Liu X; Sun F; Xiao Y; Xiao G; Qu Z",
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    "id": "pubmed:42111772",
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    "headline": "Antiangiogenic DPPA-nanoparticles combined with an immune checkpoint inhibitor for the treatment of unresectable hepatocellular carcinoma.",
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    "authors": "Huang Z; Tan J; Tan S; Long Y; Li S; Zhang W; Zhang F; Liang Y; Fang J; Lin L; Li W; Saw PE; Zhang L",
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    "headline": "Decoding allergy in vitro: Challenges and clinical use of humoral and cellular methods.",
    "summary": "Allergologie select. Allergol Select. 2026-05-05",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42111357/",
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    "headline": "Delayed type I interferon response and the subsequent out-of-sequence cytokine signal inhibit T cell induction in non-surviving Ebola virus-infected patients.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42112364/",
    "source": "PubMed",
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    "journal": "Frontiers in immunology",
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    "authors": "Zhao G; Korva M; Muñoz-Fontela C; Günther S; Kerber R; Binder SC; Meyer-Hermann M",
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    "headline": "Bridging clinical gaps in personalized cancer neoantigen vaccines.",
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    "authors": "Khaddour K; Ott PA",
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    "headline": "AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD",
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    "authors": "Bodansky, A.; Ahyong, V.; Dayao, M.; Asaki, J.; Vanasupa, S.; Dandekar, R.; Chen, S.; Sabatino, J.; Klauer, S.; Knudsen, G.; Lizama Valenzuela, C.; McCutcheon, K.; Zorn, K.; Sidhu, S.; Yu, D.; Garcia, S.; Quandt, Z.; Wang, C.-Y.; Castillo Rojas, B.; Tilton, I.; Citron, Y. R.; Sharathchandra, A.; Gerungan, C.; Tomko, S.; Robbins, N. M.; McKeon, A.; Cooper, T.; Harms, M.; Gomez, R.; Fancy, S. P. J.; Green, A. J.; Caliskan, I.; Cadwell, C. R.; Ostrem, B. E.; Karalius, M.; Braun, L.; Gupta, S.; Francisco, C.; Peng, G.; Reddy, A. T.; Nash, K.; Pleasure, S. J.; Mandel-Brehm, C.; Arnold, T. D.; Conso",
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    "headline": "Spatial and Cellular Architecture of the Glioblastoma Microenvironment Associated with Tumor-Infiltrating Lymphocyte Expansion",
    "summary": "bioRxiv glioblastoma TIL study links spatial immune architecture with TIL expansion and TCR clonality, useful patient-derived repertoire context.",
    "url": "https://doi.org/10.1101/2025.03.26.645566",
    "source": "bioRxiv",
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    "authors": "Hotchkiss, K. M.; Zhang, K.; Corcoran, A. M.; Owens, E.; Jepson, J.; Van Batavia, K.; Noldner, P.; Ayasoufi, K.; Singh, K.; Brown, M. C.; Shaz, B. H.; Conejo-Garcia, J.; Hickey, J. W.; Khasraw, M.",
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    "headline": "Engineered artificial antigen-presenting cells for tumor immunotherapy: Design strategies, clinical applications, and translational challenges.",
    "summary": "Review of engineered artificial antigen-presenting cell designs for tumor immunotherapy; pMHC-adjacent platform context, not a named TCR program.",
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    "source": "PubMed",
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    "match_reason": "Antigen presentation platform context: engineered artificial antigen-presenting cells",
    "journal": "Materials today. Bio",
    "pmid": "42111759",
    "doi": "10.1016/j.mtbio.2026.103192",
    "preprint_id": "",
    "authors": "Cai H; Zhao Y; Cai Y; Luo X; Li J; Wu Y; Yang J; Wang C; Zhang Y; Ding H; Cheng S; Wang Y",
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    "canonical_key": "pmid:42115783",
    "headline": "A Bispecific Anti-Fluorescein × Anti-CD3 T-cell Engager in Combination with Fluoresceinated Adaptors Enables Lysis of AML Cells.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42115783/",
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    "match_reason": "TCR therapeutic modality adjacent: anti-CD3 T-cell engager | Oncology lysis assay",
    "journal": "Molecular cancer therapeutics",
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    "authors": "Volta LG; Gobbi C; Koch C; Harrer N; Hofstetter M; Maurer M; Schneiter F; Manfredi F; Pellegrino C; Magnani CF; Schroeder T; Neri D; Manz MG",
    "assignee": "",
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    "headline": "The radioactive 3D-printed template-assisted CT-guided 125I seed implantation for refractory bone metastases: A multicenter retrospective analysis of efficacy, safety, and immune function changes.",
    "summary": "PloS one. PLoS One. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42113827/",
    "source": "PubMed",
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    "authors": "Zhao GS; Zhou HZ; Wang QS; Zhou XY; Sun JB; Gao F; Wang RY; Wang Z; Zhou J; Liu S; Zhuang BQ",
    "assignee": "",
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    "headline": "Whole blood transcriptome profiling in patients treated with deucravacitinib and novel mechanistic insights into TYK2 inhibition in lupus: results from a post hoc analysis of the PAISLEY SLE phase 2 trial.",
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    "source": "PubMed",
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    "match_reason": "Clinical or translational importance: phase 2",
    "journal": "Annals of the rheumatic diseases",
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    "authors": "Vital E; Wu C; Kahlenberg JM; Arriens C; Crow MK; Saxena A; Catlett IM; Hobar C; Hu Y",
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    "canonical_key": "doi:10.64898/2026.05.07.723402",
    "headline": "HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microglia",
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    "url": "https://doi.org/10.64898/2026.05.07.723402",
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    "match_reason": "Watchlist hits: KRAS",
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    "authors": "Reinsberg, F.; Schiering, K.; Lingstaedt, M. G.; Mensching, L.; Adiba, M.; Kraus, T. V.; Engler, J. B.; Liebold, I.; Bosurgi, L.; Schloer, S.; Altfeld, M.; Friese, M. A.; Krasemann, S.; Lange, U. C.; Garcia-Beltran, W. F.; Hoelzemer, A.",
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    "headline": "3DBrainOne: an integrated end-to-end platform for 3D histological analysis of whole mouse brains",
    "summary": "Three-dimensional (3D) whole-organ imaging and analysis at cellular resolution (termed 3D histology) provide profound insights into the organization and interactions of cells throughout organs.",
    "url": "https://doi.org/10.64898/2026.05.06.723327",
    "source": "bioRxiv",
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    "authors": "Park, Y.-G.; Kim, D.",
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    "headline": "A bare host cell membrane with minimal glycocalyx is an optimal surface for targeting by virulence-primed Salmonella Typhimurium",
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    "url": "https://doi.org/10.64898/2026.05.11.724231",
    "source": "bioRxiv",
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    "authors": "Geiser, P.; Westman, J.; Ceylan, M.; Bosman, W.; von Beek, C.; Artursson, P.; Kjellen, L.; Pelaseyed, T.; Sellin, M. E.",
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    "headline": "A circular RNA vaccine induces durable and cross-protective immunity against Neisseria meningitidis serogroup B in mice.",
    "summary": "PLoS pathogens. PLoS Pathog. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42113852/",
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    "doi": "10.1371/journal.ppat.1013741",
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    "authors": "Zhang Q; Niu D; Jia Y; Lu L; Wu W; Qu C; Sun Z; Li S; Liu Z; Lv J; Wang W; Yu J; Zhang L; Li C; Peng W; Zhang Q; Wei S",
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    "id": "pubmed:42114689",
    "canonical_key": "pmid:42114689",
    "headline": "A Functional TNFRSF13B Variant Disrupts B-Cell Enhancer Activity and Increases Susceptibility to EBV-Negative Lymphoma.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42114689/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Gene",
    "pmid": "42114689",
    "doi": "10.1016/j.gene.2026.150200",
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    "authors": "Nakano J; Viet NH; Giang Nguyen HT; Dac DT; Long Hai LH; Thao PP; Nagaya S; Morishita E; Espinoza JL",
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    "id": "biorxiv:10.64898/2026.05.07.723413",
    "canonical_key": "doi:10.64898/2026.05.07.723413",
    "headline": "A mechanistic framework for photon-to-carbon efficiency: coupling photosynthetic energy supply and light respiration in microalgae",
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    "url": "https://doi.org/10.64898/2026.05.07.723413",
    "source": "bioRxiv",
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    "headline": "A RIG-I targeting nanozyme induces PANoptosis for cancer immunotherapy.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42115183/",
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    "headline": "A Shifting Immune Landscape: T-Cell Activation and Food Allergy Susceptibility After Pediatric Liver Transplantation.",
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    "headline": "A symbiotic MLO gene regulates root development via RALF34-triggered Ca2+ signalling in Lotus japonicus",
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    "url": "https://doi.org/10.1101/2025.09.18.676995",
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    "headline": "Allele frequency patterns of 78,122,254 SNPs illuminate diverse possible evolutionary trajectories of human populations.",
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    "headline": "Antibody subclass deficiency accelerates tumorigenesis in genetically engineered mouse models of pancreatic cancer.",
    "summary": "JCI insight. JCI Insight. 2026-05-05",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42113908/",
    "source": "PubMed",
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    "journal": "JCI insight",
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    "authors": "Foote JB; Sarvesh S; Al Diffalha S; Crossman DK; Cheng C; Kim MH; Hardy C; Carstens JL; Kojima K; Rose BJ; Klug CA",
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    "headline": "Author Correction: Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection.",
    "summary": "Nature communications. Nat Commun. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115193/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Nature communications",
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    "authors": "Pfefferkorn AM; Jahn L; Gauthier PT; Kulow VA; Roeles J; Müller-Bötticher N; Gerhardt LMS; Leiz J; Sarfraz S; Plumbom I; Greite R; Lovric S; Gamrekelashvili J; Limbourg F; Schmitz J; Bräsen JH; Scheffner I; Sauer IM; Aigner F; Altmüller J; Conrad T; Gwinner W; Ishaque N; Fähling M; Schmidt-Ott KM; Halloran PF; Ashraf MI; Hinze C",
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    "headline": "Axial spondyloarthritis: Moving beyond cytokine based therapies to cellular targets and advanced therapeutics.",
    "summary": "Best practice & research. Clinical rheumatology. Best Pract Res Clin Rheumatol. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115014/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Best practice & research. Clinical rheumatology",
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    "doi": "10.1016/j.berh.2026.102155",
    "preprint_id": "",
    "authors": "Patel S; Patel R; Bittar M; Deodhar A",
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    "canonical_key": "pmid:42115004",
    "headline": "Basophils in the regulation of allergies and inflammatory disorders.",
    "summary": "Allergology international : official journal of the Japanese Society of Allergology. Allergol Int. 2026-05-10",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115004/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Allergology international : official journal of the Japanese Society of Allergology",
    "pmid": "42115004",
    "doi": "10.1016/j.alit.2026.04.002",
    "preprint_id": "",
    "authors": "Miyake K; Homma A; Takasawa S; Ito J; Karasuyama H",
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    "canonical_key": "pmid:42115179",
    "headline": "BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression.",
    "summary": "Nature communications. Nat Commun. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115179/",
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    "canonical_key": "pmid:42114000",
    "headline": "Beyond antibodies in GAD65 autoimmunity: Reframing pathogenesis through intrathecal B-T cell cross-talk.",
    "summary": "Proceedings of the National Academy of Sciences of the United States of America. Proc Natl Acad Sci U S A. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42114000/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Proceedings of the National Academy of Sciences of the United States of America",
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    "doi": "10.1073/pnas.2609144123",
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    "authors": "Faissner S; Gold R",
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    "canonical_key": "pmid:42114778",
    "headline": "Breaking the oncogene-immune suppression cycle through dual HER2 silencing and innate immune activation by biomineralized DNA nanocomplexes.",
    "summary": "Journal of controlled release : official journal of the Controlled Release Society. J Control Release. 2026-05-09",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42114778/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of controlled release : official journal of the Controlled Release Society",
    "pmid": "42114778",
    "doi": "10.1016/j.jconrel.2026.115009",
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    "authors": "Duan Y; Huang J; Huang T; Yang K; Qi L; Yu B; Li F; Yin M; Zhao L; Chai Z; Liang W; Zhang H; Fei J; Ding J; Luo C; Zhou W; Hu J",
    "assignee": "",
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    "id": "pubmed:42114140",
    "canonical_key": "pmid:42114140",
    "headline": "Can antioxidants' supplementation modulate the impact of dietary deoxynivalenol and zearalenone co-contamination on the systemic and mucosal immune response of weaned pigs?",
    "summary": "Journal of animal science. J Anim Sci. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42114140/",
    "source": "PubMed",
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    "doi": "10.1093/jas/skag080",
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    "authors": "Verso LL; Lessard M; Lauzon K; Chorfi Y; Guay F",
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    "id": "biorxiv:10.1101/2025.07.22.666189",
    "canonical_key": "doi:10.1101/2025.07.22.666189",
    "headline": "Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole",
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    "url": "https://doi.org/10.1101/2025.07.22.666189",
    "source": "bioRxiv",
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    "headline": "Cardiac Mitochondrial Dysfunction Following Bleomycin-Induced Acute Lung Injury in Rats",
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    "url": "https://doi.org/10.64898/2026.05.06.723353",
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    "headline": "CD16(+) γδ T cells and antibody-dependent cellular cytotoxicity: a new axis of immune control in hepatitis B virus infection?",
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    "canonical_key": "pmid:42115470",
    "headline": "Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.",
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    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 24,
    "id": "pubmed:41771111",
    "canonical_key": "pmid:41771111",
    "headline": "Clinical characteristics and outcomes of cardiomyopathies related to immune-mediated diseases.",
    "summary": "European journal of heart failure. Eur J Heart Fail. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41771111/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "European journal of heart failure",
    "pmid": "41771111",
    "doi": "10.1093/ejhf/xuaf030",
    "preprint_id": "",
    "authors": "Rossi VA; Sikking MA; Folgheraiter A; Loco CP; Dominguez F; Nihant BSC; Stroeks SLVM; Henkens MTHM; Mora-Ayestarán N; Ramos-López N; Sinagra G; Garcia-Pavia P; Ruschitzka F; Merlo M; Verdonschot JAJ; Heymans SRB",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 27,
    "score": 24,
    "id": "pubmed:42115789",
    "canonical_key": "pmid:42115789",
    "headline": "Comparison of prognostic models for predicting severe noninfectious complications in common variable immunodeficiency.",
    "summary": "Allergologia et immunopathologia. Allergol Immunopathol (Madr). 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115789/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Allergologia et immunopathologia",
    "pmid": "42115789",
    "doi": "10.15586/aei.v54i3.1596",
    "preprint_id": "",
    "authors": "Kahraman S; Çölkesen F; Gerek ME; Kolak S; Önalan T; Aykan FS; Kılınç M; Evcen R; Akkuş FA; Arslan Ş",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 28,
    "score": 24,
    "id": "pubmed:42115715",
    "canonical_key": "pmid:42115715",
    "headline": "Complement factor B deficiency promotes lung cancer progression via FOS-mediated tryptophan metabolism and immune suppression.",
    "summary": "Communications medicine. Commun Med (Lond). 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115715/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Communications medicine",
    "pmid": "42115715",
    "doi": "10.1038/s43856-026-01648-w",
    "preprint_id": "",
    "authors": "He C; Gong R; Zhang F; Xu Q; Zhao Y; Zhang C; Fu Y; Li Y; Duan Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 29,
    "score": 24,
    "id": "pubmed:42115560",
    "canonical_key": "pmid:42115560",
    "headline": "Computational Design and Biopharmaceutical Evaluation of a Chimeric Nanoparticle Vaccine for Targeted Delivery against BK Polyomavirus.",
    "summary": "Pharmaceutical research. Pharm Res. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115560/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Pharmaceutical research",
    "pmid": "42115560",
    "doi": "10.1007/s11095-026-04100-9",
    "preprint_id": "",
    "authors": "Zahmatkesh A; Faraji SN; Hosseini SY; Yaghobi R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 30,
    "score": 24,
    "id": "pubmed:41707115",
    "canonical_key": "pmid:41707115",
    "headline": "CRLF2 rearrangement and extramedullary disease in B-cell acute lymphoblastic leukemia: a possible link?",
    "summary": "Blood advances. Blood Adv. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41707115/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Blood advances",
    "pmid": "41707115",
    "doi": "10.1182/bloodadvances.2025018480",
    "preprint_id": "",
    "authors": "Gava F; Yates B; Sun Z; Li G; O'Koren C; Adhikari B; Lugar S; Shalabi H; Mattison R; Turkbey EB; Yuan CM; Paietta E; Wang HW; Mullighan C; Silbert SK; Litzow M; Shah NN",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 31,
    "score": 24,
    "id": "pubmed:42068317",
    "canonical_key": "pmid:42068317",
    "headline": "Denileukin diftitox (Lymphir) for cutaneous T-cell lymphoma.",
    "summary": "The Medical letter on drugs and therapeutics. Med Lett Drugs Ther. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42068317/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "The Medical letter on drugs and therapeutics",
    "pmid": "42068317",
    "doi": "10.58347/tml.2026.1754f",
    "preprint_id": "",
    "authors": "",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 32,
    "score": 24,
    "id": "pubmed:42109509",
    "canonical_key": "pmid:42109509",
    "headline": "Diagnostics and monitoring in Hymenoptera venom allergy: current and future perspectives.",
    "summary": "Frontiers in allergy. Front Allergy. 2026-04-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42109509/",
    "source": "PubMed",
    "published_date": "2026-04-24",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in allergy",
    "pmid": "42109509",
    "doi": "10.3389/falgy.2026.1757776",
    "preprint_id": "",
    "authors": "Wilińska W; Starosz A; Grubczak K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 33,
    "score": 24,
    "id": "pubmed:42112839",
    "canonical_key": "pmid:42112839",
    "headline": "Differences in T-cell densities and neighborhood patterns in human colorectal adenomas and sessile serrated lesions.",
    "summary": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Cancer Epidemiol Biomarkers Prev. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42112839/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology",
    "pmid": "42112839",
    "doi": "10.1158/1055-9965.EPI-26-0083",
    "preprint_id": "",
    "authors": "Seal S; Fanning LR; Bagley E; Bookhout C; Barry EL; O'Quinn EC; Snover DC; Lewin DN; Guglietta S; Kourtidis A; Shrubsole MJ; Baron JA; Mackenzie TA; Alekseyenko AV; Wallace K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 34,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.06.723139",
    "canonical_key": "doi:10.64898/2026.05.06.723139",
    "headline": "Differential Expression Analysis for Longitudinal Single-Cell RNA-Sequencing Studies Using REBEL",
    "summary": "Longitudinal scRNA-seq experiments offer a powerful approach for dissecting temporal gene expression dynamics in individual cell types. However, few methods have been developed specifically to address the unique statistical challenges of repeated measures in scRNA-seq data.",
    "url": "https://doi.org/10.64898/2026.05.06.723139",
    "source": "bioRxiv",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.06.723139",
    "preprint_id": "biorxiv:10.64898/2026.05.06.723139",
    "authors": "Wynn, E. A.; Mould, K. J.; Vestal, B. E.; Moore, C. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; genomics"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 35,
    "score": 24,
    "id": "pubmed:42111272",
    "canonical_key": "pmid:42111272",
    "headline": "Divergent immuno-landscapes: comparing the tumor microenvironment of Indian and Western HNSCC patients.",
    "summary": "Frontiers in cell and developmental biology. Front Cell Dev Biol. 2026-04-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42111272/",
    "source": "PubMed",
    "published_date": "2026-04-23",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in cell and developmental biology",
    "pmid": "42111272",
    "doi": "10.3389/fcell.2026.1725978",
    "preprint_id": "",
    "authors": "Kumar Rai P; Choudhary B",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 36,
    "score": 24,
    "id": "pubmed:42110544",
    "canonical_key": "pmid:42110544",
    "headline": "Diverse effects of calcineurin in vascular smooth muscle cells: physiological activators and the controversial actions of clinical inhibitors.",
    "summary": "Frontiers in pharmacology. Front Pharmacol. 2026-04-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42110544/",
    "source": "PubMed",
    "published_date": "2026-04-24",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in pharmacology",
    "pmid": "42110544",
    "doi": "10.3389/fphar.2026.1819168",
    "preprint_id": "",
    "authors": "Nolze A; Grossmann C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 37,
    "score": 24,
    "id": "pubmed:42115669",
    "canonical_key": "pmid:42115669",
    "headline": "Domain arrangement-driven immunogenicity of a computationally designed mRNA vaccine targeting PPE68, IrtA, and PE9 of Mycobacterium tuberculosis.",
    "summary": "Scientific reports. Sci Rep. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42115669/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Scientific reports",
    "pmid": "42115669",
    "doi": "10.1038/s41598-026-47531-5",
    "preprint_id": "",
    "authors": "Dorbutr T; Stylianou E; McShane H; Pinpathomrat N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 38,
    "score": 24,
    "id": "biorxiv:10.64898/2026.03.08.709729",
    "canonical_key": "doi:10.64898/2026.03.08.709729",
    "headline": "Double-edged swords: Anthracyclines inhibit -1 programmed ribosomal frameshifting and restrict HCoV-OC43 infection but show cytotoxicity",
    "summary": "Human coronavirus OC43 (HCoV-OC43) constitutes one of the most common causes of the seasonal cold but can also cause severe disease among elderly and immuno-compromised. Currently, there are no approved antiviral drugs to combat HCoV-OC43 infection.",
    "url": "https://doi.org/10.64898/2026.03.08.709729",
    "source": "bioRxiv",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.03.08.709729",
    "preprint_id": "biorxiv:10.64898/2026.03.08.709729",
    "authors": "Scheller, D.; Islam, K.; Vaitkevicius, K.; Ignatov, D.; Pettersson, L.; Lindgren, L.; Arnberg, N.; Johansson, J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 39,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.06.723346",
    "canonical_key": "doi:10.64898/2026.05.06.723346",
    "headline": "Dual role of the OMM E3 Ub ligase MARCH5 in de novo peroxisome biogenesis and mitochondrial quality control through direct regulation of Pex26.",
    "summary": "Recent evidence indicates that mitochondria, through the activity of the E3 Ub ligase MARCH5, are critical for de novo peroxisome biogenesis. Here we report that peroxisome biogenesis factor Pex26 is a MARCH5 client protein.",
    "url": "https://doi.org/10.64898/2026.05.06.723346",
    "source": "bioRxiv",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.06.723346",
    "preprint_id": "biorxiv:10.64898/2026.05.06.723346",
    "authors": "Bhattacharjee, D.; Bippes, C. C.; ZHAO, G.; Boyman, L.; Weldemariam, M. M.; Kane, M. A.; Neutzner, A.; Karbowski, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 40,
    "score": 24,
    "id": "pubmed:42114776",
    "canonical_key": "pmid:42114776",
    "headline": "Dual-adjuvanted GPC3 mRNA vaccine delivered by lipid nanoparticles for hepatocellular carcinoma immunotherapy.",
    "summary": "Journal of controlled release : official journal of the Controlled Release Society. J Control Release. 2026-05-09",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42114776/",
    "source": "PubMed",
    "published_date": "2026-05-09",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of controlled release : official journal of the Controlled Release Society",
    "pmid": "42114776",
    "doi": "10.1016/j.jconrel.2026.114992",
    "preprint_id": "",
    "authors": "Jiang Y; Luo J; Liu C; Xue W; Liu J; Wang M; Shi S; Yin X; Li X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 41,
    "score": 24,
    "id": "biorxiv:10.1101/2025.04.08.647764",
    "canonical_key": "doi:10.1101/2025.04.08.647764",
    "headline": "Easydecon: Efficient Cell Type Mapping for High-Definition Spatial Transcriptomic Data",
    "summary": "The emergence of high-resolution spatial transcriptomics platforms, such as VisiumHD, has enabled transcriptome-wide spatial profiling at near-single-cell resolution. However, existing analysis tools often lack scalability or compatibility with this new resolution, limiting their utility for multimodal cell type analysis.",
    "url": "https://doi.org/10.1101/2025.04.08.647764",
    "source": "bioRxiv",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.04.08.647764",
    "preprint_id": "biorxiv:10.1101/2025.04.08.647764",
    "authors": "Umu, S. U.; Karlsen, V. T.; Baekkevold, E. S.; Jahnsen, F. L.; Domanska, D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-12",
    "window_start": "2026-05-11T05:15:00.000Z",
    "window_end": "2026-05-12T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 42,
    "score": 24,
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    "headline": "PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity.",
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    "headline": "Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial.",
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    "authors": "Garfinkle EAR; Perales-Linares R; Gimple RC; Livingstone AJ; Roberts KF; Butt OH; Goedegebuure SP; McLellan MD; Chang GS; Hundal J; Yan J; Navarro JB; Paxton SA; Chattopadhyay S; Cooch N; Perales-Puchalt A; Stavroulaki K; Rochestie S; Peters J; Junker B; Campian JL; Chheda MG; Chicoine MR; Kim AH; Willie JT; Zipfel GJ; Dowling JL; Miller CA; Griffith OL; Griffith M; Gillanders WE; Miller KE; Mardis ER; Sardesai NY; Dunn GP; Johanns TM",
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    "headline": "Whole-protein screening and multi-modal profiling of antigen-specific CD4(+) T cells at single-cell resolution.",
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    "headline": "The subset of M1-paired MHC class II conformers is critical for CD4+ T cell activation.",
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    "headline": "ENTRÉE Lung Platform Trial Sub-study 1: Phase II Randomized Efficacy and Safety Analysis of Feladilimab Plus Docetaxel Versus Docetaxel Monotherapy in Advanced/Recurrent NSCLC.",
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    "headline": "Phase 1/2 trials of donor regulatory T cells for the treatment of steroid-refractory chronic graft-versus-host disease.",
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    "headline": "Crude Fucus vesiculosus fucoidan demonstrates superior SARS-CoV-2 antiviral activity compared to its pure form: binding kinetics and functional studies",
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    "headline": "Small extracellular vesicles mediate the antihyperalgesic effect of bone marrow stromal cells: the role of \"priming\"",
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    "canonical_key": "pmid:42118449",
    "headline": "T-cell fitness, metabolic tumor volume, and serum LDH levels are associated with response to axicabtagene ciloleucel.",
    "summary": "International journal of hematology. Int J Hematol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42118449/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Watchlist hits: Takeda",
    "journal": "International journal of hematology",
    "pmid": "42118449",
    "doi": "10.1007/s12185-026-04219-w",
    "preprint_id": "",
    "authors": "Nishiyama R; Hiratsuka A; Ochi T; Miyagi Maeshima A; Takeda W; Ito K; Aruga Y; Ikeda C; Matsui H; Iwaki N; Fukuhara S; Munakata W; Makita S; Izutsu K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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    "rank_index": 6,
    "score": 28,
    "id": "pubmed:42120015",
    "canonical_key": "pmid:42120015",
    "headline": "The IL-10/IL-10Rα axis in fibroblasts limits large intestinal pathology by suppressing type I interferon signaling.",
    "summary": "International immunology. Int Immunol. 2026-05-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42120015/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "Watchlist hits: Takeda",
    "journal": "International immunology",
    "pmid": "42120015",
    "doi": "10.1093/intimm/dxag022",
    "preprint_id": "",
    "authors": "Ito T; Li B; Sakaguchi T; Yagita-Sakamaki M; Itoi H; Murakami M; Wu R; Fukada A; Motooka D; Ogino T; Nakamura S; Okuzaki D; Takeda K; Kayama H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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  {
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    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 7,
    "score": 24,
    "id": "pubmed:42116791",
    "canonical_key": "pmid:42116791",
    "headline": "[Treatment mechanism of the thermal stimuli of moxibustion on rheumatoid arthritis based on the responses of primary lesion cells to temperature].",
    "summary": "Zhongguo zhen jiu = Chinese acupuncture & moxibustion. Zhongguo Zhen Jiu. 2026-02-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116791/",
    "source": "PubMed",
    "published_date": "2026-02-27",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Zhongguo zhen jiu = Chinese acupuncture & moxibustion",
    "pmid": "42116791",
    "doi": "10.13703/j.0255-2930.20241009-0002",
    "preprint_id": "",
    "authors": "An S; Lan T; Tseng Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 8,
    "score": 24,
    "id": "pubmed:42116186",
    "canonical_key": "pmid:42116186",
    "headline": "A case of mixed histiocytosis (Erdheim-Chester disease and Langerhans cell histiocytosis) with STEAP3-associated anemia and type 4 hemochromatosis.",
    "summary": "Orphanet journal of rare diseases. Orphanet J Rare Dis. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116186/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Orphanet journal of rare diseases",
    "pmid": "42116186",
    "doi": "10.1186/s13023-026-04379-2",
    "preprint_id": "",
    "authors": "Buianova AA; Gaydina TA; Reznik EV; Iarovoi MD; Kuznetsova AA; Belova VA; Ignatyuk MA; Shatalov PA; Repinskaia ZA; Shinkarina AP; Volodkin AV; Atiakshin DA; Korostin DO",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 9,
    "score": 24,
    "id": "pubmed:42119177",
    "canonical_key": "pmid:42119177",
    "headline": "A click-compatible BmTyr platform for biotin-free proximity labeling and subcellular proteome profiling in primary T cells.",
    "summary": "Biochemical and biophysical research communications. Biochem Biophys Res Commun. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42119177/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Biochemical and biophysical research communications",
    "pmid": "42119177",
    "doi": "10.1016/j.bbrc.2026.153918",
    "preprint_id": "",
    "authors": "Zheng XN; Zeng JM; Huang HY; Zhao C; Ma SS; Feng L; Zhu H; Tian L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 10,
    "score": 24,
    "id": "pubmed:42116231",
    "canonical_key": "pmid:42116231",
    "headline": "A Deep-Red-Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death.",
    "summary": "Angewandte Chemie (International ed. in English). Angew Chem Int Ed Engl. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116231/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Angewandte Chemie (International ed. in English)",
    "pmid": "42116231",
    "doi": "10.1002/anie.8677989",
    "preprint_id": "",
    "authors": "Zhang Y; Mesdom P; Izquierdo-García E; António JPM; Gao R; Saubaméa B; Seguin J; Moinard M; Arnoux P; Frochot C; Cariou K; Doan BT; Gasser G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 11,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.08.723767",
    "canonical_key": "doi:10.64898/2026.05.08.723767",
    "headline": "A genome-wide RNAi screen identifies host cell cycle regulation as a determinant of Orientia tsutsugamushi infection",
    "summary": "Orientia tsutsugamushi (Ot) is an obligate intracellular bacterium that causes scrub typhus, a potentially life-threatening disease. To systematically identify host factors regulating early stages of infection, we performed a microscopy-based genome-wide siRNA screen in HeLa cells.",
    "url": "https://doi.org/10.64898/2026.05.08.723767",
    "source": "bioRxiv",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.08.723767",
    "preprint_id": "biorxiv:10.64898/2026.05.08.723767",
    "authors": "Chusorn, P.; Pittayasathornthun, Y.; Kanchanapiboon, P.; Saharat, K.; Phongkitkarun, K.; Sampattavanich, S.; Salje, J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 12,
    "score": 24,
    "id": "pubmed:42119166",
    "canonical_key": "pmid:42119166",
    "headline": "A hierarchical self-adjuvanted nanoCRISPR-based vaccine restores endogenous immune recognition and surveillance to amplify adaptive immune responses.",
    "summary": "Biomaterials. Biomaterials. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42119166/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Biomaterials",
    "pmid": "42119166",
    "doi": "10.1016/j.biomaterials.2026.124285",
    "preprint_id": "",
    "authors": "Huang D; Sun D; Ou C; Zhang X; Luo R; Kou X; Li X; Li Y; Le H; Li W; You Y; Gong C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 13,
    "score": 24,
    "id": "pubmed:42119364",
    "canonical_key": "pmid:42119364",
    "headline": "A Krüppel of factors regulate T cell residency and exhaustion.",
    "summary": "Immunity. Immunity. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42119364/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Immunity",
    "pmid": "42119364",
    "doi": "10.1016/j.immuni.2026.04.007",
    "preprint_id": "",
    "authors": "Albao DS; Nagaraja SD; Pipkin ME",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 14,
    "score": 24,
    "id": "pubmed:42117355",
    "canonical_key": "pmid:42117355",
    "headline": "A Novel Approach to Targeting DLL3 with Tarlatamab in a Patient with Medullary Thyroid Carcinoma after Progression on Selpercatinib.",
    "summary": "Thyroid : official journal of the American Thyroid Association. Thyroid. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42117355/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Thyroid : official journal of the American Thyroid Association",
    "pmid": "42117355",
    "doi": "10.1177/10507256261448706",
    "preprint_id": "",
    "authors": "Roberts TJ; Meador CB; Fuld AD; Lasko A; Frigault M; Hangar KM; Reynolds K; Sadow PM; Wirth LJ",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 15,
    "score": 24,
    "id": "pubmed:42116169",
    "canonical_key": "pmid:42116169",
    "headline": "A novel mRNA-based multi-cytokine strategy to reprogram the peritoneal tumor microenvironment in ovarian cancer.",
    "summary": "Journal of nanobiotechnology. J Nanobiotechnology. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116169/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of nanobiotechnology",
    "pmid": "42116169",
    "doi": "10.1186/s12951-026-04543-7",
    "preprint_id": "",
    "authors": "Lee YS; Lee J; Lee Y; Yoon H; Bae SH; Yoon S; Lee S; Roh G; Cho Y; Cho S; Ha D; Oh A; Lee SY; Choi EJ; Choi H; Jo S; Kim J; Lee S; Park HJ; Jeon S; Park SI; Yang W; Kim JH; Choi TG; Nam JH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 16,
    "score": 24,
    "id": "pubmed:42119789",
    "canonical_key": "pmid:42119789",
    "headline": "A Novel Mutation in the STK4 Gene (Serine/Threonine Kinase 4) in a Chinese Blang Child.",
    "summary": "Immunology letters. Immunol Lett. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42119789/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Immunology letters",
    "pmid": "42119789",
    "doi": "10.1016/j.imlet.2026.107182",
    "preprint_id": "",
    "authors": "Liu Y; Lei Y; Li M; Sun Y; Liu X; Zhou Y; Yu J; Min J; Lu J; Liu Q; Li L; Xu Q",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.07.723640",
    "canonical_key": "doi:10.64898/2026.05.07.723640",
    "headline": "A novel vaccine and drug targets for global eradication of bovine tuberculosis: Holistic frameworks for construction of a potent vaccine and identification of drug targets",
    "summary": "Bovine tuberculosis (TB), caused by Mycobacterium bovis, has become a global concern over the last two decades. Bovine TB primarily affects cattle, but other domestic livestock are also affected and it is more common in less developed and developing countries.",
    "url": "https://doi.org/10.64898/2026.05.07.723640",
    "source": "bioRxiv",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.07.723640",
    "preprint_id": "biorxiv:10.64898/2026.05.07.723640",
    "authors": "Pawar, P.; samarasinghe, s.; Kulasiri, D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 18,
    "score": 24,
    "id": "pubmed:42118848",
    "canonical_key": "pmid:42118848",
    "headline": "A relative methylation ordering biomarker of lactylation-related genes predicts prognosis and therapeutic response in cutaneous melanoma.",
    "summary": "Epigenetics. Epigenetics. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42118848/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Epigenetics",
    "pmid": "42118848",
    "doi": "10.1080/15592294.2026.2670909",
    "preprint_id": "",
    "authors": "Ruan J; Wang L; Liu F; He Y; Li H; Hong G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 24,
    "id": "pubmed:42120591",
    "canonical_key": "pmid:42120591",
    "headline": "A role for CD8(+) T cells in lupus nephritis.",
    "summary": "Nature reviews. Immunology. Nat Rev Immunol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42120591/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Nature reviews. Immunology",
    "pmid": "42120591",
    "doi": "10.1038/s41577-026-01310-5",
    "preprint_id": "",
    "authors": "Bordon Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 24,
    "id": "pubmed:42003680",
    "canonical_key": "pmid:42003680",
    "headline": "Acetylcholinesterase inhibitor therapy mitigates hypertension in lupus mice.",
    "summary": "Clinical science (London, England : 1979). Clin Sci (Lond). 2026-05-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42003680/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Clinical science (London, England : 1979)",
    "pmid": "42003680",
    "doi": "10.1042/CS20250432",
    "preprint_id": "",
    "authors": "Das-Earl P; Shimoura CG; Young-Stubbs CM; Chaudhari SK; Dinh VQ; Mathis KW",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 21,
    "score": 24,
    "id": "medrxiv:10.64898/2026.05.08.26352713",
    "canonical_key": "doi:10.64898/2026.05.08.26352713",
    "headline": "Adjusting for random centre effects in large trials with a binary outcome: A case study using data from the international multi-centre WOMAN randomised controlled trial",
    "summary": "Background The multicentre WOMAN trial showed that tranexamic acid reduces postpartum haemorrhage (PPH) deaths. Several studies have recommended adjusting for clustering at the country and centre level to improve power and reduce bias in the standard errors. We reanalysed data from the WOMAN trial, adjusting for these centre effects.",
    "url": "https://doi.org/10.64898/2026.05.08.26352713",
    "source": "medRxiv",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.08.26352713",
    "preprint_id": "medrxiv:10.64898/2026.05.08.26352713",
    "authors": "Mansukhani, R.; Roberts, I.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; obstetrics and gynecology"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 22,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.08.723726",
    "canonical_key": "doi:10.64898/2026.05.08.723726",
    "headline": "Amphiphilic Peptide Fusion Promotes Endocytic Uptake of Nanodiscs",
    "summary": "A major limitation across nanoparticle delivery platforms is sequestration within endosomal compartments, which restricts access to intracellular targets despite efficient cellular uptake.",
    "url": "https://doi.org/10.64898/2026.05.08.723726",
    "source": "bioRxiv",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.08.723726",
    "preprint_id": "biorxiv:10.64898/2026.05.08.723726",
    "authors": "Pizarro, B. S.; Reinhardt, T. G.; Semenske, J. A.; Ji, Z.; Jacobs, C. O.; Zeno, W. F.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 23,
    "score": 24,
    "id": "pubmed:42116071",
    "canonical_key": "pmid:42116071",
    "headline": "An intramuscular prime-intranasal boost strategy for mRNA-LNP vaccine induces mucosal immune response against SARS-CoV-2 in murine model.",
    "summary": "Journal of translational medicine. J Transl Med. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116071/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of translational medicine",
    "pmid": "42116071",
    "doi": "10.1186/s12967-026-08251-6",
    "preprint_id": "",
    "authors": "Zhang J; Fu Y; Liu G; Zhang Y; Zhang X; Gao J; Gao F; Wu X; Wang Q; Liu M; Li K; Fu Z; Ma X; Xu M; Liang Z; Mao Q; He Q",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 24,
    "score": 24,
    "id": "pubmed:42120751",
    "canonical_key": "pmid:42120751",
    "headline": "Anti-neutrophil cytoplasmic antibody-associated vasculitis: biological insights and biomarker-guided disease management.",
    "summary": "Nature reviews. Nephrology. Nat Rev Nephrol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42120751/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Nature reviews. Nephrology",
    "pmid": "42120751",
    "doi": "10.1038/s41581-026-01081-1",
    "preprint_id": "",
    "authors": "Antonelou M; Anwari KJ; Salama AD",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 24,
    "id": "pubmed:42120292",
    "canonical_key": "pmid:42120292",
    "headline": "Anti-PAD4 antibodies link autoimmunity to PAD4 with CTL-associated rheumatoid arthritis.",
    "summary": "Annals of the rheumatic diseases. Ann Rheum Dis. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42120292/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Annals of the rheumatic diseases",
    "pmid": "42120292",
    "doi": "10.1016/j.ard.2026.04.006",
    "preprint_id": "",
    "authors": "Ananth K; Moosic KB; Gomez-Banuelos E; Wang H; Trejo-Zambrano I; Johnson R; Kirschmann JM; Deddens T; Elghawy O; Shemo B; Robinson WH; Kimpel D; Bingham CO; Feith DJ; Antiochos B; Andrade F; Loughran TP Jr; Darrah E",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.07.722994",
    "canonical_key": "doi:10.64898/2026.05.07.722994",
    "headline": "Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer Metastasis",
    "summary": "Background Antibody-mediated blockade of innate receptor-MHC-I interactions represents a promising strategy to enhance anti-tumor immunity, particularly against metastatic cancers resistant to conventional checkpoint inhibitors.",
    "url": "https://doi.org/10.64898/2026.05.07.722994",
    "source": "bioRxiv",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.07.722994",
    "preprint_id": "biorxiv:10.64898/2026.05.07.722994",
    "authors": "Panda, A. K.; Sinha, S.; Natarajan, K.; Jiang, J.; Chempati, S.; Kazmi, S.; Kim, Y.-h.; Sharma, S.; Schaughency, P.; Boyd, L. F.; Hernandez, J. M.; Margulies, D. H.; Shevach, E. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 27,
    "score": 24,
    "id": "pubmed:42119960",
    "canonical_key": "pmid:42119960",
    "headline": "Antitumor Effects of leishmania donovani by inducing a pro-inflammatory tumor microenvironment in Hepatocellular Carcinoma.",
    "summary": "Acta tropica. Acta Trop. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42119960/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Acta tropica",
    "pmid": "42119960",
    "doi": "10.1016/j.actatropica.2026.108125",
    "preprint_id": "",
    "authors": "Lu X; Zhang Z; Zhang Y; Wang L; Hu Y; Wang Y; Chen J; Zhang J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 28,
    "score": 24,
    "id": "pubmed:42119665",
    "canonical_key": "pmid:42119665",
    "headline": "Association of MRD status with survival outcomes and cytokine release syndrome in outpatient transplantation after reduced intensity conditioning for acute lymphoblastic leukemia: experience from a low and middle-income country reference center.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-10",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42119665/",
    "source": "PubMed",
    "published_date": "2026-05-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Transplantation and cellular therapy",
    "pmid": "42119665",
    "doi": "10.1016/j.jtct.2026.04.055",
    "preprint_id": "",
    "authors": "Jaime-Pérez JC; Villalón-López A; Méndez-Ramírez N; Salazar-Riojas R; Gutiérrez-Aguirre CH; Cantú-Rodríguez OG; Gómez-Almaguer D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 29,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.10.724074",
    "canonical_key": "doi:10.64898/2026.05.10.724074",
    "headline": "Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14",
    "summary": "Glioblastomas are incurable and lethal brain cancers. Immunotherapies offer new and promising treatment options for glioblastoma patients, but the highly immunosuppressive nature of these cancers presents a challenging clinical obstacle.",
    "url": "https://doi.org/10.64898/2026.05.10.724074",
    "source": "bioRxiv",
    "published_date": "2026-05-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.10.724074",
    "preprint_id": "biorxiv:10.64898/2026.05.10.724074",
    "authors": "Clement, M.; Gibbs, A.; Begum, A.; Siebzehnrubl, D.; Kaushik, S.; Singh, N.; Gupta, B.; Eftychidis, V.; Siebzehnrubl, F. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 30,
    "score": 24,
    "id": "pubmed:42117299",
    "canonical_key": "pmid:42117299",
    "headline": "Bacteroides thetaiotaomicron Improves Colorectal Cancer Prognosis by Remodeling the Immune Microenvironment.",
    "summary": "Journal of gastroenterology and hepatology. J Gastroenterol Hepatol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42117299/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of gastroenterology and hepatology",
    "pmid": "42117299",
    "doi": "10.1111/jgh.70412",
    "preprint_id": "",
    "authors": "Shi Z; Zou D; Hong S; Yu Y; Guo Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 31,
    "score": 24,
    "id": "pubmed:42116942",
    "canonical_key": "pmid:42116942",
    "headline": "Barriers, Perceptions, and Predictors for Utilizing Health-Related Technology Among Individuals Receiving Radiation Oncology Care.",
    "summary": "Cureus. Cureus. 2026-04-10",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116942/",
    "source": "PubMed",
    "published_date": "2026-04-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cureus",
    "pmid": "42116942",
    "doi": "10.7759/cureus.106788",
    "preprint_id": "",
    "authors": "Serafini M; Heal C; Ansinelli HA; Morrison CM; Ho QA; Gonzalez V; Yi S; Hsu CC; Robbins JR",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 32,
    "score": 24,
    "id": "pubmed:42116350",
    "canonical_key": "pmid:42116350",
    "headline": "Bidirectional mediation between microbiota and immune system in Parkinson disease: A two-sample Mendelian randomization study.",
    "summary": "Medicine. Medicine (Baltimore). 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116350/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Medicine",
    "pmid": "42116350",
    "doi": "10.1097/MD.0000000000048681",
    "preprint_id": "",
    "authors": "Qu T; Zhao Q; Fang J; Liang Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 33,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.08.723329",
    "canonical_key": "doi:10.64898/2026.05.08.723329",
    "headline": "C57BL/6 BAC-CAG Huntingtons disease mice show somatic CAG expansion and responses to small interfering RNAs comparable to the FVB strain",
    "summary": "Huntingtons disease (HD) is a neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene, with longer repeats linked to earlier onset. Somatic CAG expansion, particularly in the striatum, contributes to disease progression and is influenced by HTT biology and genetic modifiers.",
    "url": "https://doi.org/10.64898/2026.05.08.723329",
    "source": "bioRxiv",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.08.723329",
    "preprint_id": "biorxiv:10.64898/2026.05.08.723329",
    "authors": "Belgrad, J.; Summers, A.; Hildebrand, S.; Sapp, E.; Luu, E.; Yamada, N.; O'Reilly, D.; Vogt, T. F.; Howland, D.; Yang, X. W.; DiFiglia, M.; Aronin, N.; Khvorova, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 34,
    "score": 24,
    "id": "pubmed:42116703",
    "canonical_key": "pmid:42116703",
    "headline": "Cancer epitope prediction tools and analysis pipelines in CEDAR.",
    "summary": "Nucleic acids research. Nucleic Acids Res. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116703/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Nucleic acids research",
    "pmid": "42116703",
    "doi": "10.1093/nar/gkag457",
    "preprint_id": "",
    "authors": "Carri I; Greenbaum J; Yan Z; Kim K; Kim H; Premlal ALR; Marrama D; Blazeska N; Carter H; Lee KH; Sears T; Nielsen M; Sette A; Peters B; Koşaloğlu-Yalçın Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 35,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.08.723719",
    "canonical_key": "doi:10.64898/2026.05.08.723719",
    "headline": "Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation",
    "summary": "Many phytopathogenic bacteria have evolved large, diverse arsenals of Carbohydrate Active enZymes (CAZymes) that liberate simple sugars, and thus nutrition and energy, from the complex lignocellulosic matrices of their plant hosts.",
    "url": "https://doi.org/10.64898/2026.05.08.723719",
    "source": "bioRxiv",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.08.723719",
    "preprint_id": "biorxiv:10.64898/2026.05.08.723719",
    "authors": "Hobbs, E. E. M.; Gloster, T. M.; Pritchard, L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 36,
    "score": 24,
    "id": "pubmed:42116650",
    "canonical_key": "pmid:42116650",
    "headline": "CD30+ High Grade Neoplasm With Expression of β-HCG and T-Cell Markers: Hybrid Germ Cell Tumor and T-Cell Lymphoma?",
    "summary": "Pathology international. Pathol Int",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42116650/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Pathology international",
    "pmid": "42116650",
    "doi": "10.1111/pin.70120",
    "preprint_id": "",
    "authors": "Wang WJ; Jeffrey Medeiros L; Tang G; Garces S; Guo C; Gan Q; Li S; Lin P; Wang W; Xu J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-13",
    "window_start": "2026-05-12T05:15:00.000Z",
    "window_end": "2026-05-13T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 37,
    "score": 24,
    "id": "pubmed:42119365",
    "canonical_key": "pmid:42119365",
    "headline": "CD8(+) T cells turn resilient under stress.",
    "summary": "Immunity. Immunity. 2026-05-12",
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    "headline": "Conserved and Lineage-Specific Roles of KEA-Mediated Ion Homeostasis in Chlamydomonas",
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    "headline": "Candida albicans, HIV And Immune System in a Holobiont Perspective.",
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    "headline": "CD155-CD96 keeps quiescent persister tumor cells in check.",
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    "headline": "CD24 in Melanoma: Biomarker, Innate Immune Checkpoint and Emerging Therapeutic Target.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42126185/",
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    "authors": "Yang Z; Lan T; Diao R; Zhang Z; Ma Y; Zhang X; Feng Y; Chen Y; Li Y; Wei Y; Fang W; Jing Z; Fan A; Wang J; Liang X; Zhang X",
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    "headline": "Cell-Level Virtual Screening",
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    "headline": "Chirality-engineered nanomaterials for biomedical applications.",
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    "canonical_key": "pmid:42129307",
    "headline": "Circadian engineering of in vivo CAR T cell therapy for precision oncology.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42122121/",
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    "headline": "Clinical outcomes of heart failure with improved ejection fraction in patients treated with angiotensin receptor-neprilysin inhibitor.",
    "summary": "The Korean journal of internal medicine. Korean J Intern Med. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42128388/",
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    "authors": "Kim DE; Kong MG; Kim S; Moon I; Park HW; Choi HO; Seo HS; Cho YH; Lee NH; Lee KY; Jang HJ; Kim JS; Choi IJ; Suh J",
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    "headline": "Clinicopathological Characteristics of Acute Antibody-Mediated Rejection in Pediatric Liver Transplantation-A Single-Center Study.",
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    "source": "PubMed",
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    "id": "biorxiv:10.64898/2026.05.10.723715",
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    "headline": "Collective cancer cell calcium activity drives brain metastasis",
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    "doi": "10.64898/2026.05.10.723715",
    "preprint_id": "biorxiv:10.64898/2026.05.10.723715",
    "authors": "Hebach, N. R.; Olshausen, N.; Schlag, J.; Mayer, C. D.; Henkenjohann, J.; Kraft, T.; Bang, S.; Thommek, C.; Nürnberg, C.; Horsak, N. E.; Hoffmann, D. C.; Kourtesakis, A.; Porzberg, N.; Flores Valle, A.; Linke, C. Z.; Yang, Y.; Azorin, D. D.; Hausmann, D.; Venkataramani, V.; Meier, F.; Ratliff, M.; Seifert, M.; Westphal, D.; Breckwoldt, M. O.; Timmer, J.; Johnsson, K.; Wick, W.; Winkler, F.; Karreman, M. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-14",
    "window_start": "2026-05-13T05:15:00.000Z",
    "window_end": "2026-05-14T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 47,
    "score": 24,
    "id": "pubmed:42121946",
    "canonical_key": "pmid:42121946",
    "headline": "Combining Tumor Treating Fields with Immunotherapy in Pancreatic Ductal Adenocarcinoma: Mechanisms, Preclinical Evidence, and Emerging Therapeutic Synergy.",
    "summary": "Cells. Cells. 2026-05-05",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42121946/",
    "source": "PubMed",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cells",
    "pmid": "42121946",
    "doi": "10.3390/cells15090845",
    "preprint_id": "",
    "authors": "Albelal D; Rachamala HK; Saha I; Bhattacharya S; Mukhopadhyay D; Babiker HM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-14",
    "window_start": "2026-05-13T05:15:00.000Z",
    "window_end": "2026-05-14T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 48,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.12.724504",
    "canonical_key": "doi:10.64898/2026.05.12.724504",
    "headline": "Comparative analyses of prolonged stress responses of breast carcinoma cells after hypofractionated irradiation in vitro and in vivo",
    "summary": "The anticancer efficacy of radiotherapy (RT) is limited by acquired radioresistance (RR). Here, we aim to characterize prolonged responses of breast carcinoma cells to hypofractionated irradiation (hFI).",
    "url": "https://doi.org/10.64898/2026.05.12.724504",
    "source": "bioRxiv",
    "published_date": "2026-05-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.12.724504",
    "preprint_id": "biorxiv:10.64898/2026.05.12.724504",
    "authors": "Sivakumar, N.; Fritz, G.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-14",
    "window_start": "2026-05-13T05:15:00.000Z",
    "window_end": "2026-05-14T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 49,
    "score": 24,
    "id": "pubmed:42128297",
    "canonical_key": "pmid:42128297",
    "headline": "Cord Blood Transplantation versus Other Donor Sources in High-risk Acute Myeloid Leukemia.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42128297/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Transplantation and cellular therapy",
    "pmid": "42128297",
    "doi": "10.1016/j.jtct.2026.05.009",
    "preprint_id": "",
    "authors": "Hirao T; Yamamoto H; Kuno M; Watanabe O; Yamaguchi K; Kageyama K; Kaji D; Taya Y; Nishida A; Takagi S; Asano-Mori Y; Yamamoto G; Wake A; Taniguchi S; Uchida N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 1,
    "score": 48,
    "id": "biorxiv:10.1101/2025.08.25.672079",
    "canonical_key": "doi:10.1101/2025.08.25.672079",
    "headline": "Pan-cancer landscape of cancer-testis genes revealed by single-cell and spatial transcriptomics",
    "summary": "Single-cell and spatial pan-cancer atlas of cancer-testis genes as potential immunotherapy targets; useful antigen-discovery background, not a direct pMHC/TCR platform.",
    "url": "https://doi.org/10.1101/2025.08.25.672079",
    "source": "bioRxiv",
    "published_date": "2026-05-14",
    "match_reason": "Antigen and target discovery: cancer-testis",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.08.25.672079",
    "preprint_id": "biorxiv:10.1101/2025.08.25.672079",
    "authors": "Fu, C.; Yin, S.; Li, L.; Jin, X.; Liu, X.; Liu, K.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 2,
    "score": 46,
    "id": "pubmed:42134327",
    "canonical_key": "pmid:42134327",
    "headline": "Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity.",
    "summary": "Immunity paper linking TCR engagement to mevalonate-pathway control of T follicular helper cell generation; mechanistic TCR-signaling signal, not antigen-mapping or pMHC therapeutic work.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42134327/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "TCR therapeutic modality / TCR biology: TCR engagement",
    "journal": "Immunity",
    "pmid": "42134327",
    "doi": "10.1016/j.immuni.2026.04.009",
    "preprint_id": "",
    "authors": "Wang L; Jiang J; Yin H; Wu J; Su X; Meng L; Wang L; Bao J; Li Q; Wei Y; Chen Z; Gong J; Cañete PF; Zheng M; Li W; Zhou Q; Zhao M; Yu D; Lu Q",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 3,
    "score": 44,
    "id": "pubmed:42135629",
    "canonical_key": "pmid:42135629",
    "headline": "Clinical applications and methodology updates in HLA typing.",
    "summary": "BMC Immunology update on clinical HLA typing methods; relevant HLA-restriction infrastructure for antigen-selection workflows, but not a therapeutic pMHC/TCR readout.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42135629/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "Direct pMHC or peptide-MHC targeting: HLA context",
    "journal": "BMC immunology",
    "pmid": "42135629",
    "doi": "10.1186/s12865-026-00845-5",
    "preprint_id": "",
    "authors": "Feng K; Chang L; Yan Y; Sun H; Liu Y; Song S; Nuermaimaiti A; Halemubieke S; Mei L; Su Q; Liu X; Lu Z; Ji H; Wang L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 4,
    "score": 42,
    "id": "pubmed:42131824",
    "canonical_key": "pmid:42131824",
    "headline": "Characterisation of tumor-infiltrating gamma-delta T cells in human colorectal cancer with MHC-I loss.",
    "summary": "Clinical & Translational Immunology study of tumor-infiltrating gamma-delta T cells in colorectal cancer with MHC-I loss; useful MHC immune-escape context, not alpha-beta TCR target discovery.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42131824/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Direct pMHC or peptide-MHC targeting: MHC-I context",
    "journal": "Clinical & translational immunology",
    "pmid": "42131824",
    "doi": "10.1002/cti2.70097",
    "preprint_id": "",
    "authors": "Li TA; Quigley LT; Chan KF; Williams DS; Mielke LA; Behren A; Da Gama Duarte J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 5,
    "score": 40,
    "id": "pubmed:42134534",
    "canonical_key": "pmid:42134534",
    "headline": "Evaluating T-Cell Clonality In Skin Using a Quantitative TRBC1-Clonality Score.",
    "summary": "JID paper validating a quantitative TRBC1 clonality score in skin; lower-strength T-cell clonality signal without paired antigen specificity.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42134534/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "Patient-derived TCR data: T-cell clonality",
    "journal": "The Journal of investigative dermatology",
    "pmid": "42134534",
    "doi": "10.1016/j.jid.2026.03.045",
    "preprint_id": "",
    "authors": "Iselin C; Prompsy P; Tsai YC; Bernard P; André F; Blanchard M; Blanchard G; Roccuzzo G; Calvão J; Quaglino P; Levesque M; Hötzenecker W; Chang YT; Guenova E",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 1,
    "score": 24,
    "id": "pubmed:42129775",
    "canonical_key": "pmid:42129775",
    "headline": "A CSF disease-associated macrophage signature defines progressive multiple sclerosis.",
    "summary": "Journal of neuroinflammation. J Neuroinflammation. 2026-05-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42129775/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of neuroinflammation",
    "pmid": "42129775",
    "doi": "10.1186/s12974-026-03861-9",
    "preprint_id": "",
    "authors": "Börsch AL; Riethues F; Schulte-Mecklenbeck A; Wang X; Heming M; Lu IN; Müller-Miny L; Wiendl H; Gross CC; Bernard-Valnet R; Meyer Zu Hörste G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 2,
    "score": 24,
    "id": "pubmed:42130809",
    "canonical_key": "pmid:42130809",
    "headline": "A novel clustering of down syndrome and coeliac disease complicated by enteritis and small intestinal strictures: a case series.",
    "summary": "Therapeutic advances in gastroenterology. Ther Adv Gastroenterol. 2026-05-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42130809/",
    "source": "PubMed",
    "published_date": "2026-05-06",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Therapeutic advances in gastroenterology",
    "pmid": "42130809",
    "doi": "10.1177/17562848261446854",
    "preprint_id": "",
    "authors": "Kanagasundaram C; Efklides J; Koh E; Ryan S; Elliott T; Prideaux L; Kong XF; Yeoh SW; Cruickshank J; Tye-Din JA",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 3,
    "score": 24,
    "id": "pubmed:42131624",
    "canonical_key": "pmid:42131624",
    "headline": "A Phase 1b Study of Botensilimab and Balstilimab in Treatment-Refractory Hepatocellular Carcinoma.",
    "summary": "Liver cancer. Liver Cancer. 2026-03-30",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42131624/",
    "source": "PubMed",
    "published_date": "2026-03-30",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Liver cancer",
    "pmid": "42131624",
    "doi": "10.1159/000551630",
    "preprint_id": "",
    "authors": "El-Khoueiry AB; Lieu CH; Abou-Alfa GK; Tsimberidou AM; Mahadevan D; Hanna DL; Bockorny B; Wilky BA; Leal A; Stebbing J; Avagyan M; Wu W; Chand D; Grossman JE; Johnson B; Bullock AJ",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 4,
    "score": 24,
    "id": "pubmed:42133438",
    "canonical_key": "pmid:42133438",
    "headline": "A Probiotic Approach Targeting Hypersialylation Revives CD8+ T-cell Immunity and Boosts Photodynamic Therapy Efficacy in Solid Tumors.",
    "summary": "Cancer research. Cancer Res. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42133438/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Cancer research",
    "pmid": "42133438",
    "doi": "10.1158/0008-5472.CAN-25-3070",
    "preprint_id": "",
    "authors": "Wang Y; Chen X; Zhang W; Zhou W; Zhang S; Dang S; Ma Y; Miao Y; Wu C; Liu C; Ji Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 5,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.14.725236",
    "canonical_key": "doi:10.64898/2026.05.14.725236",
    "headline": "A repressive regulatory cascade shapes temporal patterning of activity-regulated gene expression in a defined sensory neuron type",
    "summary": "Long-term neuronal plasticity is driven by activity-regulated gene (ARG) expression programs that encode stimulus features in a neuron type-specific manner 1-6.",
    "url": "https://doi.org/10.64898/2026.05.14.725236",
    "source": "bioRxiv",
    "published_date": "2026-05-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.14.725236",
    "preprint_id": "biorxiv:10.64898/2026.05.14.725236",
    "authors": "Bates, S. G.; Harris, N.; Sengupta, P.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 6,
    "score": 24,
    "id": "pubmed:42135010",
    "canonical_key": "pmid:42135010",
    "headline": "A stochastic agent-based model for simulating tumor-immune dynamics and evaluating therapeutic strategies.",
    "summary": "Mathematical biosciences and engineering : MBE. Math Biosci Eng. 2026-04-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42135010/",
    "source": "PubMed",
    "published_date": "2026-04-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Mathematical biosciences and engineering : MBE",
    "pmid": "42135010",
    "doi": "10.3934/mbe.2026052",
    "preprint_id": "",
    "authors": "Zhang Y; Li C; Wang B; Lei J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 7,
    "score": 24,
    "id": "pubmed:42130719",
    "canonical_key": "pmid:42130719",
    "headline": "A Trypanothione Synthetase-Based Subunit Vaccine Induces Protective Th1 Immunity against Visceral Leishmaniasis in Mice.",
    "summary": "ACS pharmacology & translational science. ACS Pharmacol Transl Sci. 2026-04-10",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42130719/",
    "source": "PubMed",
    "published_date": "2026-04-10",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "ACS pharmacology & translational science",
    "pmid": "42130719",
    "doi": "10.1021/acsptsci.6c00119",
    "preprint_id": "",
    "authors": "Khan E; Chatterjee A; Kumar S; Madhukar P; Singh VK; Singh SS; Sundar S; Kumar R; Dubey VK",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-15",
    "window_start": "2026-05-14T05:15:00.000Z",
    "window_end": "2026-05-15T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 8,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.11.724294",
    "canonical_key": "doi:10.64898/2026.05.11.724294",
    "headline": "Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathway",
    "summary": "Glypican-3 (GPC3) is an oncofetal protein widely being explored as a diagnostic and therapeutic target in hepatocellular carcinoma (HCC).",
    "url": "https://doi.org/10.64898/2026.05.11.724294",
    "source": "bioRxiv",
    "published_date": "2026-05-14",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.11.724294",
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    "headline": "Cardiopulmonary Failure in Hantavirus Disease: Mechanisms, Recognition, and ECMO-Based Management",
    "summary": "Lee DS, Hasan A.",
    "url": "https://doi.org/10.20944/preprints202605.0912.v1",
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    "headline": "Case Series: Malignant Flower Cells in Peripheral Blood.",
    "summary": "Turk patoloji dergisi. Turk Patoloji Derg. 2026-05-12",
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    "doi": "10.5146/tjpath.2026.15185",
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    "authors": "Matos U; Tan WY; Meleveedu K; Hamadah Y; Vankina R; Forbes V; Chen D",
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    "headline": "CB2R promotes T cell gut homing and exacerbates ileitis in a murine Crohn's model.",
    "summary": "Inflammatory bowel diseases. Inflamm Bowel Dis. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42133571/",
    "source": "PubMed",
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    "pmid": "42133571",
    "doi": "10.1093/ibd/izag066",
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    "authors": "Leddy RS; Hudachek CL; Phelan HM; Aherne CM; Romero J; Hillard CJ; Wang Z; Eissner G; Jedlicka P; Collins CB",
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    "canonical_key": "pmid:42048120",
    "headline": "Celecoxib Mitigates Paclitaxel-Induced Peripheral Neuropathy Through Modulation of the COX-2/PGE2 Pathway in Rats.",
    "summary": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology. FASEB J. 2026-05-15",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42048120/",
    "source": "PubMed",
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    "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
    "pmid": "42048120",
    "doi": "10.1096/fj.202600194R",
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    "authors": "Qian K; Gao H; Huang N; Cao T; Zhu T; Cheng M; Wang K",
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    "headline": "Chimeric antigen receptor T-cell therapy in neurological disorders: Emerging applications, evidence, and challenges.",
    "summary": "Journal of the neurological sciences. J Neurol Sci. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42134213/",
    "source": "PubMed",
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    "journal": "Journal of the neurological sciences",
    "pmid": "42134213",
    "doi": "10.1016/j.jns.2026.125982",
    "preprint_id": "",
    "authors": "Luo JJ; Wang S; Si X",
    "assignee": "",
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    "id": "pubmed:42130710",
    "canonical_key": "pmid:42130710",
    "headline": "Chimeric Antigen Receptor T‑Cell Therapy Targeting Tumor Necrosis Factor Receptor Superfamily Member 8 (CD30) for Relapsed or Refractory Anaplastic Large Cell Lymphoma: Rationale, Strategies, and Emerging Clinical Evidence.",
    "summary": "ACS pharmacology & translational science. ACS Pharmacol Transl Sci. 2026-04-09",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42130710/",
    "source": "PubMed",
    "published_date": "2026-04-09",
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    "journal": "ACS pharmacology & translational science",
    "pmid": "42130710",
    "doi": "10.1021/acsptsci.6c00103",
    "preprint_id": "",
    "authors": "Boretti A",
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    "canonical_key": "pmid:42132052",
    "headline": "CMV reactivation post allogeneic stem cell transplantation decreases relapse risk and survival, and increases NRM - a single center analysis.",
    "summary": "Leukemia & lymphoma. Leuk Lymphoma. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42132052/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Leukemia & lymphoma",
    "pmid": "42132052",
    "doi": "10.1080/10428194.2026.2668034",
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    "authors": "Stavi V; Chen C; Novitzky-Basso I; Remberger M; Law A; Gerbitz A; Viswabandya A; Kim DDH; Michelis FV; Pasic I; Kumar R; Lam W; Mattsson J; Lipton JH",
    "assignee": "",
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    "id": "pubmed:42129772",
    "canonical_key": "pmid:42129772",
    "headline": "Co-detection of antimicrobial resistance and virulence-associated determinants in Staphylococcus aureus isolated from radicular cysts in a post-disaster region of Türkiye.",
    "summary": "BMC oral health. BMC Oral Health. 2026-05-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42129772/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "BMC oral health",
    "pmid": "42129772",
    "doi": "10.1186/s12903-026-08449-6",
    "preprint_id": "",
    "authors": "CanHaskan A; Duran N; Colak EY; Selimli F; Dagli S",
    "assignee": "",
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    "rank_index": 33,
    "score": 24,
    "id": "pubmed:42134608",
    "canonical_key": "pmid:42134608",
    "headline": "Commentary on Endotypes in Chronic Spontaneous Urticaria: Where we go wrong.",
    "summary": "The Journal of allergy and clinical immunology. J Allergy Clin Immunol. 2026-05-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42134608/",
    "source": "PubMed",
    "published_date": "2026-05-13",
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    "journal": "The Journal of allergy and clinical immunology",
    "pmid": "42134608",
    "doi": "10.1016/j.jaci.2026.05.002",
    "preprint_id": "",
    "authors": "Kaplan AP; Puga MF; Marina SB",
    "assignee": "",
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    "id": "biorxiv:10.64898/2026.05.13.724469",
    "canonical_key": "doi:10.64898/2026.05.13.724469",
    "headline": "Comparative benchmarking of CRISPRi and CasRx in standardized pluripotent stem cell platforms reveals context-dependent knockdown performance",
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    "source": "bioRxiv",
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    "authors": "Ni, L.; Murakami, T.; Suzuki, S.; Hamao, M.; Nakamura, M.; Okubo, C.; Takahashi, K.",
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    "id": "pubmed:42130143",
    "canonical_key": "pmid:42130143",
    "headline": "Construction of a Prognostic Model for Hepatocellular Carcinoma Based on Cell Death-related Genes and Characterization of Immune Microenvironment.",
    "summary": "Iranian journal of allergy, asthma, and immunology. Iran J Allergy Asthma Immunol. 2026-04-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42130143/",
    "source": "PubMed",
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    "doi": "10.18502/ijaai.v25i3.21259",
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    "authors": "Wu W; Wang Y; Zhao X; Dong K; Li M; An X; Xu Y; Wang S; Li D",
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    "canonical_key": "doi:10.64898/2026.05.13.724746",
    "headline": "Covalent tumor anchoring spatially orchestrates antitumor immunity",
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    "url": "https://doi.org/10.64898/2026.05.13.724746",
    "source": "bioRxiv",
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    "doi": "10.64898/2026.05.13.724746",
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    "authors": "Li, Q.; Chen, H.; Zhang, P.; Cao, L.; Yu, B.; Wang, L.",
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    "score": 24,
    "id": "europepmc:PPR1207789",
    "canonical_key": "doi:10.21203/rs.3.rs-9648114/v1",
    "headline": "Critical Dynamics of Peripheral Immune Tolerance: A Treg-Tpex Antagonism Framework for Phase Transition and Immune State Stratification",
    "summary": "Zhang Y.",
    "url": "https://doi.org/10.21203/rs.3.rs-9648114/v1",
    "source": "Europe PMC / PPR",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "doi": "10.21203/rs.3.rs-9648114/v1",
    "preprint_id": "",
    "authors": "Zhang Y.",
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    "id": "pubmed:42134609",
    "canonical_key": "pmid:42134609",
    "headline": "CXCL16 as a Potential Therapeutic Target to Limit the Activity of Asthmatic CD4 Memory T cells.",
    "summary": "The Journal of allergy and clinical immunology. J Allergy Clin Immunol. 2026-05-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42134609/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "The Journal of allergy and clinical immunology",
    "pmid": "42134609",
    "doi": "10.1016/j.jaci.2026.05.004",
    "preprint_id": "",
    "authors": "Sethi GS; Croft M",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "rank_index": 39,
    "score": 24,
    "id": "pubmed:42130011",
    "canonical_key": "pmid:42130011",
    "headline": "Cytotoxic Profiling of 3',4',5'-Trimethoxychalcones Reveals Cell-Line-Dependent Cytotoxic Activity: An In Vitro and In Silico Study.",
    "summary": "Chemistry & biodiversity. Chem Biodivers",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42130011/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Chemistry & biodiversity",
    "pmid": "42130011",
    "doi": "10.1002/cbdv.71336",
    "preprint_id": "",
    "authors": "Mehandzhiyski AY; Beraich A; Velkov Z; Zaharieva M; Konstantinov S; Batovska D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 40,
    "score": 24,
    "id": "pubmed:42134785",
    "canonical_key": "pmid:42134785",
    "headline": "Decoding CD8(+) T-Cell Senescence Reversal in HCC: Limitations of a PI3K/AKT-Centric Model.",
    "summary": "Journal of gastroenterology and hepatology. J Gastroenterol Hepatol. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42134785/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of gastroenterology and hepatology",
    "pmid": "42134785",
    "doi": "10.1111/jgh.70447",
    "preprint_id": "",
    "authors": "Asghar M; Makkar S; Shah A; Opene C; Haris M; Khalid H",
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    "primary_source": "PubMed",
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    "rank_index": 41,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.11.724091",
    "canonical_key": "doi:10.64898/2026.05.11.724091",
    "headline": "Deep immune profiling of the peripheral blood reveals disease- and sex-associated immune cell signatures in patients with systemic sclerosis",
    "summary": "Objective: Systemic sclerosis (SSc) predominantly affects females but exhibits greater disease severity in males, suggesting sex differences underlying SSc pathogenesis. We sought to define sex-associated alterations in the peripheral immune landscape of patients with SSc.",
    "url": "https://doi.org/10.64898/2026.05.11.724091",
    "source": "bioRxiv",
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    "headline": "Atmospheric pressure plasma promotes T lymphocytes activation.",
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    "headline": "Identification of the HLA-A*24:02:24 Full-Length Sequence Using PacBio Third-Generation Sequencing in Chinese Voluntary Blood Donor.",
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    "headline": "Molecular and Clinical Characteristics of Patients with Non-Small Cell Lung Cancer Harboring KRAS G12V Mutations.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/41417462/",
    "source": "PubMed",
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    "authors": "John F; Ruge L; Verheyen M; Scharpenseel H; Michels SYF; Riedel R; Fischer R; Jakob C; Siemanowski-Hrach J; Fassunke J; Heydt C; Ihle MA; Lyu SI; Rasokat A; Schulte W; Franke KJ; Graeven U; Kappes J; Kron A; Siebolts U; Merkelbach-Bruse S; Quaas A; Büttner R; Wolf J; Scheffler M",
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    "headline": "TP53 mutations and baseline lymphocytes indicate response to glofitamab in relapsed or refractory diffuse large B-cell lymphoma.",
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    "source": "PubMed",
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    "match_reason": "Watchlist hits: TP53",
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    "authors": "Ruan J; Zhang Y; Zhou D; Zhang Y; Zhao D; Wei C; Zhang W; Li J",
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    "headline": "A 68Ga–BCMA Ectodomain Tracer Enables PET/MR Longitudinal Tracking of Clinical-Grade BCMA/CD19 CAR T Cells",
    "summary": "Yang M, Zhou W, Wang X, Hou R, Yan J, Pan D, Chen C, Xu Y, Wang L, Shi M, Zhou X.",
    "url": "https://doi.org/10.21203/rs.3.rs-9063774/v1",
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    "canonical_key": "doi:10.64898/2026.05.13.724763",
    "headline": "A chimeric, half-life extended lysin with a unique mode of action",
    "summary": "Anti-staphylococcal lytic agents, such as lysostaphin (LSN), a glycyl-glycyl (Gly-Gly) peptidase, have long been considered for the management of chronic and complicated bacterial infections typically resistant to conventional antibiotics, but their use is restricted by poor pharmacokinetic properties.",
    "url": "https://doi.org/10.64898/2026.05.13.724763",
    "source": "bioRxiv",
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    "authors": "Visram, Z.; Kestemont, D.; Bauer, B.; Qiao, R.; Durica-Mitic, S.; Majoros-Hashempour, A.; Schmidt, J.; Berdaguer, R.; Krey, K.; Mutti, M.; Zerbs, M.; von Freyberg, M.; Corsini, L.; Badarau, A.",
    "assignee": "",
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    "headline": "A Complement and Coagulation Cascade-Related Prognostic Signature Predicts Survival and Immune Landscape in Lung Adenocarcinoma.",
    "summary": "Current gene therapy. Curr Gene Ther. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42136237/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Current gene therapy",
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    "doi": "10.2174/0115665232473551260504092329",
    "preprint_id": "",
    "authors": "He B; Zhu R; Li N; Li W",
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    "canonical_key": "doi:10.64898/2026.05.14.725198",
    "headline": "A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles",
    "summary": "The binding of transmembrane (TM) ligands to their cognate TM receptors on neighboring cells governs intercellular adhesion and direct cell-cell communication.",
    "url": "https://doi.org/10.64898/2026.05.14.725198",
    "source": "bioRxiv",
    "published_date": "2026-05-15",
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    "authors": "Kim, C.; Gaballa, M.; Lee, D.; Jouanguy, E.; Zhang, S.-Y.; Casanova, J.-L.; Yatim, A.",
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    "headline": "A high dimensionality approach reveals immunopathogenic responses driving severe pediatric acute respiratory distress syndrome.",
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    "canonical_key": "pmid:42136666",
    "headline": "A new era of natural killer cell immunotherapy in tumor treatment: latest advances and cutting-edge perspectives from basic research to clinical practice.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-29",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42136666/",
    "source": "PubMed",
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    "journal": "Frontiers in immunology",
    "pmid": "42136666",
    "doi": "10.3389/fimmu.2026.1795143",
    "preprint_id": "",
    "authors": "Du X; Shi S; Liu H",
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    "canonical_key": "pmid:42141342",
    "headline": "A new regulatory axis in cross-presentation: MS4A7 licenses cDC1s for effective CD8(+) T-cell priming.",
    "summary": "Science China. Life sciences. Sci China Life Sci. 2026-05-07",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42141342/",
    "source": "PubMed",
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    "journal": "Science China. Life sciences",
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    "doi": "10.1007/s11427-025-3335-3",
    "preprint_id": "",
    "authors": "Liu Y; Xu MM",
    "assignee": "",
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    "id": "pubmed:42137990",
    "canonical_key": "pmid:42137990",
    "headline": "A Novel HLA Class I Allele, HLA-C*15:299, Identified by Next-Generation Sequencing in an Indian Individual.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42137990/",
    "source": "PubMed",
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    "doi": "10.1111/tan.70751",
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    "authors": "Agarwal S; Kumari S; Bairagi N; Bamal M; Rana V",
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    "id": "biorxiv:10.64898/2026.05.12.724311",
    "canonical_key": "doi:10.64898/2026.05.12.724311",
    "headline": "A novel pipeline for the validation of manganese chelators for the treatment of manganese overload",
    "summary": "Manganese neurotoxicity, arising from environmental overexposure or inherited transporter disorders due to pathogenic variants in SLC30A10 and SLC39A14, leads to manganism, a debilitating Parkinsonian movement disorder.",
    "url": "https://doi.org/10.64898/2026.05.12.724311",
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    "authors": "Vogt, H.; Pojani, C.; Devonport, J.; McGown, A.; Firth, G.; Doykov, I.; Nikolaenko, V.; Anagianni, S.; Valdivia, L. E.; Khalil, Y.; Bodnar, N.; Kallay, C.; Dadswell, C.; Gonzalez-Mendez, R.; Purchase, R.; Platt, F. M.; Zacconi, F. C. M.; Geard, A. F.; Heywood, W. E.; Mills, K.; Mills, P. B.; Rahim, A. A.; Rihel, J.; Wilson, S. W.; Kostakis, G. E.; Spencer, J.; Tuschl, K.",
    "assignee": "",
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    "rank_index": 19,
    "score": 24,
    "id": "pubmed:42140948",
    "canonical_key": "pmid:42140948",
    "headline": "A phase II peri-operative study of pembrolizumab plus lenvatinib for mucosal melanoma.",
    "summary": "Nature communications. Nat Commun. 2026-05-16",
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    "source": "PubMed",
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    "doi": "10.1038/s41467-026-73190-1",
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    "authors": "Mao L; Lai Y; Zheng H; Cui M; Li L; Liu Z; Zhou H; Sun L; Li C; Wei X; Gu J; Bai X; Kong Y; Cui C; Chi Z; Sheng X; Lian B; Li S; Yan X; Tang B; Li J; Zhou L; Wang X; Guo J; Dai J; Si L",
    "assignee": "",
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    "primary_source": "PubMed",
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    "score": 24,
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    "headline": "A sensitive and cost-effective \"turn-on\" aptasensor for carcinoembryonic antigen using Ce-UiO-66 as an ultraefficient nanoquencher.",
    "summary": "Mikrochimica acta. Mikrochim Acta. 2026-05-16",
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    "doi": "10.1007/s00604-026-08132-1",
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    "assignee": "",
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    "id": "biorxiv:10.64898/2026.05.13.724735",
    "canonical_key": "doi:10.64898/2026.05.13.724735",
    "headline": "AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD",
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    "url": "https://doi.org/10.64898/2026.05.13.724735",
    "source": "bioRxiv",
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    "authors": "Wang, S.; Zhao, S.; Daniels, A.; Naaman, E.; Gardner, A.; Wang, T.; Sun, Y.; Fu, Z.; Smith, L. E. H.; Cepko, C. L.",
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    "authors": "Deng Y; Jia Z; Mu XQ; Mao Y; Zhang Q; Ma J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
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    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 39,
    "score": 24,
    "id": "pubmed:42138652",
    "canonical_key": "pmid:42138652",
    "headline": "CD19 CAR T cells for B-ALL with EMD.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42138652/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Blood advances",
    "pmid": "42138652",
    "doi": "10.1182/bloodadvances.2026019818",
    "preprint_id": "",
    "authors": "Llaurador Caraballo G; Steffin D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 40,
    "score": 24,
    "id": "pubmed:42141373",
    "canonical_key": "pmid:42141373",
    "headline": "CD19/BCMA-Targeted Chimeric Antigen Receptor-T Cell Therapy for Anti-HLA Antibody Sensitisation in Patients With Acute Leukaemia: A Pilot Clinical Study.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42141373/",
    "source": "PubMed",
    "published_date": "2026-05-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "HLA",
    "pmid": "42141373",
    "doi": "10.1111/tan.70701",
    "preprint_id": "",
    "authors": "Zheng H; Zhao H; Zhu X; Feng J; Wei G; Han S; Huang S; Cui J; Fu S; Zhang M; Zhang Y; Shi J; Luo Y; Chang AH; Hu Y; Huang H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 41,
    "score": 24,
    "id": "pubmed:42140572",
    "canonical_key": "pmid:42140572",
    "headline": "CD20-Targeted Immunotherapies in B-Cell Malignancies: Mechanistic and Clinical Advances.",
    "summary": "Experimental hematology. Exp Hematol. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42140572/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Experimental hematology",
    "pmid": "42140572",
    "doi": "10.1016/j.exphem.2026.105444",
    "preprint_id": "",
    "authors": "Hasani R; Pourseif MM; Alizadeh E; Tohidkia MR; Rahmati M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 42,
    "score": 24,
    "id": "pubmed:42141174",
    "canonical_key": "pmid:42141174",
    "headline": "CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8(+) T cells.",
    "summary": "Nature cancer. Nat Cancer. 2026-05-15",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42141174/",
    "source": "PubMed",
    "published_date": "2026-05-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Nature cancer",
    "pmid": "42141174",
    "doi": "10.1038/s43018-026-01169-4",
    "preprint_id": "",
    "authors": "Wang C; Zheng P; Wang A; Fan X; Li T; Hong J; Wang R; Zhang C; Luo C; Yang W; Gao D; Salai A; Luo M; Lu Z; Li D; Lin M; Peng J; Li G; Han S; Zhao Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 43,
    "score": 24,
    "id": "pubmed:42136659",
    "canonical_key": "pmid:42136659",
    "headline": "Cell-mediated immune responses of beta-glucan on the pathogenesis of chronic tuberculosis infection.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-04-29",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42136659/",
    "source": "PubMed",
    "published_date": "2026-04-29",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42136659",
    "doi": "10.3389/fimmu.2026.1784128",
    "preprint_id": "",
    "authors": "Chakraborty S; V DR",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 44,
    "score": 24,
    "id": "pubmed:42140164",
    "canonical_key": "pmid:42140164",
    "headline": "cGAS-STING Signalling in the tumour microenvironment: Implications for immune surveillance and therapeutic strategies.",
    "summary": "International immunopharmacology. Int Immunopharmacol. 2026-05-15",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42140164/",
    "source": "PubMed",
    "published_date": "2026-05-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "International immunopharmacology",
    "pmid": "42140164",
    "doi": "10.1016/j.intimp.2026.116832",
    "preprint_id": "",
    "authors": "Al-Adayleh TYM; Ahmad W; Rahiman SSF; Murugaiyah V; Mohamed R; Afzal S; Al-Ramamneh RS; Attiq A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 45,
    "score": 24,
    "id": "pubmed:42138570",
    "canonical_key": "pmid:42138570",
    "headline": "Characterisation of the Novel HLA-DQB1*03:609 Allele by Next Generation Sequencing.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42138570/",
    "source": "PubMed",
    "published_date": "2026-05-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "HLA",
    "pmid": "42138570",
    "doi": "10.1111/tan.70752",
    "preprint_id": "",
    "authors": "Merschman J; Barnes R; Benidt D; Kreuter J; Gandhi MJ",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 46,
    "score": 24,
    "id": "pubmed:42137270",
    "canonical_key": "pmid:42137270",
    "headline": "Chemistry-mediated synthetic virus-cell interaction as a generic approach to enhance gene delivery to mammalian cells.",
    "summary": "Molecular therapy. Advances. Mol Ther Adv. 2026-01-03",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42137270/",
    "source": "PubMed",
    "published_date": "2026-01-03",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Molecular therapy. Advances",
    "pmid": "42137270",
    "doi": "10.1016/j.omta.2025.201665",
    "preprint_id": "",
    "authors": "Tannir R; Chan L; Grzywa TM; Arevalo O; Neeser A; Kahn S; Cozzone A; Ramamurthi A; Olenick L; Mason NJ; Liu X; Ma L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 47,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.14.725087",
    "canonical_key": "doi:10.64898/2026.05.14.725087",
    "headline": "Chloroplast movements in siphonous macroalgae in response to high light and grazing",
    "summary": "Fast cytoplasmic streaming enables extensive chloroplast movements in the giant cells of unicellular, siphonous macroalgae. Here, we studied chloroplast movements in two such algae: the Dasycladalean Acetabularia acetabulum and the Bryopsidales Bryopsis sp..",
    "url": "https://doi.org/10.64898/2026.05.14.725087",
    "source": "bioRxiv",
    "published_date": "2026-05-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.14.725087",
    "preprint_id": "biorxiv:10.64898/2026.05.14.725087",
    "authors": "Mattila, H.; Lopes, P.; Havurinne, V.; Goessling, J. W.; Cartaxana, P.; Cruz, S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 48,
    "score": 24,
    "id": "pubmed:42140176",
    "canonical_key": "pmid:42140176",
    "headline": "Clinical characteristics of central nervous system talaromycosis: A comparative analysis with cryptococcal meningitis and tuberculous meningitis in patients with AIDS.",
    "summary": "Journal de mycologie medicale. J Mycol Med. 2026-05-05",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42140176/",
    "source": "PubMed",
    "published_date": "2026-05-05",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal de mycologie medicale",
    "pmid": "42140176",
    "doi": "10.1016/j.mycmed.2026.101628",
    "preprint_id": "",
    "authors": "Chen X; Xia L; Guo P; Huang Y; Lin W; He Y; Xu F; Liu B; Cai W; Tang X; Li L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 49,
    "score": 24,
    "id": "pubmed:42139635",
    "canonical_key": "pmid:42139635",
    "headline": "Clinical, Electrophysiological, and Neuropathological Features of Peripheral Neuropathies in People With T-Cell Lymphoproliferative Disorder.",
    "summary": "Neurology. Neurology. 2026-05-15",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42139635/",
    "source": "PubMed",
    "published_date": "2026-05-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Neurology",
    "pmid": "42139635",
    "doi": "10.1212/WNL.0000000000218057",
    "preprint_id": "",
    "authors": "Pacoureau L; Bicart-Sée L; Morgane LG; Viala K; Maisonobe T; Beaudonnet G; Adam C; Vicino A; Théaudin M; Boutboul D; Roos-Weil D; Camdessanche JP; Pereon Y; Dormeuil A; Lipsker D; Acket B; Svahn J; Cluse F; Pegat A; Urbain F; Lambotte O; Labeyrie C; Noël N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-16",
    "window_start": "2026-05-15T05:15:00.000Z",
    "window_end": "2026-05-16T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 50,
    "score": 24,
    "id": "pubmed:42136146",
    "canonical_key": "pmid:42136146",
    "headline": "COL1A1(+) Epithelial Cells Orchestrate VEGFA-VEGFR Signaling in Endometritis Revealed by Single-Cell Analysis.",
    "summary": "Journal of clinical laboratory analysis. J Clin Lab Anal. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42136146/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of clinical laboratory analysis",
    "pmid": "42136146",
    "doi": "10.1002/jcla.70221",
    "preprint_id": "",
    "authors": "Tian C; Li Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-17",
    "window_start": "2026-05-16T05:15:00.000Z",
    "window_end": "2026-05-17T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 1,
    "score": 24,
    "id": "pubmed:42141502",
    "canonical_key": "pmid:42141502",
    "headline": "A rapid phage-free platform for antigen-specific VNAR screening with BATCH system.",
    "summary": "Rapid antigen-specific VNAR screening platform; adjacent to antigen-recognition discovery, but not a direct TCR/pMHC mapping or therapeutic pMHC-targeting paper.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42141502/",
    "source": "PubMed",
    "published_date": "2026-05-16",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Protein science : a publication of the Protein Society",
    "pmid": "42141502",
    "doi": "10.1002/pro.70620",
    "preprint_id": "",
    "authors": "Tang W; Hu J; Zhu Y; Zeng Y; Li J; Gu M; Yang J; Zhong B; Chen Y; Yan X; Chen J; Jiang X; Lyu Z; Li F; Chen G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-17",
    "window_start": "2026-05-16T05:15:00.000Z",
    "window_end": "2026-05-17T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 2,
    "score": 24,
    "id": "pubmed:42141809",
    "canonical_key": "pmid:42141809",
    "headline": "An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer.",
    "summary": "Colorectal cancer organoid model for early CD8 T-cell dysfunction and immunotherapy response; useful tumor-immunology context with limited direct pMHC discovery relevance.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42141809/",
    "source": "PubMed",
    "published_date": "2026-05-16",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Oncoimmunology",
    "pmid": "42141809",
    "doi": "10.1080/2162402X.2026.2674362",
    "preprint_id": "",
    "authors": "Lucantonio L; Schiano L; Sozio F; Kosta A; Peruzzi G; Molfetta R; Pietropaolo G; Laffranchi M; Campese AF; Bernardini G; Sozzani S; Gismondi A; Santoni A; Sciumè G; Helena S; Fionda C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-17",
    "window_start": "2026-05-16T05:15:00.000Z",
    "window_end": "2026-05-17T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 3,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.12.724215",
    "canonical_key": "doi:10.64898/2026.05.12.724215",
    "headline": "ATF4 programs proline-dependent immune evasion in β-Catenin-driven hepatocellular carcinoma",
    "summary": "Preprint on beta-catenin/ATF4-driven immune evasion in HCC; relevant to tumor immune exclusion biology, not direct TCR/pMHC discovery.",
    "url": "https://doi.org/10.64898/2026.05.12.724215",
    "source": "bioRxiv",
    "published_date": "2026-05-16",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.12.724215",
    "preprint_id": "biorxiv:10.64898/2026.05.12.724215",
    "authors": "Infante, S.; Santa Maria, E.; Finnemore, A.; Arcelus, S.; Barace, S.; Martinez-Montes, A.; Garcia-Porrero, G.; Hosseini-Giv, N.; Miraval, E.; de Andrea, C. E.; Llopiz, D.; Reig, M.; Finkelstein, Y.; Sangro, B.; Sarobe, P.; Fortes, P.; Uriz-Huarte, A.; Bayo, J.; Argemi, J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-17",
    "window_start": "2026-05-16T05:15:00.000Z",
    "window_end": "2026-05-17T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 1,
    "score": 24,
    "id": "pubmed:42141800",
    "canonical_key": "pmid:42141800",
    "headline": "Avian Malaria Infections Are Not Associated With Host Genetic Diversity: A Meta-Analysis.",
    "summary": "Molecular ecology. Mol Ecol",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42141800/",
    "source": "PubMed",
    "published_date": "2026-05-16",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Molecular ecology",
    "pmid": "42141800",
    "doi": "10.1111/mec.70374",
    "preprint_id": "",
    "authors": "Podmokła E; Pluciński B; Dubiec A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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  },
  {
    "digest_date": "2026-05-17",
    "window_start": "2026-05-16T05:15:00.000Z",
    "window_end": "2026-05-17T07:15:00.000Z",
    "source_type": "papers",
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    "headline": "Confirmation of the HLA-DPA1*01:03:35 Allele by Next-Generation Sequencing.",
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    "headline": "Green genetically encoded IP3 biosensor for hierarchical analysis of its signaling network",
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    "headline": "Hydraulic fracturing-induced delamination and extravasation extends medial damage beyond the false lumen in aortic dissection",
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    "headline": "Identifying Treatment Related Signatures In Glioblastoma Using KaleidoCell",
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    "headline": "Dendritic cells as orchestrators in the allergen-specific immunotherapy of allergic diseases.",
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    "headline": "Diabetes Mellitus Enhances Immune Suppression in Ovarian Cancer via CD155 Upregulation Mediated by the HSP70/P65 Axis.",
    "summary": "Journal of biochemical and molecular toxicology. J Biochem Mol Toxicol",
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    "headline": "Eltrombopag restores T-cell homeostasis in aplastic anemia by regulating oxidative metabolism and reactive oxygen species levels.",
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    "headline": "EpiReasoner: An Integrated Artificial Intelligence Framework for Phenotype-to-Genotype Reasoning in Plant Epidermal Development",
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    "url": "https://doi.org/10.64898/2026.05.13.724792",
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    "headline": "Exosomes derived from first-trimester human decidual mesenchymal stem cell.",
    "summary": "Tissue & cell. Tissue Cell. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42143411/",
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    "headline": "Expert Panel Review and Practical Guidance on Biomarker Testing With Engineered Immune Effector Cells.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-16",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42144191/",
    "source": "PubMed",
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    "journal": "Transplantation and cellular therapy",
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    "doi": "10.1016/j.jtct.2026.05.005",
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    "authors": "Blumenberg V; Diorio C; Gauthier J; Agrusa JE; Dreyzin A; Hänel G; Espinoza-Gutarra MR; Geer M; Perales MA; Ramakrishna S; Jain MD; Gill S; Locke FL; Shouval R; Subklewe M; Komanduri KV; Chapuis AG; Paczesny S; Rejeski K; Shah NN",
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    "headline": "Expression levels and dimer abundance of lamin A/C direct nuclear shape integrity in malignant cancer cells",
    "summary": "Abnormalities in nuclear morphology are an important diagnostic tool to determine malignancy in cancer cells and are characterised by nuclear blebbing and deformations.",
    "url": "https://doi.org/10.64898/2026.05.11.724268",
    "source": "bioRxiv",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
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    "authors": "Hensgens, M. N. F.; Mhaskar, A.; Geertsema, H.",
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    "canonical_key": "doi:10.64898/2026.05.13.724930",
    "headline": "Fibronectin and laminin differentially affect the inflammatory environment in microphysiological systems",
    "summary": "Tissue engineered constructs are increasingly used for both modeling organs and disease in vitro as well as for therapeutic intervention. In addition to collagen, these constructs commonly include native extracellular matrix proteins (ECM), such as fibronectin and laminin.",
    "url": "https://doi.org/10.64898/2026.05.13.724930",
    "source": "bioRxiv",
    "published_date": "2026-05-17",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "doi": "10.64898/2026.05.13.724930",
    "preprint_id": "biorxiv:10.64898/2026.05.13.724930",
    "authors": "Radke, M.; Calo, C. J.; Hind, L. E.",
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    "primary_source": "bioRxiv",
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    "id": "pubmed:42144157",
    "canonical_key": "pmid:42144157",
    "headline": "From Passive Protection to Lasting Immunity: The Potential Vaccinal Effect of Antiviral Monoclonal Antibodies.",
    "summary": "International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. Int J Infect Dis. 2026-05-16",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42144157/",
    "source": "PubMed",
    "published_date": "2026-05-16",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases",
    "pmid": "42144157",
    "doi": "10.1016/j.ijid.2026.108803",
    "preprint_id": "",
    "authors": "Sedó-Nicolaisen S; Larsen TN; Gunst JD; Søgaard OS",
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    "id": "pubmed:42144883",
    "canonical_key": "pmid:42144883",
    "headline": "Functional immune profiling reveals CD4(+) T cell dysregulation in coeliac disease.",
    "summary": "Immunology and cell biology. Immunol Cell Biol. 2026-05-17",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42144883/",
    "source": "PubMed",
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    "journal": "Immunology and cell biology",
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    "doi": "10.1111/imcb.70132",
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    "authors": "Farchione AJ; Cheon H; Vremec D; Neumann J; Verstappen GM; Hardy MY; Margetts MB; Howson LJ; Henneken LM; Forde M; Tye-Din JA; Heinzel S; Hodgkin PD; Bryant VL",
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    "id": "biorxiv:10.64898/2026.05.08.723705",
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    "headline": "Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells",
    "summary": "Dormancy is a reversible cellular state characterised by suspended proliferation and increased stress resilience, enabling long-term viability under adverse conditions. Although dormant cells are critical for the life cycle of diverse organisms, from microbes to humans, they are understudied compared to proliferating cells.",
    "url": "https://doi.org/10.64898/2026.05.08.723705",
    "source": "bioRxiv",
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    "doi": "10.64898/2026.05.08.723705",
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    "authors": "Hassan, S.; Rodriguez-Lopez, M.; Townsend, S.; Koksal, B.; Akkus, S.; Ori, A.; Cellerino, A.; Ralser, M.; Bahler, J.",
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    "id": "biorxiv:10.64898/2026.05.10.724123",
    "canonical_key": "doi:10.64898/2026.05.10.724123",
    "headline": "Genomic analysis of BCG unresponsive non-muscle-invasive bladder cancer identifies drivers of sensitivity to intravesical Gemcitabine/Docetaxel",
    "summary": "Background and Objectives: Intravesical gemcitabine/docetaxel (Gem/Doce) is an effective therapy for Bacillus Calmette-Guerin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC), achieving 50% complete responses at 2 years. However, the genomic determinants underlying response and resistance to Gem/Doce remain poorly defined.",
    "url": "https://doi.org/10.64898/2026.05.10.724123",
    "source": "bioRxiv",
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    "doi": "10.64898/2026.05.10.724123",
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    "authors": "Yim, K.; Vergara, M.; Lee, J.; Reardon, B.; Park, J.; Melnick, K.; Clinton, T. N.; Matthew, M.; Steele, G. S.; Bolduc, J.; Hirsch, M. S.; Rizzo, N.; Wu, C.-L.; Wszolek, M. F.; Salari, K.; Feldman, A. S.; Kibel, A. S.; Mouw, K. W.; Van Allen, E. M.; Preston, M. A.; Carvalho, F. L.",
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    "id": "pubmed:42144646",
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    "headline": "Genomic characterization of uterine adenomatoid tumors reveals recurrent alterations in KMT5A and KMT2C.",
    "summary": "Clinical epigenetics. Clin Epigenetics. 2026-05-17",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42144646/",
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    "headline": "Impact of Renal Impairment and Lymphodepletion Regimen on Outcomes after CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-16",
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    "authors": "Grieb N; Wiemers T; Born P; Fandrei D; Fischer L; Ferle M; Franke S; Keller J; Wang SY; Jentzsch M; Herling C; Metzeler KH; Herling M; Heyn S; Neumuth T; Platzbecker U; Vučinić V; Franke GN; Merz M",
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    "id": "pubmed:42144624",
    "canonical_key": "pmid:42144624",
    "headline": "Infection timing and immuno-inflammatory profiles determine prognosis of Pneumocystis jirovecii pneumonia in kidney transplant recipients.",
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    "score": 24,
    "id": "pubmed:42151258",
    "canonical_key": "pmid:42151258",
    "headline": "A bioinformatics and experimental approach identifies glycoprotein-based diagnostic and prognostic biomarkers for colon adenocarcinoma.",
    "summary": "Scientific reports. Sci Rep. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42151258/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Scientific reports",
    "pmid": "42151258",
    "doi": "10.1038/s41598-026-52427-5",
    "preprint_id": "",
    "authors": "Liu H; Wan L; Fang Q",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "rank_index": 5,
    "score": 24,
    "id": "pubmed:42148101",
    "canonical_key": "pmid:42148101",
    "headline": "A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42148101/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42148101",
    "doi": "10.3389/fimmu.2026.1816737",
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    "authors": "Bettin L; Unterweger C; Dippel M; Borysova T; Stadler M; Harris J; Rozzelle J; Arroyo D; Fairman J; Poston TB; Perouzel E; Lioux T; Hernandez-Franco JF; HogenEsch H; Buzanich-Ladinig A; Darville T; Käser T",
    "assignee": "",
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    "primary_source": "PubMed",
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    "id": "pubmed:42151118",
    "canonical_key": "pmid:42151118",
    "headline": "A high-throughput modular microfluidic platform for versatile functional assays at single-cell level.",
    "summary": "Microsystems & nanoengineering. Microsyst Nanoeng. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42151118/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Microsystems & nanoengineering",
    "pmid": "42151118",
    "doi": "10.1038/s41378-026-01310-4",
    "preprint_id": "",
    "authors": "Shao N; Mai J; Godin B; Liu X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "score": 24,
    "id": "pubmed:42152066",
    "canonical_key": "pmid:42152066",
    "headline": "A new hope with CAR T-cell therapy for refractory idiopathic inflammatory myopathies: a systematic review.",
    "summary": "Journal of translational medicine. J Transl Med. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42152066/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of translational medicine",
    "pmid": "42152066",
    "doi": "10.1186/s12967-026-08262-3",
    "preprint_id": "",
    "authors": "Shan X; Pang F; Wang G; Ge Y; Lu X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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  {
    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 8,
    "score": 24,
    "id": "pubmed:42153321",
    "canonical_key": "pmid:42153321",
    "headline": "A novel machine learning-based algorithm for eQTL identification reveals complex pleiotropic effects in the MHC region.",
    "summary": "Briefings in bioinformatics. Brief Bioinform. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42153321/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Briefings in bioinformatics",
    "pmid": "42153321",
    "doi": "10.1093/bib/bbag238",
    "preprint_id": "",
    "authors": "Li RY; Su C; Qin ZS",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 9,
    "score": 24,
    "id": "pubmed:42145843",
    "canonical_key": "pmid:42145843",
    "headline": "A Peptide Inhibitor of Lymphocyte Activation Gene-3 Interaction with Fibrinogen-like Protein 1 Synergizes with Programmed Death-Ligand 1 Blockade to Restore T Cell Activity and Inhibit Tumor Growth.",
    "summary": "Biomaterials research. Biomater Res. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42145843/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Biomaterials research",
    "pmid": "42145843",
    "doi": "10.34133/bmr.0364",
    "preprint_id": "",
    "authors": "Lee SM; Gurung S; Park MS; Vadevoo SMP; Gunassekaran GR; Kim MJ; Kim SH; Kim HJ; Park EJ; Lee S; Im W; Kim S; Lee B",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
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  {
    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 10,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.18.725832",
    "canonical_key": "doi:10.64898/2026.05.18.725832",
    "headline": "A Polygenic Route to Thermal Melanism and high-elevation adaptation in Honey Bees",
    "summary": "Thermal melanism, whereby darker pigmentation occurs in colder environments, is a widespread adaptive pattern, yet its genetic and physiological basis in eusocial insects remains poorly understood.",
    "url": "https://doi.org/10.64898/2026.05.18.725832",
    "source": "bioRxiv",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.18.725832",
    "preprint_id": "biorxiv:10.64898/2026.05.18.725832",
    "authors": "Mazzoni, M.; Loidolt, F.; Kersten, S.; Otieno, M.; Lasway, J. V.; Njovu, H.; Scheiner, R.; Hasselmann, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; evolutionary biology"
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    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 11,
    "score": 24,
    "id": "pubmed:42146058",
    "canonical_key": "pmid:42146058",
    "headline": "A porcine circovirus type 2d-based virus-like particle subunit vaccine effectively protects pigs against homologous challenge.",
    "summary": "Frontiers in microbiology. Front Microbiol. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42146058/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in microbiology",
    "pmid": "42146058",
    "doi": "10.3389/fmicb.2026.1802883",
    "preprint_id": "",
    "authors": "Chen P; Sun Y; Wang M; Li C; Xia Y; Liu H; Qi L; Si F; Miao D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 12,
    "score": 24,
    "id": "medrxiv:10.64898/2026.05.13.26353158",
    "canonical_key": "doi:10.64898/2026.05.13.26353158",
    "headline": "A qualitative study exploring opportunities for poverty alleviation interventions amongst people with severe mental health conditions in Eastern Cape, South Africa",
    "summary": "Background People with severe mental health conditions (SMHC) and caregivers in South Africa experience high rates of poverty. The PRIZE feasibility trial found that recovery groups were broadly acceptable and feasible and potentially effective in reducing relapse. Addressing economic needs was identified as a means to increase impact.",
    "url": "https://doi.org/10.64898/2026.05.13.26353158",
    "source": "medRxiv",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.13.26353158",
    "preprint_id": "medrxiv:10.64898/2026.05.13.26353158",
    "authors": "Asher, L.; Rapiya, B.; Chiliza, B.; Hanlon, C.; Petersen, I.; Brooke-Sumner, C.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "medRxiv",
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    "keywords": "medrxiv; public and global health"
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    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 13,
    "score": 24,
    "id": "pubmed:42147443",
    "canonical_key": "pmid:42147443",
    "headline": "A single-cell multi-omics assay for simultaneous measurement of vector copy number and protein expression in CAR T cells.",
    "summary": "Molecular therapy. Advances. Mol Ther Adv. 2026-04-15",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42147443/",
    "source": "PubMed",
    "published_date": "2026-04-15",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Molecular therapy. Advances",
    "pmid": "42147443",
    "doi": "10.1016/j.omta.2026.201738",
    "preprint_id": "",
    "authors": "Yang Y; Parikh S; Li CY; Murphy L; Patel K; Ayaz Q; Mohiuddin M; Elliott JT; He HJ; He Z; Maragh S; Schroeder B; Fry TJ; Winters A; Wang S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 14,
    "score": 24,
    "id": "pubmed:42150409",
    "canonical_key": "pmid:42150409",
    "headline": "A thiosemicarbazone-based dinuclear copper(II) complex: potent antiproliferative activity, distinct cell-type-specific anticancer mechanisms and robust in vivo antitumor efficacy.",
    "summary": "Bioorganic chemistry. Bioorg Chem. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42150409/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Bioorganic chemistry",
    "pmid": "42150409",
    "doi": "10.1016/j.bioorg.2026.109981",
    "preprint_id": "",
    "authors": "Wu S; Feng Q; Wu YB; Feng S; Peng Z; Yuan C; Li X; Lu L; Qiu L; Wang A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 15,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.15.725398",
    "canonical_key": "doi:10.64898/2026.05.15.725398",
    "headline": "A unified law for inhibitory control in active dendrites",
    "summary": "Neuronal computation depends on the balance between excitation and inhibition, yet how this balance is implemented across the dendritic tree remains unclear.",
    "url": "https://doi.org/10.64898/2026.05.15.725398",
    "source": "bioRxiv",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.15.725398",
    "preprint_id": "biorxiv:10.64898/2026.05.15.725398",
    "authors": "HE, Y.; Huang, B.; Du, K.; Huang, T.; He, G.; Poirazi, P.",
    "assignee": "",
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    "primary_source": "bioRxiv",
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    "keywords": "biorxiv; neuroscience"
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    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 16,
    "score": 24,
    "id": "pubmed:42151514",
    "canonical_key": "pmid:42151514",
    "headline": "Aberrant activation of tissue-resident lymphocytes and pro-fibrotic GZMK⁺ CD8⁺ T cells in IPF.",
    "summary": "Communications biology. Commun Biol. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42151514/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Communications biology",
    "pmid": "42151514",
    "doi": "10.1038/s42003-026-10299-5",
    "preprint_id": "",
    "authors": "Gao F; Wang Z; Su Y; Chi S; Yan T; Wei D; Huang Y; Shao J; Dai Z; Huang M; Wang C; Chen J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 24,
    "id": "pubmed:42146106",
    "canonical_key": "pmid:42146106",
    "headline": "Aberrant intra-epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103-β7-receptor-mediated granzyme-B degranulation which can be restored by etrolizumab.",
    "summary": "Clinical & translational immunology. Clin Transl Immunology. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42146106/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Clinical & translational immunology",
    "pmid": "42146106",
    "doi": "10.1002/cti2.70099",
    "preprint_id": "",
    "authors": "Castelijn DAR; van de Water JMW; de Baaij LR; McGlinchy BS; van Leeuwen M; Joosten SPJ; Alberts N; Rossi M; Reijm M; Hollander JC; Bonnet P; Kooy-Winkelaar YMC; Koning F; Pals ST; Bouma G; Meijer CJLM; Bontkes HJ; Mulder CJJ; Cillessen SAGM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 18,
    "score": 24,
    "id": "pubmed:42147912",
    "canonical_key": "pmid:42147912",
    "headline": "Acquired immunodeficiency syndrome-associated cytomegalovirus encephalitis: clinical, imaging, and follow-up characteristics of 11 cases.",
    "summary": "Quantitative imaging in medicine and surgery. Quant Imaging Med Surg. 2026-04-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42147912/",
    "source": "PubMed",
    "published_date": "2026-04-13",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Quantitative imaging in medicine and surgery",
    "pmid": "42147912",
    "doi": "10.21037/qims-2025-aw-2399",
    "preprint_id": "",
    "authors": "Wu D; Ma C; Gan D; Zhang S; Lu Y; Song S",
    "assignee": "",
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    "jurisdiction": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-19",
    "window_start": "2026-05-18T05:15:00.000Z",
    "window_end": "2026-05-19T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 24,
    "id": "pubmed:42149544",
    "canonical_key": "pmid:42149544",
    "headline": "Activation of Intestinal Type 3 Innate Lymphoid Cells and Regulatory T Cells Through Free Fatty Acid Receptor 2 Ameliorates Type 1 Diabetes in Mice.",
    "summary": "Diabetes. Diabetes. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42149544/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Diabetes",
    "pmid": "42149544",
    "doi": "10.2337/db25-0742",
    "preprint_id": "",
    "authors": "Koprivica I; Jonić N; Dimitrijević M; Jevtić B; Mićanović D; Stegnjaić G; Lazarević M; Stanisavljević S; Pilipović I; Radulović N; Saksida T; Mišić D; Zdravković V; Fraser G; Miljković Đ; Stojanović I",
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    "primary_source": "PubMed",
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    "window_start": "2026-05-18T05:15:00.000Z",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 24,
    "id": "biorxiv:10.64898/2026.05.14.725258",
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    "headline": "Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats",
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    "headline": "Beyond ex vivo and in vivo CAR T: antigen-driven CAR T (adCAR-T) expansion method enables rapid, physiological CAR T cells programming.",
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    "headline": "Tumour neoantigen repertoire computational predictions in malignant peripheral nerve sheath tumours define potential targets for immunotherapy",
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    "url": "https://doi.org/10.64898/2026.04.05.713607",
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    "headline": "Unveiling Gloriosine as a Dual-Acting Regulator of Glutamine Metabolism and Ferroptosis in Triple-Negative Breast Cancer: Insights from Network Pharmacology and Experimental Validation",
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    "url": "https://doi.org/10.64898/2026.05.15.26353286",
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    "headline": "GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42156357/",
    "source": "PubMed",
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    "authors": "Moës B; Krueger J; Liu C; Anto NP; Nemati A; Attias M; Kazanova A; Gao Y; Castoun-Puckett L; Oroya AC; Nguyen LH; Cabald AL; Tu TH; Rudd CE",
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    "authors": "Park YW; Korotcov A; Bosomtwi A; Cramer NP; Xu X; Deelchand DK; Marjańska M; Galdzicki Z",
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    "headline": "[HTLV-1-Associated Myelopathy].",
    "summary": "Brain and nerve = Shinkei kenkyu no shinpo. Brain Nerve",
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    "journal": "Brain and nerve = Shinkei kenkyu no shinpo",
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    "authors": "Nakashima M; Yamano Y",
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    "canonical_key": "pmid:42156035",
    "headline": "[Human Herpesvirus-6B Encephalitis].",
    "summary": "Brain and nerve = Shinkei kenkyu no shinpo. Brain Nerve",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42156035/",
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    "authors": "Ogata M",
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    "headline": "A genomic and proteomic characterization of mannan-degradable Bacillus sp. TTS1, isolated from Tomakomai Forest in Hokkaido",
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    "url": "https://doi.org/10.64898/2026.05.18.725066",
    "source": "bioRxiv",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "authors": "Mitsumasu, S.; Kasuga, Y.; Nagano, T.; Kumar, V.; Hasegawa, Y.; Maeda, T.; Takasuka, T. E.",
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    "headline": "A human epithelial co-culture system reveals distinct host cell interaction behaviours for Treponema pallidum",
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    "url": "https://doi.org/10.64898/2026.02.04.703719",
    "source": "bioRxiv",
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    "authors": "Capuccini, K.; Govender, D.; Goulding, D.; Kyanya, C.; Pasricha, S.; Giacani, L.; Thomson, N. R.; Grillova, L.",
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    "headline": "A strategic approach to managing Immune Effector Cell-Associated Hematotoxicity (ICAHT) during chimeric antigen receptor T-cell therapy.",
    "summary": "Blood research. Blood Res. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42154115/",
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    "headline": "Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression",
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    "url": "https://doi.org/10.64898/2026.05.16.725632",
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    "headline": "Activation of GABBR1 by New Ligand Valerate Transcriptionally Regulates ATF4-NRF2-CXCL13 Axis Mediating CD8(+) T Cell Anti-Tumor Immunity.",
    "summary": "International journal of biological sciences. Int J Biol Sci. 2026-04-16",
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    "authors": "Zhai Z; Huang J; Qiu J; Wang Y; Liao J; Xie C; Xu J; Jiang Z; Xie Y; Ren W; Zhang Y; Yan H; Wang M; Huang C; Leung ELH",
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    "headline": "An automated genetic screen identifies modulators of stress-induced sleep in Caenorhabditis elegans",
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    "url": "https://doi.org/10.64898/2026.05.16.725661",
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    "score": 24,
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    "canonical_key": "pmid:42156591",
    "headline": "An epigenetic switch in vascular phenotype augments anti-tumor immunity.",
    "summary": "Angiogenesis. Angiogenesis. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42156591/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Angiogenesis",
    "pmid": "42156591",
    "doi": "10.1007/s10456-026-10042-y",
    "preprint_id": "",
    "authors": "Kim DJ; McGinty M; Anandh S; Riedstra C; Sethi Y; Rutkowski MR; Dudley AC",
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    "headline": "Aortic valve stenosis promotes pathological shear stress-dependent epigenomic dysregulation in circulating T cells.",
    "summary": "Background. Calcific aortic valve stenosis (AVS) is the most prevalent valvular heart disease in Western adults, yet no disease-modifying therapy exists.",
    "url": "https://doi.org/10.64898/2026.05.17.722103",
    "source": "bioRxiv",
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    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.17.722103",
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    "authors": "Zhang, Y.; Kleiner, J. L.; Zheng, J.; Splettstoesser, F.; Zimmer, S.; Coburn, M.; Weisheit, C.; Frede, S.; Pepin, M. E.",
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    "canonical_key": "doi:10.64898/2026.05.16.725598",
    "headline": "Aqp1aa and Aqp4a mediate collecting duct water permeability in a marine teleost",
    "summary": "Regulation of water permeability in the collecting duct is important for osmoregulatory acclimation in teleost fish. In hyperosmotic environments such as seawater (SW), the teleost kidney functions as a site of divalent ion excretion.",
    "url": "https://doi.org/10.64898/2026.05.16.725598",
    "source": "bioRxiv",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.16.725598",
    "preprint_id": "biorxiv:10.64898/2026.05.16.725598",
    "authors": "Watanabe, E.; Ota, C.; Imaizumi, G.; Sakamoto, Y.; Suzuki, Y.; Kato, A.",
    "assignee": "",
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    "headline": "Association Between Immunosenescence and High Bacterial Load in Elderly Patients with Pulmonary Tuberculosis: A Retrospective Cohort Study Conducted in Southwest China, 2013-2020.",
    "summary": "Microbial pathogenesis. Microb Pathog. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42155908/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Microbial pathogenesis",
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    "authors": "Cheng J; Tang D; Hong S; Wang Q; He JQ",
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    "score": 24,
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    "canonical_key": "pmid:42155009",
    "headline": "Association between miR-155 expression and Th17/Treg balance in URPL patients: a single-centre retrospective study.",
    "summary": "Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. J Obstet Gynaecol. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42155009/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology",
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    "doi": "10.1080/01443615.2026.2661211",
    "preprint_id": "",
    "authors": "Chen Y; Xu M; Li L; Dong M; Wang H; Zhang M",
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    "window_start": "2026-05-19T05:15:00.000Z",
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    "score": 24,
    "id": "pubmed:42155956",
    "canonical_key": "pmid:42155956",
    "headline": "ATR inhibition in combination with hypofractionated radiotherapy is superior to ATM inhibition with regard to ex vivo CD8 + T cell activation particularly for HPV-negative head and neck cancer cells.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42155956/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Oral oncology",
    "pmid": "42155956",
    "doi": "10.1016/j.oraloncology.2026.108019",
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    "authors": "Schäfer A; Zülch L; Steinsdörfer L; Donaubauer AJ; Reichardt C; Frey B; Fietkau R; Haderlein M; Corradini S; Gaipl US; Jost T",
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    "canonical_key": "pmid:42157421",
    "headline": "Autophagy functions in lung macrophages and dendritic cells to regulate allergen-dependent inflammatory responses.",
    "summary": "Autophagy. Autophagy. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42157421/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Autophagy",
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    "doi": "10.1080/15548627.2026.2668861",
    "preprint_id": "",
    "authors": "Dubey N; Woodson R; Hendrix SV; Rosen AL; Kinsella RL; McKee SR; Starick M; Rivera-Espinal N; Naik SK; Smirnov A; Kreamalmeyer D; Kau AL; Stallings CL",
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    "id": "biorxiv:10.64898/2026.05.18.725942",
    "canonical_key": "doi:10.64898/2026.05.18.725942",
    "headline": "B3GNT7 regulates mucin glycosylation and protects against colitis and infection",
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    "url": "https://doi.org/10.64898/2026.05.18.725942",
    "source": "bioRxiv",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.18.725942",
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    "authors": "Burns, M. W. N.; Chongsaritsinsuk, J.; Propheter, D. C.; YIN, J.; Zuo, V.; Huang, C.; Peng, L.; Ruhn, K. A.; Moremen, K. W.; Burstein, E.; Hooper, L.; Malaker, S. A.; Kohler, J. J.",
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    "canonical_key": "pmid:42158525",
    "headline": "Biomimetic M1 Macrophage Membrane-Camouflaged Nanoplatform Remodels Tumor Microenvironment for Enhanced Antitumor Immunity.",
    "summary": "International journal of nanomedicine. Int J Nanomedicine. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42158525/",
    "source": "PubMed",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "International journal of nanomedicine",
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    "doi": "10.2147/IJN.S604156",
    "preprint_id": "",
    "authors": "Bai X; Han X; Wang W; Wang N; Li L; Hu J; Zhang Q; Qian X",
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    "id": "pubmed:42157138",
    "canonical_key": "pmid:42157138",
    "headline": "Burden of malaria-HIV coinfection and associated adverse outcomes in Ethiopia: a systematic review and meta-analysis.",
    "summary": "BMC infectious diseases. BMC Infect Dis. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42157138/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "BMC infectious diseases",
    "pmid": "42157138",
    "doi": "10.1186/s12879-026-13609-8",
    "preprint_id": "",
    "authors": "Yeshanew TM; Gidey B; Abebe B; Waktole G; Getie B; Getu T; Birhane N",
    "assignee": "",
    "publication_number": "",
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    "headline": "Case study of resecabtagene autoleucel in a subject with diffuse cutaneous systemic sclerosis treated in the RESET-SSc trial.",
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    "source": "PubMed",
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    "journal": "Molecular therapy. Advances",
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    "authors": "Nunez D; Volkov JR; Little C; Ghosh M; Tsou PS; Furmanak T; Dey P; Tsoi LC; Zahn C; Bogle R; Cai Y; Fox J; Stadanlick J; Werner M; Vorndran Z; Ishikawa L; Ellis A; Williams J; Cicarelli J; Flannagan S; Kobulsky D; Lam Q; Schmitt C; Nezhad F; Thompson D; Braccia D; Rivera TG; Tummala R; Gudjonsson JE; Ross C; Binder G; Chang D; Basu S; Khanna D",
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    "canonical_key": "doi:10.64898/2026.05.15.725461",
    "headline": "CDK12 and CDK13 suppress distinct intronic polyadenylation sites",
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    "source": "bioRxiv",
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    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "id": "pubmed:42154859",
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    "headline": "Chronic myelomonocytic leukemia without increased classical monocyte subsets exhibits a distinct genetic profile, including frequent CBL mutations.",
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    "source": "PubMed",
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    "doi": "10.1093/ajcp/aqag045",
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    "authors": "Yan M; Younes IE; Song J; Zhang L",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/41703718/",
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    "authors": "Zhu Z; Zhu Y; Xuan Y; Wu Y; Liu Y; Wang X; Zhang L; Xiang L; Zhang C",
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    "score": 24,
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    "canonical_key": "pmid:42153608",
    "headline": "Clinical Implications of Early vs Late Development of Donor-Specific Antibodies Among Lung Transplant Recipients: A Single-Center Experience.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42153608/",
    "source": "PubMed",
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    "authors": "Sindu D; Pham C; Kohler N; Bitar G; Bowman D; Grief K; Walia R; Franz BJ; Tokman S",
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    "id": "pubmed:42152401",
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    "headline": "Combination scRNA-seq with GWAS identifies genetic risk factors in IgA nephropathy: An observational study.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42152401/",
    "source": "PubMed",
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    "authors": "Zhang J; Lu S; Liang G; Wang R; Zhou H; Na N; Liu M; Zhong Z",
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    "headline": "Common, Intermediate and Well-Documented HLA Alleles in the Chinese Population: CIWD Version 2025.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42153631/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
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    "pmid": "42153631",
    "doi": "10.1111/tan.70758",
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    "authors": "He Y; Cai J; Li J; Mao W; He J; Deng Z; Shen J; Chen Q; Zhang D; Zhu C; Wang D; Huo M; Wu B; Han Y; Zhang Z; Zhu F",
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    "id": "biorxiv:10.1101/2025.10.09.681376",
    "canonical_key": "doi:10.1101/2025.10.09.681376",
    "headline": "Conformational Variability of HIV-1 Env Trimer and Viral Vulnerability",
    "summary": "HIV-1 envelope glycoprotein (Env) is critical for viral fusion and entry into host cells and remains a primary target for vaccine and antiviral drug development. Advances in soluble gp140 trimer design have provided insight into the ectodomain structure and dynamics.",
    "url": "https://doi.org/10.1101/2025.10.09.681376",
    "source": "bioRxiv",
    "published_date": "2026-05-19",
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    "pmid": "",
    "doi": "10.1101/2025.10.09.681376",
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    "authors": "Cao, Y.; Im, W.",
    "assignee": "",
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    "headline": "Consensus Recommendations for CAR T-Cell Administration in Adult Acute Lymphoblastic Leukemia: a Modified Delphi Study.",
    "summary": "Blood. Blood. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42154904/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Blood",
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    "doi": "10.1182/blood.2026033559",
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    "authors": "Muffly L; Frey NV; Roloff GW; Park JH; Dholaria B; Advani AS; Bachanova V; Cassaday RD; Daunov M; Dykes KC; Irizarry Gatell V; Grunwald MR; Hilal T; Hill LC; Jamy O; Kota VK; Kumaran M; Lin C; Logan AC; Luskin MR; O'Dwyer KM; Oliai C; Oluwole OO; Sasine JP; Schwartz MS; Solh MM; Stock W; Tsai SB; Ulrickson ML; Vasu S; Wang ES; Yalniz FF; Strickland SA; Leonard JT; Shah BD; Aldoss I",
    "assignee": "",
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    "headline": "Context-dependent reconfiguration and spatial reorganisation of the miR-199a-5p/XIAP axis in high-grade serous ovarian cancer",
    "summary": "Background: High-grade serous ovarian cancer (HGSOC) remains a leading cause of gynaecological cancer mortality, largely owing to late diagnosis and the emergence of platinum resistance. A defining feature of resistant disease is impaired apoptotic execution despite persistent survival signalling.",
    "url": "https://doi.org/10.64898/2026.03.11.711019",
    "source": "bioRxiv",
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    "doi": "10.64898/2026.03.11.711019",
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    "authors": "Munoz de Galdeano, T.; Reigada, D.; Nieto-Diaz, M.; Palka Kotlowska, M.; Gonzalez Gea, L.; Garcia Pena, M.; Santacruz, B.; Iglesias, G.; Martinez Maza, R.",
    "assignee": "",
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    "primary_source": "bioRxiv",
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    "canonical_key": "pmid:42157184",
    "headline": "Correction: Peptide nanofibers and PAMP agonist combinations enhance pulmonary CD4 + T cell functionality of immune recall to vaccination.",
    "summary": "Journal of nanobiotechnology. J Nanobiotechnology. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42157184/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Journal of nanobiotechnology",
    "pmid": "42157184",
    "doi": "10.1186/s12951-026-04563-3",
    "preprint_id": "",
    "authors": "Files MA; Das A; Kim D; Buck J; Endsley JJ; Rudra JS",
    "assignee": "",
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    "id": "pubmed:42154426",
    "canonical_key": "pmid:42154426",
    "headline": "CRISPR-Cas and Infectious Diseases: A Decade of Translational Advances in Molecular Biotechnology.",
    "summary": "Biochemical genetics. Biochem Genet. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42154426/",
    "source": "PubMed",
    "published_date": "2026-05-19",
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    "journal": "Biochemical genetics",
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    "doi": "10.1007/s10528-026-11391-5",
    "preprint_id": "",
    "authors": "Mayuri K; Saravanan KM; Somala CS; Selvaraj C; Anand T; Vickram S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "score": 24,
    "id": "pubmed:42158823",
    "canonical_key": "pmid:42158823",
    "headline": "Current Status and Evolution of Immunotherapy in Glioma Management.",
    "summary": "International journal of medical sciences. Int J Med Sci. 2026-05-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42158823/",
    "source": "PubMed",
    "published_date": "2026-05-01",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "International journal of medical sciences",
    "pmid": "42158823",
    "doi": "10.7150/ijms.132708",
    "preprint_id": "",
    "authors": "Liu J; Yang G; Cao Z; Qin H; Zhu M; Zou C; Liu X; He Y; Gu J",
    "assignee": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "score": 24,
    "id": "pubmed:42158862",
    "canonical_key": "pmid:42158862",
    "headline": "Cytokine release syndrome after allogeneic hematopoietic stem cell transplantation using posttransplant cyclophosphamide: current understanding and management.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42158862/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in immunology",
    "pmid": "42158862",
    "doi": "10.3389/fimmu.2026.1642583",
    "preprint_id": "",
    "authors": "Wang J; Arora K; de Lima M",
    "assignee": "",
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    "score": 24,
    "id": "pubmed:42156901",
    "canonical_key": "pmid:42156901",
    "headline": "Decoding the crosstalk between ubiquitination and other post-translational modifications in cancer immunity: from mechanisms to clinical prospects.",
    "summary": "NPJ precision oncology. NPJ Precis Oncol. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42156901/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "NPJ precision oncology",
    "pmid": "42156901",
    "doi": "10.1038/s41698-026-01488-w",
    "preprint_id": "",
    "authors": "Li KQ; Ding SQ; Lei Y; Bai X; Liu HZ; Zhao ZM; Dai DQ",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 38,
    "score": 24,
    "id": "pubmed:42158597",
    "canonical_key": "pmid:42158597",
    "headline": "Delineating novel diagnostic biomarkers and therapeutic targets for oral submucosal fibrosis: an integrative multi-omics and machine learning approach.",
    "summary": "Frontiers in bioinformatics. Front Bioinform. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42158597/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Frontiers in bioinformatics",
    "pmid": "42158597",
    "doi": "10.3389/fbinf.2026.1803111",
    "preprint_id": "",
    "authors": "Nitin Mokal C; Agrawal P",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-20",
    "window_start": "2026-05-19T05:15:00.000Z",
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    "source_type": "papers",
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    "score": 24,
    "id": "pubmed:42154400",
    "canonical_key": "pmid:42154400",
    "headline": "Design, synthesis, anticancer estimation, and computational studies of novel benzochromenoimidazopyrimidines as CDK-2 inhibitors and apoptosis stimulators.",
    "summary": "Molecular diversity. Mol Divers. 2026-05-19",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42154400/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Molecular diversity",
    "pmid": "42154400",
    "doi": "10.1007/s11030-026-11578-3",
    "preprint_id": "",
    "authors": "Abdulrahman FG; Sarg MT; Sheta YS; Nossier ES; Husseiny EM",
    "assignee": "",
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    "jurisdiction": "",
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    "digest_date": "2026-05-20",
    "window_start": "2026-05-19T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 40,
    "score": 24,
    "id": "pubmed:42152658",
    "canonical_key": "pmid:42152658",
    "headline": "Determinants of Epitope Immunodominance Hierarchies in Protein Antigens at the Molecular, Structural, and Cellular Levels, Including MHC-Dependent Mechanisms.",
    "summary": "Current protein & peptide science. Curr Protein Pept Sci. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42152658/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Matched broad pMHC/TCR collection terms but needs editorial review.",
    "journal": "Current protein & peptide science",
    "pmid": "42152658",
    "doi": "10.2174/0113892037456975260410060342",
    "preprint_id": "",
    "authors": "Pedroza-Escobar D; González-Cortés T; Castillo-Maldonado I; Delgadillo-Guzmán D; Flores-Loyola E; Ramirez-Moreno A; Avalos-Soto J; Téllez-López MÁ; Velázquez-Gauna SE; Santa Cruz JH; Michel Ramírez G; García-Garza R; Arellano Pérez Vertti RD; Meza-Velázquez R; Rosales-González MG",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-21",
    "window_start": "2026-05-20T05:15:00.000Z",
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    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 1,
    "score": 100,
    "id": "pubmed:42163062",
    "canonical_key": "pmid:42163062",
    "headline": "Tebentafusp (IMCgp100), a first in class immune-mobilizing monoclonal T-cell receptors against cancer (ImmTAC) for HLA-A*02:01 positive uveal melanoma: Product review.",
    "summary": "Product review of tebentafusp/IMCgp100, a soluble TCR ImmTAC that targets gp100 peptide-HLA-A*02:01 in uveal melanoma; directly relevant pMHC-targeting therapeutic context.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42163062/",
    "source": "PubMed",
    "published_date": "2026-05-20",
    "match_reason": "Direct pMHC or peptide-HLA targeting: immtac, hla-a*02:01, peptide-hla | Named pMHC/TCR therapeutic: tebentafusp, imcgp100 | TCR-TCE or TCR bispecific therapeutic format: immtac",
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    "pmid": "42163062",
    "doi": "10.1080/21645515.2026.2675068",
    "preprint_id": "",
    "authors": "Cohen JE; Mehmi I; Avner M; Moyers J; Hamid O",
    "assignee": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "source_type": "papers",
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    "id": "biorxiv:10.64898/2026.05.17.725710",
    "canonical_key": "doi:10.64898/2026.05.17.725710",
    "headline": "T-cell Receptor (TCR) targeting with Multivalent T-cell Engagers",
    "summary": "bioRxiv preprint on multivalent T-cell engager design built around TCR targeting and CD3 recruitment; directly relevant to TCR-targeting therapeutic format engineering.",
    "url": "https://doi.org/10.64898/2026.05.17.725710",
    "source": "bioRxiv",
    "published_date": "2026-05-20",
    "match_reason": "TCR-TCE or TCR bispecific therapeutic format: t-cell receptor (tcr) targeting | Structural or quantitative binding validation: affinity | Generic T-cell engager modality: t-cell engagers, multivalent t-cell engagers",
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    "doi": "10.64898/2026.05.17.725710",
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    "authors": "Paul, D.; Kulkarni, A.; Rodriguez, F.; Dahlberg, D.; Rozumalski, L.; Wagner, C. R.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
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    "source_type": "papers",
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    "score": 72,
    "id": "pubmed:42165161",
    "canonical_key": "pmid:42165161",
    "headline": "Escape From Synthetic T Cell Activator Tebentafusp by Genomic HLA Loss: A Case Report.",
    "summary": "Case report of escape from tebentafusp, a pMHC/TCR-bispecific therapeutic, through genomic HLA loss; relevant resistance mechanism for HLA-restricted pMHC targeting.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42165161/",
    "source": "PubMed",
    "published_date": "2026-05-21",
    "match_reason": "Named pMHC/TCR therapeutic: tebentafusp, synthetic t cell activator | Resistance or escape in pMHC/TCR therapy context: hla loss, genomic hla loss, escape from | Low-specificity pMHC/TCR field anchor: hla",
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    "authors": "Kalkavan H; Heinold A; Liu S; Borse GM; Heinemann FM; Dertnig T; Hense J; Ingenwerth M; Cheung FY; Antonopoulou G; Pretzell I; Fleischhauer K; Bechrakis NE; Schuler M",
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    "id": "pubmed:42162665",
    "canonical_key": "pmid:42162665",
    "headline": "Five-Year Survival with Tebentafusp in Metastatic Uveal Melanoma.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42162665/",
    "source": "PubMed",
    "published_date": "2026-05-19",
    "match_reason": "Named pMHC/TCR therapeutic: tebentafusp",
    "journal": "Annals of oncology : official journal of the European Society for Medical Oncology",
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    "authors": "Piperno-Neumann S; Rutkowski P; Hassel JC; Butler MO; Schlaak M; Sullivan RJ; Dummer R; Kirkwood JM; Sacco JJ; Shoushtari AN; Piulats JM; Salama AKS; Orloff MM; Joshua AM; Ochsenreither S; Gastaud L; Curti BD; Demidov LV; Milhem MM; Chmielowski B; Kendra KL; Ascierto PA; Bernicker EH; Carvajal RD; Collins L; Lockwood S; Patel JM; Hamid OA; Baurain JF; Nathan PD",
    "assignee": "",
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    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.26353109",
    "preprint_id": "medrxiv:10.64898/2026.05.19.26353109",
    "authors": "Perez, C. N.; Pistone, C.; Romero, C.; Carrillo, A.; Manzur, M. J.; Chialva, C.; Quiroz, H.; Juri Ayub, M.",
    "assignee": "",
    "publication_number": "",
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    "claims": "",
    "company_name": "",
    "drug_name": "",
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    "primary_source": "medRxiv",
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    "keywords": "medrxiv; genetic and genomic medicine"
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    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
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    "rank_index": 5,
    "score": 3,
    "id": "europepmc:PMC13192205",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13192205",
    "headline": "Speedy Spirochetes: An Unusually Rapid Progression of Multisystem Manifestations of Syphilis",
    "summary": "Santharam Y, Choudhry H, Fazio A, Chang J, Dyrda M, Grover S.",
    "url": "https://europepmc.org/article/PMC/PMC13192205",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "Watchlist hits: Roche",
    "journal": "Cureus",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Santharam Y;  Choudhry H;  Fazio A;  Chang J;  Dyrda M;  Grover S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; case reports; case-report"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 6,
    "score": 3,
    "id": "pubmed:42165443",
    "canonical_key": "pmid:42165443",
    "headline": "Connexin 43 promotes stemness of leukemia cells and chemoresistance in T-cell acute lymphoblastic leukemia via the RAC1/AKT/GSK3β axis.",
    "summary": "Chinese medical journal. Chin Med J (Engl). 2026-05-21",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42165443/",
    "source": "PubMed",
    "published_date": "2026-05-21",
    "match_reason": "Watchlist hits: GSK",
    "journal": "Chinese medical journal",
    "pmid": "42165443",
    "doi": "10.1097/CM9.0000000000004141",
    "preprint_id": "",
    "authors": "Ji R; An H; Liu L; Wang X; Yang G; Cheng X; Yang L; Wang M; Liu J; Li C; Dou Y; Yang S; Zhang X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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    "digest_date": "2026-05-22",
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    "source_type": "papers",
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    "rank_index": 7,
    "score": 3,
    "id": "pubmed:42168203",
    "canonical_key": "pmid:42168203",
    "headline": "Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers.",
    "summary": "Nature communications. Nat Commun. 2026-05-21",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42168203/",
    "source": "PubMed",
    "published_date": "2026-05-21",
    "match_reason": "Watchlist hits: TP53",
    "journal": "Nature communications",
    "pmid": "42168203",
    "doi": "10.1038/s41467-026-73163-4",
    "preprint_id": "",
    "authors": "Boruah N; Hoyos D; Moses R; Hausler R; Desai H; Le AN; Good M; Kelly G; Raghavakaimal A; Tayeb M; Narasimhamurthy M; Doucette A; Gabriel P; Feldman MJ; Park J; Lopez de Rodas M; Schalper KA; Goldfarb SB; Nayak A; Levine AJ; Greenbaum BD; Maxwell KN",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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  {
    "digest_date": "2026-05-22",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 8,
    "score": 0,
    "id": "europepmc:PMC13187950",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13187950",
    "headline": "Multifunctional conductive dressings for wound healing support",
    "summary": "Yang J, Pilkington L, Travas-Sejdic J.",
    "url": "https://europepmc.org/article/PMC/PMC13187950",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Chem Sci",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Yang J;  Pilkington L;  Travas-Sejdic J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; review-article; review; journal article"
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    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 9,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.19.726324",
    "canonical_key": "doi:10.64898/2026.05.19.726324",
    "headline": "Glucagon-like peptide-1 receptor agonist, semaglutide, attenuates intravenous self-administration of fentanyl in female rats",
    "summary": "Current treatments for opioid use disorder (OUD) have major barriers to access. As such, researching new potential therapies for OUD is important to public health. Previous research has implicated glucagon-like peptide-1 (GLP-1) receptor agonists in decreasing the use of addictive substances by animals.",
    "url": "https://doi.org/10.64898/2026.05.19.726324",
    "source": "bioRxiv",
    "published_date": "2026-05-21",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.726324",
    "preprint_id": "biorxiv:10.64898/2026.05.19.726324",
    "authors": "Rojas, K. E.; Gee, S. C.; Wernette, C. L.; Wang, E. X.; Nguyen, E. T.; Nguyen, J. D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
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    "keywords": "biorxiv; pharmacology and toxicology"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 10,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726763",
    "canonical_key": "doi:10.64898/2026.05.21.726763",
    "headline": "Slow to Start, Free at Last: Dual Effects of Mucin on Escherichia coli Phage T4",
    "summary": "Bacteriophages traversing the gastrointestinal tract are exposed to extreme physicochemical stresses that may rapidly compromise virion integrity and shape infection dynamics.",
    "url": "https://doi.org/10.64898/2026.05.21.726763",
    "source": "bioRxiv",
    "published_date": "2026-05-21",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726763",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726763",
    "authors": "Koonce, K. C.; Rasmussen, A.; Goncalo, R. B.; Middelboe, M.; Xavier, K. B.; Mauritzen, J. J.; Hoyland-Kroghsbo, N. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 11,
    "score": 0,
    "id": "europepmc:PMC13189733",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189733",
    "headline": "Adaptive radiation and structural tailoring of the Vietnamese Blec2 immunogenetic reservoir",
    "summary": "Luu A, Budi T, Singchat W, Nguyen C, Panthum T, Tanglertpaibul N, Vangnai K, Chaiyes A, Yokthongwattana C, Sinthuvanich C, Sawatdichaikul O, Han K, Muangmai N, Griffin D, Duengkae P, Nguyen N, Srikulnath K.",
    "url": "https://europepmc.org/article/PMC/PMC13189733",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Genet",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Luu A;  Budi T;  Singchat W;  Nguyen C;  Panthum T;  Tanglertpaibul N;  Vangnai K;  Chaiyes A;  Yokthongwattana C;  Sinthuvanich C;  Sawatdichaikul O;  Han K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 12,
    "score": 0,
    "id": "europepmc:PMC13189907",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189907",
    "headline": "Adipose-derived mesenchymal stromal cell-microenvironment interaction network in metabolic syndrome: ADMSC injury response, adaptive regulation, and regenerative potential",
    "summary": "Yuan L, Yuan Q, Guo D, Tan H, Guan X.",
    "url": "https://europepmc.org/article/PMC/PMC13189907",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cell Dev Biol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Yuan L;  Yuan Q;  Guo D;  Tan H;  Guan X.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 13,
    "score": 0,
    "id": "europepmc:PMC13189925",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189925",
    "headline": "Adjuvant endocrine therapy in estrogen-low breast cancer in the era of CDKI: are we at another uncertain crossroads?",
    "summary": "Valerio M, Scandurra G, Greco M, Mesi C, Gebbia V, Sambataro D.",
    "url": "https://europepmc.org/article/PMC/PMC13189925",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Oncol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Valerio M;  Scandurra G;  Greco M;  Mesi C;  Gebbia V;  Sambataro D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 14,
    "score": 0,
    "id": "europepmc:PMC13190199",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190199",
    "headline": "An appraisal of the role of asymmetric dimethylarginine on endothelial impairment in preeclampsia comorbid with HIV infection",
    "summary": "Mthembu M, Sibiya S, Moodley J, Mkhwanazi N, Naicker T.",
    "url": "https://europepmc.org/article/PMC/PMC13190199",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Med (Lausanne)",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Mthembu M;  Sibiya S;  Moodley J;  Mkhwanazi N;  Naicker T.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 15,
    "score": 0,
    "id": "europepmc:PMC13191092",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13191092",
    "headline": "Anti-senescence Effects of Nanovesicles Derived from Cluster of Differentiation-146-Positive Tonsil Mesenchymal Stem Cells via Modulation of the Tumor Protein 53 Pathway",
    "summary": "Kim D, Jeon H, Shim K, Park J, Yoon J, Lee J, Park J, Park J, Kim J, Yoon J, Lee J, Baek W.",
    "url": "https://europepmc.org/article/PMC/PMC13191092",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Biomater Res",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Kim D;  Jeon H;  Shim K;  Park J;  Yoon J;  Lee J;  Park J;  Park J;  Kim J;  Yoon J;  Lee J;  Baek W.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 16,
    "score": 0,
    "id": "europepmc:PMC13190582",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190582",
    "headline": "Antimycobacterial peptides as natural therapeutics for tuberculosis: mechanisms and structural features",
    "summary": "Pritam P, Das S, Behera S, Sahoo M, Subudhi L, Mohapatra S, Panda A.",
    "url": "https://europepmc.org/article/PMC/PMC13190582",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Antibiot",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Pritam P;  Das S;  Behera S;  Sahoo M;  Subudhi L;  Mohapatra S;  Panda A.",
    "assignee": "",
    "publication_number": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 0,
    "id": "europepmc:PMC13189954",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189954",
    "headline": "Artesunate repurposing for cytomegalovirus management: a systematic review of efficacy, mechanisms, and perspectives",
    "summary": "Zhang H, Zhou F, Song J, Deng C, He X, Ni S.",
    "url": "https://europepmc.org/article/PMC/PMC13189954",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cell Infect Microbiol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhang H;  Zhou F;  Song J;  Deng C;  He X;  Ni S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; systematic-review; review"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 18,
    "score": 0,
    "id": "europepmc:PMC13189753",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189753",
    "headline": "Artificial intelligence in ovarian cancer: advancing in precision diagnosis and clinical management",
    "summary": "Shao M, Wang T, Ji L, Xu L, Zhang Y, Wang D, Jia C, Chen L, Zhang H, Yan W, Cui X, Tong R.",
    "url": "https://europepmc.org/article/PMC/PMC13189753",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Shao M;  Wang T;  Ji L;  Xu L;  Zhang Y;  Wang D;  Jia C;  Chen L;  Zhang H;  Yan W;  Cui X;  Tong R.",
    "assignee": "",
    "publication_number": "",
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    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 0,
    "id": "europepmc:PMC13193219",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13193219",
    "headline": "Assessment of Local Recurrence and Distant Metastasis After Curative Resection of Rectal Tumors: A Retrospective Study",
    "summary": "Yasin F, Kazim S, Atiq H, Maqbool A, Shakeel S, Awais M, Tu Zahara F, Abaid A, Khattak S, Syed A.",
    "url": "https://europepmc.org/article/PMC/PMC13193219",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cureus",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Yasin F;  Kazim S;  Atiq H;  Maqbool A;  Shakeel S;  Awais M;  Tu Zahara F;  Abaid A;  Khattak S;  Syed A.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 0,
    "id": "europepmc:PMC13190168",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190168",
    "headline": "Association between hypertension and risk of respiratory failure and mortality in patients with COVID-19: a retrospective cohort study with predictive model development",
    "summary": "Hu X, Ye K, Miao B, Dai Y, Guo L, Zeng L, Chen X, Zhu C, Zhang Q, Song B, Xiao J.",
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    "source": "Europe PMC / PMC",
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    "journal": "Front Med (Lausanne)",
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    "doi": "",
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    "authors": "Hu X;  Ye K;  Miao B;  Dai Y;  Guo L;  Zeng L;  Chen X;  Zhu C;  Zhang Q;  Song B;  Xiao J.",
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    "id": "europepmc:PMC13189795",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189795",
    "headline": "ATP13A2 promoted cell stemness, cisplatin resistance, autophagy, and cell progression of bladder cancer",
    "summary": "Zhu C, Lu J, Zhu B, Liu B, Li G, Guo Y, Guo X, Yin Z.",
    "url": "https://europepmc.org/article/PMC/PMC13189795",
    "source": "Europe PMC / PMC",
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    "journal": "Front Immunol",
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    "authors": "Zhu C;  Lu J;  Zhu B;  Liu B;  Li G;  Guo Y;  Guo X;  Yin Z.",
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    "journal": "Front Vet Sci",
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    "authors": "Fonseca-Alves C;  Biondi L;  dos Anjos D;  de Oliveira K;  Batschinski K;  Lucas S;  Cirillo J;  Germano K;  de Oliveira A;  Vasconcellos C;  Fukumasu H;  Matera J",
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    "url": "https://europepmc.org/article/PMC/PMC13189866",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Pediatr",
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    "authors": "Oberwegner S;  Hettler S;  Hensen L;  Heinz A;  Braun C;  Döring M;  Lang P.",
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    "headline": "Case Report: Multimodal treatment for two unresectable intraductal papillary mucinous neoplasms of the bile duct and literature review",
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    "url": "https://europepmc.org/article/PMC/PMC13189876",
    "source": "Europe PMC / PMC",
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    "journal": "Front Med (Lausanne)",
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    "authors": "Fu Y;  Liang Y;  Song Y;  Chen L;  Luo X;  Chen Y;  Xiao Y;  Chen H;  Xu H.",
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    "headline": "Case Report: Neurolymphomatosis of the sciatic nerve as a presentation of relapsed diffuse large B-cell lymphoma",
    "summary": "Wang J, Fu Y, Hu J, Zhang M, Yu P.",
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    "source": "Europe PMC / PMC",
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    "preprint_id": "",
    "authors": "Wang J;  Fu Y;  Hu J;  Zhang M;  Yu P.",
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    "score": 0,
    "id": "europepmc:PMC13190204",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190204",
    "headline": "Case Report: Ochronotic arthropathy mimicking spondyloarthritis: a case-based review of diagnostic pitfalls and a novel likely pathogenic HGD variant",
    "summary": "Liu Z, Xu X, Yang Y, Li S, Bai R, Zhang Z, Guo Y, Cui R, Xu J, Liu S.",
    "url": "https://europepmc.org/article/PMC/PMC13190204",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Genet",
    "pmid": "",
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    "preprint_id": "",
    "authors": "Liu Z;  Xu X;  Yang Y;  Li S;  Bai R;  Zhang Z;  Guo Y;  Cui R;  Xu J;  Liu S.",
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    "id": "europepmc:PMC13189721",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189721",
    "headline": "Childhood malignancy-associated hemophagocytic lymphohistiocytosis: a retrospective, single-center study of 44 patients",
    "summary": "Huang C, Huang J, Le Q, Zhou Y.",
    "url": "https://europepmc.org/article/PMC/PMC13189721",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "preprint_id": "",
    "authors": "Huang C;  Huang J;  Le Q;  Zhou Y.",
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    "id": "europepmc:PMC13189943",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189943",
    "headline": "Clinical and tissue evidence of immune dysregulation in osteosarcoma: altered peripheral neutrophil-related indices and reduced APOE expression",
    "summary": "Zhu J, Huang C, Tan W.",
    "url": "https://europepmc.org/article/PMC/PMC13189943",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "preprint_id": "",
    "authors": "Zhu J;  Huang C;  Tan W.",
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    "id": "europepmc:PMC13189910",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189910",
    "headline": "Clinical evidence of exercise intervention in improving adults with type 2 diabetes mellitus and frailty: a narrative literature review",
    "summary": "Mo X, Duan Z, Zhang W, Jia Y.",
    "url": "https://europepmc.org/article/PMC/PMC13189910",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Physiol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Mo X;  Duan Z;  Zhang W;  Jia Y.",
    "assignee": "",
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    "primary_source": "Europe PMC / PMC",
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    "score": 0,
    "id": "europepmc:PMC13189835",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189835",
    "headline": "Clinical retrospective study on serum sCD163 and CXCL10 in the immune microenvironment of carotid atherosclerosis: association with inflammatory cytokines, immune cell subsets, and disease progression",
    "summary": "Pan H, Zheng H, Li M.",
    "url": "https://europepmc.org/article/PMC/PMC13189835",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Pan H;  Zheng H;  Li M.",
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    "headline": "Comparative effectiveness and safety of biologics and targeted small-molecule therapies plus stable background therapy in systemic lupus erythematosus: a systematic review and network meta-analysis",
    "summary": "Li W, Zhao Y, Shu S, Li R, Huang Y, Gong Y, Zhao G, Fan Y, He J.",
    "url": "https://europepmc.org/article/PMC/PMC13188964",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
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    "authors": "Li W;  Zhao Y;  Shu S;  Li R;  Huang Y;  Gong Y;  Zhao G;  Fan Y;  He J.",
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    "headline": "Decoding the spatiotemporal dynamics of tumor immune niche remodeling in cancer immunotherapy",
    "summary": "Fu Z, Wu H, Xu H, Li D, Chen J, Min X, Yang H, Wu W, Liu Z, Cai W, Chen J, Mei A.",
    "url": "https://europepmc.org/article/PMC/PMC13189881",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
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    "journal": "Front Immunol",
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    "preprint_id": "",
    "authors": "Fu Z;  Wu H;  Xu H;  Li D;  Chen J;  Min X;  Yang H;  Wu W;  Liu Z;  Cai W;  Chen J;  Mei A.",
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    "headline": "Development and validation of a TLS-associated signature for prognosis prediction in breast cancer: new insights into QPRT",
    "summary": "Li Q, Yang X, Wei L, Wang X, Wang X, Chen J, Zhao L, Wen S.",
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    "source": "Europe PMC / PMC",
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    "headline": "Digestive properties in fermentation driven interactions of plant polysaccharides with gut microbiota and their health implications",
    "summary": "Jiang Z, Li B, Zhao R, Zhao X, Zhang X, Jiao L.",
    "url": "https://europepmc.org/article/PMC/PMC13190522",
    "source": "Europe PMC / PMC",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Pharmacol",
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    "preprint_id": "",
    "authors": "Jiang Z;  Li B;  Zhao R;  Zhao X;  Zhang X;  Jiao L.",
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    "headline": "Editorial: Epigenetic alterations in tumors and therapeutic resistance",
    "summary": "Peng Z, Huang C, Huang J, Chen Y, Huang S.",
    "url": "https://europepmc.org/article/PMC/PMC13193748",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Genet",
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    "preprint_id": "",
    "authors": "Peng Z;  Huang C;  Huang J;  Chen Y;  Huang S.",
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    "headline": "Editorial: Exploring human-autonomous interactions: agency, awareness, and ethical implications",
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    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Psychol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Lo Bue S;  Prével A;  Salatino A.",
    "assignee": "",
    "publication_number": "",
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    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; editorial"
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 37,
    "score": 0,
    "id": "europepmc:PMC13186783",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13186783",
    "headline": "Editorial: Overcoming resistance to immune checkpoint inhibitors: mechanisms and strategies in cancer therapy",
    "summary": "Piccinelli M, Pizzutilo E, Gemelli M, Sarhan D, Cavalieri S.",
    "url": "https://europepmc.org/article/PMC/PMC13186783",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Piccinelli M;  Pizzutilo E;  Gemelli M;  Sarhan D;  Cavalieri S.",
    "assignee": "",
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    "jurisdiction": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; editorial"
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  {
    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 38,
    "score": 0,
    "id": "europepmc:PMC13191583",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13191583",
    "headline": "Effective photocatalytic and antibacterial nanomembranes from a GO-grafted dapsone-incorporated chitosan/gelatin blend for enhancing the removal of toxic dyes from wastewater",
    "summary": "Moustafa H, Abdel-Haleem F, Hemida M, Isawi H.",
    "url": "https://europepmc.org/article/PMC/PMC13191583",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "RSC Adv",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Moustafa H;  Abdel-Haleem F;  Hemida M;  Isawi H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 39,
    "score": 0,
    "id": "europepmc:PMC13190180",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190180",
    "headline": "Engagement of chymase-positive mast cells in myocardial damage associated with COVID-19",
    "summary": "Budnevsky A, Avdeev S, Arkhipova E, Kosanovic D, Shishkina V, Chernik T, Ovsyannikov E, Perveeva I, Filin A, Tokmachev R, Pertsev A, Ivanova E, Samoylenko T, Antakova L.",
    "url": "https://europepmc.org/article/PMC/PMC13190180",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cardiovasc Med",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Budnevsky A;  Avdeev S;  Arkhipova E;  Kosanovic D;  Shishkina V;  Chernik T;  Ovsyannikov E;  Perveeva I;  Filin A;  Tokmachev R;  Pertsev A;  Ivanova E",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 40,
    "score": 0,
    "id": "europepmc:PMC13189901",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189901",
    "headline": "EV-associated non-coding RNAs in paediatric asthma airway remodelling: current mechanistic evidence and therapeutic perspectives",
    "summary": "Liu Y, Wang D, Gao H.",
    "url": "https://europepmc.org/article/PMC/PMC13189901",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Pharmacol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Liu Y;  Wang D;  Gao H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 41,
    "score": 0,
    "id": "europepmc:PMC13189724",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189724",
    "headline": "Exercise and tissue-resident memory T cells: from circulating numbers to spatial immune remodeling",
    "summary": "Xie E, He Y, Cao T, Li C, Wang Z.",
    "url": "https://europepmc.org/article/PMC/PMC13189724",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Xie E;  He Y;  Cao T;  Li C;  Wang Z.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 42,
    "score": 0,
    "id": "europepmc:PMC13192007",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13192007",
    "headline": "Human leukocyte antigen-incompatible living donor kidney transplantation after desensitization: experience from a major transplant centre in Mexico",
    "summary": "Reynoso de la Torre H, Rojas-Campos E, Cerrillos-Gutiérrez J, Evangelista-Carrillo L, Banda-López A, Cruz-Landino M, Aguilar-Fletes L, González-Correa L, Alatorre-Moreno E, Simancas-Ruiz P, Salazar López C, Miranda-Díaz A, Sutto S, Cardona Muñoz E, Carvallo-Venegas M, Mendoza-Cabrera S, Mendoza Cerpa C, Romo-Álvarez C...",
    "url": "https://europepmc.org/article/PMC/PMC13192007",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Transpl Int",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Reynoso de la Torre H;  Rojas-Campos E;  Cerrillos-Gutiérrez J;  Evangelista-Carrillo L;  Banda-López A;  Cruz-Landino M;  Aguilar-Fletes L;  González-Correa L;  Alatorre-Moreno E;  Simancas-Ruiz P;  Salazar López C;  Miranda-Díaz A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; letter"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 43,
    "score": 0,
    "id": "europepmc:PMC13189798",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189798",
    "headline": "Human pathological findings in Kawasaki disease: a narrative review of autopsy and biopsy evidence",
    "summary": "Zhang J, Chen J, Wang Y, Liu Y, Li J, Wang D, Liu P, Liu Z, Zhang M, You T, Tang Q, Wang C, Lv H, Huang H.",
    "url": "https://europepmc.org/article/PMC/PMC13189798",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhang J;  Chen J;  Wang Y;  Liu Y;  Li J;  Wang D;  Liu P;  Liu Z;  Zhang M;  You T;  Tang Q;  Wang C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 44,
    "score": 0,
    "id": "europepmc:PMC13191902",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13191902",
    "headline": "Humoral immune response to polyvalent pneumococcal vaccine in healthy participants receiving efgartigimod: a randomized, open-label, placebo-controlled, parallel-group phase 1 trial",
    "summary": "Azar A, Sleasman J, Steeland S, Verhamme F, Winthrop K.",
    "url": "https://europepmc.org/article/PMC/PMC13191902",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Azar A;  Sleasman J;  Steeland S;  Verhamme F;  Winthrop K.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 45,
    "score": 0,
    "id": "pubmed:42168697",
    "canonical_key": "pmid:42168697",
    "headline": "Humoral immunity in pancreatic cancer: B-cell heterogeneity, regulatory networks, and therapeutic opportunities.",
    "summary": "Cancer metastasis reviews. Cancer Metastasis Rev. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42168697/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer metastasis reviews",
    "pmid": "42168697",
    "doi": "10.1007/s10555-026-10342-1",
    "preprint_id": "",
    "authors": "Kalapala J; Turunen AM; Burton KA; Principe DR",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 46,
    "score": 0,
    "id": "europepmc:PMC13189875",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189875",
    "headline": "Hyperglycemia- induced innate immune tolerance involves the metabolic and epigenetic rewiring in human alveolar macrophages",
    "summary": "Wang J, Yuan N, Wang B, Qiu Y, Wang B, Xie L.",
    "url": "https://europepmc.org/article/PMC/PMC13189875",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Wang J;  Yuan N;  Wang B;  Qiu Y;  Wang B;  Xie L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 47,
    "score": 0,
    "id": "europepmc:PMC13188013",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13188013",
    "headline": "IgG4-Related Retroperitoneal Fibrosis Presenting as Obstructive Acute Kidney Injury: A Case Report",
    "summary": "Jarai M, Haider S, Eldesouki S, Hashemi S, Nejad S, Elbadawi F, Mahjoor Azad E, Bagheri F.",
    "url": "https://europepmc.org/article/PMC/PMC13188013",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cureus",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Jarai M;  Haider S;  Eldesouki S;  Hashemi S;  Nejad S;  Elbadawi F;  Mahjoor Azad E;  Bagheri F.",
    "assignee": "",
    "publication_number": "",
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    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; case reports; case-report"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 48,
    "score": 0,
    "id": "europepmc:PMC13190586",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190586",
    "headline": "Immunogenic cell death in cold tumors: transforming immune-excluded tumors into immunotherapy-sensitive lesions",
    "summary": "Zhao H, Dai S.",
    "url": "https://europepmc.org/article/PMC/PMC13190586",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Pharmacol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhao H;  Dai S.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; review-article; review; journal article"
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  {
    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 49,
    "score": 0,
    "id": "europepmc:PMC13189962",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189962",
    "headline": "Impact of aging on CD146+ mesenchymal stromal cells-mediated regulation of bone marrow CD34+ hematopoietic stem/progenitor cell mobilization",
    "summary": "Campanile M, Naie M, Bertolotti M, Muradore I, Riccardi C, Rampin A, Noto G, Laviano P, Melone V, Palumbo D, Tarallo R, Fantin A, Butoi E, Spinetti G.",
    "url": "https://europepmc.org/article/PMC/PMC13189962",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Bioeng Biotechnol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Campanile M;  Naie M;  Bertolotti M;  Muradore I;  Riccardi C;  Rampin A;  Noto G;  Laviano P;  Melone V;  Palumbo D;  Tarallo R;  Fantin A",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 50,
    "score": 0,
    "id": "europepmc:PMC13193696",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13193696",
    "headline": "Impact of Regular Yoga and Meditation on Immune Cell Populations: A Small-Sample, Single-Arm, Pre-Post Interventional Pilot Study",
    "summary": "Castillo-Torres L, Velázquez-Moreno S, Tovar-Leyva C, Reyes-Martínez C, Martínez-Martínez R, Rivera-Luque C, Vitales-Noyola M.",
    "url": "https://europepmc.org/article/PMC/PMC13193696",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cureus",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Castillo-Torres L;  Velázquez-Moreno S;  Tovar-Leyva C;  Reyes-Martínez C;  Martínez-Martínez R;  Rivera-Luque C;  Vitales-Noyola M.",
    "assignee": "",
    "publication_number": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 51,
    "score": 0,
    "id": "europepmc:PMC13190610",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190610",
    "headline": "Integrated metagenomic and culture-dependent profiling reveals electric shavers as selective reservoirs for multidrug-resistant opportunistic pathogens",
    "summary": "Chen S, Hu X, Pan W, Chen T, Xie X, Zhang Y.",
    "url": "https://europepmc.org/article/PMC/PMC13190610",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Microbiol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Chen S;  Hu X;  Pan W;  Chen T;  Xie X;  Zhang Y.",
    "assignee": "",
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    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 52,
    "score": 0,
    "id": "europepmc:PMC13189976",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189976",
    "headline": "Integrating biocomputational techniques for vaccine development for glioblastoma multiforme: a possible way of enhancing precision",
    "summary": "Alare K, Odunitan T, Alare T, Ojo T, Alare F, Uthman U.",
    "url": "https://europepmc.org/article/PMC/PMC13189976",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Alare K;  Odunitan T;  Alare T;  Ojo T;  Alare F;  Uthman U.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 53,
    "score": 0,
    "id": "europepmc:PMC13189722",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189722",
    "headline": "Integrative circRNA landscape of intrauterine adhesions: putative ceRNA axes and circRNA-associated splicing usage linked to contractility and immunity",
    "summary": "Chen Y, Jin J, Xiang Y, Wang Y, Wu S, Zhan N, Xiong M, Deng A.",
    "url": "https://europepmc.org/article/PMC/PMC13189722",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Mol Biosci",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Chen Y;  Jin J;  Xiang Y;  Wang Y;  Wu S;  Zhan N;  Xiong M;  Deng A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 54,
    "score": 0,
    "id": "europepmc:PMC13190464",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190464",
    "headline": "Intranasal administration of stem cells and their derivatives for neurological and respiratory disorders: a systematic review of human clinical trials",
    "summary": "Habiba U, Sathyanarayanan R, Shamim S, Manian A, Haider A, Sarwar I, Greene D.",
    "url": "https://europepmc.org/article/PMC/PMC13190464",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Aging Neurosci",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Habiba U;  Sathyanarayanan R;  Shamim S;  Manian A;  Haider A;  Sarwar I;  Greene D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; systematic-review; review"
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    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 55,
    "score": 0,
    "id": "europepmc:PMC13189752",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189752",
    "headline": "Isorhamnetin inhibits migration and promotes apoptosis via modulation of oxidative stress, mitochondrial dysfunction, and the TIGIT/CD155 axis in 4T1 breast cancer cells",
    "summary": "Chen F, Liu Y, Zhang H, Yang Q, Li G, Zhu Y, Zhang R.",
    "url": "https://europepmc.org/article/PMC/PMC13189752",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cell Dev Biol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Chen F;  Liu Y;  Zhang H;  Yang Q;  Li G;  Zhu Y;  Zhang R.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 56,
    "score": 0,
    "id": "biorxiv:10.1101/2025.11.11.687795",
    "canonical_key": "doi:10.1101/2025.11.11.687795",
    "headline": "JPT2/HN1L functions as an NAADP-binding protein in a cell type-specific manner",
    "summary": "Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger evoking Ca2+ release from intracellular Ca2+ stores by targeting several Ca2+ channels including two-pore channels (TPC1/2), transient receptor potential mucolipin-1 (TRPML1), or ryanodine receptor type 1 (RYR1).",
    "url": "https://doi.org/10.1101/2025.11.11.687795",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.11.11.687795",
    "preprint_id": "biorxiv:10.1101/2025.11.11.687795",
    "authors": "Ottenheijm, R.; Winterberg, K.; Throm, V.; Malz, M. V.; Bukva, M.; Tsvilovskyy, V.; Medert, R.; Guse, A.; Freichel, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; pharmacology and toxicology"
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    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 57,
    "score": 0,
    "id": "europepmc:PMC13192400",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13192400",
    "headline": "Leukemia disease burden and quality of care among adolescents and young adults in China compared to global patterns: a comprehensive analysis from 1990 to 2021",
    "summary": "Liu Y, Zhu M, Gao L, Wang L.",
    "url": "https://europepmc.org/article/PMC/PMC13192400",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Public Health",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Liu Y;  Zhu M;  Gao L;  Wang L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 58,
    "score": 0,
    "id": "europepmc:PMC13189931",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189931",
    "headline": "Metabolic and post-translational modifications in sepsis-associated immune dysfunction: a conceptual framework",
    "summary": "Xu M, Zhang Z, Zhu M, Zhang S, Deng J, Du Z, Wang Z, Zhao H, Qiu Z.",
    "url": "https://europepmc.org/article/PMC/PMC13189931",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Xu M;  Zhang Z;  Zhu M;  Zhang S;  Deng J;  Du Z;  Wang Z;  Zhao H;  Qiu Z.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 59,
    "score": 0,
    "id": "europepmc:PMC13187501",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13187501",
    "headline": "Methyltransferase-Like 3 Inhibition-Activated cGAS/STING Axis Enhances Immunotherapy and Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity in Lung Adenocarcinoma",
    "summary": "Zhou J, He J, Lu Y, Yi C, Chang X, Tao L, Zhong K, Zhang H, Niu H, Wang X, Chen Z, Wang H.",
    "url": "https://europepmc.org/article/PMC/PMC13187501",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Research (Wash D C)",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhou J;  He J;  Lu Y;  Yi C;  Chang X;  Tao L;  Zhong K;  Zhang H;  Niu H;  Wang X;  Chen Z;  Wang H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 60,
    "score": 0,
    "id": "europepmc:PMC13187488",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13187488",
    "headline": "MFGE8-primed fibroblasts reprogram the immunosuppressed microenvironment to promote diabetic wound healing",
    "summary": "Pan L, Huang Y, Wu X, Li D, Wang H.",
    "url": "https://europepmc.org/article/PMC/PMC13187488",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cell Dev Biol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Pan L;  Huang Y;  Wu X;  Li D;  Wang H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 61,
    "score": 0,
    "id": "europepmc:PMC13189975",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189975",
    "headline": "MicroRNAs in cancer: biogenesis, biomarkers and therapeutic strategies",
    "summary": "Rawat N, Babu N, Hussain A, Panwar A.",
    "url": "https://europepmc.org/article/PMC/PMC13189975",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Med (Lausanne)",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Rawat N;  Babu N;  Hussain A;  Panwar A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 62,
    "score": 0,
    "id": "europepmc:PMC13189833",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189833",
    "headline": "Morphological details contribute to neuronal response variability within the same cell type",
    "summary": "Sandbote K, Arkhypchuk I, Kretzberg J.",
    "url": "https://europepmc.org/article/PMC/PMC13189833",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cell Neurosci",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Sandbote K;  Arkhypchuk I;  Kretzberg J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 63,
    "score": 0,
    "id": "europepmc:PMC13189801",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189801",
    "headline": "Multidimensional exploration of the relationship between gut microbiota and colorectal cancer: focus on clinical tumorigenesis and treatment",
    "summary": "Zhang H, Zhang K, Liu J, Luo H.",
    "url": "https://europepmc.org/article/PMC/PMC13189801",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhang H;  Zhang K;  Liu J;  Luo H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 64,
    "score": 0,
    "id": "europepmc:PMC13187696",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13187696",
    "headline": "Multimodal Imaging in Indolent Nonprogressive Multifocal Choroidal Lesions: A Case Report",
    "summary": "Ando R, Tomita S, Kimura M, Nozaki M.",
    "url": "https://europepmc.org/article/PMC/PMC13187696",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cureus",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Ando R;  Tomita S;  Kimura M;  Nozaki M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; case reports; case-report"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 65,
    "score": 0,
    "id": "europepmc:PMC13189234",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189234",
    "headline": "Multisystemic Granulomatosis Induced by Red Tattoo Pigment: Course Over 10 Years",
    "summary": "Cathebras P, Habougit C, Grange S, Catinon M, Vincent M.",
    "url": "https://europepmc.org/article/PMC/PMC13189234",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cureus",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Cathebras P;  Habougit C;  Grange S;  Catinon M;  Vincent M.",
    "assignee": "",
    "publication_number": "",
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    "claims": "",
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    "event_type": "",
    "primary_source": "Europe PMC / PMC",
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    "keywords": "europe pmc; case reports; case-report"
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  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 66,
    "score": 0,
    "id": "europepmc:PMC13188867",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13188867",
    "headline": "Muscular involvement in Sjögren’s disease is associated with male gender, Ro52 autoantibodies, and a higher clinical activity",
    "summary": "Gründges C, Benz S, Meinecke A, Gaedecke L, Murray A, Seeliger T, Konen F, Skripuletz T, Witte T, Zehrfeld N, Ernst D.",
    "url": "https://europepmc.org/article/PMC/PMC13188867",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Med (Lausanne)",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Gründges C;  Benz S;  Meinecke A;  Gaedecke L;  Murray A;  Seeliger T;  Konen F;  Skripuletz T;  Witte T;  Zehrfeld N;  Ernst D.",
    "assignee": "",
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    "primary_source": "Europe PMC / PMC",
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    "digest_date": "2026-05-22",
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    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 67,
    "score": 0,
    "id": "europepmc:PMC13191088",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13191088",
    "headline": "Nanozymes-Armed Probiotic Lactobacillus plantarum Coordinates Ferroptosis-like Bacterial Death for Diabetic Wound Therapy",
    "summary": "Hou J, Fu R, Zhao M, Zou A, Wang Y, Wang Z, Xianyu Y.",
    "url": "https://europepmc.org/article/PMC/PMC13191088",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Research (Wash D C)",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Hou J;  Fu R;  Zhao M;  Zou A;  Wang Y;  Wang Z;  Xianyu Y.",
    "assignee": "",
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    "source_type": "papers",
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    "rank_index": 68,
    "score": 0,
    "id": "europepmc:PMC13189772",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189772",
    "headline": "Natural killer T cells in intracerebral hemorrhage: phase-dependent immune responses and therapeutic implications",
    "summary": "Zhao X, Wang L, Ren S, Yang Z, Wu G.",
    "url": "https://europepmc.org/article/PMC/PMC13189772",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhao X;  Wang L;  Ren S;  Yang Z;  Wu G.",
    "assignee": "",
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    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189806",
    "headline": "Neurological manifestations in Wiskott–Aldrich syndrome: a systematic review",
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    "url": "https://europepmc.org/article/PMC/PMC13189806",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
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    "journal": "Front Immunol",
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    "authors": "Raccagni N;  Milanesi V;  Lucchini G;  Balduzzi A;  Occhino G;  Invernizzi P;  Gasperini S.",
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    "headline": "Neurosyphilis and limbic encephalitis: practical guidance for diagnosis and treatment sequencing at an infection–autoimmunity interface",
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    "url": "https://europepmc.org/article/PMC/PMC13189898",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
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    "journal": "Front Neurol",
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    "doi": "",
    "preprint_id": "",
    "authors": "Demas A.",
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    "headline": "Neutrophil efferocytosis in chronic inflammatory gastrointestinal diseases: mechanistic insights and therapeutic potential",
    "summary": "Ye S, Qu Y, Zhang J, Wang X, Wang J, Xue Y, Liu J.",
    "url": "https://europepmc.org/article/PMC/PMC13189977",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Ye S;  Qu Y;  Zhang J;  Wang X;  Wang J;  Xue Y;  Liu J.",
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    "headline": "Novel insights into triple-negative breast cancer heterogeneity, prognosis, and treatment response based on matrix stiffness: a combined single-Cell and transcriptome analysis",
    "summary": "Shi W, Wang H, Guan Y, Zhou Y, Cui J, Wang X, Yu J.",
    "url": "https://europepmc.org/article/PMC/PMC13189971",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Oncol",
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    "doi": "",
    "preprint_id": "",
    "authors": "Shi W;  Wang H;  Guan Y;  Zhou Y;  Cui J;  Wang X;  Yu J.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Europe PMC / PMC",
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    "source_type": "papers",
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    "rank_index": 73,
    "score": 0,
    "id": "europepmc:PMC13187947",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13187947",
    "headline": "pH-activatable brominated pentamethine cyanine dyes for imaging-guided photodynamic immunotherapy of tumors",
    "summary": "Tang W, Cao Y, Wang R, Qiu T, Hu Y, Shi S, Zeng X, Fan J, Sun W, Peng X.",
    "url": "https://europepmc.org/article/PMC/PMC13187947",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Chem Sci",
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    "doi": "",
    "preprint_id": "",
    "authors": "Tang W;  Cao Y;  Wang R;  Qiu T;  Hu Y;  Shi S;  Zeng X;  Fan J;  Sun W;  Peng X.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Europe PMC / PMC",
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    "rank_index": 74,
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    "url": "https://europepmc.org/article/PMC/PMC13192298",
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    "published_date": "2026-05-22",
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    "doi": "",
    "preprint_id": "",
    "authors": "Alkaltham G;  Almulhim A;  Shaikh L;  Alsebayel M.",
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    "primary_source": "Europe PMC / PMC",
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    "rank_index": 75,
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    "id": "europepmc:PMC13190545",
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    "summary": "Tian Y, Li X, He L, Cui S, Liu P, Wang W.",
    "url": "https://europepmc.org/article/PMC/PMC13190545",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Med (Lausanne)",
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    "doi": "",
    "preprint_id": "",
    "authors": "Tian Y;  Li X;  He L;  Cui S;  Liu P;  Wang W.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Europe PMC / PMC",
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    "rank_index": 76,
    "score": 0,
    "id": "europepmc:PMC13189878",
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    "headline": "Preoperative neutrophil-to-lymphocyte ratio as an early risk-stratification and prognostic biomarker in Wilms tumor: a retrospective study",
    "summary": "Feng D, Zhang C, Li J, Chen L, Qi C.",
    "url": "https://europepmc.org/article/PMC/PMC13189878",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Oncol",
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    "doi": "",
    "preprint_id": "",
    "authors": "Feng D;  Zhang C;  Li J;  Chen L;  Qi C.",
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    "publication_number": "",
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    "rank_index": 77,
    "score": 0,
    "id": "europepmc:PMC13191554",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13191554",
    "headline": "Questing for Integrin Targeting Theranostics for Cancer Cell-Selective Molecules",
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    "url": "https://europepmc.org/article/PMC/PMC13191554",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "doi": "",
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    "authors": "Giraldi V;  Pecoraro T;  Maurizio A;  Milana A;  De Cola L;  Baiula M;  Giacomini D.",
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    "source_type": "papers",
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    "rank_index": 78,
    "score": 0,
    "id": "europepmc:PMC13189755",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189755",
    "headline": "Rapid and simultaneous detection of Candida albicans and Cryptococcus neoformans using a duplex real-time RPA assay: a potential point-of-care tool for invasive fungal infections",
    "summary": "Ma Q, He Z, Duan G, Wei J, Duan C, Zhu Y, Long F.",
    "url": "https://europepmc.org/article/PMC/PMC13189755",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cell Infect Microbiol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Ma Q;  He Z;  Duan G;  Wei J;  Duan C;  Zhu Y;  Long F.",
    "assignee": "",
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    "source_type": "papers",
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    "rank_index": 79,
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    "id": "europepmc:PMC13189242",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189242",
    "headline": "Rapidly Progressive Fulminant Perimyocarditis Requiring Early Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support in a Previously Healthy Young Adult",
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    "url": "https://europepmc.org/article/PMC/PMC13189242",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cureus",
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    "authors": "Hamada J;  McCormack L;  Chang R;  Chou E.",
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    "rank_index": 80,
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    "id": "europepmc:PMC13189948",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189948",
    "headline": "RAS mutation status and immune microenvironment define distinct prognostic landscapes and predict chemotherapy benefit in pMMR colorectal cancer",
    "summary": "Wu S, Li J, Chen Z, Liu J, Luo F, Li B, Zeng J, Liu K.",
    "url": "https://europepmc.org/article/PMC/PMC13189948",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
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    "doi": "",
    "preprint_id": "",
    "authors": "Wu S;  Li J;  Chen Z;  Liu J;  Luo F;  Li B;  Zeng J;  Liu K.",
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    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13193615",
    "headline": "Recent progress in cGAS–STING agonist design and mechanisms of cancer immune modulation",
    "summary": "Wang L, Nafees M, Fei H, Hanif M, Yang P.",
    "url": "https://europepmc.org/article/PMC/PMC13193615",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "RSC Chem Biol",
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    "doi": "",
    "preprint_id": "",
    "authors": "Wang L;  Nafees M;  Fei H;  Hanif M;  Yang P.",
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    "id": "europepmc:PMC13189837",
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    "headline": "Regulatory T cell therapy in solid organ transplantation: mechanisms, translational progress, and remaining barriers",
    "summary": "Yang J, Zeng X, Jiang K, Pang X, Huang A.",
    "url": "https://europepmc.org/article/PMC/PMC13189837",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Yang J;  Zeng X;  Jiang K;  Pang X;  Huang A.",
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    "headline": "Research progress of tertiary lymphoid structure in hepatocellular carcinoma: from prognostic biomarkers to new strategies for immunotherapy",
    "summary": "Yuan S, Luo X, Li S, Cao L, Chen X, Wang L, Liu Y, Li Z, Wu T, Fang H, Tong M.",
    "url": "https://europepmc.org/article/PMC/PMC13191192",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Yuan S;  Luo X;  Li S;  Cao L;  Chen X;  Wang L;  Liu Y;  Li Z;  Wu T;  Fang H;  Tong M.",
    "assignee": "",
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    "rank_index": 84,
    "score": 0,
    "id": "europepmc:PMC13188182",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13188182",
    "headline": "Role of DZ2002 in reducing corneal graft rejection in rats by influencing Th17 activation via inhibition of the PI3K/AKT pathway and downregulation of TRAF1",
    "summary": "Li Y, Zhang Y, Tan S, Long J, Tian E, Dong J, Li L.",
    "url": "https://europepmc.org/article/PMC/PMC13188182",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Open Life Sci",
    "pmid": "",
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    "preprint_id": "",
    "authors": "Li Y;  Zhang Y;  Tan S;  Long J;  Tian E;  Dong J;  Li L.",
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    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189729",
    "headline": "Sepsis in end-stage liver disease and acute-on-chronic liver failure: pathophysiology, diagnostic challenges, and pharmacological management",
    "summary": "Belfiore J, Taddei R, Suardi L.",
    "url": "https://europepmc.org/article/PMC/PMC13189729",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Pharmacol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Belfiore J;  Taddei R;  Suardi L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 86,
    "score": 0,
    "id": "europepmc:PMC13189760",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189760",
    "headline": "Sequential versus concurrent neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma: a randomized, controlled, open-label, phase 2 trial (HCHTOG1906)",
    "summary": "Zheng Y, Wu J, Zhao L, Shen Y, Liang G, Li K, Gao Q, Xing W.",
    "url": "https://europepmc.org/article/PMC/PMC13189760",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zheng Y;  Wu J;  Zhao L;  Shen Y;  Liang G;  Li K;  Gao Q;  Xing W.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 87,
    "score": 0,
    "id": "europepmc:PMC13189809",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189809",
    "headline": "Testosterone and androgen receptor pathway modulation in sepsis: immunometabolic mechanisms and therapeutic implications — a scoping review",
    "summary": "Szczupak M, Kobak J, Kreczko M, Wierzchowska J, Krupa-Nurcek S.",
    "url": "https://europepmc.org/article/PMC/PMC13189809",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Endocrinol (Lausanne)",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Szczupak M;  Kobak J;  Kreczko M;  Wierzchowska J;  Krupa-Nurcek S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 88,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726833",
    "canonical_key": "doi:10.64898/2026.05.21.726833",
    "headline": "The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear",
    "summary": "The nervous system wiring requires the precise coordination of axon guidance, neuronal migration, and target cell recognition. Here, we show that inner ear circuit formation, relies on pioneer cells extending an axonal scaffold that selectively target nascent hair cells.",
    "url": "https://doi.org/10.64898/2026.05.21.726833",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726833",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726833",
    "authors": "Rumbo, M.; Banon, A.; Nechiporuk, A.; Alsina, B.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; developmental biology"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 89,
    "score": 0,
    "id": "europepmc:PMC13189927",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189927",
    "headline": "The dual role of extracellular vesicles in vascular calcification: from molecular mechanisms to clinical translation",
    "summary": "Zhang Y, Wang Y, Lu J, Li X, Chen Z, Wang X, Tang T, Tang R.",
    "url": "https://europepmc.org/article/PMC/PMC13189927",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cardiovasc Med",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhang Y;  Wang Y;  Lu J;  Li X;  Chen Z;  Wang X;  Tang T;  Tang R.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 90,
    "score": 0,
    "id": "europepmc:PMC13189784",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189784",
    "headline": "The immune dysregulation landscape and dynamic regulation of competing endogenous RNAs in spinal cord injury",
    "summary": "Yao Y, Guo W, Cai X, Gui Y, Yao J, Lu Y, Liang Y, Wang W, Tan Z, Zhang J, Xu J.",
    "url": "https://europepmc.org/article/PMC/PMC13189784",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Yao Y;  Guo W;  Cai X;  Gui Y;  Yao J;  Lu Y;  Liang Y;  Wang W;  Tan Z;  Zhang J;  Xu J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 91,
    "score": 0,
    "id": "europepmc:PMC13190572",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13190572",
    "headline": "The role of the gut mycobiota in neurodevelopmental disorders: a multikingdom disruption of the gut-brain axis",
    "summary": "Hu Y, Yu X, Zhang X, Ma L.",
    "url": "https://europepmc.org/article/PMC/PMC13190572",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Microbiol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Hu Y;  Yu X;  Zhang X;  Ma L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 92,
    "score": 0,
    "id": "europepmc:PMC13189969",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189969",
    "headline": "Thyroid autoimmunity in relation to islet autoantibodies in newly diagnosed type 1 diabetes mellitus in children and adolescents",
    "summary": "Zhu Y, Yang H, Hu C, Qiao L, Li C, Hu S.",
    "url": "https://europepmc.org/article/PMC/PMC13189969",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Endocrinol (Lausanne)",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Zhu Y;  Yang H;  Hu C;  Qiao L;  Li C;  Hu S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 93,
    "score": 0,
    "id": "europepmc:PMC13192383",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13192383",
    "headline": "Tonsillar Post-transplant Lymphoproliferative Disorder Presenting With Hemoptysis After Heart Transplantation: A Case Report and Review of the Literature",
    "summary": "Surma J, Schneider T, Cress J, Krowiak E.",
    "url": "https://europepmc.org/article/PMC/PMC13192383",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cureus",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Surma J;  Schneider T;  Cress J;  Krowiak E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; case reports; case-report"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 94,
    "score": 0,
    "id": "europepmc:PMC13189747",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189747",
    "headline": "Translating advances in primary central nervous system lymphoma: from prognostic stratification to treatment innovation",
    "summary": "Pan Z, Bao J, Wei S.",
    "url": "https://europepmc.org/article/PMC/PMC13189747",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Oncol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Pan Z;  Bao J;  Wei S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 95,
    "score": 0,
    "id": "europepmc:PMC13188971",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13188971",
    "headline": "Unseen, untreated: chronic Giardia lamblia infections and the gaps in health systems",
    "summary": "Calegar D, Carvalho-Costa F, Da-Cruz A, Fantinatti M.",
    "url": "https://europepmc.org/article/PMC/PMC13188971",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Mem Inst Oswaldo Cruz",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Calegar D;  Carvalho-Costa F;  Da-Cruz A;  Fantinatti M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 96,
    "score": 0,
    "id": "europepmc:PMC13189763",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189763",
    "headline": "Vaccinia virus for lung cancer therapy: preclinical progress and prospects as a systemic immunotherapy platform",
    "summary": "Li L, Chen Z, Yan Y, Zhang L.",
    "url": "https://europepmc.org/article/PMC/PMC13189763",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Li L;  Chen Z;  Yan Y;  Zhang L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 97,
    "score": 0,
    "id": "europepmc:PMC13189928",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13189928",
    "headline": "Why are long-lived plasma cells long-lived?",
    "summary": "Reinke J, Schorr C, Lee K.",
    "url": "https://europepmc.org/article/PMC/PMC13189928",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Immunol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Reinke J;  Schorr C;  Lee K.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 98,
    "score": 0,
    "id": "europepmc:PMC13193201",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13193201",
    "headline": "A case of gastrointestinal tuberculosis in a 3-mo-old infant with profound immunodeficiency",
    "summary": "Karanja-Chege C, Mwashigadi D, Mbuthia J, Ngwatu P, Kamwetu J, Oliwa J.",
    "url": "https://europepmc.org/article/PMC/PMC13193201",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-21",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "J Hum Immun",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Karanja-Chege C;  Mwashigadi D;  Mbuthia J;  Ngwatu P;  Kamwetu J;  Oliwa J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; research-article; journal article"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 99,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.19.726422",
    "canonical_key": "doi:10.64898/2026.05.19.726422",
    "headline": "A confining microfluidic platform for disparate density coculture reveals the dynamics of macrophage-mediated adipocyte clearance",
    "summary": "Co-culturing cells with mismatched densities, where one cell type adheres to surfaces while the other floats, represents a fundamental challenge in cell biology.",
    "url": "https://doi.org/10.64898/2026.05.19.726422",
    "source": "bioRxiv",
    "published_date": "2026-05-21",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.726422",
    "preprint_id": "biorxiv:10.64898/2026.05.19.726422",
    "authors": "Lim, Y. B.; Kabigting, J. E.; Cheam, M. S.; Toyama, Y.; Holle, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-22",
    "window_start": "2026-05-21T05:15:00.000Z",
    "window_end": "2026-05-22T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 100,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.19.726226",
    "canonical_key": "doi:10.64898/2026.05.19.726226",
    "headline": "A key role for chromosome compartment interactions in directing Xist RNA localisation",
    "summary": "X-chromosome inactivation, the mechanism for dosage compensation in mammals, is orchestrated by the long non-coding RNA Xist which localises across the X chromosome in cis. The basis for in cis localisation remains poorly understood.",
    "url": "https://doi.org/10.64898/2026.05.19.726226",
    "source": "bioRxiv",
    "published_date": "2026-05-21",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.726226",
    "preprint_id": "biorxiv:10.64898/2026.05.19.726226",
    "authors": "Coker, H.; Lister, G.; Migliorini, G.; Wei, G.; Accalai, C.; Rodermund, L.; Davies, J.; Schermelleh, L.; Brockdorff, N.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; genetics"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 1,
    "score": 77,
    "id": "europepmc:PPR1237060",
    "canonical_key": "doi:10.64898/2026.05.20.726502",
    "headline": "Characterization of HLA-restricted GAD65-specific CD8+ T cell responses in patients with GAD65 antibody-associated neurological disorders",
    "summary": "Preprint characterizing HLA-restricted GAD65-specific CD8 T-cell responses in patients with GAD65 antibody-associated neurologic disease; relevant pMHC/TCR response biology, not a cancer therapy paper.",
    "url": "https://doi.org/10.64898/2026.05.20.726502",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-22",
    "match_reason": "Direct pMHC or peptide-HLA targeting: hla-restricted | Low-specificity pMHC/TCR field anchor: hla",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726502",
    "preprint_id": "",
    "authors": "Shang P;  Clarkson BD;  Overlee BL;  Howe CL.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
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    "doi": "10.1016/j.ejca.2026.116808",
    "preprint_id": "",
    "authors": "Hashii Y; Fujisaki H; Terashima K; Goto H; Horibe K; Sugiyama K; Takahara-Matsubara M; Goto M; Yanagisawa T; Kikuta A; Kawamoto H; Hashimoto N; Oka Y; Sugiyama H; Hara J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 0,
    "id": "pubmed:42171954",
    "canonical_key": "pmid:42171954",
    "headline": "Beyond B Cell Depletion: Adhesion and Activation Network Remodeling During Repeated Intravenous Anti-CD20 Therapy in Multiple Sclerosis.",
    "summary": "Neurology and therapy. Neurol Ther. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42171954/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Neurology and therapy",
    "pmid": "42171954",
    "doi": "10.1007/s40120-026-00949-5",
    "preprint_id": "",
    "authors": "Feige J; Moser T; Akgün K; Schwenker K; Hitzl W; Ziemssen T; Sellner J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 18,
    "score": 0,
    "id": "pubmed:42169682",
    "canonical_key": "pmid:42169682",
    "headline": "Thymic output in human newborns is shaped by environmental exposures and a common TCRD genetic variant.",
    "summary": "Journal of human immunity. J Hum Immun. 2026-05-04",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42169682/",
    "source": "PubMed",
    "published_date": "2026-05-04",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of human immunity",
    "pmid": "42169682",
    "doi": "10.70962/jhi.20260003",
    "preprint_id": "",
    "authors": "Tan Z; Kergaravat C; Gonzalez L; Johnsson A; Negrini E; Pou C; Bernhardsson AK; Barcenilla H; Ivanchenko M; Chen Y; Henckel E; Lakshmikanth T; Mikeš J; James A; Cieslak A; Asnafi V; Desponds J; Fontes M; Irla M; Milieu Interieur Consortium; Duffy D; Patin E; Quintana-Murci L; Clave E; Toubert A; Brodin P",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 0,
    "id": "pubmed:42175549",
    "canonical_key": "pmid:42175549",
    "headline": "Testosterone and docetaxel treatment effect on mortality risk in nonmetastatic high-risk prostate cancer: A predictive biomarker analysis.",
    "summary": "Cancer. Cancer. 2026-06-01",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42175549/",
    "source": "PubMed",
    "published_date": "2026-06-01",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer",
    "pmid": "42175549",
    "doi": "10.1002/cncr.70469",
    "preprint_id": "",
    "authors": "Zeng J; Chen MH; Wu J; Xie W; Ravi P; Nguyen P; Sandler H; D'Amico AV",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 0,
    "id": "pubmed:42176335",
    "canonical_key": "pmid:42176335",
    "headline": "A Morphology-Driven Cascade Delivery of Antigens for Potent T Cell Immunity.",
    "summary": "Advanced materials (Deerfield Beach, Fla.). Adv Mater. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176335/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Advanced materials (Deerfield Beach, Fla.)",
    "pmid": "42176335",
    "doi": "10.1002/adma.73396",
    "preprint_id": "",
    "authors": "Bai S; Xue Y; He C; Xiong K; Luo T; Tang X; Xu Y; Qiao N; Qin M; Zhong X; He P; Wei H; Ou Y; Du G; Sun X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 21,
    "score": 0,
    "id": "pubmed:42178061",
    "canonical_key": "pmid:42178061",
    "headline": "Antigen-delivering biomaterials for local enrichment and reprogramming of immune cells.",
    "summary": "Journal of controlled release : official journal of the Controlled Release Society. J Control Release. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178061/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of controlled release : official journal of the Controlled Release Society",
    "pmid": "42178061",
    "doi": "10.1016/j.jconrel.2026.115042",
    "preprint_id": "",
    "authors": "Wheeler SN; Morris AH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 22,
    "score": 0,
    "id": "pubmed:42176071",
    "canonical_key": "pmid:42176071",
    "headline": "Bioinformatics-driven dissection of PANoptosis-related molecular subtypes and tumor immune microenvironment heterogeneity in pediatric acute myeloid leukemia.",
    "summary": "Annals of hematology. Ann Hematol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176071/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Annals of hematology",
    "pmid": "42176071",
    "doi": "10.1007/s00277-026-07082-1",
    "preprint_id": "",
    "authors": "Pei WT; Liu CL; Li XL",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 23,
    "score": 0,
    "id": "pubmed:42176073",
    "canonical_key": "pmid:42176073",
    "headline": "Breakthroughs in HBV-related HCC Therapy: The Unmatched Potential of Immune Checkpoint Inhibitors.",
    "summary": "Current treatment options in oncology. Curr Treat Options Oncol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176073/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Current treatment options in oncology",
    "pmid": "42176073",
    "doi": "10.1007/s11864-026-01395-z",
    "preprint_id": "",
    "authors": "Liu C; Chang L; Yan Y; Ji H; Ma J; Sun H; Wang L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 24,
    "score": 0,
    "id": "europepmc:PPR1237641",
    "canonical_key": "doi:10.64898/2026.05.21.726797",
    "headline": "Decoding Immune Reconstitution Failure in People Living with HIV through Single-cell Genomics",
    "summary": "Wang Y, Yang S, Yuan Y, Zhu M, Chen J, Bai Y, Duan S, Shi X, Lu T, Yang Z, Huang Z, Yan D, Zheng Y, Zhou X, Yan J, Liu C, Zhang W, Huang Y, Xu C, Lin X, Wang X, Shi J, Xu X, Ge L, Yin J, Feng Y, Wan H, Li W, Wang B, Hong X, Wang X, Yang X, Liu S, Zhao Y, Chen L, Che Y, Lyu W, Su B, Chen R, Chen Z, Li H, Liu X, Gu Y, J...",
    "url": "https://doi.org/10.64898/2026.05.21.726797",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726797",
    "preprint_id": "",
    "authors": "Wang Y;  Yang S;  Yuan Y;  Zhu M;  Chen J;  Bai Y;  Duan S;  Shi X;  Lu T;  Yang Z;  Huang Z;  Yan D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 0,
    "id": "pubmed:42177178",
    "canonical_key": "pmid:42177178",
    "headline": "Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells.",
    "summary": "Nature communications. Nat Commun. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177178/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature communications",
    "pmid": "42177178",
    "doi": "10.1038/s41467-026-72817-7",
    "preprint_id": "",
    "authors": "Rius Rigau A; Xu M; Liu Z; Chenguiti Fakhouri S; Auth J; Garantziotis P; Zoli A; Selvaraju MK; Raimondo MG; Tur C; Filla T; Gehringer P; Eckstein M; Müller F; Atzinger A; Ronicke M; Ekici A; Schmid R; Wirsching A; Hagen M; Böltz S; Krickau T; Horch RE; Berking C; Grieshaber-Bouyer R; Ramming A; Gupta P; Bozec A; Mackensen A; Distler JH; Schett G; Li YN; Bergmann C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727215",
    "canonical_key": "doi:10.64898/2026.05.22.727215",
    "headline": "Detoxification of host-relevant H2O2 shapes Pseudomonas aeruginosa population gradients in flow",
    "summary": "During infection, bacterial populations need to overcome low levels of host-generated H2O2. However, experiments almost always use high H2O2 levels that are rarely found in hosts. Here, we use microfluidics to investigate how host-relevant H2O2 impacts populations of the human pathogen Pseudomonas aeruginosa in flow.",
    "url": "https://doi.org/10.64898/2026.05.22.727215",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727215",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727215",
    "authors": "Sharma, A.; Shuppara, A. M.; Sanfilippo, J. E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 27,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.726666",
    "canonical_key": "doi:10.64898/2026.05.20.726666",
    "headline": "Developmental conversion of the nucleolus into an RNA Polymerase II transcriptional platform in Drosophila spermatocytes",
    "summary": "The nucleolus is widely regarded as a specialized compartment for RNA polymerase I (Pol I)-driven ribosomal RNA transcription and ribosome biogenesis.",
    "url": "https://doi.org/10.64898/2026.05.20.726666",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726666",
    "preprint_id": "biorxiv:10.64898/2026.05.20.726666",
    "authors": "Fingerhut, J. M. M.; Park, J. I.; Li, R. Y.; Lannes, R.; Ashok, A.; Yamashita, Y. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; developmental biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 28,
    "score": 0,
    "id": "pubmed:42177422",
    "canonical_key": "pmid:42177422",
    "headline": "Drug-induced psoriasis following sacubitril/valsartan: a case report and literature review.",
    "summary": "BMC cardiovascular disorders. BMC Cardiovasc Disord. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177422/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "BMC cardiovascular disorders",
    "pmid": "42177422",
    "doi": "10.1186/s12872-026-06004-3",
    "preprint_id": "",
    "authors": "Tang T; Guo M; Yu H; Zhang Y; Lei S; Li S; Chen W; Lou Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 29,
    "score": 0,
    "id": "pubmed:42174336",
    "canonical_key": "pmid:42174336",
    "headline": "Durable remission despite transplantation with active disease in therapy-related NUP98::TOP1-rearranged acute myeloid leukemia.",
    "summary": "Annals of hematology. Ann Hematol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174336/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Annals of hematology",
    "pmid": "42174336",
    "doi": "10.1007/s00277-026-07073-2",
    "preprint_id": "",
    "authors": "Cimino G; Sembenico R; Zorutti F; Saldi S; Caridi M; Cardinali V; Sciabolacci S; Crescenzi B; Matteucci C; La Starza R; Pucciarini A; Zei T; Iacucci Ostini R; Aristei C; Carotti A; Mecucci C; Ruggeri L; Martelli MP; Pierini A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 30,
    "score": 0,
    "id": "biorxiv:10.64898/2026.04.21.720000",
    "canonical_key": "doi:10.64898/2026.04.21.720000",
    "headline": "Entrenchment of germline amino-acid differences in antibody affinity maturation",
    "summary": "Entrenchment - epistasis that locks in amino acid differences between homologous proteins, so each disfavors substitutions toward the other's state - has been demonstrated along individual protein lineages over deep evolutionary time.",
    "url": "https://doi.org/10.64898/2026.04.21.720000",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.21.720000",
    "preprint_id": "biorxiv:10.64898/2026.04.21.720000",
    "authors": "Harel, N.; Sung, K.; Dumm, W.; Johnson, M. M.; Rich, D.; Fukuyama, J.; Haddox, H. K.; Matsen, F. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; evolutionary biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 31,
    "score": 0,
    "id": "pubmed:42177561",
    "canonical_key": "pmid:42177561",
    "headline": "ERVK activity in CD8(+) T cell immune cell compartment in patients with ALS.",
    "summary": "Journal of neuroinflammation. J Neuroinflammation. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177561/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of neuroinflammation",
    "pmid": "42177561",
    "doi": "10.1186/s12974-026-03871-7",
    "preprint_id": "",
    "authors": "Sharma S; Cortés-Pérez C; Bird S; Di Curzio D; Vandenakker A; Schellenberg K; Douville RN",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 32,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727136",
    "canonical_key": "doi:10.64898/2026.05.22.727136",
    "headline": "Extracellular vesicles associate with infectious geminiviral particles in the apoplast of infected plants.",
    "summary": "Plant viruses have evolved diverse strategies to facilitate their movement and survival within the host. Among them, geminiviruses co-opt host cellular machinery to replicate and disseminate.",
    "url": "https://doi.org/10.64898/2026.05.22.727136",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727136",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727136",
    "authors": "Morales-Martinez, P.; Cana-Quijada, P.; Koch, B. L.; Marulanda-Pulgarin, J.; Lozano-Duran, R.; Innes, R. W.; Bejarano, E.; Castillo, A. G.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; plant biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 33,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727216",
    "canonical_key": "doi:10.64898/2026.05.22.727216",
    "headline": "Flow-driven delivery boosts antibiotic effectiveness by overwhelming bacterial defenses",
    "summary": "Physical, chemical, and biological factors collectively determine antibiotic effectiveness. However, laboratory studies often consider only one or two of these factors and fail to capture key interaction effects.",
    "url": "https://doi.org/10.64898/2026.05.22.727216",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727216",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727216",
    "authors": "Shuppara, A. M.; Koch, M. D.; Sanfilippo, J. E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 34,
    "score": 0,
    "id": "pubmed:42178050",
    "canonical_key": "pmid:42178050",
    "headline": "From \"cold\" to \"hot\": Icariin reshapes the tumor immune microenvironment through programmed cell death.",
    "summary": "Biochemical pharmacology. Biochem Pharmacol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178050/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Biochemical pharmacology",
    "pmid": "42178050",
    "doi": "10.1016/j.bcp.2026.118105",
    "preprint_id": "",
    "authors": "Yang M; Liu J; Li Y; Zuo L; Liu H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 35,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727209",
    "canonical_key": "doi:10.64898/2026.05.22.727209",
    "headline": "Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilization",
    "summary": "-Lipoic acid (LA) is widely included in mitochondrial cocktails recommended to patients with primary mitochondrial disorders, yet its mechanism of action remains unclear. Here, we define the intracellular availability and functional utilization of LA in mammalian cells.",
    "url": "https://doi.org/10.64898/2026.05.22.727209",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727209",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727209",
    "authors": "Norden, P. R.; Wedan, R. J.; Ellis, A. E.; Hart, M. L.; Gendjar, M. R.; Sheldon, R. D.; Nowinski, S. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; biochemistry"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 36,
    "score": 0,
    "id": "pubmed:42176216",
    "canonical_key": "pmid:42176216",
    "headline": "Gastric sarcoidosis presenting as multiple, discolored mucosal lesions after Helicobacter pylori eradication.",
    "summary": "Clinical journal of gastroenterology. Clin J Gastroenterol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176216/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinical journal of gastroenterology",
    "pmid": "42176216",
    "doi": "10.1007/s12328-026-02366-5",
    "preprint_id": "",
    "authors": "Shintaku M; Watanabe Y; Sumitomo Y; Torii I",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 37,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.726976",
    "canonical_key": "doi:10.64898/2026.05.22.726976",
    "headline": "Glycogen deficiency impairs diurnal energy metabolism and cell division in Synechocystis",
    "summary": "Diurnal changes in light availability are a defining feature of life on Earth. Photoautotrophic organisms therefore store reduced carbon during the day to sustain energy metabolism at night. In cyanobacteria, glycogen is the primary carbon storage compound and supports both energy homeostasis and stress responses.",
    "url": "https://doi.org/10.64898/2026.05.22.726976",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.726976",
    "preprint_id": "biorxiv:10.64898/2026.05.22.726976",
    "authors": "Hofer, J. M.; Schulze, T.; Witting, L.; Laker, B.; Krueger, S.; Westhoff, P.; Kohlheyer, D.; Weber, A. P. M.; Eisenhut, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; plant biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 38,
    "score": 0,
    "id": "pubmed:42176172",
    "canonical_key": "pmid:42176172",
    "headline": "Gut microbiome-mediated bioactive ingredients and health benefits of medicinal and edible fermented products: A comprehensive review.",
    "summary": "Folia microbiologica. Folia Microbiol (Praha). 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176172/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Folia microbiologica",
    "pmid": "42176172",
    "doi": "10.1007/s12223-026-01468-4",
    "preprint_id": "",
    "authors": "Liu C; Zhang S; Yue Q; Sun X; Zheng K; Li K; Su L; Zhao L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 39,
    "score": 0,
    "id": "pubmed:42177200",
    "canonical_key": "pmid:42177200",
    "headline": "Heterologous vaccination with a next-generation vaccinia virus and Ad26 induces Ebola-specific immunity in macaques.",
    "summary": "NPJ vaccines. NPJ Vaccines. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177200/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "NPJ vaccines",
    "pmid": "42177200",
    "doi": "10.1038/s41541-026-01494-w",
    "preprint_id": "",
    "authors": "Vijayan A; Cooper T; Kolfschoten MVN; Heinemann G; Van Kampen M; Boedhoe S; van Diepen H; Serroyen J; Hayball J; Hobbs L; Collins A; Custers J; Zahn R; Vogels R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 40,
    "score": 0,
    "id": "pubmed:42175694",
    "canonical_key": "pmid:42175694",
    "headline": "Identification of Lipid Metabolism-Related Gene GM2A as a Potential Biomarker in Atopic Dermatitis by Combining Weighted Gene Co-Expression Network Analysis and Machine Learning.",
    "summary": "DNA and cell biology. DNA Cell Biol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42175694/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "DNA and cell biology",
    "pmid": "42175694",
    "doi": "10.1177/10445498261449596",
    "preprint_id": "",
    "authors": "Wang L; Mao YH; Zhang LT",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 41,
    "score": 0,
    "id": "pubmed:42176139",
    "canonical_key": "pmid:42176139",
    "headline": "Immunopathogenesis and Experimental Models of Alopecia Areata: From Mechanistic Insights to Translational Platforms.",
    "summary": "Clinical reviews in allergy & immunology. Clin Rev Allergy Immunol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176139/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinical reviews in allergy & immunology",
    "pmid": "42176139",
    "doi": "10.1007/s12016-026-09171-5",
    "preprint_id": "",
    "authors": "Wang Y; Li Y; Feng Y; Zhang Y; Li D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 42,
    "score": 0,
    "id": "pubmed:42177286",
    "canonical_key": "pmid:42177286",
    "headline": "Impact of JAK-inhibition on pain and biphasic P2X7R expression on CD4(+) T cells in experimental arthritis.",
    "summary": "Scientific reports. Sci Rep. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177286/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Scientific reports",
    "pmid": "42177286",
    "doi": "10.1038/s41598-026-54494-0",
    "preprint_id": "",
    "authors": "Biton J; Hervé R; Breckler M; Lemeiter D; Decker P; Sigaux J; Assier E; Semerano L; Bessis N; Boissier MC; Rivière E",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 43,
    "score": 0,
    "id": "pubmed:42176558",
    "canonical_key": "pmid:42176558",
    "headline": "Integrated histopathology-transcriptomic biomarker enhances survival prediction in HNSCC patients treated with immunotherapy.",
    "summary": "Translational oncology. Transl Oncol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176558/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Translational oncology",
    "pmid": "42176558",
    "doi": "10.1016/j.tranon.2026.102822",
    "preprint_id": "",
    "authors": "Belete M; Thakkar N; Khatri I; Guan M; Sun Y; Muthuswamy A; Kolder I; Si H; Soong D; Higgs BW; Brady LK; Zou J; Sridhar S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 44,
    "score": 0,
    "id": "pubmed:42175671",
    "canonical_key": "pmid:42175671",
    "headline": "Integrating oncolytic adenoviruses into combination cancer therapy: Mechanisms, advances and clinical outlook.",
    "summary": "Clinical and translational medicine. Clin Transl Med",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42175671/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinical and translational medicine",
    "pmid": "42175671",
    "doi": "10.1002/ctm2.70702",
    "preprint_id": "",
    "authors": "Iova V; Iova GM; Tudosie MS; Scrobota I; Smarandache CG",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 45,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.19.725170",
    "canonical_key": "doi:10.64898/2026.05.19.725170",
    "headline": "Mechanical licensing of functional dendritic cell states for enhanced T cell priming",
    "summary": "The plasticity of dendritic cell (DC) functional state is a major hurdle in DC therapy, yet how DCs acquire distinct states independent of ontogeny remains poorly understood.",
    "url": "https://doi.org/10.64898/2026.05.19.725170",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.725170",
    "preprint_id": "biorxiv:10.64898/2026.05.19.725170",
    "authors": "Chen, Y.-C.; Bluem, A. S.; Joorabi, F. T.; Zhang, K.; Tran, N. M.; Zhang, S.; Makkar, H.; Vining, K. H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 46,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726902",
    "canonical_key": "doi:10.64898/2026.05.21.726902",
    "headline": "Molecular underpinning of Hydra viridissima-algal facultative symbiosis and vertical algal transmission",
    "summary": "The symbiosis between algae and animals represents a relatively recent evolutionary innovation, and exemplified by species in the Cnidaria phylum. Cnidaria can harbor algae within a modified cellular organelle called the symbiosome in a process called endosymbiosis. This animal-algal symbiosis can be facultative or obligate.",
    "url": "https://doi.org/10.64898/2026.05.21.726902",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726902",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726902",
    "authors": "Tran, J. R.; Sittmann, J.; Ma, B.; Zhu, M.; Zheng, Y.; Hu, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; molecular biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 47,
    "score": 0,
    "id": "pubmed:42174402",
    "canonical_key": "pmid:42174402",
    "headline": "Nano-Therapeutics for In Vivo Immune Cell Engineering.",
    "summary": "Small methods. Small Methods",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174402/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Small methods",
    "pmid": "42174402",
    "doi": "10.1002/smtd.202501973",
    "preprint_id": "",
    "authors": "Geng Y; Wang Z; Liu X; Yao H; Sun J; Lao YH; Lv S; Xie X; Tao Y; Li M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 48,
    "score": 0,
    "id": "pubmed:42174293",
    "canonical_key": "pmid:42174293",
    "headline": "Ofatumumab therapy modulates the meningeal lymphatic draining function in patients with multiple sclerosis: a pilot study.",
    "summary": "Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Neurol Sci. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174293/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology",
    "pmid": "42174293",
    "doi": "10.1007/s10072-026-09112-2",
    "preprint_id": "",
    "authors": "Yang S; Fu XW; Liu ZX; Zhu L; Liu J; Liu Z; Zhang TX; Wang SQ; Feng B; Wang JP; Zhang C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
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    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 49,
    "score": 0,
    "id": "biorxiv:10.1101/2025.11.10.687568",
    "canonical_key": "doi:10.1101/2025.11.10.687568",
    "headline": "Optical tweezers combined with FRET tension sensor reveal force-dependent vinculin dynamics",
    "summary": "Visualizing and quantifying molecular responses to local forces exerted at cell adhesions is crucial to elucidate how physical forces control cellular behavior.",
    "url": "https://doi.org/10.1101/2025.11.10.687568",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.11.10.687568",
    "preprint_id": "biorxiv:10.1101/2025.11.10.687568",
    "authors": "Dubois, C.; Cohen, R. I.; Boustany, N. N.; Westbrook, N.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; biophysics"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 50,
    "score": 0,
    "id": "pubmed:42176070",
    "canonical_key": "pmid:42176070",
    "headline": "p53 expression and NLR could recognize distinct subtypes of lung adenocarcinoma with high expression of PD-L1 (TPS ≥ 50%), defined with 22C3 antibody.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176070/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42176070",
    "doi": "10.1007/s12672-026-05228-1",
    "preprint_id": "",
    "authors": "Li M; Huang M; Huang Y; Zhang X; Wu H; Feng Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 51,
    "score": 0,
    "id": "pubmed:42177154",
    "canonical_key": "pmid:42177154",
    "headline": "Papulonodular rash and destructive palatal lesion with systemic symptoms.",
    "summary": "European journal of internal medicine. Eur J Intern Med. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177154/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "European journal of internal medicine",
    "pmid": "42177154",
    "doi": "10.1016/j.ejim.2026.106969",
    "preprint_id": "",
    "authors": "Bachmeyer C; Moguelet P; Savey L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 52,
    "score": 0,
    "id": "pubmed:42176353",
    "canonical_key": "pmid:42176353",
    "headline": "Receptor-Guided AAV Tropism Engineering via MATCH.",
    "summary": "ACS synthetic biology. ACS Synth Biol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176353/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "ACS synthetic biology",
    "pmid": "42176353",
    "doi": "10.1021/acssynbio.5c00910",
    "preprint_id": "",
    "authors": "Graham N; Kumar S; Rainaldi J; Yang S; Portell A; Santoso B; Mali P",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 53,
    "score": 0,
    "id": "pubmed:42175736",
    "canonical_key": "pmid:42175736",
    "headline": "Reprogramming the Immune Landscape of Inflammatory Breast Cancer.",
    "summary": "Advanced science (Weinheim, Baden-Wurttemberg, Germany). Adv Sci (Weinh). 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42175736/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
    "pmid": "42175736",
    "doi": "10.1002/advs.75766",
    "preprint_id": "",
    "authors": "Martinez-Rodriguez V; Ogata S; Wang X; Ueno NT",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 54,
    "score": 0,
    "id": "pubmed:42177352",
    "canonical_key": "pmid:42177352",
    "headline": "SCRUM-Japan MONSTAR3 hematology cohort: a nationwide multi-omics integrated platform for next-generation precision medicine in hematologic malignancies.",
    "summary": "International journal of clinical oncology. Int J Clin Oncol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177352/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "International journal of clinical oncology",
    "pmid": "42177352",
    "doi": "10.1007/s10147-026-03049-4",
    "preprint_id": "",
    "authors": "Matsuda K; Yuda J; Yoshimaru R; Harima I; Sakuma H; Uehara A; Oto M; Fukatsu M; Ikezoe T; Araie H; Hosono N; Ohwada C; Nakaseko C; Kakiuchi S; Fujisawa T; Hashimoto T; Shibuki T; Imai M; Nagamine M; Sakashita S; Yamashita R; Dodo A; Horasawa S; Nakamura Y; Bando H; Yoshino T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 55,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.18.26353507",
    "canonical_key": "doi:10.64898/2026.05.18.26353507",
    "headline": "Sexually Transmitted and Bloodborne Infections, Methamphetamine Use, and COVID-19 Vaccination in Manitoba, Canada: A Retrospective Matched Cohort Analysis Using Population-Based Administrative Healthcare Data (2020-2022)",
    "summary": "ObjectivesTo examine COVID-19 vaccine uptake among people diagnosed with sexually transmitted and bloodborne infections (STBBI) and reported methamphetamine users in Manitoba, Canada, during the acute phase of the COVID-19 pandemic.",
    "url": "https://doi.org/10.64898/2026.05.18.26353507",
    "source": "medRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.18.26353507",
    "preprint_id": "medrxiv:10.64898/2026.05.18.26353507",
    "authors": "Shaw, S. Y. Y.; Mahar, A.; Bailey, K.; Payne, M.; Kindrachuk, J.; Kelly, C.; Friesen, K. J.; Bernstein, C. N.; Reimer, J.; Becker, M. L.; McClarty, L. M.; Stein, D.; Nickel, N. C.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; epidemiology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 56,
    "score": 0,
    "id": "pubmed:42177544",
    "canonical_key": "pmid:42177544",
    "headline": "Spatial and single-cell transcriptomic profiling reveals interplay between SRGN-associated epithelial programs and C1QC+ macrophages in early LUAD progression.",
    "summary": "Journal of translational medicine. J Transl Med. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177544/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of translational medicine",
    "pmid": "42177544",
    "doi": "10.1186/s12967-026-08241-8",
    "preprint_id": "",
    "authors": "Mao S; Pang C; Hang H; Li Y; Zhang L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 57,
    "score": 0,
    "id": "biorxiv:10.1101/2025.10.20.683497",
    "canonical_key": "doi:10.1101/2025.10.20.683497",
    "headline": "The human neuroblastoma SH-SY5Y cell line as a model to assess β-amyloid neurotoxicity: A systematic review and meta-analysis",
    "summary": "The SH-SY5Y human neuroblastoma cell line is widely used as an in vitro model of {beta}-amyloid (A{beta}) neurotoxicity in Alzheimer's disease (AD). However, the lack of standardized protocols for assessing A{beta} toxicity - including differentiation strategies for SH-SY5Y cells - limits the comparability of results across studies.",
    "url": "https://doi.org/10.1101/2025.10.20.683497",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.10.20.683497",
    "preprint_id": "biorxiv:10.1101/2025.10.20.683497",
    "authors": "Reges Pinheiro, N.; Franca Dias Carneiro, C.; Scarcella Cancelliero, G.; Orlovski Nogueira, G.; Almeida, G.; Fernandes, N.; Wasilewska-Sampaio, A. P.; Martins, S.; Felix, A.; Amaral, O. B.; Sebollela, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 58,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727130",
    "canonical_key": "doi:10.64898/2026.05.22.727130",
    "headline": "The origin of mechanical advantage in angiosperms",
    "summary": "O_LIMechanical interaction between guard cells and epidermal pavement cells enables large stomatal apertures and high productivity in angiosperms. We do not know when this response evolved, but over the last 169 years we have found that mechanical advantage has been tested in at least 230 species from 85 families.",
    "url": "https://doi.org/10.64898/2026.05.22.727130",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727130",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727130",
    "authors": "Manandhar, A.; McAdam, S.; Rockwell, F. E.; Fang, y.; Brodribb, T.; Holbrook, N. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; plant biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 59,
    "score": 0,
    "id": "biorxiv:10.64898/2026.03.20.712775",
    "canonical_key": "doi:10.64898/2026.03.20.712775",
    "headline": "Time-Resolved Phosphoproteomics-Guided BFS Beam Search Reveals Cell-Type-Specific EGFR Signaling Architectures and SHP2 Inhibitor-Induced Pathway Rewiring",
    "summary": "Adaptive resistance to kinase- and phosphatase-targeted therapies is frequently driven by pharmacological rewiring of intracellular signaling networks, yet systematic computational methods for quantifying cross-condition pathway changes from phosphoproteomic data remain limited.",
    "url": "https://doi.org/10.64898/2026.03.20.712775",
    "source": "bioRxiv",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.03.20.712775",
    "preprint_id": "biorxiv:10.64898/2026.03.20.712775",
    "authors": "Lee, H.; Lee, G.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 60,
    "score": 0,
    "id": "pubmed:42178078",
    "canonical_key": "pmid:42178078",
    "headline": "Traditional Chinese Medicine Reverses Immune Checkpoint Resistance Through Lactate Metabolic Reprogramming in Hepatocellular Carcinoma: Mechanisms and Therapeutic Implications.",
    "summary": "Journal of ethnopharmacology. J Ethnopharmacol. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178078/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of ethnopharmacology",
    "pmid": "42178078",
    "doi": "10.1016/j.jep.2026.121885",
    "preprint_id": "",
    "authors": "Liu L; Wang J; Hu K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 61,
    "score": 0,
    "id": "pubmed:42174637",
    "canonical_key": "pmid:42174637",
    "headline": "Ultrasound-responsive biomimetic nanocarrier triggers spatiotemporal PROTAC release and ROS storm to disrupt TNBC immunosuppression via coordinated apoptosis/ferroptosis/senescence activation.",
    "summary": "Journal of nanobiotechnology. J Nanobiotechnology. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174637/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of nanobiotechnology",
    "pmid": "42174637",
    "doi": "10.1186/s12951-026-04578-w",
    "preprint_id": "",
    "authors": "Liao Z; Liao H; Luo Y; Chen S; Shen Y; Zhang M; Xu Y; Wang L; Niu C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 62,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.724359",
    "canonical_key": "doi:10.64898/2026.05.20.724359",
    "headline": "4-Phenylbutyrate Rescue in GABRA1 Variants Associated with Developmental Epileptic Encephalopathies: from Cell and Mouse Models to Human",
    "summary": "Disease variants in GABR genes encoding {gamma}-Aminobutyric acid type A receptor (GABAAR) subunits are major causes of developmental and epileptic encephalopathies (DEEs). There is no effective treatment for these DEEs although the GABAAR is a major target for antiseizure drugs.",
    "url": "https://doi.org/10.64898/2026.05.20.724359",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.724359",
    "preprint_id": "biorxiv:10.64898/2026.05.20.724359",
    "authors": "Song, Z.; Kang, J.; Zavalin, K.; Shen, W.; DeLeeuw, M. B.; Hunn, G. X.; Eda, R. S.; Ma, L.; Carson, R.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 63,
    "score": 0,
    "id": "europepmc:PPR1237041",
    "canonical_key": "doi:10.64898/2026.05.21.726863",
    "headline": "A community machine learning challenge to predict the effects of gene perturbations on T cell differentiation for cancer immunotherapy",
    "summary": "Zhang J, Schwartz MA, Mutaher M, Olajide O, Pritykin Y, Ashenberg O, Hacohen N, Uhler C.",
    "url": "https://doi.org/10.64898/2026.05.21.726863",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726863",
    "preprint_id": "",
    "authors": "Zhang J;  Schwartz MA;  Mutaher M;  Olajide O;  Pritykin Y;  Ashenberg O;  Hacohen N;  Uhler C.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 64,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.20.26353581",
    "canonical_key": "doi:10.64898/2026.05.20.26353581",
    "headline": "A longitudinal cohort study comparing clinical trials registered on ClinicalTrials.gov that stopped during the first three years of the SARS-CoV-2 pandemic with trials that stopped in the three years prior",
    "summary": "BackgroundThe global SARS-CoV-2 pandemic disrupted healthcare systems worldwide, raising concerns about its impact on clinical research.",
    "url": "https://doi.org/10.64898/2026.05.20.26353581",
    "source": "medRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.26353581",
    "preprint_id": "medrxiv:10.64898/2026.05.20.26353581",
    "authors": "Carlisle, B. G.; Hutchinson, N.; Moyer, H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
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    "keywords": "medrxiv; public and global health"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 65,
    "score": 0,
    "id": "europepmc:PPR1236998",
    "canonical_key": "doi:10.64898/2026.05.20.726561",
    "headline": "A murine model to study chronic airway fungal colonisation that recapitulates human disease",
    "summary": "Sey EA, Irere H, Warris A, Salazar F.",
    "url": "https://doi.org/10.64898/2026.05.20.726561",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726561",
    "preprint_id": "",
    "authors": "Sey EA;  Irere H;  Warris A;  Salazar F.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 66,
    "score": 0,
    "id": "europepmc:PPR1237751",
    "canonical_key": "doi:10.20944/preprints202605.1493.v1",
    "headline": "A Novel Anti-Cadherin-17 Monoclonal Antibody, Ca17Mab-5, for Multiple Applications",
    "summary": "Ito R, Suzuki H, Ishikawa K, Yagi K, Ohkoshi A, Katori Y, Kaneko MK, Kato Y.",
    "url": "https://doi.org/10.20944/preprints202605.1493.v1",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.20944/preprints202605.1493.v1",
    "preprint_id": "",
    "authors": "Ito R;  Suzuki H;  Ishikawa K;  Yagi K;  Ohkoshi A;  Katori Y;  Kaneko MK;  Kato Y.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 67,
    "score": 0,
    "id": "pubmed:42174291",
    "canonical_key": "pmid:42174291",
    "headline": "A Novel MSN Mutation Impairs CD4(+) T cell Differentiation and Drives Autoantibody Production.",
    "summary": "Journal of clinical immunology. J Clin Immunol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174291/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of clinical immunology",
    "pmid": "42174291",
    "doi": "10.1007/s10875-026-02034-w",
    "preprint_id": "",
    "authors": "Zhu K; Sun B; Zhang W; Liu L; Wang W; Wang C; Xiao F; Zhou Q; Wang X; Sun J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 68,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.726376",
    "canonical_key": "doi:10.64898/2026.05.20.726376",
    "headline": "A Simulation of Semi-Infectious Particles and Genome Complementation Reproduces Interferon Response by Respiratory Epithelial Cells in vitro during Influenza A Virus Infection",
    "summary": "In the respiratory epithelium, interferon (IFN)-induced antiviral resistance acts as a defense against infection. Influenza A viruses (IAVs) have evolved multiple strategies to counteract these defenses, including expression of the viral protein NS1, which inhibits both IFN production and the IFN-mediated transcription of Interferon Stim...",
    "url": "https://doi.org/10.64898/2026.05.20.726376",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726376",
    "preprint_id": "biorxiv:10.64898/2026.05.20.726376",
    "authors": "Dal-Castel, P. C.; Resnick, J. D.; Sluka, J. P.; Gallagher, M. E.; Helfers, M.; Bird, I. M.; Ratcliff, J. D.; Grady, S. L.; Glazier, J. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; systems biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 69,
    "score": 0,
    "id": "europepmc:PPR1237022",
    "canonical_key": "doi:10.64898/2026.05.20.726477",
    "headline": "AbSolution: interactive exploration of sequence-derived features in AIRR-seq repertoires",
    "summary": "García-Valiente R, Triantafyllou C, van Schaik B, Jongejan A, Pollastro S, Anang D, Guikema JEJ, de Vries N, Hoefsloot H, van Kampen AH.",
    "url": "https://doi.org/10.64898/2026.05.20.726477",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726477",
    "preprint_id": "",
    "authors": "García-Valiente R;  Triantafyllou C;  van Schaik B;  Jongejan A;  Pollastro S;  Anang D;  Guikema JEJ;  de Vries N;  Hoefsloot H;  van Kampen AH.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 70,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726689",
    "canonical_key": "doi:10.64898/2026.05.21.726689",
    "headline": "Adaptive Replication Fork Acceleration by CDK1-Cyclin B1 Sustains Genome Duplication despite Impaired Origin Firing",
    "summary": "Although MTBP is essential for replication origin firing, we show here that strong depletion of MTBP can have minor effects on DNA replication rates. This suggests an adaptive process in the DNA replication program, so we examined mechanisms underlying this plasticity.",
    "url": "https://doi.org/10.64898/2026.05.21.726689",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726689",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726689",
    "authors": "Hossain, M. S.; Sansam, C. G.; Dhar, K.; Sansam, C. L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; molecular biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 71,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.726465",
    "canonical_key": "doi:10.64898/2026.05.20.726465",
    "headline": "An integrated protocol for multiplexed DNA FISH and protein detection in large tissue sections",
    "summary": "Different omics types such as genomics and proteomics all contribute to deciphering biology. Applying these omics approaches in a spatial context helps reveal biology in situ at a single cell level.",
    "url": "https://doi.org/10.64898/2026.05.20.726465",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726465",
    "preprint_id": "biorxiv:10.64898/2026.05.20.726465",
    "authors": "O'Roberts, E.; Panshikar, P. R.; Li-Wang, X.; Avenel, C.; Verron, Q.; Coulier, E.; Bienko, M.; Stadler, C.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 72,
    "score": 0,
    "id": "biorxiv:10.1101/2024.04.19.590313",
    "canonical_key": "doi:10.1101/2024.04.19.590313",
    "headline": "Asymmetric Contrastive Objectives for Efficient Phenotypic Screening",
    "summary": "Phenotypic screening experiments produce many microscope images of cells under diverse perturbations, with biologically significant responses often subtle or difficult to identify visually. A central challenge is to extract image representations that distinguish activity from controls and group phenotypically similar perturbations.",
    "url": "https://doi.org/10.1101/2024.04.19.590313",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2024.04.19.590313",
    "preprint_id": "biorxiv:10.1101/2024.04.19.590313",
    "authors": "Nightingale, L.; Tuersley, J.; Warchal, S.; Cairoli, A.; Howes, J.; Shand, C.; Powell, A.; Green, D.; Strange, A.; Howell, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 73,
    "score": 0,
    "id": "pubmed:42171217",
    "canonical_key": "pmid:42171217",
    "headline": "ATG5 in DCs attenuates anti-malarial cellular immune responses through interfering with TLR2-mediated CD209A/DC-SIGN expression.",
    "summary": "Autophagy. Autophagy. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42171217/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Autophagy",
    "pmid": "42171217",
    "doi": "10.1080/15548627.2026.2679173",
    "preprint_id": "",
    "authors": "Fan Y; Jiao S; Li H; Gao Y; Fang J; Zhang K; Guo S; Xu W; Liu T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 74,
    "score": 0,
    "id": "pubmed:42177028",
    "canonical_key": "pmid:42177028",
    "headline": "Autologous T Cell Antigen Coupler Targeting HER2 (TAC01-HER2) in Advanced or Metastatic Solid Tumors.",
    "summary": "Annals of oncology : official journal of the European Society for Medical Oncology. Ann Oncol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177028/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Annals of oncology : official journal of the European Society for Medical Oncology",
    "pmid": "42177028",
    "doi": "10.1016/j.annonc.2026.05.696",
    "preprint_id": "",
    "authors": "Dumbrava EE; Olson D; Gouda MA; George MA; Saibil SD; Apostolopoulou M; Bishop M; Gavriliuc MN; Kennon AM; Weiss JA; Ayers C; Moss K; Helsen CW; Rill D; Bader AG; Adib D; Schlechter BL",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 75,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.19.26353586",
    "canonical_key": "doi:10.64898/2026.05.19.26353586",
    "headline": "Bayesian Spatio-Temporal Modeling and Hotspot Mapping of Malaria Risk in Ghana",
    "summary": "PurposeThis study developed a Bayesian hierarchical spatio-temporal modeling framework to analyze factors and trends in malaria risk across Ghanas 16 administrative regions from 2020 to 2024.",
    "url": "https://doi.org/10.64898/2026.05.19.26353586",
    "source": "medRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.26353586",
    "preprint_id": "medrxiv:10.64898/2026.05.19.26353586",
    "authors": "Antwi, P.; Muhua, G.; Nyarko, E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; epidemiology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 76,
    "score": 0,
    "id": "europepmc:PPR1237459",
    "canonical_key": "doi:10.64898/2026.05.20.26353724",
    "headline": "Biological aging clock from routine clinical and anthropometric measurements in diverse populations",
    "summary": "Mejia-Garcia A, Su C, Zheng TM, Tsao HM, Richard A, Hamitouche D, Yoshiji S, Mooser V, Lettre G, Harroud A, Zhou S.",
    "url": "https://doi.org/10.64898/2026.05.20.26353724",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.20.26353724",
    "preprint_id": "",
    "authors": "Mejia-Garcia A;  Su C;  Zheng TM;  Tsao HM;  Richard A;  Hamitouche D;  Yoshiji S;  Mooser V;  Lettre G;  Harroud A;  Zhou S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 77,
    "score": 0,
    "id": "pubmed:42174730",
    "canonical_key": "pmid:42174730",
    "headline": "CD155 and its receptors in glioma: prospects for emerging immune checkpoint inhibitors.",
    "summary": "Acta neuropathologica communications. Acta Neuropathol Commun. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174730/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Acta neuropathologica communications",
    "pmid": "42174730",
    "doi": "10.1186/s40478-026-02327-6",
    "preprint_id": "",
    "authors": "Huang M; Cui Y; Wang X; Weng Y; Huang H; Su W; Zhao S; Li Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 78,
    "score": 0,
    "id": "pubmed:42173902",
    "canonical_key": "pmid:42173902",
    "headline": "Chaperone-mediated autophagy is required for regulatory T cell function.",
    "summary": "Nature communications. Nat Commun. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42173902/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature communications",
    "pmid": "42173902",
    "doi": "10.1038/s41467-026-73417-1",
    "preprint_id": "",
    "authors": "Harrison R; Gjergjova F; Pelka S; Macho-Gonzalez A; Chavda B; Lindenau K; Gazteluiturri Garcia A; Khawaja RR; Aguilan JT; Sidoli S; Kaushik S; Botbol Y; Cuervo AM; Macian F",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 79,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.19.726211",
    "canonical_key": "doi:10.64898/2026.05.19.726211",
    "headline": "CMPK2 restricts Mycobacterium tuberculosis replication and regulates macrophage gene expression",
    "summary": "Host cell metabolic pathways influence innate immune responses to intracellular pathogens, but the contribution of nucleotide metabolism to antimicrobial defense remains incompletely defined.",
    "url": "https://doi.org/10.64898/2026.05.19.726211",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.726211",
    "preprint_id": "biorxiv:10.64898/2026.05.19.726211",
    "authors": "Neff, J.; Ektnitphong, V. A.; Campos, P. C.; Naqvi, K. F.; Dias, B. R. S.; Rahlwes, K. C.; Zhong, Z.; Shiloh, M. U.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 80,
    "score": 0,
    "id": "pubmed:42171853",
    "canonical_key": "pmid:42171853",
    "headline": "Comprehensive bioinformatics analysis of EXOSC family genes in lung adenocarcinoma.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42171853/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42171853",
    "doi": "10.1007/s12672-026-05258-9",
    "preprint_id": "",
    "authors": "Li N; Wang X; Chu T; Pan Y; Zhang X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 81,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.726299",
    "canonical_key": "doi:10.64898/2026.05.20.726299",
    "headline": "CRISPR-mediated engineering of bovine satellite cells for Alpha-Gal Syndrome-compatible cultivated meat",
    "summary": "Alpha-gal Syndrome (AGS) is a potentially life-threatening allergy caused by an IgE-mediated immune response to galactose--1,3-galactose (alpha-gal), a carbohydrate epitope present in most mammalian meats.",
    "url": "https://doi.org/10.64898/2026.05.20.726299",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726299",
    "preprint_id": "biorxiv:10.64898/2026.05.20.726299",
    "authors": "D'Costa, S.; Choudhary, S. K.; Kenney, G. E.; Shine, J.; Diekman, B. O.; Commins, S. P.; Phanstiel, D. H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 82,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.20.26353707",
    "canonical_key": "doi:10.64898/2026.05.20.26353707",
    "headline": "Determinants, Barriers, and Completion Patterns of Routine Childhood Immunization in Bayelsa State, Nigeria",
    "summary": "BackgroundIncomplete childhood vaccination undermines individual and herd immunity and increases vulnerability to vaccine-preventable diseases. Understanding local determinants of vaccination adherence is essential for targeted interventions.",
    "url": "https://doi.org/10.64898/2026.05.20.26353707",
    "source": "medRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.26353707",
    "preprint_id": "medrxiv:10.64898/2026.05.20.26353707",
    "authors": "Promise, V. I.; Raimi, M. O.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; epidemiology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 83,
    "score": 0,
    "id": "pubmed:42171608",
    "canonical_key": "pmid:42171608",
    "headline": "Distinct immune landscapes characterize highly versus minimally invasive brain metastases.",
    "summary": "JCI insight. JCI Insight. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42171608/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "JCI insight",
    "pmid": "42171608",
    "doi": "10.1172/jci.insight.199498",
    "preprint_id": "",
    "authors": "Maritan SM; Karimi E; Dankner M; Hernandez-Corchado A; Yu MW; Annis MG; Aghazadeh Habashi Y; Rezanejad M; Liu B; Koudieh N; Pichette E; Fallah P; Fiset B; Wei Y; Nehme A; Lee CG; Elias JA; Park M; Riazalhosseini Y; Najafabadi H; Petrecca K; Guiot MC; Quail DF; Walsh LA; Siegel PM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 84,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.726269",
    "canonical_key": "doi:10.64898/2026.05.20.726269",
    "headline": "Domain Dissolution in Supported Lipid Bilayers Triggered by Unsaturated Phospholipid Addition",
    "summary": "Significant cellular processes, including protein sorting, signal transduction, and pathogen entry, amongst others, are associated with membrane microdomains, also known as lipid rafts.",
    "url": "https://doi.org/10.64898/2026.05.20.726269",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726269",
    "preprint_id": "biorxiv:10.64898/2026.05.20.726269",
    "authors": "Odudimu, A. T.; Wittenberg, N. J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; biophysics"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 85,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.20.26353683",
    "canonical_key": "doi:10.64898/2026.05.20.26353683",
    "headline": "Effects of oxycodone versus sufentanil on postoperative sleep quality and analgesia in patients after modified radical mastectomy: study protocol for a randomized, double-blind, controlled trial using wearable sleep monitoring",
    "summary": "BackgroundPostoperative sleep disorder, a frequently observed complication, is associated with heightened pain sensitivity, exacerbated inflammatory reactions, and compromised tissue repair.",
    "url": "https://doi.org/10.64898/2026.05.20.26353683",
    "source": "medRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.26353683",
    "preprint_id": "medrxiv:10.64898/2026.05.20.26353683",
    "authors": "deng, q.; Hu, J.; Huang, L.; Zheng, J.; Zheng, L.; Wu, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; anesthesia"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 86,
    "score": 0,
    "id": "pubmed:42175479",
    "canonical_key": "pmid:42175479",
    "headline": "Efficacy of traditional Chinese medicine in treating severe pneumonia: A meta-analysis and systematic review.",
    "summary": "Medicine. Medicine (Baltimore). 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42175479/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Medicine",
    "pmid": "42175479",
    "doi": "10.1097/MD.0000000000048983",
    "preprint_id": "",
    "authors": "Zhou A; Lin H; Chen Z; Luo L; Ye X; Li L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 87,
    "score": 0,
    "id": "pubmed:42171610",
    "canonical_key": "pmid:42171610",
    "headline": "ELN orchestrates prometastatic and immunosuppressive niche in bladder cancer via TGFB1 autocrine signaling.",
    "summary": "JCI insight. JCI Insight. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42171610/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "JCI insight",
    "pmid": "42171610",
    "doi": "10.1172/jci.insight.194700",
    "preprint_id": "",
    "authors": "Xu W; Gao J; Wu S; Huang J; An C; Jiang C; Liu N; Cheng C; Wang Z; Dong Z; Xu Y; Zhou J; Dai H; Li X; Xu H; Zhao S; Fan Q; Li Y; Dai Y; Zuo L; Wang H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 88,
    "score": 0,
    "id": "pubmed:42171362",
    "canonical_key": "pmid:42171362",
    "headline": "Engineering strategies of bacterial outer membrane vesicles for enhancing tumor immunotherapy.",
    "summary": "Nanoscale. Nanoscale. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42171362/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nanoscale",
    "pmid": "42171362",
    "doi": "10.1039/d6nr01038e",
    "preprint_id": "",
    "authors": "Yu Z; Ma Y; Guo Q; Liu H; Li Z; Zhang J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 89,
    "score": 0,
    "id": "pubmed:42172506",
    "canonical_key": "pmid:42172506",
    "headline": "Epigenetic drug control of Clec4g/LSECtin expression reduces fibrosis burden in cirrhosis.",
    "summary": "Hepatology communications. Hepatol Commun. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42172506/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Hepatology communications",
    "pmid": "42172506",
    "doi": "10.1097/HC9.0000000000000961",
    "preprint_id": "",
    "authors": "Ángel-Gomis E; Gómez-Hurtado I; Fernández-Barrena MG; Juanola O; Martínez-López S; Boix P; Ávila MA; Caparrós E; Francés R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 90,
    "score": 0,
    "id": "pubmed:42172622",
    "canonical_key": "pmid:42172622",
    "headline": "Epigenetic Dynamics of Human Spermatogenesis and Their Dysregulation in Non-Obstructive Azoospermia.",
    "summary": "Protein & cell. Protein Cell. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42172622/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Protein & cell",
    "pmid": "42172622",
    "doi": "10.1093/procel/pwag033",
    "preprint_id": "",
    "authors": "Xie H; Li J; Zhang L; Xu X; Jiang Z; Cao Y; Wen L; Qiao J; Tang F",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 91,
    "score": 0,
    "id": "pubmed:42176785",
    "canonical_key": "pmid:42176785",
    "headline": "Evaluation of the Immunological Efficacy of EsxA Subunit Vaccine and DNA Vaccine against Streptococcus iniae in golden pompano (Trachinotus anak).",
    "summary": "Fish & shellfish immunology. Fish Shellfish Immunol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176785/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Fish & shellfish immunology",
    "pmid": "42176785",
    "doi": "10.1016/j.fsi.2026.111446",
    "preprint_id": "",
    "authors": "Huang Z; Sun H; Wang H; Jia X; Li H; Rejoice Abla D; Li W; Wang L; Lu Y; Huang Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 92,
    "score": 0,
    "id": "pubmed:42174653",
    "canonical_key": "pmid:42174653",
    "headline": "Extracellular vesicles from chemotherapy-induced senescent tumor cells reprogram hepatic phospholipid metabolism to promote pancreatic cancer liver metastasis.",
    "summary": "Journal of experimental & clinical cancer research : CR. J Exp Clin Cancer Res. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174653/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of experimental & clinical cancer research : CR",
    "pmid": "42174653",
    "doi": "10.1186/s13046-026-03741-3",
    "preprint_id": "",
    "authors": "Tao B; Xu Y; Miao W; Chen Z; Gu J; Guo Y; Chen L; Di Y; He H; Jin C; Li J; Fu D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 93,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.726470",
    "canonical_key": "doi:10.64898/2026.05.20.726470",
    "headline": "EYA1/EYA2 and EYA3/EYA4 act as stage-specific SIX cofactors in embryonic and adult regenerative skeletal myogenesis",
    "summary": "Eya3 and Eya4 are two Eya genes expressed in adult myogenic stem cells, where they may act as SIX cofactors. We analyzed muscle regeneration in single and compound Eya3 and satellite cell-specific Eya4 mutant mice.",
    "url": "https://doi.org/10.64898/2026.05.20.726470",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726470",
    "preprint_id": "biorxiv:10.64898/2026.05.20.726470",
    "authors": "Viaut, C.; Wurmser, M.; Jauliac, E.; Ben Driss, L.; Backer, S.; Madani, R.; Issa, F.; PIROZHKOVA, I.; Sotiropoulos, A.; Amthor, H.; Maire, P.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; developmental biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 94,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.727061",
    "canonical_key": "doi:10.64898/2026.05.21.727061",
    "headline": "FERONIA limits jasmonic acid overaccumulation and oxidative stress to enable plant survival at elevated temperatures",
    "summary": "Plants, as sessile organisms, must continually adapt to fluctuating temperatures to ensure survival. The plasma membrane-localized receptor-like kinase FERONIA (FER) coordinates diverse physiological processes and responses to various biotic and abiotic stresses.",
    "url": "https://doi.org/10.64898/2026.05.21.727061",
    "source": "bioRxiv",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.727061",
    "preprint_id": "biorxiv:10.64898/2026.05.21.727061",
    "authors": "Park, J.; Park, J.; Hwang, G.; Lee, N.; Oh, E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; plant biology"
  },
  {
    "digest_date": "2026-05-23",
    "window_start": "2026-05-22T17:15:00.000Z",
    "window_end": "2026-05-23T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 95,
    "score": 0,
    "id": "europepmc:PPR1237377",
    "canonical_key": "doi:10.64898/2026.05.20.726599",
    "headline": "Fibroblast TGF-β3 promotes tissue-residency and survival of CD8 T cells in barrier tissues and tumors",
    "summary": "Wu SZ, Lane RS, Castiglioni A, Santosa EK, Guarnieri A, Vollmers AC, Cox C, Yang Y, Bender H, Sun T, Shyer JA, Krishnamurty AT, Muller S, Turley SJ.",
    "url": "https://doi.org/10.64898/2026.05.20.726599",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726599",
    "preprint_id": "",
    "authors": "Wu SZ;  Lane RS;  Castiglioni A;  Santosa EK;  Guarnieri A;  Vollmers AC;  Cox C;  Yang Y;  Bender H;  Sun T;  Shyer JA;  Krishnamurty AT",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
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    "headline": "Flagellar toxicity: flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1",
    "summary": "Flagella are large transenvelope nanomachines but how they transit the peptidoglycan in Gram positive bacteria is poorly understood. A recent model suggested that flagellar basal bodies diffuse in the membrane and become captured at locations in the peptidoglycan with a pore diameter that could accommodate the axle-like flagellar rod.",
    "url": "https://doi.org/10.64898/2026.05.21.726928",
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    "canonical_key": "pmid:42175426",
    "headline": "Focus on CCL19: A Mendelian randomization study on genetic evidence of immune cells influencing osteoarthritis severity via inflammatory proteins.",
    "summary": "Medicine. Medicine (Baltimore). 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42175426/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Medicine",
    "pmid": "42175426",
    "doi": "10.1097/MD.0000000000048948",
    "preprint_id": "",
    "authors": "Chen S; Gan Y; Wang F; Jin Y; Wu Z; Liu Z; Wu T; Zhang Z",
    "assignee": "",
    "publication_number": "",
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    "canonical_key": "pmid:42174277",
    "headline": "Functional and mechanistic inactivation of immune hubs orchestrates tumor development and progression in lung adenocarcinoma.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174277/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42174277",
    "doi": "10.1007/s12672-026-05157-z",
    "preprint_id": "",
    "authors": "Alghamdi A; Alissa M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
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    "rank_index": 99,
    "score": 0,
    "id": "pubmed:42173096",
    "canonical_key": "pmid:42173096",
    "headline": "Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression.",
    "summary": "Cell reports. Medicine. Cell Rep Med. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42173096/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cell reports. Medicine",
    "pmid": "42173096",
    "doi": "10.1016/j.xcrm.2026.102833",
    "preprint_id": "",
    "authors": "Hu J; Ju X; Deng B; Tang K; Yuan D; Sun X; Kong L; Xu Y; Fu Z; Koda S; Shao S; Chen Y; Sun G; Zheng S; Zhao H; Liu Y; Chen H; Zong Z; Ma Y; Yu H; Qin Y; Li X; Hua H; Zhao Y; Tang R; Zheng K; Tong C; Ling Teng MW; Dong X; Deng X; Li Y; Yang YL; Chen Y; Yan J",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 100,
    "score": 0,
    "id": "pubmed:42171268",
    "canonical_key": "pmid:42171268",
    "headline": "Genetic-Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis.",
    "summary": "Annals of neurology. Ann Neurol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42171268/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Annals of neurology",
    "pmid": "42171268",
    "doi": "10.1002/ana.78256",
    "preprint_id": "",
    "authors": "Ding Y; Hamitouche D; Thebault S; Kearns P; Abdelhak A; Harroud A",
    "assignee": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-24",
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    "source_type": "papers",
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    "id": "biorxiv:10.64898/2026.01.22.701106",
    "canonical_key": "doi:10.64898/2026.01.22.701106",
    "headline": "Towards understanding nitrate-reducing Fe(II) oxidation in Ferrigenium straubiae: spotlight on old and new key protein candidates",
    "summary": "Autotrophic Fe(II) oxidation is a key microbial process linking iron cycling to global carbon and nitrogen turnover in anoxic and low-oxygen environments.",
    "url": "https://doi.org/10.64898/2026.01.22.701106",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.01.22.701106",
    "preprint_id": "biorxiv:10.64898/2026.01.22.701106",
    "authors": "Becker, S.; Straub, D.; Kappler, A.; Hemp, J.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "bioRxiv",
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    "source_type": "papers",
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    "rank_index": 2,
    "score": 0,
    "id": "biorxiv:10.1101/2025.09.13.676037",
    "canonical_key": "doi:10.1101/2025.09.13.676037",
    "headline": "Vascular Patterning affects Intramembranous Ossification through HIF1α-Vegf Signaling",
    "summary": "Organs and tissues develop in close association with vasculature which transports blood and nutrients and helps to remove waste. The vasculature is composed primarily of endothelial cells, which provide structure, form barriers, and are a source of developmental signals.",
    "url": "https://doi.org/10.1101/2025.09.13.676037",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.09.13.676037",
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    "authors": "Dash, S.; Rettig, J. R.; Gogol, M. M.; Trainor, P.",
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    "primary_source": "bioRxiv",
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    "id": "pubmed:42176790",
    "canonical_key": "pmid:42176790",
    "headline": "Immunomodulatory and cellular effects of Aeromonas salmonicida melanin in Atlantic salmon (Salmo salar).",
    "summary": "Fish & shellfish immunology. Fish Shellfish Immunol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176790/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Fish & shellfish immunology",
    "pmid": "42176790",
    "doi": "10.1016/j.fsi.2026.111419",
    "preprint_id": "",
    "authors": "Maqsood A; Kwabiah RR; Duglas S; Paramanathan T; Vasquez I; Hall JR; Koppang EO; Gendron RL; Santander J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-24",
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    "source_type": "papers",
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    "rank_index": 4,
    "score": 0,
    "id": "pubmed:42176975",
    "canonical_key": "pmid:42176975",
    "headline": "Integrated multi-omics reveals key drivers and immune cell phenotypes of infrapopliteal atherosclerosis and calcification.",
    "summary": "Annals of vascular surgery. Ann Vasc Surg. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176975/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Annals of vascular surgery",
    "pmid": "42176975",
    "doi": "10.1016/j.avsg.2026.05.073",
    "preprint_id": "",
    "authors": "Li X; Huang Y; Yu Y; Zheng X; Sun X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-24",
    "window_start": "2026-05-23T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 5,
    "score": 0,
    "id": "pubmed:42176887",
    "canonical_key": "pmid:42176887",
    "headline": "Intracellular Ca(2+) modulates hERG channel expression involving Ca(2+)/calmodulin-dependent kinase and MEK-ERK pathways.",
    "summary": "Life sciences. Life Sci. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176887/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Life sciences",
    "pmid": "42176887",
    "doi": "10.1016/j.lfs.2026.124471",
    "preprint_id": "",
    "authors": "Wei M; Sun H; Yin Y; Yoshimura K; Kume S; Kurokawa T; Ding L; Ono K; Zheng M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-24",
    "window_start": "2026-05-23T05:15:00.000Z",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 6,
    "score": 0,
    "id": "pubmed:42176394",
    "canonical_key": "pmid:42176394",
    "headline": "Janus TiO(2)-CoO(X) heterojunction enabling sonodynamic driving multi-pathway cell death for enhanced immune activation.",
    "summary": "Biomaterials. Biomaterials. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176394/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Biomaterials",
    "pmid": "42176394",
    "doi": "10.1016/j.biomaterials.2026.124322",
    "preprint_id": "",
    "authors": "Cheng Z; Ning M; Zhu Y; Tian R; Jia F; Chen H",
    "assignee": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-24",
    "window_start": "2026-05-23T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 7,
    "score": 0,
    "id": "pubmed:42176930",
    "canonical_key": "pmid:42176930",
    "headline": "Mitochondrial metabolism and succinylation-related gene signatures for predicting prognosis and drug resistance in colon adenocarcinoma.",
    "summary": "Clinica chimica acta; international journal of clinical chemistry. Clin Chim Acta. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176930/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinica chimica acta; international journal of clinical chemistry",
    "pmid": "42176930",
    "doi": "10.1016/j.cca.2026.121113",
    "preprint_id": "",
    "authors": "Wei X; Qiu Z; Dong J; Liu J; Hong T; Yang J",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-24",
    "window_start": "2026-05-23T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 8,
    "score": 0,
    "id": "pubmed:42174699",
    "canonical_key": "pmid:42174699",
    "headline": "Multi-omics analysis reveals that Danggui Buxue decoction ameliorates benzene-induced blood deficiency syndrome via the restoration of hematopoietic lineage and remodeling of the immune microenvironment.",
    "summary": "Chinese medicine. Chin Med. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174699/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Chinese medicine",
    "pmid": "42174699",
    "doi": "10.1186/s13020-026-01365-5",
    "preprint_id": "",
    "authors": "Liu H; Ren J; Hu Y; Yang Y; Sun H; Fang H; Yan G; Han Y; Wang X",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-24",
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    "source_type": "papers",
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    "rank_index": 9,
    "score": 0,
    "id": "pubmed:42176866",
    "canonical_key": "pmid:42176866",
    "headline": "Radiation dose-dependent skin toxicity and therapeutic advantage of FLASH radiotherapy via immune modulation.",
    "summary": "International journal of radiation oncology, biology, physics. Int J Radiat Oncol Biol Phys. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42176866/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "International journal of radiation oncology, biology, physics",
    "pmid": "42176866",
    "doi": "10.1016/j.ijrobp.2026.05.015",
    "preprint_id": "",
    "authors": "Paillas S; Then CK; Suárez-Bonnet A; Priestnall SL; Kumaran G; Ruan JL; Tullis IDC; Olcina MM; Bottomley MJ; Petersson K",
    "assignee": "",
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    "score": 0,
    "id": "pubmed:42174527",
    "canonical_key": "pmid:42174527",
    "headline": "Risk factors for ocular complications in HIV/AIDS patients: a retrospective analysis of ophthalmology consultations in a tertiary hospital in Central China.",
    "summary": "BMC ophthalmology. BMC Ophthalmol. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174527/",
    "source": "PubMed",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "BMC ophthalmology",
    "pmid": "42174527",
    "doi": "10.1186/s12886-026-04916-4",
    "preprint_id": "",
    "authors": "Zhang R; Zheng T; Chen X; Yang L; Zeng W; Ke M",
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    "rank_index": 11,
    "score": 0,
    "id": "pubmed:42174674",
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    "headline": "Single-cell transcriptomic mapping of immune heterogeneity across angioimmunoblastic T-cell lymphoma subtypes.",
    "summary": "Biomarker research. Biomark Res. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42174674/",
    "source": "PubMed",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Biomarker research",
    "pmid": "42174674",
    "doi": "10.1186/s40364-026-00931-1",
    "preprint_id": "",
    "authors": "Liu H; Tong Y; Wu M; Zhang Z; Yao Y; Li Z; Shi Y; Yu Z; An G; Qiu L; Yang Y; Yang H; Zou D; Yuan J",
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    "rank_index": 12,
    "score": 0,
    "id": "pubmed:42175453",
    "canonical_key": "pmid:42175453",
    "headline": "Study on the expression characteristics of CA125 in patients with SLE and its correlation with clinical indicators.",
    "summary": "Medicine. Medicine (Baltimore). 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42175453/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Medicine",
    "pmid": "42175453",
    "doi": "10.1097/MD.0000000000048959",
    "preprint_id": "",
    "authors": "Xu S; Guo X; Lu T; Zhang C",
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    "headline": "A Geographic Disparities Analysis Between Standard of Care and Clinical Trial CAR-T Patients in Kansas.",
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    "headline": "A hybrid multiscale model for predicting CAR-T therapy outcomes in solid tumors.",
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    "rank_index": 2,
    "score": 0,
    "id": "pubmed:42178626",
    "canonical_key": "pmid:42178626",
    "headline": "[Elucidation of Natural Killer (NK) Cell Evasion Mechanisms in Colorectal Carcinogenesis Using Single-Cell RNA Sequencing and Spatial Gene Expression Analysis].",
    "summary": "Gan to kagaku ryoho. Cancer & chemotherapy. Gan To Kagaku Ryoho",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178626/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Gan to kagaku ryoho. Cancer & chemotherapy",
    "pmid": "42178626",
    "doi": "",
    "preprint_id": "",
    "authors": "Mimori K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 3,
    "score": 0,
    "id": "pubmed:42161652",
    "canonical_key": "pmid:42161652",
    "headline": "[Research advances in the value of tertiary lymphoid structures for gastrointestinal tumors during the immunotherapy era].",
    "summary": "Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery. Zhonghua Wei Chang Wai Ke Za Zhi. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42161652/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery",
    "pmid": "42161652",
    "doi": "10.3760/cma.j.cn441530-20250912-000335",
    "preprint_id": "",
    "authors": "Sun YW; Ai SC; Shen XF; Guan WX",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 4,
    "score": 0,
    "id": "pubmed:42178625",
    "canonical_key": "pmid:42178625",
    "headline": "[The Current Landscape of Clinical Implementation of Whole Genome Sequencing].",
    "summary": "Gan to kagaku ryoho. Cancer & chemotherapy. Gan To Kagaku Ryoho",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178625/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Gan to kagaku ryoho. Cancer & chemotherapy",
    "pmid": "42178625",
    "doi": "",
    "preprint_id": "",
    "authors": "Fujii H; Sunami K; Kohno T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 5,
    "score": 0,
    "id": "pubmed:42178939",
    "canonical_key": "pmid:42178939",
    "headline": "Microbial-Semiconductor Hybrids Enable Near Infrared-Driven Photosynthetic Hydrogen Production for Tumor-Targeted Immunotherapy.",
    "summary": "Advanced materials (Deerfield Beach, Fla.). Adv Mater. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178939/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Advanced materials (Deerfield Beach, Fla.)",
    "pmid": "42178939",
    "doi": "10.1002/adma.73476",
    "preprint_id": "",
    "authors": "Xue R; Yu C; Wang T; Yang Y; Wang S; Zhu Y; Jin W; Hu T; Tan C; Liang R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 6,
    "score": 0,
    "id": "pubmed:42178273",
    "canonical_key": "pmid:42178273",
    "headline": "Mosunetuzumab for relapsed follicular lymphoma presenting with chylothorax: A case report and literature review.",
    "summary": "Journal of clinical and experimental hematopathology : JCEH. J Clin Exp Hematop. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178273/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of clinical and experimental hematopathology : JCEH",
    "pmid": "42178273",
    "doi": "10.3960/jslrt.26025",
    "preprint_id": "",
    "authors": "Naganuma K; Hirata K; Arai Y; Tezuka S; Matsunaga T; Kawada T; Sakata N; Takahashi Y; Yamashita T; Momose S; Higashi M; Tabayashi T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 7,
    "score": 0,
    "id": "pubmed:42178747",
    "canonical_key": "pmid:42178747",
    "headline": "Neoplasm Adverse Events Associated With Anti-Type 2 Biologics: An FAERS Database Pharmacovigilance Analysis Study.",
    "summary": "Cancer medicine. Cancer Med",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178747/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer medicine",
    "pmid": "42178747",
    "doi": "10.1002/cam4.71979",
    "preprint_id": "",
    "authors": "Lyu W; Xu R; Chen L; Lei W; Chen C; Liao J; Lin X; Ma R; Wen W; Li H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 8,
    "score": 0,
    "id": "pubmed:42124500",
    "canonical_key": "pmid:42124500",
    "headline": "Oral antibiotics promote triple-negative breast cancer progression by inducing gut microbiota dysbiosis and taurocholic acid accumulation.",
    "summary": "Acta biochimica et biophysica Sinica. Acta Biochim Biophys Sin (Shanghai). 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42124500/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Acta biochimica et biophysica Sinica",
    "pmid": "42124500",
    "doi": "10.3724/abbs.2026059",
    "preprint_id": "",
    "authors": "Wen Y; Ye P; Shao L; Li Q; Dong C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 9,
    "score": 0,
    "id": "pubmed:42178397",
    "canonical_key": "pmid:42178397",
    "headline": "Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication.",
    "summary": "Acta pharmacologica Sinica. Acta Pharmacol Sin. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178397/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Acta pharmacologica Sinica",
    "pmid": "42178397",
    "doi": "10.1038/s41401-026-01829-2",
    "preprint_id": "",
    "authors": "Chen JH; Li HH; Chen CX; Yan CX; Liang XM; Guo C; Han Y; Tang YH; Liu Y; Cai J; Lin Y; Liang JK; Hu J; Yan GM; Li JJ; Zhu WB",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 10,
    "score": 0,
    "id": "pubmed:42178576",
    "canonical_key": "pmid:42178576",
    "headline": "Streptococcus intermedius cerebellar abscess as first presentation of sarcoidosis: a case report.",
    "summary": "Journal of medical case reports. J Med Case Rep. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178576/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of medical case reports",
    "pmid": "42178576",
    "doi": "10.1186/s13256-026-06095-8",
    "preprint_id": "",
    "authors": "Al-Ahmadi A; Pinchuk A; Stein KP; Neyazi B; Zautner AE; Kaasch AJ; Sandalcioglu IE; Rashidi A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 11,
    "score": 0,
    "id": "pubmed:42178533",
    "canonical_key": "pmid:42178533",
    "headline": "Targeting EpCAM expression via near-infrared fluorescent antibodies enables microscopic delineation of primary and recurrent HNSCC.",
    "summary": "BMC cancer. BMC Cancer. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178533/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "BMC cancer",
    "pmid": "42178533",
    "doi": "10.1186/s12885-026-16172-2",
    "preprint_id": "",
    "authors": "Uhl B; Eggert D; Smiljanov B; von Thun Und Hohenstein K; Walz C; Kranz G; Schwenk-Zieger S; Haring F; Luft J; Song J; Holtmann V; Baumeister P; Reichel CA; Gires O; Canis M; Betz C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 12,
    "score": 0,
    "id": "pubmed:42179066",
    "canonical_key": "pmid:42179066",
    "headline": "Utility of combined CD39/CD73/CD38 expression for the detection of malignant T cells in Sézary syndrome.",
    "summary": "British journal of haematology. Br J Haematol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42179066/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "British journal of haematology",
    "pmid": "42179066",
    "doi": "10.1111/bjh.70562",
    "preprint_id": "",
    "authors": "Marchisio S; Yakymiv Y; Lin L; Ortolan E; Pullano V; Ponti R; de Bie FJ; van der Sluijs-Gelling AJ; Zoutman WH; Pala V; Scheeren FA; Vermeer MH; Funaro A; Quaglino P; Roccuzzo G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 13,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726749",
    "canonical_key": "doi:10.64898/2026.05.21.726749",
    "headline": "A fusion Cell-Permeable C16orf74 Peptide Selectively Disrupts Calcineurin-NFAT Interaction and Inhibits T-cell Activation Without Cytotoxicity",
    "summary": "Calcineurin (Cn) is a protein phosphatase that initiates T cell activation by dephosphorylating the transcription factor NFAT, driving its nuclear translocation and the transcription of immune-related genes.",
    "url": "https://doi.org/10.64898/2026.05.21.726749",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726749",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726749",
    "authors": "Cohen, A.; Gabay, M.; Gupta, S.; Sova, M.; Bar, D. Z.; Tubiana, J.; Gal, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 14,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.24.727544",
    "canonical_key": "doi:10.64898/2026.05.24.727544",
    "headline": "A Moonlighting Function of Kinetochore Complex Proteins in Golgi Assembly of Neural Stem Cells",
    "summary": "Kinetochores play an essential role in mitosis, and human kinetochore variants are associated with microcephaly. However, their functions in quiescent/interphase cells are unknown.",
    "url": "https://doi.org/10.64898/2026.05.24.727544",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.24.727544",
    "preprint_id": "biorxiv:10.64898/2026.05.24.727544",
    "authors": "Gujar, M.; Aung, H. Y.; Gao, Y.; Ma, D.; Suresh, D.; Lin, J.; Teng, X.; Toyama, Y.; Yu, F.; Wang, H.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 15,
    "score": 0,
    "id": "pubmed:42177914",
    "canonical_key": "pmid:42177914",
    "headline": "A novel adaptor protein, ARAP, orchestrates Fcγ receptor signaling in mouse dendritic cells via Rap1 activation and NF-κB-mediated cytokine production.",
    "summary": "Immunology and cell biology. Immunol Cell Biol. 2026-05-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177914/",
    "source": "PubMed",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Immunology and cell biology",
    "pmid": "42177914",
    "doi": "10.1111/imcb.70133",
    "preprint_id": "",
    "authors": "Park C; Yu MJ; Lee JR",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 16,
    "score": 0,
    "id": "pubmed:42177720",
    "canonical_key": "pmid:42177720",
    "headline": "A prognostic exosome-related mRNAs risk signature correlates with the immune microenvironment in breast cancer.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177720/",
    "source": "PubMed",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42177720",
    "doi": "10.1007/s12672-026-05261-0",
    "preprint_id": "",
    "authors": "Su D; Peng B; Peng W; Bai N; Chen Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 0,
    "id": "pubmed:42177747",
    "canonical_key": "pmid:42177747",
    "headline": "Angiogenic T cells and cognitive function in older adults with type 2 diabetes treated with GLP-1 receptor agonists.",
    "summary": "Aging clinical and experimental research. Aging Clin Exp Res. 2026-05-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42177747/",
    "source": "PubMed",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Aging clinical and experimental research",
    "pmid": "42177747",
    "doi": "10.1007/s40520-026-03417-0",
    "preprint_id": "",
    "authors": "Longo M; Caruso P; Auriemma MC; Maio A; Di Meo I; Scappaticcio L; Maiorino MI; Bellastella G; Rizzo MR; Paolisso G; Esposito K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 18,
    "score": 0,
    "id": "biorxiv:10.1101/2025.10.04.680446",
    "canonical_key": "doi:10.1101/2025.10.04.680446",
    "headline": "Ca2+ signature-dependent control of auxin sensitivity in Arabidopsis",
    "summary": "Plants must continually balance growth with arrest, especially under stress. Auxin signaling acts as a central regulatory hub in this process, yet the mechanisms that dynamically tune auxin sensitivity in real time remain unknown.",
    "url": "https://doi.org/10.1101/2025.10.04.680446",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.10.04.680446",
    "preprint_id": "biorxiv:10.1101/2025.10.04.680446",
    "authors": "Song, H.; Baudon, A.; Freund, M.; Randuch, M.; Pencik, A.; Ondrej, N.; He, Z.; Kaufmann, K.; Gilliham, M.; Friml, J.; Hedrich, R.; Huang, S.; Li, N.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; plant biology"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 0,
    "id": "biorxiv:10.1101/2024.09.19.609743",
    "canonical_key": "doi:10.1101/2024.09.19.609743",
    "headline": "FcγR- and CD9-dependent synapse engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage",
    "summary": "Various states of microglia appear in neuroinflammation, but their impact on brain function and behavior is not fully understood. Here we report that synapse engulfing microglia in the thalamus are crucial for cognitive impairment after cortical brain injury.",
    "url": "https://doi.org/10.1101/2024.09.19.609743",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2024.09.19.609743",
    "preprint_id": "biorxiv:10.1101/2024.09.19.609743",
    "authors": "Matoba, K.; Kochi, T.; Mreyoud, Y. R.; Badrani, J. H.; Patel, H.; Tsujioka, H.; Yamashita, T.; Crossman, D. K.; Niwa, M.; Kano, S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 0,
    "id": "pubmed:42178870",
    "canonical_key": "pmid:42178870",
    "headline": "From Cold to Hot: Nanozyme-Based Strategies for Reprogramming the Tumour Immunoenvironment.",
    "summary": "Cell proliferation. Cell Prolif. 2026-05-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178870/",
    "source": "PubMed",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cell proliferation",
    "pmid": "42178870",
    "doi": "10.1111/cpr.70235",
    "preprint_id": "",
    "authors": "Wang Y; Xu M; Wang Y; Lin X; Zhang Q; Lin X; Wu X; Zhang C; Huang W; Shen J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 21,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.17.26353417",
    "canonical_key": "doi:10.64898/2026.05.17.26353417",
    "headline": "Identification of amino acid metabolism-related biomarkers in liver fibrosis: a transcriptomic analysis with experimental validation",
    "summary": "Background Liver fibrosis (LF) represents a pivotal pathological phase in the advancement of chronic liver disorders toward cirrhosis. Amino acid metabolism reprogramming plays a pivotal role in its pathogenesis, yet the underlying molecular mechanisms remain incompletely understood.",
    "url": "https://doi.org/10.64898/2026.05.17.26353417",
    "source": "medRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.17.26353417",
    "preprint_id": "medrxiv:10.64898/2026.05.17.26353417",
    "authors": "Liu, Z.; Liu, X.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; gastroenterology"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 22,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.17.26352909",
    "canonical_key": "doi:10.64898/2026.05.17.26352909",
    "headline": "Macrophage spatial polarity to T cells predicts prognosis in young women with luminal breast cancer",
    "summary": "Purpose: The prognostic role of tumor-infiltrating lymphocytes in luminal breast cancer remains uncertain, partly because density-based metrics do not capture spatial interactions between immune cell subsets. We developed a density-independent spatial metric quantifying macrophage-T cell proximity and assessed its prognostic value.",
    "url": "https://doi.org/10.64898/2026.05.17.26352909",
    "source": "medRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.17.26352909",
    "preprint_id": "medrxiv:10.64898/2026.05.17.26352909",
    "authors": "Mezheyeuski, A.; Serna, G.; Martin-Bernabe, A.; Hekmati, N.; Zerdes, I.; Denes, A.; Fredholm, H.; Mauchanski, S.; Guardia, X.; Alonso, L.; De Mey, L.; Lahoutte, T.; Keyaerts, M.; Lindblad, J.; Sladoje, N.; Warnberg, F.; Sund, M.; Rask, G.; Wadsten, C.; Ponten, F.; Micke, P.; Fredriksson, I.; Nuciforo, P.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; oncology"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 23,
    "score": 0,
    "id": "pubmed:42178546",
    "canonical_key": "pmid:42178546",
    "headline": "NUDT1 drives osteosarcoma progression and serves as a robust predictor of clinical outcomes.",
    "summary": "Cancer cell international. Cancer Cell Int. 2026-05-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178546/",
    "source": "PubMed",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer cell international",
    "pmid": "42178546",
    "doi": "10.1186/s12935-026-04347-7",
    "preprint_id": "",
    "authors": "Zhang Z; Wan L; Ai K; Liu J; Tang X; Duan Z; Chen R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 24,
    "score": 0,
    "id": "europepmc:PPR1237592",
    "canonical_key": "doi:10.64898/2026.05.21.725073",
    "headline": "p63 and PITX1 sustain a pre-invasive malignant keratinocyte population in squamous cell carcinoma precursors",
    "summary": "Staeger R, Tastanova A, Ghosh A, Gueguen P, Kolm I, Ramelyte E, Lattmann E, Haunerdinger V, Karakaya T, Slaufova M, Di Filippo M, Beer H, Levesque M, Dummer R.",
    "url": "https://doi.org/10.64898/2026.05.21.725073",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.21.725073",
    "preprint_id": "",
    "authors": "Staeger R;  Tastanova A;  Ghosh A;  Gueguen P;  Kolm I;  Ramelyte E;  Lattmann E;  Haunerdinger V;  Karakaya T;  Slaufova M;  Di Filippo M;  Beer H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.21.26353795",
    "canonical_key": "doi:10.64898/2026.05.21.26353795",
    "headline": "Patient and caregiver lived experiences and mental health service engagement during first-episode psychosis in Uganda: a longitudinal mixed-methods study protocol",
    "summary": "Introduction: Engagement with mental health services (MHCS) during the first episode of psychosis (FEP) is critical for symptom control, quality of life, and relapse prevention. However, disengagement rates remain high in Uganda with severe consequences for patients and caregivers.",
    "url": "https://doi.org/10.64898/2026.05.21.26353795",
    "source": "medRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.26353795",
    "preprint_id": "medrxiv:10.64898/2026.05.21.26353795",
    "authors": "Oroma, P.; SSEMATA, A. S.; Ssembajjwe, W.; Auma, R.; Balinga, S.; Aujo, B. T.; Kaddu, A. K.; Ampiire, M.; Muhwezi, W.; Mwesiga, E. K.; Nakimuli-Mpungu, E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; psychiatry and clinical psychology"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 0,
    "id": "biorxiv:10.64898/2026.04.10.717694",
    "canonical_key": "doi:10.64898/2026.04.10.717694",
    "headline": "Photon-Resolved Excitation-Denoised (PRED) Three-Photon Imaging Improves Detection of Neuronal Activity in Awake and Behaving Mice",
    "summary": "Three-photon microscopy (3PM) has enabled the optical access of neurons ~500-1500 micron below the brain surface but has been limited to slow imaging frame rates or small total imaged areas by competing constraints: a high peak power requirement for nonlinear excitation, and the need to limit total average power.",
    "url": "https://doi.org/10.64898/2026.04.10.717694",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.04.10.717694",
    "preprint_id": "biorxiv:10.64898/2026.04.10.717694",
    "authors": "Losonczy, A.; Mihaila, T. S.; Kong, E.; Negrean, A.; Geiller, T.; Peterka, D. S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 27,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727149",
    "canonical_key": "doi:10.64898/2026.05.22.727149",
    "headline": "Predicting cellular functions of human phosphosites",
    "summary": "Protein phosphorylation is a regulatory switch that controls essentially all cellular processes, including metabolism, cell cycle progression, and DNA repair.",
    "url": "https://doi.org/10.64898/2026.05.22.727149",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727149",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727149",
    "authors": "van Gerwen, J.; Gallagher, D.; Sala, I.; Jänes, J.; Ogata, K.; Corn, J. E.; Beltrao, P.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; genomics"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 28,
    "score": 0,
    "id": "pubmed:42178414",
    "canonical_key": "pmid:42178414",
    "headline": "Role of the Wnt5A pathway in resistance to immune checkpoint inhibitors in advanced Non-Small Cell Lung Cancer.",
    "summary": "Cancer immunology, immunotherapy : CII. Cancer Immunol Immunother. 2026-05-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178414/",
    "source": "PubMed",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer immunology, immunotherapy : CII",
    "pmid": "42178414",
    "doi": "10.1007/s00262-026-04437-5",
    "preprint_id": "",
    "authors": "Takam Kamga P; Costantini A; Capron C; Glorion M; Julie C; Emile JF; Giroux-Leprieur É",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 29,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727179",
    "canonical_key": "doi:10.64898/2026.05.22.727179",
    "headline": "SAD-dependent thylakoid lipid desaturation and FDX5-associated electron transfer during copper deficiency in Chlamydomonas reinhardtii",
    "summary": "Photosynthetic membranes undergo structural remodeling in response to environmental stress by altering fatty acid composition and desaturation levels. These changes, mediated by fatty acid desaturases (FADs), are essential for maintaining photosynthetic performance and adaptation.",
    "url": "https://doi.org/10.64898/2026.05.22.727179",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727179",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727179",
    "authors": "Warakanont, J.; Schmollinger, S.; Purvine, S. O.; Nicora, C. D.; Benning, C.; Strenkert, D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; biochemistry"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 30,
    "score": 0,
    "id": "biorxiv:10.64898/2026.02.28.708160",
    "canonical_key": "doi:10.64898/2026.02.28.708160",
    "headline": "scDynOmics: An Optimized Transformer Model for Representation Learning from Single-Cell Multiomics",
    "summary": "As foundation models have become increasingly prevalent in several fields for multiple purposes, pretraining models with single-cell transcriptomic data has gained significant interest.",
    "url": "https://doi.org/10.64898/2026.02.28.708160",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.02.28.708160",
    "preprint_id": "biorxiv:10.64898/2026.02.28.708160",
    "authors": "Yu, G.; Ramnarine, T. J. S.; Klughammer, J.; Mages, S. W.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 31,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726207",
    "canonical_key": "doi:10.64898/2026.05.21.726207",
    "headline": "Snhg26 long non-coding RNA regulates pluripotent cell states through a SINEB2-derived sequence",
    "summary": "Long-non coding RNAs (lncRNAs) are now well established players in gene expression regulation, but their detailed molecular mechanisms of action and underlying regulating sequences remain poorly understood.",
    "url": "https://doi.org/10.64898/2026.05.21.726207",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726207",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726207",
    "authors": "Fort, V.; Khelifi, G.; Hussein, S. M. I.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 32,
    "score": 0,
    "id": "pubmed:42178725",
    "canonical_key": "pmid:42178725",
    "headline": "Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.",
    "summary": "Gut microbes. Gut Microbes. 2026-05-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178725/",
    "source": "PubMed",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Gut microbes",
    "pmid": "42178725",
    "doi": "10.1080/19490976.2026.2675089",
    "preprint_id": "",
    "authors": "Szurek EA; Ngo VL; Abo H; Cebula A; Chassaing B; Howard RA; Hart M; Hori S; Weaver CT; Gewirtz AT; Ignatowicz L; Denning TL; Kuczma MP",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-25",
    "window_start": "2026-05-24T05:15:00.000Z",
    "window_end": "2026-05-25T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 33,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.726983",
    "canonical_key": "doi:10.64898/2026.05.22.726983",
    "headline": "Spatial Regulation of CAR Signaling Enables Logic-Gated Activity",
    "summary": "Chimeric antigen receptors (CARs) can induce T cells to kill cancer cells but also to kill normal cells that express the same antigens. Designing CARs to recognize combinations of antigens, via Boolean logic, can simultaneously expand the scope of targetable antigens and make CAR T cells more specific to cancer.",
    "url": "https://doi.org/10.64898/2026.05.22.726983",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.726983",
    "preprint_id": "biorxiv:10.64898/2026.05.22.726983",
    "authors": "Nichakawade, T. D.; Mog, B.; Pearlman, A. D.; Ahmedna, T. S.; Marcou, N.; Mora-Cartin, R.; Watson, E.; Seok Lee, B.; DiNapoli, S. R.; Papadopoulos, N.; Bettegowda, C.; Dal Molin, M.; Wirtz, D.; Pardoll, D. M.; Paul, S.; Sur, S.; Gabrielson, K. L.; Zhou, S.; Vogelstein, B.; Kinzler, K. W.",
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    "company_name": "",
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    "primary_source": "bioRxiv",
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    "headline": "The combination of EWSR1-FLI1 and loss of one EWSR1 allele leads to the induction of trisomy 8",
    "summary": "Ewing sarcoma is a pediatric cancer that develops in skeletal elements. The majority of Ewing sarcoma patients carry the aberrant EWSR1-FLI1 fusion gene. Despite trisomy 8 being an additional common aberration associated with a poor prognosis for patients, its induction mechanism remains unknown.",
    "url": "https://doi.org/10.64898/2026.05.21.726567",
    "source": "bioRxiv",
    "published_date": "2026-05-24",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726567",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726567",
    "authors": "Hapugaswatta, H.; Parrales, A.; Park, H.; Kim, H.; Iwakuma, T.; Azuma, M.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "bioRxiv",
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    "keywords": "biorxiv; cancer biology"
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    "id": "pubmed:42178190",
    "canonical_key": "pmid:42178190",
    "headline": "Tuning PI3K: striking the right balance for optimal CD8 T-cell responses.",
    "summary": "Journal of immunology (Baltimore, Md. : 1950). J Immunol. 2026-05-14",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178190/",
    "source": "PubMed",
    "published_date": "2026-05-14",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of immunology (Baltimore, Md. : 1950)",
    "pmid": "42178190",
    "doi": "10.1093/jimmun/vkaf296",
    "preprint_id": "",
    "authors": "Cannons JL; Pichler AC; Schwartzberg PL",
    "assignee": "",
    "publication_number": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "score": 0,
    "id": "pubmed:42178281",
    "canonical_key": "pmid:42178281",
    "headline": "Screening and structural characterization of a nanobody targeting a thermostable green fluorescent protein.",
    "summary": "Acta biochimica et biophysica Sinica. Acta Biochim Biophys Sin (Shanghai). 2026-04-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178281/",
    "source": "PubMed",
    "published_date": "2026-04-23",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Acta biochimica et biophysica Sinica",
    "pmid": "42178281",
    "doi": "10.3724/abbs.2025256",
    "preprint_id": "",
    "authors": "Li Y; Gu W; Ni A; Li D; Li T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-25",
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    "rank_index": 37,
    "score": 0,
    "id": "pubmed:42178729",
    "canonical_key": "pmid:42178729",
    "headline": "Impaired IL-35/Treg Axis Facilitates Neuropathic Pain Via TNF-α, TLR4, and HMGB1 Activation.",
    "summary": "Immunity, inflammation and disease. Immun Inflamm Dis",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178729/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "Downranked for Non-therapeutic broad immunology: inflammation",
    "journal": "Immunity, inflammation and disease",
    "pmid": "42178729",
    "doi": "10.1002/iid3.70416",
    "preprint_id": "",
    "authors": "You P; Shen L; Huang Z; Yuan C; Wei C; Lin S; Wang B; Chen Y",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-25",
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    "rank_index": 38,
    "score": 0,
    "id": "pubmed:42178054",
    "canonical_key": "pmid:42178054",
    "headline": "Chronic low-grade hippocampal inflammation blunts exercise-induced neurogenesis and alters the exercise-induced microglia transcriptome in the rat hippocampus.",
    "summary": "Brain, behavior, and immunity. Brain Behav Immun. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178054/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "Downranked for Non-therapeutic broad immunology: inflammation",
    "journal": "Brain, behavior, and immunity",
    "pmid": "42178054",
    "doi": "10.1016/j.bbi.2026.106815",
    "preprint_id": "",
    "authors": "Nicolas S; Caruso MG; Dohm-Hansen S; Foley T; Lucassen PJ; Mul JD; Lavelle A; English JE; O'Leary OF; Nolan YM",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "id": "pubmed:42178058",
    "canonical_key": "pmid:42178058",
    "headline": "Impact of ASTCT toxicity grading system on outcomes after CAR-T for mature B-cell malignancies.",
    "summary": "Transplantation and cellular therapy. Transplant Cell Ther. 2026-05-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42178058/",
    "source": "PubMed",
    "published_date": "2026-05-23",
    "match_reason": "Downranked for Generic T cell biology without antigen specificity: car-t",
    "journal": "Transplantation and cellular therapy",
    "pmid": "42178058",
    "doi": "10.1016/j.jtct.2026.05.032",
    "preprint_id": "",
    "authors": "Gomez-Llobell M; Serrat SE; Bromberg M; Seshan V; Devlin S; Einarsdottir S; Valid OB; Golan-Aceb N; Marcus R; Simoni A; Beyar-Katz O; Perek S; Wahad AAA; Corona M; Rejeski K; Raj SS; Dahi P; Scordo M; Shah G; Palomba ML; Salles G; Park JH; Shouval R; Avigdor A; Sanz J; Perales MA",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
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    "source_type": "papers",
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    "rank_index": 1,
    "score": 57,
    "id": "pubmed:42181250",
    "canonical_key": "pmid:42181250",
    "headline": "Kinase inhibition rewires the HLA-I immunopeptidome in chronic myeloid leukemia.",
    "summary": "iScience paper showing kinase inhibition rewires the HLA-I immunopeptidome in chronic myeloid leukemia; relevant to pMHC ligand discovery and therapy-induced antigen presentation changes.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42181250/",
    "source": "PubMed",
    "published_date": "2026-04-30",
    "match_reason": "Immunopeptidomics and HLA ligand discovery: immunopeptidome | Low-specificity pMHC/TCR field anchor: hla",
    "journal": "iScience",
    "pmid": "42181250",
    "doi": "10.1016/j.isci.2026.115944",
    "preprint_id": "",
    "authors": "Venafra V; Wahle M; Massacci G; Bica V; Chiusolo P; Mougiakakos D; Boettcher M; Fischer T; Perfetto L; Mann M; Sacco F",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
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    "source_type": "papers",
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    "rank_index": 2,
    "score": 54,
    "id": "pubmed:42184246",
    "canonical_key": "pmid:42184246",
    "headline": "The Landscape of Clinical Trials for TCR-T Cell Therapy.",
    "summary": "Clinical oncology review of the current TCR-T cell therapy trial landscape; useful therapeutic-modality context rather than a new single trial readout.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184246/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "TCR-T and adoptive TCR therapy: tcr-t | Low-specificity pMHC/TCR field anchor: tcr | Watchlist hits: TCR-T",
    "journal": "American journal of clinical oncology",
    "pmid": "42184246",
    "doi": "10.1097/COC.0000000000001335",
    "preprint_id": "",
    "authors": "Fan X; Yu T; Liao Q; Song Y; Liu G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
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    "source_type": "papers",
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    "score": 18,
    "id": "pubmed:42184607",
    "canonical_key": "pmid:42184607",
    "headline": "Efficacy of bispecific T-cell engagers after CAR T-cell therapy failure in aggressive large B-cell lymphoma.",
    "summary": "Current research in translational medicine. Curr Res Transl Med. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184607/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Generic T-cell engager modality: t-cell engagers",
    "journal": "Current research in translational medicine",
    "pmid": "42184607",
    "doi": "10.1016/j.retram.2026.103590",
    "preprint_id": "",
    "authors": "Kharfan-Dabaja MA; Reljic T; Abdel-Razeq S; Sarhan Z; Mohty R; Keller K; Iqbal M; Chavez JC; Luo Y; Qin H; Aljurf M; Kumar A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 2,
    "score": 9,
    "id": "biorxiv:10.64898/2026.05.21.726907",
    "canonical_key": "doi:10.64898/2026.05.21.726907",
    "headline": "The in vivo inhibitory function of the MHC-I alpha3 domain/CD8alpha interaction",
    "summary": "The interaction between the Major Histocompatibility Complex Class I (MHC-I) alpha3 domain and CD8alpha; has classically been viewed as a positive coreceptor interaction that stabilizes TCR signaling during antigen recognition. However, its physiological function in mature peripheral CD8+ T cells in vivo remains incompletely understood.",
    "url": "https://doi.org/10.64898/2026.05.21.726907",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc, tcr, major histocompatibility",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726907",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726907",
    "authors": "Zhao, J.; Feng, L.; Xu, Y.; Alsbei, K.; Wang, J.; Zhou, T.; Zhan, Q.; Sun, S.; Hong, E.; Meng, L.; Jin, N.; Cheng, X.; Wen, H.; Xin, G.; Rubinstein, M.; Huang, S.; Li, Z.; Han, X.; Zheng, L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
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    "keywords": "biorxiv; immunology"
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 3,
    "score": 9,
    "id": "pubmed:42182166",
    "canonical_key": "pmid:42182166",
    "headline": "TMEM119+ microglia MHC class I restricted antigen presentation impacts CD8 T cell memory, effector status, and blood-brain barrier disruption during neurotropic virus infection.",
    "summary": "bioRxiv : the preprint server for biology. bioRxiv. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42182166/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc, antigen presentation",
    "journal": "bioRxiv : the preprint server for biology",
    "pmid": "42182166",
    "doi": "10.64898/2026.05.08.722741",
    "preprint_id": "",
    "authors": "Seady M; Maynes MA; Thelwell JS; Jin F; Hansen MJ; Jensen HE; Witter RK; Owens CA; Hassani A; Lewis CL; Forston MD; Johnson AJ",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 4,
    "score": 9,
    "id": "pubmed:42183379",
    "canonical_key": "pmid:42183379",
    "headline": "Astrocytic but not Microglial Antigen Presentation Shapes Protective Immunity to Toxoplasma gondii in the Brain.",
    "summary": "Research square. Res Sq. 2026-05-11",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183379/",
    "source": "PubMed",
    "published_date": "2026-05-11",
    "match_reason": "Low-specificity pMHC/TCR field anchor: antigen presentation",
    "journal": "Research square",
    "pmid": "42183379",
    "doi": "10.21203/rs.3.rs-9544619/v1",
    "preprint_id": "",
    "authors": "Labuzan SA; Schuster AE; Kovacs MA; Cowan MN; Lawson MJ; Babcock IW; Sibley LA; Kelly AG; Marchildon AE; Harris TH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 5,
    "score": 9,
    "id": "pubmed:42180970",
    "canonical_key": "pmid:42180970",
    "headline": "Characterizing immune heterogeneity in gastric cancer by high-throughput T-cell receptor sequencing: predictive clonotypes and functional signatures.",
    "summary": "Translational cancer research. Transl Cancer Res. 2026-04-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42180970/",
    "source": "PubMed",
    "published_date": "2026-04-28",
    "match_reason": "Low-specificity pMHC/TCR field anchor: t-cell receptor",
    "journal": "Translational cancer research",
    "pmid": "42180970",
    "doi": "10.21037/tcr-2026-0652",
    "preprint_id": "",
    "authors": "Liu T; Chen Z; Cheng G; Xu L; Gan L; Ye Z; Shen X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 6,
    "score": 9,
    "id": "pubmed:42185657",
    "canonical_key": "pmid:42185657",
    "headline": "HLA polymorphisms shape divergent outcomes of Toxoplasma and Plasmodium infection in Eastern Indian HbE/β-thalassemia cohort.",
    "summary": "Communications biology. Commun Biol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185657/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Communications biology",
    "pmid": "42185657",
    "doi": "10.1038/s42003-026-10222-y",
    "preprint_id": "",
    "authors": "Bhattacharya S; Rahaman M; Suman S; Rout DK; Mondal S; Purwar S; Dhingra B; Shukla PC; Mukherjee G; Gupta M; Guha D; Bhattacharya MK; Dolai TK; Chakravorty N; Mukherjee B",
    "assignee": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 7,
    "score": 9,
    "id": "pubmed:42183197",
    "canonical_key": "pmid:42183197",
    "headline": "Classical HLA class II associations with ALS in Kuwait reveal a DR7-DQ2.2 risk haplotype.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183197/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Frontiers in immunology",
    "pmid": "42183197",
    "doi": "10.3389/fimmu.2026.1820694",
    "preprint_id": "",
    "authors": "Dashti M; AlAbdulghafour F; AlMutairi O; Mohammad A; Malik MZ; AlRefaie K; Nizam R; Jacob S; Chalabi A; Al Khleifat A; Al-Mulla F",
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    "digest_date": "2026-05-26",
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    "source_type": "papers",
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    "rank_index": 8,
    "score": 9,
    "id": "pubmed:42183265",
    "canonical_key": "pmid:42183265",
    "headline": "Empowered pro-inflammatory features in Ly6C monocytes and altered antigen-presenting capacity in Ly6C(high) monocytes in diabetic mice.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183265/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Low-specificity pMHC/TCR field anchor: antigen-presenting",
    "journal": "Frontiers in immunology",
    "pmid": "42183265",
    "doi": "10.3389/fimmu.2026.1794704",
    "preprint_id": "",
    "authors": "Yang P; Fang P; Sun L; Liu L; Fu L; Xi H; Wang X; Bouchareb R; Zhang D; Wu Q; Ji Y; Yang X; Wang H",
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    "headline": "Distinct CD8(+) T cell types associated with COVID-19 severity in unvaccinated HLA-A2(+) patients.",
    "summary": "iScience. iScience. 2026-04-24",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42181242/",
    "source": "PubMed",
    "published_date": "2026-04-24",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "iScience",
    "pmid": "42181242",
    "doi": "10.1016/j.isci.2026.115880",
    "preprint_id": "",
    "authors": "Masuda K; Iketani S; Liu L; Huang J; Qiao Y; Shah J; McNairy ML; Groso C; Ricupero CL; Loffredo LF; Wang Q; Purpura L; Coelho-Dos-Reis JGA; Sheng Z; Yin MT; Tsuji M",
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    "canonical_key": "pmid:42183154",
    "headline": "Nanoparticle induction of antigen-presenting monocyte-derived dendritic cells relieves immunosuppression and inhibits metastasis.",
    "summary": "Cell biomaterials. Cell Biomater. 2026-04-21",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183154/",
    "source": "PubMed",
    "published_date": "2026-04-21",
    "match_reason": "Low-specificity pMHC/TCR field anchor: antigen-presenting",
    "journal": "Cell biomaterials",
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    "doi": "10.1016/j.celbio.2025.100343",
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    "id": "pubmed:42180855",
    "canonical_key": "pmid:42180855",
    "headline": "Clinical significance of circulating tumor DNA monitoring based on TP53 mutation in high-grade serous ovarian cancer patients.",
    "summary": "Translational cancer research. Transl Cancer Res. 2026-04-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42180855/",
    "source": "PubMed",
    "published_date": "2026-04-28",
    "match_reason": "Watchlist hits: TP53",
    "journal": "Translational cancer research",
    "pmid": "42180855",
    "doi": "10.21037/tcr-2026-1-0241",
    "preprint_id": "",
    "authors": "Jung H; Kang OJ; Lee YJ; Kang SW; Lee MS; Lee SW; Kim YM",
    "assignee": "",
    "publication_number": "",
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    "digest_date": "2026-05-26",
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    "canonical_key": "pmid:42180795",
    "headline": "Stakeholders Want a Menu of Choices: Findings from a Consultation Workshop on Improving Access to Secondary Prophylaxis of Rheumatic Fever and Rheumatic Heart Disease.",
    "summary": "Global heart. Glob Heart. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42180795/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Global heart",
    "pmid": "42180795",
    "doi": "10.5334/gh.1555",
    "preprint_id": "",
    "authors": "Hla TK; Enkel SL; Kado J; Eadie-Mirams E; Wyber R; Carapetis J; Manning L",
    "assignee": "",
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    "primary_source": "PubMed",
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    "canonical_key": "pmid:42186061",
    "headline": "Enhanced measures of neoantigenicity capture unique tumor-immune interactions across primary melanoma subtypes.",
    "summary": "Genome medicine. Genome Med. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186061/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Genome medicine",
    "pmid": "42186061",
    "doi": "10.1186/s13073-026-01673-3",
    "preprint_id": "",
    "authors": "Shteinman ER; Attrill GH; Maher NG; Gnana K; Addala V; Mao Y; Palendira U; Conway JW; Colebatch AJ; Waddell N; Hayward NK; Pearson JV; Long GV; Scolyer RA; Wilmott JS; Vergara IA",
    "assignee": "",
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    "primary_source": "PubMed",
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    "id": "biorxiv:10.64898/2026.05.21.726796",
    "canonical_key": "doi:10.64898/2026.05.21.726796",
    "headline": "Hydrogel confinement enables subcutaneous delivery of vesicant antibody-drug conjugates",
    "summary": "Antibody-drug conjugates (ADCs) deliver cytotoxic payloads to tumors with antibody selectivity, yet all approved ADCs are administered by intravenous (IV) infusion despite a strong patient and clinical preference for subcutaneous (SC) delivery.",
    "url": "https://doi.org/10.64898/2026.05.21.726796",
    "source": "bioRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726796",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726796",
    "authors": "Jacquot, G.; Hervy, C.; Belarouci, E.; Gasser, A.; Hoernel, C.; Traissard, O.; Gutierrez-Blanco, M.; Draussin, J.; Erb, S.; Brun, S.; Fellmann, L.; Mallard, J.; Hucteau, E.; Coliat, P.; Bernhard, S.; Tibbitt, M. W.; Combet, J.; Graff, J.; Antal, M. C.; Carvalho, A.; David, L.; Mirjolet, C.; CIANFERANI, S.; Lux, F.; Tillement, O.; Harlepp, S.; Grange, C.; Pivot, X.; Detappe, A.",
    "assignee": "",
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    "digest_date": "2026-05-26",
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    "id": "pubmed:42186763",
    "canonical_key": "pmid:42186763",
    "headline": "NK Cells Promote Macrophage Foam Cell Formation via TIGIT/CD155-Mediated Cholesterol Metabolism.",
    "summary": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology. FASEB J. 2026-05-31",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186763/",
    "source": "PubMed",
    "published_date": "2026-05-31",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
    "pmid": "42186763",
    "doi": "10.1096/fj.202601178R",
    "preprint_id": "",
    "authors": "Li J; Lian Z; Huang Q; Zhao C; Wang G; Shi J; Shao D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "digest_date": "2026-05-26",
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    "score": 0,
    "id": "pubmed:42186386",
    "canonical_key": "pmid:42186386",
    "headline": "CTLA-4 and TNFRSF1B genetic variants in clinicopathological aspects and outcome of cutaneous melanoma.",
    "summary": "Melanoma research. Melanoma Res. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186386/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Melanoma research",
    "pmid": "42186386",
    "doi": "10.1097/CMR.0000000000001108",
    "preprint_id": "",
    "authors": "Carron J; Ferreira AMC; Carvalho BF; Lourenço GJ; Lima CSP",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 0,
    "id": "pubmed:41779512",
    "canonical_key": "pmid:41779512",
    "headline": "A phase 1 trial of romidepsin, azacitidine, dexamethasone, and lenalidomide in relapsed or refractory T-cell lymphoma.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41779512/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41779512",
    "doi": "10.1182/bloodadvances.2025019186",
    "preprint_id": "",
    "authors": "Gordon MJ; Miljkovic MD; Milhon P; Lakhotia R; Melani C; Johnson K; Bryant B; Pittaluga S; Jaffe ES; Conlon K; Staudt LM; Wilson WH; Roschewski M; Ng S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 18,
    "score": 0,
    "id": "pubmed:42186691",
    "canonical_key": "pmid:42186691",
    "headline": "A single-institution demographic study of pathologically proven renal disease in kidney transplant recipients over the last 33 years.",
    "summary": "Journal of pathology and translational medicine. J Pathol Transl Med. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186691/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of pathology and translational medicine",
    "pmid": "42186691",
    "doi": "10.4132/jptm.2026.03.28",
    "preprint_id": "",
    "authors": "Noh H; Kim J; Choi YJ",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 19,
    "score": 0,
    "id": "pubmed:42185863",
    "canonical_key": "pmid:42185863",
    "headline": "Arecoline-induced EV-mediated ZNF582 hypermethylation drives IFIT1-PD-L1 immune evasion in oral squamous cell carcinoma.",
    "summary": "Clinical epigenetics. Clin Epigenetics. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185863/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinical epigenetics",
    "pmid": "42185863",
    "doi": "10.1186/s13148-026-02066-4",
    "preprint_id": "",
    "authors": "Ko HH; Peng HH; Chiang CP; Kao HF; Lin HY; Kuo MY; Cheng SJ",
    "assignee": "",
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    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 20,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.727628",
    "canonical_key": "doi:10.64898/2026.05.25.727628",
    "headline": "ATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo",
    "summary": "The DNA damage response kinase ATR restrains CDK1 activity during S and G2 phases of the cell cycle, confining CDK1-driven processes to mitosis. ATR kinase inhibitors were originally developed to potentiate chemotherapy-induced DNA damage at stalled replication forks and to disrupt DNA damage-induced cell cycle checkpoints.",
    "url": "https://doi.org/10.64898/2026.05.25.727628",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727628",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727628",
    "authors": "Vendetti, F. P.; Sclafani, C. R.; Zhang, Y.; Pandya, P.; Mowery, Y. M.; Kim, S. H.; Cumberland, R. L.; Ganakammal, S. R.; Conrads, T. P.; Calderon, M. J.; Watkins, S. C.; Van Houten, B.; Clump, A.; Ferris, R. L.; Beumer, J. H.; Delgoffe, G. M.; Kane, L. P.; Bakkenist, C. J.",
    "assignee": "",
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    "primary_source": "bioRxiv",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 21,
    "score": 0,
    "id": "pubmed:41915889",
    "canonical_key": "pmid:41915889",
    "headline": "BCL2 overexpression in donor lymphocytes reduces the risk of graft-versus-host disease.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41915889/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41915889",
    "doi": "10.1182/bloodadvances.2025017700",
    "preprint_id": "",
    "authors": "Bejarano-García JA; Nufer M; Palacios-Barea MJ; Guijarro-Albaladejo B; Sierro-Martínez B; Bella Á; Robles-Benítez C; García-Guerrero E; Carrasco-Brocal I; Lara-Chica M; Sanoja-Flores L; Mendendez NV; Caballero-Velázquez T; Rodríguez-Gil A; Pérez-Simón JA",
    "assignee": "",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 22,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726618",
    "canonical_key": "doi:10.64898/2026.05.21.726618",
    "headline": "Bronchus associated lymphoid tissue induced by an attenuated Mycobacterium tuberculosis vaccine prevents tuberculosis from heterologous TB challenge",
    "summary": "Tuberculosis remains a leading cause of death from infectious disease worldwide, underscoring the urgent need for vaccines with greater and more consistent efficacy than BCG.",
    "url": "https://doi.org/10.64898/2026.05.21.726618",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726618",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726618",
    "authors": "Singh, D. K.; Arora, G.; Devireddy, V. S. R.; Devi, A.; Ahmed, M.; Shivanna, V.; Weldon, K. S.; Hall-Ursone, S.; Lai, Z.; Mehra, S.; Alvarez, X.; Khader, S. A.; Kaushal, D.",
    "assignee": "",
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    "headline": "CD19 CAR T-cell outcomes in relapsed/refractory extramedullary B-ALL: a multisite, retrospective cohort review.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41701972/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
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    "doi": "10.1182/bloodadvances.2025018604",
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    "authors": "Rankin AW; Myers RM; Lamble AJ; Hsieh EM; Sankaran H; Chen L; Annesley C; DiNofia AM; Grupp SA; Pulsipher MA; Dolan JG; Bhojwani D; Gardner RA; Shah NN; Rheingold SR",
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    "id": "biorxiv:10.1101/2025.08.04.668400",
    "canonical_key": "doi:10.1101/2025.08.04.668400",
    "headline": "Chromatin priming by transcription factor ELF3 confers transcriptional competence for amniotic differentiation on primed human embryonic stem cells",
    "summary": "The self-organizing emergence of the amniotic lineage in synthetic human embryo models suggests that embryonic pluripotent cells possess an intrinsic potential to initiate extraembryonic amniotic differentiation.",
    "url": "https://doi.org/10.1101/2025.08.04.668400",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.08.04.668400",
    "preprint_id": "biorxiv:10.1101/2025.08.04.668400",
    "authors": "Ohgushi, M.; Honda, K.; Niwa, H.; Eiraku, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; developmental biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726986",
    "canonical_key": "doi:10.64898/2026.05.21.726986",
    "headline": "Decoding Multicellular Communication Motifs from Spatial Transcriptomics with ALARMIST",
    "summary": "Cellular organization is driven by recurrent, coordinated interactions between multiple cell types, each sending and receiving multiple signals.",
    "url": "https://doi.org/10.64898/2026.05.21.726986",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726986",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726986",
    "authors": "Fan, J.; Hood, J.; Strong, J.; Quinn, J. F.; Dai, Y.; Data Science TeamLab,; Schein, A.; Yu, K. K. H.; Tansey, W.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726570",
    "canonical_key": "doi:10.64898/2026.05.21.726570",
    "headline": "Developmental switch dichotomizes kidney response to NPHP3 inactivation and treatment outcome",
    "summary": "Nephronophthisis (NPH) is an orphan recessive kidney disease caused by biallelic variants in more than 25 NPHP genes encoding proteins that localize to primary cilia.",
    "url": "https://doi.org/10.64898/2026.05.21.726570",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726570",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726570",
    "authors": "Martin, J.; Serafin, A. S.; Chereau, F.; Achouri, Y.; Cagnard, N.; Verpont, M.-C.; Benmerah, A.; Scheers, I.; Jacquemin, P.; Saunier, S.; Viau, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; pathology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 27,
    "score": 0,
    "id": "pubmed:41894686",
    "canonical_key": "pmid:41894686",
    "headline": "Dexamethasone prophylaxis for excessive lymphocyte expansion after cilta-cel in multiple myeloma.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41894686/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41894686",
    "doi": "10.1182/bloodadvances.2025018639",
    "preprint_id": "",
    "authors": "Forsberg PA; Turner JA; Meyer M; Abbott D; Nicholson S; Schade H; Matous J; Gregory T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 28,
    "score": 0,
    "id": "pubmed:41915890",
    "canonical_key": "pmid:41915890",
    "headline": "Digenic and multigenic heterozygous FHL genotypes are common but clinically silent in the general population.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41915890/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41915890",
    "doi": "10.1182/bloodadvances.2025018781",
    "preprint_id": "",
    "authors": "Borisov O; Mann J; Walz KK; Oyen F; Lichtenfeld HC; Lehmberg K; Köttgen A; Ehl S; Wegehaupt O",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 29,
    "score": 0,
    "id": "pubmed:41824796",
    "canonical_key": "pmid:41824796",
    "headline": "Dynamic monitoring of circulating cell-free EBV-DNA for risk assessment in early-stage natural killer/T-cell lymphoma.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41824796/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41824796",
    "doi": "10.1182/bloodadvances.2025018855",
    "preprint_id": "",
    "authors": "Chen Z; Huang H; Fang X; Tian Y; Weng H; Gale RP; Zou L; Zhang W; Li Z; Guo H; Ge J; Chen N; Liang Y; Hong H; Lin T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 30,
    "score": 0,
    "id": "pubmed:41855506",
    "canonical_key": "pmid:41855506",
    "headline": "Early steroid and anakinra use to manage axicabtagene ciloleucel toxicity reduces the total duration of CRS and ICANS.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41855506/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41855506",
    "doi": "10.1182/bloodadvances.2025019031",
    "preprint_id": "",
    "authors": "Wang WL; Lee D; Cheung E; Jensen A; Rana MS; Goyal A; Hamilton M; Ghalehsari N; Latchford T; Scott B; Mallampet J; Heng E; Khan H; Zarak MS; Lohman C; Sahaf B; Sidana S; Weng WK; Smith M; Bharadwaj S; Frank MJ; Miklos DB; Dahiya S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 31,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726369",
    "canonical_key": "doi:10.64898/2026.05.21.726369",
    "headline": "Evolutionary transitions to self-fertilization influence the inference of introgression history",
    "summary": "The availability of polymorphism data and statistical inference methods allows documenting the widespread occurrence of introgression and hybridization across the tree of life.",
    "url": "https://doi.org/10.64898/2026.05.21.726369",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726369",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726369",
    "authors": "Metzger, L.; de Meaux, J.; Rahnamae, N.; Tellier, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; evolutionary biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 32,
    "score": 0,
    "id": "biorxiv:10.64898/2026.03.23.713590",
    "canonical_key": "doi:10.64898/2026.03.23.713590",
    "headline": "Flow-driven lumen remodeling and valve opening in the vas deferens",
    "summary": "Biological ducts must transport fluids while preserving structural integrity, yet how mechano-signaling coordinates wall deformation with luminal flow in vivo remains unclear.",
    "url": "https://doi.org/10.64898/2026.03.23.713590",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.03.23.713590",
    "preprint_id": "biorxiv:10.64898/2026.03.23.713590",
    "authors": "Ng, N.; Lim, Q. Y.; Yamada, G.; Hirashima, T.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; physiology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 33,
    "score": 0,
    "id": "pubmed:42186416",
    "canonical_key": "pmid:42186416",
    "headline": "From legacy subsets to auditable descriptors: implementing the 2025 T-cell nomenclature guidelines for inflammatory skin diseases.",
    "summary": "The British journal of dermatology. Br J Dermatol. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186416/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "The British journal of dermatology",
    "pmid": "42186416",
    "doi": "10.1093/bjd/ljag201",
    "preprint_id": "",
    "authors": "Kabashima K; Vocanson M; Eidsmo L; Eyerich K; Nakamizo S; Mackay LK",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 34,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726835",
    "canonical_key": "doi:10.64898/2026.05.21.726835",
    "headline": "Increased Ovarian and Colorectal Cancer Cell Sensitivity to Platinum Drugs and innovative TS Inhibitors by Electroporation",
    "summary": "Ovarian and colorectal cancers have the highest incidence and mortality in the world, after breast cancer. Despite the initial response to Pt-drugs or 5-fluorouracil (5-FU), many cancer cells develop resistance to these drugs.",
    "url": "https://doi.org/10.64898/2026.05.21.726835",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726835",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726835",
    "authors": "Marverti, G.; Belardo, A.; Mercanile, G.; Aiello, D.; Venturelli, A.; Costi, M. P.; D'Arca, D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 35,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.26.727789",
    "canonical_key": "doi:10.64898/2026.05.26.727789",
    "headline": "LINGUINE: a phylogeny-aware, orthogroup-based framework for robust ancestral linkage group inference",
    "summary": "Reconstructing the chromosomal architecture of ancestral genomes is a central challenge in comparative genomics, yet existing methods for ancestral linkage group (ALG) inference struggle in clades with rapid genome evolution.",
    "url": "https://doi.org/10.64898/2026.05.26.727789",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.26.727789",
    "preprint_id": "biorxiv:10.64898/2026.05.26.727789",
    "authors": "Vargas-Chavez, C.; Fernandez, R.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; evolutionary biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 36,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726063",
    "canonical_key": "doi:10.64898/2026.05.21.726063",
    "headline": "Lipogenesis-driven EGFR palmitoylation enables metastatic immune evasion in triple-negative breast cancer.",
    "summary": "Metastasis is the leading cause of death in triple-negative breast cancer (TNBC), yet how tumor cells evade immune recognition during dissemination remain unclear. Here, we show that de novo lipogenesis drives metastatic immune evasion through FASN-mediated palmitoylation of EGFR.",
    "url": "https://doi.org/10.64898/2026.05.21.726063",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726063",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726063",
    "authors": "Ko, M. S.; Ramchandani, D.; Simmons, G.; McCormick, J.; Carrasco, S.; Singh, A.; Yoffe, L.; Zhang, G.; Mittal, V.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 37,
    "score": 0,
    "id": "pubmed:41628317",
    "canonical_key": "pmid:41628317",
    "headline": "Long-term outcomes of 40 Gy CCRT with weekly cisplatin and systemic chemotherapy in limited-stage ENKTL.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41628317/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41628317",
    "doi": "10.1182/bloodadvances.2025019130",
    "preprint_id": "",
    "authors": "Yoon SE; Oh D; Ryu G; Cho J; Kim SJ; Kim WS",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 38,
    "score": 0,
    "id": "biorxiv:10.1101/2025.02.11.637693",
    "canonical_key": "doi:10.1101/2025.02.11.637693",
    "headline": "Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age",
    "summary": "The numerical abundance of diverse naive CD8 T cell clones is essential to provide broad protection against infection and cancer.",
    "url": "https://doi.org/10.1101/2025.02.11.637693",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.02.11.637693",
    "preprint_id": "biorxiv:10.1101/2025.02.11.637693",
    "authors": "Menzel, L.; Zschummel, M.; O'Melia, M. J.; Sandstedt, M.; Zhou, H.; Lei, P.-J.; Liu, L.; Lee, H.; Sen, D. R.; Munn, L. L.; Jonasson, L.; Padera, T. P.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 39,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726432",
    "canonical_key": "doi:10.64898/2026.05.21.726432",
    "headline": "Mapping immune cellular landscapes and vaccine responses across a spectrum of health and immunodeficiency.",
    "summary": "Immune responses to infection and vaccination exhibit diversity between individuals that can be shaped by differences in their immune cell landscapes and the signalling, transcriptional, and genetic mechanisms that coordinate immune cell function.",
    "url": "https://doi.org/10.64898/2026.05.21.726432",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726432",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726432",
    "authors": "Vespasiani, D.; Quig, A.; Lancaster, J.; Shen, C.; Cooper, J.; Tuong, Z. K.; Jackson, A.; Schulz, S.; Tsang, S.-Y.; Deckert, K.; Lucas, E. C.; Margetts, M.; Horton, M.; Chan, S.; Bosco, J. J.; Chatelier, J.; Ojaimi, S.; Slade, C.; Jin, C.; King, H. W.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 40,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.727032",
    "canonical_key": "doi:10.64898/2026.05.21.727032",
    "headline": "Metal homeostasis is remodeled in response to different quiescence triggers",
    "summary": "Cells can enter a reversible non-proliferative state called quiescence either spontaneously or in response to nutrient deprivations. Metal ions are essential nutrients and play wide-ranging regulatory and signaling roles in biological processes.",
    "url": "https://doi.org/10.64898/2026.05.21.727032",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.727032",
    "preprint_id": "biorxiv:10.64898/2026.05.21.727032",
    "authors": "Rakshit, A.; Holtzen, S. E.; Aron, A. T.; Pezacki, A. T.; Kahali, S.; Das, S. K.; Sanford, L.; Ralle, M.; Datta, A.; Palmer, A. E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 41,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.727008",
    "canonical_key": "doi:10.64898/2026.05.21.727008",
    "headline": "Motile and matrix-producing cells drive distinct modes of cell-scale motion in Bacillus subtilis colonies",
    "summary": "The physics of cell motion and growth drives the expansion of groups of cells including bacterial colonies. Under different conditions, many species of bacteria grow with strikingly different dynamics, which can arise from the physics of constituent cells.",
    "url": "https://doi.org/10.64898/2026.05.21.727008",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.727008",
    "preprint_id": "biorxiv:10.64898/2026.05.21.727008",
    "authors": "Samaroo, J.; Almodaimegh, A.; Larkin, J. W.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; biophysics"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 42,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.725517",
    "canonical_key": "doi:10.64898/2026.05.21.725517",
    "headline": "Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsets",
    "summary": "Primarily recognized as the site for T cell development, the thymus supports a complex interplay between thymic stromal cells and developing thymocytes, which is essential for T cell maturation and the establishment of central tolerance.",
    "url": "https://doi.org/10.64898/2026.05.21.725517",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.725517",
    "preprint_id": "biorxiv:10.64898/2026.05.21.725517",
    "authors": "Cordes, M.; van den Akker, E. B.; Melsen, J. E.; Bunschuh, S.; Zbinden, A.; de Bruin-Versteeg, S.; Guo, N.; Koning, F.; Kiełbasa, S. M.; Pike-Overzet, K.; van der Burg, M.; Reinders, M. J. T.; Staal, F. J. T.; Cante-Barrett, K.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 43,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.22.727236",
    "canonical_key": "doi:10.64898/2026.05.22.727236",
    "headline": "Non-Genetic Mechanisms of Fractional Resistance to Abemaciclib in Dedifferentiated Liposarcoma.",
    "summary": "Dedifferentiated liposarcoma is a rare mesenchymal malignancy driven by amplification of chromosome 12q13-15, which includes the oncogenes CDK4 and MDM2. CDK4 amplification provides a rationale for targeted therapy with CDK4/6 inhibitors, and abemaciclib has shown the most durable activity reported to date in this disease.",
    "url": "https://doi.org/10.64898/2026.05.22.727236",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727236",
    "preprint_id": "biorxiv:10.64898/2026.05.22.727236",
    "authors": "Bailey, L. E.; Wolff, S. C.; Zikry, T.; Sessions, G. A.; Whitman, A. A.; Titerina, E. K.; Raish, H.; Beane, J.; Purvis, J. E.; Spanheimer, P. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 44,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.725359",
    "canonical_key": "doi:10.64898/2026.05.25.725359",
    "headline": "Novel cumate-inducible models of MYC-driven neuroblastoma enable unconfounded mitochondrial synthetic lethality screens",
    "summary": "Oncogenic MYC transcription factors profoundly alter cellular programs, imposing dependencies that can be therapeutically exploited in MYC-driven cancers such as high-risk neuroblastoma.",
    "url": "https://doi.org/10.64898/2026.05.25.725359",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.725359",
    "preprint_id": "biorxiv:10.64898/2026.05.25.725359",
    "authors": "Kubistova, A.; Horak, I.; Barta, T.; Sulova, M.; Marek, M.; Borankova, K.; Skoda, J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 45,
    "score": 0,
    "id": "pubmed:42133365",
    "canonical_key": "pmid:42133365",
    "headline": "On the RAdR in relapsed T-cell lymphoma.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42133365/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "42133365",
    "doi": "10.1182/bloodadvances.2026019925",
    "preprint_id": "",
    "authors": "Casan JML; Van Der Weyden C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 46,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.23.727347",
    "canonical_key": "doi:10.64898/2026.05.23.727347",
    "headline": "Pathogen-specific antimicrobial activity prediction with biological large language model-based methods",
    "summary": "Driven by the rise of antimicrobial resistance, antimicrobial peptides (AMPs) have emerged as promising therapeutics capable of targeting multidrug-resistant pathogens.",
    "url": "https://doi.org/10.64898/2026.05.23.727347",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.23.727347",
    "preprint_id": "biorxiv:10.64898/2026.05.23.727347",
    "authors": "Ucar, B.; Demirsoy, E.; Salehi, A.; Sutherland, D.; Yanai, A.; Coombe, L.; Thompson, V. C.; Warren, R. L.; Helbing, C. C.; Birol, I.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 47,
    "score": 0,
    "id": "pubmed:41707114",
    "canonical_key": "pmid:41707114",
    "headline": "Patterns of care and clinical outcomes in systemic peripheral T-cell lymphoma: the LEO-MER prospective cohort study.",
    "summary": "Blood advances. Blood Adv. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41707114/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
    "pmid": "41707114",
    "doi": "10.1182/bloodadvances.2025018455",
    "preprint_id": "",
    "authors": "Ruan J; Chen Z; Larson MC; Bennani NN; Allen P; Mou E; Wallace D; Mehta-Shah N; Lossos IS; Malpica Castillo LE; Jaye DL; Vega F; Inghirami G; Pongas G; Akkad N; Casulo C; Martin P; Cohen JB; Habermann TM; Maurer MJ; Leonard JP; Friedberg JW; Kahl B; Cerhan JR; Flowers CR; Feldman AL",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 48,
    "score": 0,
    "id": "pubmed:42186225",
    "canonical_key": "pmid:42186225",
    "headline": "Restricting efferocytosis pathway to CD91 via phosphatidylserine-targeting chimeric protein augments antitumor immune responses.",
    "summary": "Molecular therapy : the journal of the American Society of Gene Therapy. Mol Ther. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186225/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Molecular therapy : the journal of the American Society of Gene Therapy",
    "pmid": "42186225",
    "doi": "10.1016/j.ymthe.2026.05.013",
    "preprint_id": "",
    "authors": "Mizote Y; Nishita H; Hashiba K; Okuma C; Akane S; Minomi K; Tahara H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 49,
    "score": 0,
    "id": "pubmed:42185655",
    "canonical_key": "pmid:42185655",
    "headline": "Single-cell eQTL-based Mendelian randomization identifies immune cell subtype-specific regulators of epigenetic aging and prioritizes candidate therapeutic targets.",
    "summary": "Biogerontology. Biogerontology. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185655/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Biogerontology",
    "pmid": "42185655",
    "doi": "10.1007/s10522-026-10453-w",
    "preprint_id": "",
    "authors": "Zhang C; Zhang J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 50,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.727505",
    "canonical_key": "doi:10.64898/2026.05.25.727505",
    "headline": "Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic Rescue",
    "summary": "Background. Cockayne syndrome (CS), primarily caused by autosomal recessive pathogenic variants in ERCC6 (CSB) or ERCC8 (CSA), is a transcription-coupled nucleotide excision repair disorder.",
    "url": "https://doi.org/10.64898/2026.05.25.727505",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727505",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727505",
    "authors": "Kose, M.; McCormick, E.; Keith, K.; Remes, C.; Haroon, S.; Nakamaru-Ogiso, E.; Falk, M. J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; molecular biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 51,
    "score": 0,
    "id": "pubmed:42185691",
    "canonical_key": "pmid:42185691",
    "headline": "The role of impaired bone marrow Tregs in hematopoietic stem cell depletion for pediatric aplastic anemia probably involves immune privilege.",
    "summary": "Blood research. Blood Res. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185691/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood research",
    "pmid": "42185691",
    "doi": "10.1007/s44313-026-00141-6",
    "preprint_id": "",
    "authors": "Huang C; Li S; Yang J; Jiao Y; Zhang T; Jiang H; Zeng F; Jiang S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 52,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.19.724853",
    "canonical_key": "doi:10.64898/2026.05.19.724853",
    "headline": "Therapeutic Potential of Dichapetalin M in Metastatic and ER-positive Breast Cancer: Evidence from Cell Line Studies",
    "summary": "BackgroundDichapetalin M (Dic M), an active compound extracted from medicinal plants in the Dichapetalum genus, has been previously shown to possess anti-proliferative activity against cancer cell lines. However, the specific mechanism through which it exerts its anticancer effects remains unknown.",
    "url": "https://doi.org/10.64898/2026.05.19.724853",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.19.724853",
    "preprint_id": "biorxiv:10.64898/2026.05.19.724853",
    "authors": "Yankson, G.; Awortwe, K. Y.; Chama, M. A.; Paemka, L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 53,
    "score": 0,
    "id": "pubmed:42185382",
    "canonical_key": "pmid:42185382",
    "headline": "Tumor genome and microenvironment alteration by trastuzumab deruxtecan as neoadjuvant therapy for HER2-mutant NSCLC.",
    "summary": "Scientific reports. Sci Rep. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185382/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Scientific reports",
    "pmid": "42185382",
    "doi": "10.1038/s41598-026-53779-8",
    "preprint_id": "",
    "authors": "Li J; Lu X; Yue S; Hang R; Dai X; Kuang X; Guo W; Huang Z; Xiong Y; Li M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 54,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.23.727321",
    "canonical_key": "doi:10.64898/2026.05.23.727321",
    "headline": "Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8+ T cells During Macrophage Activation Syndrome",
    "summary": "Macrophage activation syndrome (MAS) is driven by a hyperinflammatory response characterized by aberrant activation of lymphocytes and phagocytes. While monocytes and macrophages are thought to be important in MAS pathogenesis, their role remains poorly understood.",
    "url": "https://doi.org/10.64898/2026.05.23.727321",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.23.727321",
    "preprint_id": "biorxiv:10.64898/2026.05.23.727321",
    "authors": "Canny, S. P.; DeBerg, H. A.; Kuan, E. L.; Moss, N.; Gessay, G.; Lu, A.; Huang, A.; O'Rourke, A. R.; Layton, E. D.; Bouvatte, P.; Wittig, P. J.; Speake, C.; Mikacenic, C.; Shenoi, S.; Hui-Yuen, J.; Campbell, D. J.; Barnes, B. J.; Hamerman, J. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 55,
    "score": 0,
    "id": "pubmed:42184327",
    "canonical_key": "pmid:42184327",
    "headline": "[Capsid Protein of Bacteriophage Beihai32 as a Platform for Construction of Virus-Like Particles Displaying Foreign Polypeptides].",
    "summary": "Molekuliarnaia biologiia. Mol Biol (Mosk)",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184327/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Molekuliarnaia biologiia",
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    "headline": "A 21-year-old man with anemia and gastrointestinal bleeding caused by jejunal EBV-associated T/natural killer-cell lymphoproliferative disorder.",
    "summary": "Clinical journal of gastroenterology. Clin J Gastroenterol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183981/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinical journal of gastroenterology",
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    "authors": "MengHan W; YiJun C; WenHai W",
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    "summary": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. Biomed Pharmacother. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184756/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
    "pmid": "42184756",
    "doi": "10.1016/j.biopha.2026.119510",
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    "authors": "Mamun MAA; Rakib A; Mandal M; Chen H; Li W; Miller DD; Park F; Kumar S; Singh UP",
    "assignee": "",
    "publication_number": "",
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    "headline": "A Prognostic Model for Breast Cancer Based on Fatty Acid Metabolism and the Role of CD36 in Mediating Lipid Metabolism–Immune Interplay",
    "summary": "Wu X, Ren L, Tan X, Yan W, Qi X, Wang Y, Zhang Y.",
    "url": "https://doi.org/10.21203/rs.3.rs-9297898/v1",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.21203/rs.3.rs-9297898/v1",
    "preprint_id": "",
    "authors": "Wu X;  Ren L;  Tan X;  Yan W;  Qi X;  Wang Y;  Zhang Y.",
    "assignee": "",
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    "id": "pubmed:42184067",
    "canonical_key": "pmid:42184067",
    "headline": "Abdominal pain and jaundice secondary to duodenal monomorphic epitheliotropic intestinal T-cell lymphoma.",
    "summary": "Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. Indian J Gastroenterol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184067/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology",
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    "doi": "10.1007/s12664-026-02019-y",
    "preprint_id": "",
    "authors": "Zhao TQ; Zhang LY; Liu L; Liu W",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "score": 0,
    "id": "pubmed:42184340",
    "canonical_key": "pmid:42184340",
    "headline": "AI-Guided De Novo Design of a Caffeine-Induced Protein Dissociation System.",
    "summary": "Journal of the American Chemical Society. J Am Chem Soc. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184340/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of the American Chemical Society",
    "pmid": "42184340",
    "doi": "10.1021/jacs.6c02343",
    "preprint_id": "",
    "authors": "Nonomura T; McKee B; Price A; Cui M; Yousuf Z; Tran F; He L; Wang T; Zhou Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 61,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.24.725928",
    "canonical_key": "doi:10.64898/2026.05.24.725928",
    "headline": "Artificial initiation codons and engineered initiator tRNAs enable N-terminal noncanonical amino acid incorporation in intact cell-free translation systems",
    "summary": "Noncanonical amino acid (ncAA) incorporation at the protein N-terminus provides a powerful strategy for installing defined chemical handles while minimizing perturbation of internal protein sequences.",
    "url": "https://doi.org/10.64898/2026.05.24.725928",
    "source": "bioRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.24.725928",
    "preprint_id": "biorxiv:10.64898/2026.05.24.725928",
    "authors": "Furukawa, H.; Okamoto, Y.; Terasaka, N.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 62,
    "score": 0,
    "id": "europepmc:PPR1238374",
    "canonical_key": "doi:10.31234/osf.io/t9sjc_v1",
    "headline": "Autonomic Nervous System Dysregulation in Psychopathology: Hyperadrenergic Dysautonomia",
    "summary": "Montazeri F.",
    "url": "https://doi.org/10.31234/osf.io/t9sjc_v1",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.31234/osf.io/t9sjc_v1",
    "preprint_id": "",
    "authors": "Montazeri F.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "Europe PMC / PPR",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "rank_index": 63,
    "score": 0,
    "id": "pubmed:42185250",
    "canonical_key": "pmid:42185250",
    "headline": "Bacterial specificity of the gut microbiome predicts bone density in primary hyperparathyroidism.",
    "summary": "Bone research. Bone Res. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185250/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Bone research",
    "pmid": "42185250",
    "doi": "10.1038/s41413-026-00529-1",
    "preprint_id": "",
    "authors": "Dar HY; Fang J; Patil S; Roy NK; Agarwal S; Weitzmann MN; Jones RM; Bilezikian JP; Pacifici R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
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    "canonical_key": "pmid:42183670",
    "headline": "CAR-iNKT cells for cancer therapy: a comprehensive review of engineering, mechanisms, and clinical progress.",
    "summary": "Immunotherapy. Immunotherapy. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183670/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Immunotherapy",
    "pmid": "42183670",
    "doi": "10.1080/1750743X.2026.2674418",
    "preprint_id": "",
    "authors": "Yang Y; Gu J; Ding Y; Li Y; Sun Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 65,
    "score": 0,
    "id": "europepmc:PPR1238047",
    "canonical_key": "doi:10.21203/rs.3.rs-9683395/v1",
    "headline": "CD105 Nb-Functionalized Layered Double Hydroxides for Synergistic Phototherapy and Reprogramming of the Tumor Immune Microenvironment",
    "summary": "Lin X, Sint SMM, Huang Q, Li S, Ma X, Mo L, Zhang H, Long J, Xie X, Xie F, Yang X, Liao H.",
    "url": "https://doi.org/10.21203/rs.3.rs-9683395/v1",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.21203/rs.3.rs-9683395/v1",
    "preprint_id": "",
    "authors": "Lin X;  Sint SMM;  Huang Q;  Li S;  Ma X;  Mo L;  Zhang H;  Long J;  Xie X;  Xie F;  Yang X;  Liao H.",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Europe PMC / PPR",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 66,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.21.726757",
    "canonical_key": "doi:10.64898/2026.05.21.726757",
    "headline": "Cell-type-specific transposable element transcription tracks symbiosis and calcification programs in the reef-building coral Acropora hemprichii",
    "summary": "Transposable elements (TEs) are pervasive components of eukaryotic genomes and major drivers of genome evolution, yet their contribution to cell-type-specific regulatory landscapes remains poorly understood, particularly in non-model marine invertebrates.",
    "url": "https://doi.org/10.64898/2026.05.21.726757",
    "source": "bioRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726757",
    "preprint_id": "biorxiv:10.64898/2026.05.21.726757",
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    "assignee": "",
    "publication_number": "",
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    "source_type": "papers",
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    "rank_index": 67,
    "score": 0,
    "id": "pubmed:42185659",
    "canonical_key": "pmid:42185659",
    "headline": "Clinical utility of liquid biopsy in distinguishing true progression from radiation necrosis and pseudoprogression in malignant brain tumor.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42185659/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of neuro-oncology",
    "pmid": "42185659",
    "doi": "10.1007/s11060-026-05618-z",
    "preprint_id": "",
    "authors": "Izhar M; Hori YS; Lam FC; Kalra N; Zagzoog N; Tayag A; Ustrzynski L; Emrich SC; Park DJ; Chang SD",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 68,
    "score": 0,
    "id": "pubmed:42184009",
    "canonical_key": "pmid:42184009",
    "headline": "Construction and immunogenicity evaluation of a tuberculosis subunit vaccine based on fusion protein AP2 and novel adjuvant ASM.",
    "summary": "Archives of microbiology. Arch Microbiol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184009/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Archives of microbiology",
    "pmid": "42184009",
    "doi": "10.1007/s00203-026-04975-7",
    "preprint_id": "",
    "authors": "Wang R; Wang X; Kong L; Sun Q; Wu J; Liu G; Zhou M; Ju J; Zhang Z; Xu Y; Zhong Q",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 69,
    "score": 0,
    "id": "pubmed:42185899",
    "canonical_key": "pmid:42185899",
    "headline": "CR1(+) tumor-associated macrophages orchestrate an immunosuppressive niche in hepatocellular carcinoma: a genetic and multi-omics dissection.",
    "summary": "Journal of translational medicine. J Transl Med. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185899/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of translational medicine",
    "pmid": "42185899",
    "doi": "10.1186/s12967-026-08301-z",
    "preprint_id": "",
    "authors": "Wang Z; Wang Z; Ji X; Zhao L; Zheng K; Yu W; Zhang H; Chang H; Liu F",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 70,
    "score": 0,
    "id": "pubmed:42184990",
    "canonical_key": "pmid:42184990",
    "headline": "Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes.",
    "summary": "BMJ open diabetes research & care. BMJ Open Diabetes Res Care. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184990/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "BMJ open diabetes research & care",
    "pmid": "42184990",
    "doi": "10.1136/bmjdrc-2026-006015",
    "preprint_id": "",
    "authors": "Hohsfield KR; Carry P; Slack S; Repaci CT; Vanderlinden LA; Kechris K; Rewers M; Norris JM; Johnson RK",
    "assignee": "",
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    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 71,
    "score": 0,
    "id": "pubmed:42183626",
    "canonical_key": "pmid:42183626",
    "headline": "Dose-de-escalated focal radiotherapy for primary cutaneous T-cell lymphoma: a lesion-based retrospective cohort study.",
    "summary": "Acta oncologica (Stockholm, Sweden). Acta Oncol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183626/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Acta oncologica (Stockholm, Sweden)",
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    "doi": "10.2340/1651-226X.2026.45728",
    "preprint_id": "",
    "authors": "Linde P; Wagner K; Rosenbrock J; Oertel M; Ferdinandus S; Fan J; Fokas E; Baues C",
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    "headline": "Durvalumab plus anlotinib versus durvalumab alone as maintenance treatment in extensive-stage small-cell lung cancer (DURABLE): a multicenter, randomized, phase II trial and biomarker analysis.",
    "summary": "Nature communications. Nat Commun. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185290/",
    "source": "PubMed",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature communications",
    "pmid": "42185290",
    "doi": "10.1038/s41467-026-73562-7",
    "preprint_id": "",
    "authors": "Zhang B; Zhong R; Shi C; Chu T; Zhang W; Wang H; Gan X; Zhang Z; Zhu C; Li X; Su W; Li J; Zhang Y; Han B; Zhong H",
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    "canonical_key": "pmid:42185808",
    "headline": "Efficacy and safety of CD30-targeted chimeric antigen receptor T-cell therapy for lymphoma: a meta-analysis.",
    "summary": "BMC cancer. BMC Cancer. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185808/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "BMC cancer",
    "pmid": "42185808",
    "doi": "10.1186/s12885-026-16121-z",
    "preprint_id": "",
    "authors": "Shi J; Lu C; Song C; Wang Q",
    "assignee": "",
    "publication_number": "",
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    "canonical_key": "pmid:42186216",
    "headline": "Epithelial YPEL3 Modulates CD8(+) T-Cell Infiltration and Tumor Progression Through CREB1-CXCL16 Signaling in HNSCC.",
    "summary": "Cancer science. Cancer Sci. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186216/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer science",
    "pmid": "42186216",
    "doi": "10.1111/cas.70409",
    "preprint_id": "",
    "authors": "Li Y; Li Y; Sun C; Lu C; Chen G; Zhou T; Zhang B; Song X",
    "assignee": "",
    "publication_number": "",
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    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
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    "headline": "Evaluation of orange pulping residues as an alternative growth medium for Thraustochytrium sp.",
    "summary": "In this study, the lipid content produced by Thraustochytrium sp. in a medium prepared from orange pulp residue was compared with that obtained in a conventional medium.",
    "url": "https://doi.org/10.64898/2026.05.25.727442",
    "source": "bioRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727442",
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    "primary_source": "bioRxiv",
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    "source_type": "papers",
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    "id": "pubmed:42185288",
    "canonical_key": "pmid:42185288",
    "headline": "Explainable machine learning-guided integrated multiomics analysis reveals macrophage-driven immune suppression in breast cancer.",
    "summary": "Nature communications. Nat Commun. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185288/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature communications",
    "pmid": "42185288",
    "doi": "10.1038/s41467-026-73617-9",
    "preprint_id": "",
    "authors": "Azimzade Y; Haugen MH; Kristensen VN; Frigessi A; Köhn-Luque A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "id": "pubmed:42183637",
    "canonical_key": "pmid:42183637",
    "headline": "Expression and prognostic value of cytotoxic T-lymphocyte-associated 4 protein in classic Hodgkin lymphoma.",
    "summary": "Expert review of hematology. Expert Rev Hematol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183637/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Expert review of hematology",
    "pmid": "42183637",
    "doi": "10.1080/17474086.2026.2680139",
    "preprint_id": "",
    "authors": "Sahin TK; Gungor HN; Gezmis E; Sahin EA; Barista I; Saglam A; Akın S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 78,
    "score": 0,
    "id": "pubmed:42185478",
    "canonical_key": "pmid:42185478",
    "headline": "Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial.",
    "summary": "Nature cancer. Nat Cancer. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185478/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature cancer",
    "pmid": "42185478",
    "doi": "10.1038/s43018-026-01165-8",
    "preprint_id": "",
    "authors": "Perez KJ; Dias Costa A; Jordan A; Karasic TB; Elganainy D; Kim S; Yuan C; Gui DY; Tan R; Hong SC; Wang X; Cristea S; Coleman E; Truitt M; Oh TG; Zheng H; Furniss CS; Brais L; Bird A; Remland J; Gocheva V; Thalappillil JS; Anderson M; Cleary JM; Enzinger A; Giannakis M; Ng K; Rubinson DA; Schlechter B; Surana R; Singh H; Abrams T; Teitelbaum U; Izgur N; Allen E; Winter PS; Raghavan S; Yeh JJ; Von Hoff D; Liddle C; Downes M; Evans RM; O'Dwyer P; Aguirre A; Nowak JA; Wolpin BM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 79,
    "score": 0,
    "id": "pubmed:42179191",
    "canonical_key": "pmid:42179191",
    "headline": "GITR and GITR-L RNA Expression Levels Correlate with Better Survival and Response to Immunotherapy.",
    "summary": "Molecular cancer therapeutics. Mol Cancer Ther. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42179191/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Molecular cancer therapeutics",
    "pmid": "42179191",
    "doi": "10.1158/1535-7163.MCT-25-0713",
    "preprint_id": "",
    "authors": "Moussa P; Kurzrock R; Nishizaki D; Miyashita H; Lee S; Nikanjam M; Jensen TJ; Conroy JM; DePietro P; Sicklick JK; Kato S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 80,
    "score": 0,
    "id": "pubmed:42185270",
    "canonical_key": "pmid:42185270",
    "headline": "GPSM1 restricts CD73(+)CD103(+) T(reg) cells in adipose tissue, critical for promoting obesity-related metabolic deterioration.",
    "summary": "Nature communications. Nat Commun. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185270/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature communications",
    "pmid": "42185270",
    "doi": "10.1038/s41467-026-73349-w",
    "preprint_id": "",
    "authors": "Lyu XR; Qi RB; Hua YL; Chen W; Li YX; Wang DX; Yao LJ; Chen HL; Zheng JF; Wan BC; Hua Y; Jiang F; Yang F; Ma JY; Chen XH; Zhang R; Yan J; Jia WP; Hu C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 81,
    "score": 0,
    "id": "pubmed:42185629",
    "canonical_key": "pmid:42185629",
    "headline": "GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4.",
    "summary": "Cell death and differentiation. Cell Death Differ. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185629/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cell death and differentiation",
    "pmid": "42185629",
    "doi": "10.1038/s41418-026-01767-w",
    "preprint_id": "",
    "authors": "Du J; Yang Y; Zhao M; Zhang H; Li X; Qu D; Wang J; Wang X; Yi X; Ma J; Wang H; Wang H; Shi Q; Tian Y; Zhang B; Guo S; Gao T; Guo W; Li C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 82,
    "score": 0,
    "id": "pubmed:42184045",
    "canonical_key": "pmid:42184045",
    "headline": "Identification of prognostic genes and development of a risk model for pancreatic cancer based on hypoxia- and lipid metabolism-related genes.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184045/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42184045",
    "doi": "10.1007/s12672-026-05267-8",
    "preprint_id": "",
    "authors": "Guo X; Xiong J; Niu L; Li S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 83,
    "score": 0,
    "id": "pubmed:42186251",
    "canonical_key": "pmid:42186251",
    "headline": "Immunotherapeutic strategies in gastroenteropancreatic neuroendocrine neoplasms: present condition and future developments.",
    "summary": "Journal of chemotherapy (Florence, Italy). J Chemother. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186251/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of chemotherapy (Florence, Italy)",
    "pmid": "42186251",
    "doi": "10.1080/1120009X.2026.2676345",
    "preprint_id": "",
    "authors": "Chowdhury D; Mishra A; Muskan Rao M; Sahu R; Bodakhe SH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 84,
    "score": 0,
    "id": "pubmed:42185247",
    "canonical_key": "pmid:42185247",
    "headline": "Insulin enables acquisition of the IL7R(+) memory phenotype in PD1(+) T cells in RA tissues.",
    "summary": "Cell death & disease. Cell Death Dis. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185247/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cell death & disease",
    "pmid": "42185247",
    "doi": "10.1038/s41419-026-08916-6",
    "preprint_id": "",
    "authors": "Chandrasekaran V; Erlandsson MC; Svensson D; Malmhäll-Bah E; Silfverswärd ST; Pullerits R; Katona G; Bokarewa MI",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 85,
    "score": 0,
    "id": "pubmed:42184055",
    "canonical_key": "pmid:42184055",
    "headline": "Integrative single-cell RNA-seq and transcriptomic analysis uncovers cellular heterogeneity and immunotherapy resistance mechanisms in colorectal cancer.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42184055/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42184055",
    "doi": "10.1007/s12672-026-05284-7",
    "preprint_id": "",
    "authors": "Wang Y; Zhang Y; Mao Z; Du W; Cao X; Jiang M; Zhang Q; Zhan S; Chen Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 86,
    "score": 0,
    "id": "pubmed:42183741",
    "canonical_key": "pmid:42183741",
    "headline": "m6A RNA Methylation Mediates the Immune Gene Regulatory Mechanism in Sebastes schlegelii Against Edwardsiella piscicida Infection.",
    "summary": "Journal of agricultural and food chemistry. J Agric Food Chem. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183741/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of agricultural and food chemistry",
    "pmid": "42183741",
    "doi": "10.1021/acs.jafc.5c12739",
    "preprint_id": "",
    "authors": "Cao M; Wu R; Liu C; Li C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 87,
    "score": 0,
    "id": "pubmed:42186029",
    "canonical_key": "pmid:42186029",
    "headline": "Mechanistic insight into complement C3 regulation during chronic HBV infection: effect on viral persistence and host immune response.",
    "summary": "Journal of biomedical science. J Biomed Sci. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42186029/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of biomedical science",
    "pmid": "42186029",
    "doi": "10.1186/s12929-026-01259-6",
    "preprint_id": "",
    "authors": "Baidya A; Dey D; Mallik S; Halder S; Khatun N; Jha R; Nandi S; Chakraborty BC; Dutta A; Banerjee S; Chowdhury A; Ahammed SKM; Datta S",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 88,
    "score": 0,
    "id": "pubmed:42183887",
    "canonical_key": "pmid:42183887",
    "headline": "MEK inhibitor cobimetinib increases calreticulin and induces immune modulation in TNBC.",
    "summary": "Journal of molecular medicine (Berlin, Germany). J Mol Med (Berl). 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183887/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of molecular medicine (Berlin, Germany)",
    "pmid": "42183887",
    "doi": "10.1007/s00109-026-02684-8",
    "preprint_id": "",
    "authors": "Tseng LM; Lau KY; Chen JL; Chu PY; Huang CT; Wang WL; Chang YY; Lai JI; Huang CC; Dai MS; Liu CY",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 89,
    "score": 0,
    "id": "pubmed:42183833",
    "canonical_key": "pmid:42183833",
    "headline": "Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3-IFI6 Circuit in Breast Cancer.",
    "summary": "Advanced science (Weinheim, Baden-Wurttemberg, Germany). Adv Sci (Weinh). 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183833/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
    "pmid": "42183833",
    "doi": "10.1002/advs.75818",
    "preprint_id": "",
    "authors": "Zhu Y; Tang Y; Chen Y; Zhang Z; Lu Y; Wang X; Shi Q; Zhao W; Pang H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 90,
    "score": 0,
    "id": "pubmed:42185687",
    "canonical_key": "pmid:42185687",
    "headline": "Multi-omics analysis reveals TM4SF19 as a diagnostic and prognostic biomarker in bladder cancer.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185687/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42185687",
    "doi": "10.1007/s12672-026-05304-6",
    "preprint_id": "",
    "authors": "Aizezi X; Silafu B; Shi H; Huang J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 91,
    "score": 0,
    "id": "europepmc:PPR1238407",
    "canonical_key": "doi:10.64898/2026.05.22.26353900",
    "headline": "Multi-omics of stressful life events",
    "summary": "Azzi E, Heikkinen A, Drouard G, Palviainen T, Kabrita CS, Kaprio J, Ollikainen M.",
    "url": "https://doi.org/10.64898/2026.05.22.26353900",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.22.26353900",
    "preprint_id": "",
    "authors": "Azzi E;  Heikkinen A;  Drouard G;  Palviainen T;  Kabrita CS;  Kaprio J;  Ollikainen M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 92,
    "score": 0,
    "id": "pubmed:42183598",
    "canonical_key": "pmid:42183598",
    "headline": "Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota.",
    "summary": "International reviews of immunology. Int Rev Immunol. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183598/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "International reviews of immunology",
    "pmid": "42183598",
    "doi": "10.1080/08830185.2026.2677909",
    "preprint_id": "",
    "authors": "Yi J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 93,
    "score": 0,
    "id": "pubmed:42185255",
    "canonical_key": "pmid:42185255",
    "headline": "Pembrolizumab plus high-dose IL-2 in advanced clear cell renal cell carcinoma: six-year survival outcomes and molecular signatures from a phase 2 trial.",
    "summary": "Nature communications. Nat Commun. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185255/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature communications",
    "pmid": "42185255",
    "doi": "10.1038/s41467-026-73336-1",
    "preprint_id": "",
    "authors": "Johnson JS; Miller JW; Hatoum F; Schell MJ; Yu X; Roman Souza G; Mizelle S; Gullapalli K; Fazili A; Jain R; Chatzkel J; Cen L; Dhillon J; Cubitt C; Yao J; Whiting J; Li J; Swank J; Jameel G; Zhang J; Wang X; Spiess PE; Fishman M; Chahoud J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 94,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.20.726582",
    "canonical_key": "doi:10.64898/2026.05.20.726582",
    "headline": "Persistent Microglial HIV Infection Drives Neuroinflammation Despite Viral Suppression: Insights from Rapid Postmortem Brain Biopsies",
    "summary": "Despite suppressive antiretroviral therapy (ART), HIV persists in the central nervous system (CNS) and contributes to HIV-associated neurocognitive disorder (HAND), but cell type-specific effects remain poorly defined.",
    "url": "https://doi.org/10.64898/2026.05.20.726582",
    "source": "bioRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.20.726582",
    "preprint_id": "biorxiv:10.64898/2026.05.20.726582",
    "authors": "Nühn, M. M.; Sabet, N.; Zuidmeer, N.; van Abeelen, K. C. J.; Hermans, L. E.; Schipper, P. J.; Kübler, R.; Basson, A. E.; Omar, T.; Variava, E.; Martinson, N. A.; Giacopazzi, S.; Venter, W. D. F.; Muraro, M. J.; Wensing, A. M.; de Witte, L. D.; Papathanasopoulos, M. A.; Nijhuis, M.; Symons, J.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 95,
    "score": 0,
    "id": "pubmed:42183839",
    "canonical_key": "pmid:42183839",
    "headline": "PGK1 Suppresses CD8(+) T Cell-Mediated Antitumor Immunity Through CCL2/CCR2/Tumor-Associated Macrophages Axis in Hepatocellular Carcinoma.",
    "summary": "Advanced science (Weinheim, Baden-Wurttemberg, Germany). Adv Sci (Weinh). 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183839/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
    "pmid": "42183839",
    "doi": "10.1002/advs.75801",
    "preprint_id": "",
    "authors": "Liu X; Liu J; Zhang Z; Yu X; Qian J; Ding L; Wu Q; Yang Z; Luo XY; Ding X; Su R; Yu X; Qiao Y; Yin S; Xie H; Zhou L; Liu Y; Zheng S",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 96,
    "score": 0,
    "id": "pubmed:42183897",
    "canonical_key": "pmid:42183897",
    "headline": "Photo-triggered g-C(3)N(4)/Ag(2)S nanoenzyme based colorimetric immunosensor for carbohydrate antigen 19-9 detection.",
    "summary": "Mikrochimica acta. Mikrochim Acta. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42183897/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Mikrochimica acta",
    "pmid": "42183897",
    "doi": "10.1007/s00604-026-08120-5",
    "preprint_id": "",
    "authors": "Xue H; Cheng G; Zhang B; Zhan Y; Zhao Z; Lin J; Cheng Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 97,
    "score": 0,
    "id": "biorxiv:10.1101/2025.06.26.661736",
    "canonical_key": "doi:10.1101/2025.06.26.661736",
    "headline": "Poison exon splicing in the human brain: a new paradigm for understanding and targeting neurological disorders",
    "summary": "Background: Poison exons (PE) are highly conserved exons whose inclusion creates premature termination codons (PTCs) and triggers nonsense-mediated decay (NMD) of the mature transcript.",
    "url": "https://doi.org/10.1101/2025.06.26.661736",
    "source": "bioRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.06.26.661736",
    "preprint_id": "biorxiv:10.1101/2025.06.26.661736",
    "authors": "Pigini, P.; Xu, H.; Ji, Y.; Lindmeier, H.; Saltzman, H. R.; Shull, H.; Yun, S.; Alves, C. R. R.; Walker, M. A.; Silva, M. C.; Gao, D.; Morini, E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; genetics"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 98,
    "score": 0,
    "id": "biorxiv:10.1101/2025.08.03.668375",
    "canonical_key": "doi:10.1101/2025.08.03.668375",
    "headline": "Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation",
    "summary": "The quantitative analysis of tissue deformation at cellular resolution remains an important challenge in mammalian organogenesis. Here, we developed a new computational workflow to extract regional and temporal patterns of tissue deformation and applied it to a collection of live microscopy datasets from mouse cardiogenesis.",
    "url": "https://doi.org/10.1101/2025.08.03.668375",
    "source": "bioRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.08.03.668375",
    "preprint_id": "biorxiv:10.1101/2025.08.03.668375",
    "authors": "Raiola, M.; Sendra, M.; Dominguez, J. N.; Torres, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; developmental biology"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 99,
    "score": 0,
    "id": "pubmed:42185206",
    "canonical_key": "pmid:42185206",
    "headline": "Reduced follicular helper T cells in peripheral blood marks a distinct feature of retroperitoneal fibrosis.",
    "summary": "Rheumatology (Oxford, England). Rheumatology (Oxford). 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42185206/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Rheumatology (Oxford, England)",
    "pmid": "42185206",
    "doi": "10.1093/rheumatology/keag274",
    "preprint_id": "",
    "authors": "Gao H; Li Z; Liu S; Zhong Y; Wong UK; Wang T; Lu G; Zhu Y; Zhao W; Zhao J; Zhang X; Luo C; He J; Zhang X; Pan C; Li Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-26",
    "window_start": "2026-05-25T17:15:00.000Z",
    "window_end": "2026-05-26T19:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 100,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.23.26353958",
    "canonical_key": "doi:10.64898/2026.05.23.26353958",
    "headline": "Role of genetic risk on progression to diabetes in children with acute pancreatitis",
    "summary": "Background: Acute pancreatitis (AP) is an established risk factor for diabetes, with approximately 20% of children developing either prediabetes or diabetes within one year of their first episode. Little is known about the diabetes pathophysiology or which individuals are at highest risk.",
    "url": "https://doi.org/10.64898/2026.05.23.26353958",
    "source": "medRxiv",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.23.26353958",
    "preprint_id": "medrxiv:10.64898/2026.05.23.26353958",
    "authors": "Zhang, L.; Ahmed, F.; Sharp, S. A.; Sun, H.; Thaman, S.; Wasserfall, C. H.; Gloyn, A. L.; Abu-El-Haija, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; endocrinology"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 1,
    "score": 100,
    "id": "pubmed:42190883",
    "canonical_key": "pmid:42190883",
    "headline": "Structural basis for TCR recognition of a Rac1 neoantigen arising from anchor residue mutation.",
    "summary": "Structures of a Rac1 P29S-HLA-A2 neoantigen and tumor-specific TCR 5934 show how an anchor-residue mutation enables selective peptide presentation and TCR recognition. High relevance for structural TCR/neoantigen targeting.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42190883/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "TCR-antigen specificity mapping: tcr recognition | Immunopeptidomics and HLA ligand discovery: neoantigen | Low-specificity pMHC/TCR field anchor: tcr",
    "journal": "Journal of structural biology",
    "pmid": "42190883",
    "doi": "10.1016/j.jsb.2026.108329",
    "preprint_id": "",
    "authors": "Zeng Y; Yang D; Zhao J; Yuan P; Jin H; Liao W; Chen G; Wu D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 2,
    "score": 100,
    "id": "pubmed:42191272",
    "canonical_key": "pmid:42191272",
    "headline": "Neoantigen-based TCR-T therapy in solid tumors.",
    "summary": "Review of neoantigen-directed TCR-T therapy in solid tumors, covering target discovery, patient antigen/TCR identification, clinical status, and major safety/efficacy challenges. High field relevance, but review article and older publication date.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42191272/",
    "source": "PubMed",
    "published_date": "2025-12-01",
    "match_reason": "Immunopeptidomics and HLA ligand discovery: neoantigen | TCR-T and adoptive TCR therapy: tcr-t | Low-specificity pMHC/TCR field anchor: tcr",
    "journal": "International review of cell and molecular biology",
    "pmid": "42191272",
    "doi": "10.1016/bs.ircmb.2025.11.001",
    "preprint_id": "",
    "authors": "Feng W; Wu D; Li Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "top",
    "rank_index": 3,
    "score": 77,
    "id": "pubmed:42195005",
    "canonical_key": "pmid:42195005",
    "headline": "Transglutaminase 2 at the Interface of Gene Regulation and Antigen Processing in HLA-Restricted Immunity of Celiac Disease.",
    "summary": "Mechanistic celiac disease review linking TG2 regulation, gluten peptide modification, HLA-DQ2/DQ8 presentation, and CD4+ T-cell activation. Relevant to HLA-restricted antigen presentation, lower priority for oncology pMHC targeting.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42195005/",
    "source": "PubMed",
    "published_date": "2026-05-03",
    "match_reason": "Direct pMHC or peptide-HLA targeting: hla-restricted | Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Genes",
    "pmid": "42195005",
    "doi": "10.3390/genes17050548",
    "preprint_id": "",
    "authors": "Cannea FB; Padiglia A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-27",
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    "rank_index": 4,
    "score": 48,
    "id": "pubmed:42191093",
    "canonical_key": "pmid:42191093",
    "headline": "CD40 agonistic-monovalent streptavidin fusion antibody for targeted neoantigen peptide delivery and potent cancer vaccination.",
    "summary": "Engineered CD40 agonist-streptavidin antibody delivers biotinylated neoantigen peptides to APCs, improving dendritic-cell activation and CD8+ T-cell antitumor responses in mouse models. Adjacent neoantigen delivery work rather than direct TCR/pMHC discovery.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42191093/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "Immunopeptidomics and HLA ligand discovery: neoantigen",
    "journal": "Journal of controlled release : official journal of the Controlled Release Society",
    "pmid": "42191093",
    "doi": "10.1016/j.jconrel.2026.115053",
    "preprint_id": "",
    "authors": "Jung D; Cai X; Wan Z; Khalil EA; Lee N; Ramseier NT; Bao Q; Zhao Z; Hu Y; Lim SO; Lee SS",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "score": 9,
    "id": "pubmed:42189254",
    "canonical_key": "pmid:42189254",
    "headline": "Allelic diversity and selection at the MHC class I and class II in a long-distance migratory shorebird, the Hudsonian Godwit (Limosa haemastica).",
    "summary": "Immunogenetics. Immunogenetics. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42189254/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc",
    "journal": "Immunogenetics",
    "pmid": "42189254",
    "doi": "10.1007/s00251-026-01401-6",
    "preprint_id": "",
    "authors": "Fernández K; Senner NR; Johnson JA; Navedo JG; Verdugo C",
    "assignee": "",
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    "id": "biorxiv:10.64898/2026.05.22.727291",
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    "headline": "Epistatic evolution drives HLA-dependent CD8+ T Cell escape risk in diverse populations",
    "summary": "Understanding how viral evolution shapes HLA-dependent T cell escape is crucial to identify individuals at risk of reduced cellular immunity to emerging variants. Nevertheless, we lack frameworks to model HLA diversity and the evolutionary feasibility of T cell-evading mutations.",
    "url": "https://doi.org/10.64898/2026.05.22.727291",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727291",
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    "authors": "Hamelin, D. J.; Grenier, J.-C.; Poujol, R.; Bourdin, B.; Pare, B.; Simpson, S.; Smith, M.; Decaluwe, H.; Caron, E.; Hussin, J.",
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    "primary_source": "bioRxiv",
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    "keywords": "biorxiv; genomics"
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    "digest_date": "2026-05-27",
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    "source_type": "papers",
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    "score": 9,
    "id": "biorxiv:10.64898/2026.05.22.727243",
    "canonical_key": "doi:10.64898/2026.05.22.727243",
    "headline": "Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8+ T cells",
    "summary": "Interferon-{gamma} (IFN{gamma}) signaling is prominent in inflammatory CNS microenvironments across many neurological disorders, but the neuronal peptides presented on HLA class I under these conditions and their functional consequences for CD8+ T cells remain incompletely defined.",
    "url": "https://doi.org/10.64898/2026.05.22.727243",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.22.727243",
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    "authors": "Clarkson, B. D. S.; Pucci, S.; Shrestha, R. B.; Mangalaparthi, K. K.; Raja, R.; Curtis, M.; Pandey, A.; Howe, C. L.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
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    "primary_source": "bioRxiv",
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    "digest_date": "2026-05-27",
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    "rank_index": 4,
    "score": 9,
    "id": "pubmed:42187016",
    "canonical_key": "pmid:42187016",
    "headline": "Identification of the Novel HLA-A*30:112 Allele by Sequencing-Based Typing in a Chinese Individual.",
    "summary": "HLA. HLA",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42187016/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "HLA",
    "pmid": "42187016",
    "doi": "10.1111/tan.70769",
    "preprint_id": "",
    "authors": "Li JP; Zhang X; Lin FQ; Li XF",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
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    "primary_source": "PubMed",
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    "score": 9,
    "id": "pubmed:42191216",
    "canonical_key": "pmid:42191216",
    "headline": "Systematic Evaluation of Peptidomimetic Modifications in a Major Histocompatibility Complex Class I Model Epitope: A Framework for Immunogenic Antigen Design.",
    "summary": "ACS chemical biology. ACS Chem Biol. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42191216/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "Low-specificity pMHC/TCR field anchor: major histocompatibility",
    "journal": "ACS chemical biology",
    "pmid": "42191216",
    "doi": "10.1021/acschembio.6c00291",
    "preprint_id": "",
    "authors": "Newkirk SE; Kelly JJ; Hourn N; Bhandari S; Spencer N; Pires MM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-27",
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    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 6,
    "score": 9,
    "id": "pubmed:42196614",
    "canonical_key": "pmid:42196614",
    "headline": "GM-CSF Promotes Superior In Vitro Differentiation of MHC II(+) CD11c(+) APCs Compared to L-929 Supernatant in Mouse Bone Marrow Cultures.",
    "summary": "International journal of molecular sciences. Int J Mol Sci. 2026-05-21",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42196614/",
    "source": "PubMed",
    "published_date": "2026-05-21",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc",
    "journal": "International journal of molecular sciences",
    "pmid": "42196614",
    "doi": "10.3390/ijms27104637",
    "preprint_id": "",
    "authors": "Cordeiro G; de Mato FCP; Bonfanti AP; Verinaud L; Rapôso C",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-27",
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    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 7,
    "score": 9,
    "id": "pubmed:42195406",
    "canonical_key": "pmid:42195406",
    "headline": "Association Between Baseline Anti-HLA (Class I and II) and Anti-MICA Antibodies and Inflammatory Cell Infiltrates in Grafted Bone After Maxillary Sinus Floor Augmentation: An Exploratory Secondary Histological Study.",
    "summary": "Life (Basel, Switzerland). Life (Basel). 2026-05-20",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42195406/",
    "source": "PubMed",
    "published_date": "2026-05-20",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Life (Basel, Switzerland)",
    "pmid": "42195406",
    "doi": "10.3390/life16050851",
    "preprint_id": "",
    "authors": "Dominiak S; Dominiak M; Hadzik J; Ciszyński M; Kepinska M; Banasik M; Piotrowska A; Dzięgiel P; Gedrange T; Baranowska A; Kubasiewicz-Ross P",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-27",
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    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 8,
    "score": 9,
    "id": "pubmed:42199926",
    "canonical_key": "pmid:42199926",
    "headline": "Presentation of identical tumor antigen peptides by canine and human MHC class I.",
    "summary": "iScience. iScience. 2026-05-15",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42199926/",
    "source": "PubMed",
    "published_date": "2026-05-15",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc",
    "journal": "iScience",
    "pmid": "42199926",
    "doi": "10.1016/j.isci.2026.115975",
    "preprint_id": "",
    "authors": "Kaabinejadian S; Yari H; Cate S; Berry W; Zhang M; Cavanagh HL; Zhao S; Hildebrand WH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-27",
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    "source_type": "papers",
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    "rank_index": 9,
    "score": 9,
    "id": "pubmed:42196169",
    "canonical_key": "pmid:42196169",
    "headline": "Integrating Pharmacogenomics and Network Topology for Machine Learning Prediction of HLA-Associated Severe Cutaneous Adverse Drug Reactions.",
    "summary": "International journal of molecular sciences. Int J Mol Sci. 2026-05-08",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42196169/",
    "source": "PubMed",
    "published_date": "2026-05-08",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "International journal of molecular sciences",
    "pmid": "42196169",
    "doi": "10.3390/ijms27104187",
    "preprint_id": "",
    "authors": "Ponduan T; Kunsombut A; Paklao T; Suratanee A; Pornputtapong N; Plaimas K",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-27",
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    "source_type": "papers",
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    "rank_index": 10,
    "score": 9,
    "id": "pubmed:42194974",
    "canonical_key": "pmid:42194974",
    "headline": "Immunogenetics of Idiopathic Inflammatory Myopathies: The Role of HLA Genes Within and Beyond the Ancestral Haplotype.",
    "summary": "Genes. Genes (Basel). 2026-04-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42194974/",
    "source": "PubMed",
    "published_date": "2026-04-27",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Genes",
    "pmid": "42194974",
    "doi": "10.3390/genes17050517",
    "preprint_id": "",
    "authors": "Gumkowska-Sroka O; Kotyla K; Kotyla P",
    "assignee": "",
    "publication_number": "",
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    "digest_date": "2026-05-27",
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    "source_type": "papers",
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    "rank_index": 11,
    "score": 9,
    "id": "pubmed:42193300",
    "canonical_key": "pmid:42193300",
    "headline": "TAF1 Suppresses MHC-I Expression and Correlates with Poor Immunotherapy Response in Small Cell Lung Cancer.",
    "summary": "Biomedicines. Biomedicines. 2026-04-23",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42193300/",
    "source": "PubMed",
    "published_date": "2026-04-23",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc",
    "journal": "Biomedicines",
    "pmid": "42193300",
    "doi": "10.3390/biomedicines14050973",
    "preprint_id": "",
    "authors": "Gao Q; Wei K; Pan D; Xi Y; Xu C; Jia D",
    "assignee": "",
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    "primary_source": "PubMed",
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    "rank_index": 12,
    "score": 9,
    "id": "pubmed:42199176",
    "canonical_key": "pmid:42199176",
    "headline": "Immunohistochemical Expression of HLA Classes I and II in Neonatal Cholestatic Liver Disease.",
    "summary": "Iranian journal of pathology. Iran J Pathol. 2026-02-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42199176/",
    "source": "PubMed",
    "published_date": "2026-02-26",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Iranian journal of pathology",
    "pmid": "42199176",
    "doi": "10.22034/ijp.2025.2068085.3503",
    "preprint_id": "",
    "authors": "Taie DM; Megeed Nagi SA; Elkhadry SW; Fayed Y; Mohamady M; El Gendy WG",
    "assignee": "",
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  {
    "digest_date": "2026-05-27",
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    "source_type": "papers",
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    "score": 3,
    "id": "journal-rss:cell in press:10.1016/j.cell.2026.05.002",
    "canonical_key": "doi:10.1016/j.cell.2026.05.002",
    "headline": "Farnesylation-driven KRAS phase separation promotes colon tumor growth",
    "summary": "Through farnesylation-driven phase separation, KRAS forms cytoplasmic condensates that facilitate its processing and signaling, driving tumor growth and impacting G12C inhibition efficacy.",
    "url": "https://doi.org/10.1016/j.cell.2026.05.002",
    "source": "Cell RSS",
    "published_date": "2026-05-27",
    "match_reason": "Watchlist hits: KRAS",
    "journal": "Cell",
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    "doi": "10.1016/j.cell.2026.05.002",
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    "authors": "Xingwen Wang, Yi Zhang, Minqiao Lu, Yafan Gong, Tianqi Guan, Guixue Hou, Yutong Wei, Meiqi Wang, Hao Liu, Lisha Huang, Shanliang Zheng, Qingyu Lin, Wenxin Zhang, Zhiyuan Xiang, Jiangwen Ma, Li Li, Hongxue Meng, Xinyuan Tong, Hongbin Ji, Jian Huang, Ying Hu",
    "assignee": "",
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    "primary_source": "Cell RSS",
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    "digest_date": "2026-05-27",
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    "rank_index": 14,
    "score": 3,
    "id": "pubmed:42188939",
    "canonical_key": "pmid:42188939",
    "headline": "Chicken lncRNA-9802 Induces the S Phase Arrest in the T Lymphocyte Cells Infected by Marek's Disease Virus via the TP53BP1/p53/p21 Pathway.",
    "summary": "Veterinary sciences. Vet Sci. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42188939/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "Watchlist hits: TP53",
    "journal": "Veterinary sciences",
    "pmid": "42188939",
    "doi": "10.3390/vetsci13050469",
    "preprint_id": "",
    "authors": "Han S; Ren H; Yang J; Han K; Qiu Y; Jiang Y; Han L; Han L",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "score": 0,
    "id": "pubmed:42190708",
    "canonical_key": "pmid:42190708",
    "headline": "Incorporating the Next Generation of Immunotherapies Into the Treatment of Multiple Myeloma.",
    "summary": "Journal of the National Comprehensive Cancer Network : JNCCN. J Natl Compr Canc Netw. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42190708/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of the National Comprehensive Cancer Network : JNCCN",
    "pmid": "42190708",
    "doi": "10.6004/jnccn.2026.7004",
    "preprint_id": "",
    "authors": "Miller KC; Firestone RS; Hultcrantz M",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "source_type": "papers",
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    "rank_index": 16,
    "score": 0,
    "id": "pubmed:42200325",
    "canonical_key": "pmid:42200325",
    "headline": "[Common Variable Immunodeficiency as a Multisystem Disorder - A Case Report].",
    "summary": "Harefuah. Harefuah",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42200325/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Harefuah",
    "pmid": "42200325",
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    "preprint_id": "",
    "authors": "Benor S; Hagin D",
    "assignee": "",
    "publication_number": "",
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    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 0,
    "id": "pubmed:42192530",
    "canonical_key": "pmid:42192530",
    "headline": "A conserved capsid-based multi-epitope vaccine targeting dengue virus serotypes (DENV1-4): an integrated computational and in vivo study.",
    "summary": "BMC immunology. BMC Immunol. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42192530/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "BMC immunology",
    "pmid": "42192530",
    "doi": "10.1186/s12865-026-00857-1",
    "preprint_id": "",
    "authors": "Khatrawi EM; Ali SL; Ali A; Ali SM; Althagafi H",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
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    "primary_source": "PubMed",
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  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 18,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10579-4",
    "canonical_key": "doi:10.1038/s41586-026-10579-4",
    "headline": "A direct black-hole mass measurement in a little red dot at high redshift",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10579-4 A direct, dynamical black-hole mass measurement in a strongly lensed little red dot at high redshift indicates that it is a massive black-hole seed caught in its earliest accretion phase.",
    "url": "https://doi.org/10.1038/s41586-026-10579-4",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10579-4",
    "preprint_id": "",
    "authors": "Ignas Juodžbalis; Cosimo Marconcini; Francesco D’Eugenio; Roberto Maiolino; Alessandro Marconi; Hannah Übler; Jan Scholtz; Xihan Ji; Gareth C. Jones; Michele Perna; Santiago Arribas; Jake S. Bennett",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01456-1",
    "canonical_key": "doi:10.1038/d41586-026-01456-1",
    "headline": "AI and simple blood tests could catch lung cancer earlier",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01456-1 Lung cancer screening is not currently available to a lot of people in the United States who could benefit from it. But new tools and data could soon broaden the tests’ reach.",
    "url": "https://doi.org/10.1038/d41586-026-01456-1",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01456-1",
    "preprint_id": "",
    "authors": "Amanda Keener",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10700-7",
    "canonical_key": "doi:10.1038/s41586-026-10700-7",
    "headline": "Author Correction: Modelling late gastrulation in stem cell-derived monkey embryo models",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10700-7 Author Correction: Modelling late gastrulation in stem cell-derived monkey embryo models",
    "url": "https://doi.org/10.1038/s41586-026-10700-7",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10700-7",
    "preprint_id": "",
    "authors": "Jie Li; Jing Cao; ShenShen Shang; Liansheng Zhang; Fei Gao; Jiqiang Fu; Hongyu Chen; Guizhong Cui; Haoyuan Wu; Xiaolong Wang; Alfonso Martinez-Arias; Qiang Sun",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 21,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10553-0",
    "canonical_key": "doi:10.1038/s41586-026-10553-0",
    "headline": "Author Correction: Satellite megaconstellations will threaten space-based astronomy",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10553-0 Author Correction: Satellite megaconstellations will threaten space-based astronomy",
    "url": "https://doi.org/10.1038/s41586-026-10553-0",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10553-0",
    "preprint_id": "",
    "authors": "Alejandro S. Borlaff; Pamela M. Marcum; Steve B. Howell",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 22,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01571-z",
    "canonical_key": "doi:10.1038/d41586-026-01571-z",
    "headline": "Biobank analysis reveals more than 88,000 genetic associations with metabolic traits",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01571-z An investigation of the Estonian Biobank and the UK Biobank has identified more than 88,000 associations between more than 8,000 genomic regions and metabolic traits.",
    "url": "https://doi.org/10.1038/d41586-026-01571-z",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01571-z",
    "preprint_id": "",
    "authors": "",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 23,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10450-6",
    "canonical_key": "doi:10.1038/s41586-026-10450-6",
    "headline": "Bohmian mechanics remains unchallenged by tunnelling experiment",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10450-6 Bohmian mechanics remains unchallenged by tunnelling experiment",
    "url": "https://doi.org/10.1038/s41586-026-10450-6",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10450-6",
    "preprint_id": "",
    "authors": "Aurélien Drezet; Dustin Lazarovici; Bernard Michael Nabet",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 24,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10609-1",
    "canonical_key": "doi:10.1038/s41586-026-10609-1",
    "headline": "Cavity-driven attractive interactions in quantum materials",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10609-1 A broadband, sub-wavelength time-domain microscope is described, enabling the observation that terahertz light trapped within a cavity can mediate attractive interactions in a tunable van der Waals material.",
    "url": "https://doi.org/10.1038/s41586-026-10609-1",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10609-1",
    "preprint_id": "",
    "authors": "F. Helmrich; H. S. Adlong; M. Kroner; I. Khanonkin; G. Scalari; J. Faist; A. İmamoğlu; T. F. Nova",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10591-8",
    "canonical_key": "doi:10.1038/s41586-026-10591-8",
    "headline": "Cellular water-potential sensing through biomolecular condensation",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10591-8 Plants sense water deficiency through SAM8 protein condensation, which responds to reduced hydration and triggers stress adaptation by altering RNA export and gene translation.",
    "url": "https://doi.org/10.1038/s41586-026-10591-8",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10591-8",
    "preprint_id": "",
    "authors": "Yunhe Wang; Longchen Zhu; Yun Yang; Xiaoshuang Li; Xin Zhang; Xiaofeng Fang",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
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  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01325-x",
    "canonical_key": "doi:10.1038/d41586-026-01325-x",
    "headline": "Child sexual abuse enabled by digital technologies is widespread and under-reported",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01325-x One in six Internet-using adolescents in parts of Africa and Asia faced technology-facilitated sexual abuse in 2020–21. As digital access expands globally, better protection is crucial.",
    "url": "https://doi.org/10.1038/d41586-026-01325-x",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01325-x",
    "preprint_id": "",
    "authors": "Xiangming Fang; Greta M. Massetti",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 27,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01382-2",
    "canonical_key": "doi:10.1038/d41586-026-01382-2",
    "headline": "Could a pill prevent the world’s deadliest cancer?",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01382-2 ‘Interception’ drug trials hope to stop lung cancer before it starts.",
    "url": "https://doi.org/10.1038/d41586-026-01382-2",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01382-2",
    "preprint_id": "",
    "authors": "",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 28,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10541-4",
    "canonical_key": "doi:10.1038/s41586-026-10541-4",
    "headline": "Darkness and body size shaped end-Cretaceous marine extinction patterns",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10541-4 Trait-based ecosystem modelling shows that impact-driven darkness and body-size-dependent extinction thresholds, rather than carbon-dioxide increase or acidification, drove most of the observed end-Cretaceous marine extinction patterns.",
    "url": "https://doi.org/10.1038/s41586-026-10541-4",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10541-4",
    "preprint_id": "",
    "authors": "Rui Ying; Fanny M. Monteiro; James D. Witts; Daniela N. Schmidt",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 29,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10581-w",
    "canonical_key": "doi:10.1038/s41586-026-10581-w",
    "headline": "Direct observation of the superallowed α-decay of 104 Te",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10581-w Enhanced preformation of the α particle, a strongly bound system of two protons and two neutrons, in 104Te causes it to be the fastest ground-state α-emitting nucleus known so far.",
    "url": "https://doi.org/10.1038/s41586-026-10581-w",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10581-w",
    "preprint_id": "",
    "authors": "Ian Cox; Robert Grzywacz; T. T. King; K. P. Rykaczewski; S. Nishimura; R. Yokoyama; N. Fukuda; N. Kitamura; S. Go; C. Mazzocchi; J. M. Allmond; A. Augustyn",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 30,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10516-5",
    "canonical_key": "doi:10.1038/s41586-026-10516-5",
    "headline": "Distinct genetic architecture in the tails of complex traits",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10516-5 Genome-wide analyses in multiancestry and European cohorts show that in complex traits, rare alleles have disproportionately large effects at the tails of the phenotypic spectrum compared with common alleles.",
    "url": "https://doi.org/10.1038/s41586-026-10516-5",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10516-5",
    "preprint_id": "",
    "authors": "T. Souaiaia; H. M. Wu; A. P. S. Ori; S. W. Choi; C. J. Hoggart; P. F. O’Reilly",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 31,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01455-2",
    "canonical_key": "doi:10.1038/d41586-026-01455-2",
    "headline": "Drugs that boost immunity are making lung cancer less deadly",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01455-2 Innovative drugs can extend life and an experimental vaccine might even prevent the disease outright.",
    "url": "https://doi.org/10.1038/d41586-026-01455-2",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01455-2",
    "preprint_id": "",
    "authors": "Tammy Worth",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 32,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10585-6",
    "canonical_key": "doi:10.1038/s41586-026-10585-6",
    "headline": "Dynamical freezing for magnetometry in an interacting spin ensemble",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10585-6 Dynamical freezing, a mechanism by which a driven quantum system may not thermalize to a featureless ‘infinite-temperature’ state at long times, is experimentally observed in an ensemble of interacting nitrogen-vacancy spins in diamond.",
    "url": "https://doi.org/10.1038/s41586-026-10585-6",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10585-6",
    "preprint_id": "",
    "authors": "Ya-Nan Lu; Dong Yuan; Yixuan Ma; Yan-Qing Liu; Si Jiang; Xiang-Qian Meng; Yi-Jie Xu; Xiu-Ying Chang; Chong Zu; Hong-Zheng Zhao; Dong-Ling Deng; Lu-Ming Duan",
    "assignee": "",
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    "id": "journal-rss:nature current issue:10.1038/s41586-026-10521-8",
    "canonical_key": "doi:10.1038/s41586-026-10521-8",
    "headline": "Experimental randomness amplification",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10521-8 An experimental realization of device-independent randomness amplification is demonstrated using superconducting qubits, in which a source of weak, correlated randomness is converted into virtually perfect random bits, certified by a Bell test.",
    "url": "https://doi.org/10.1038/s41586-026-10521-8",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10521-8",
    "preprint_id": "",
    "authors": "Anatoly Kulikov; Simon Storz; Josua D. Schär; Martin Sandfuchs; Ramona Wolf; Florence Berterottière; Christoph Hellings; Andreas Wallraff; Renato Renner",
    "assignee": "",
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    "primary_source": "Nature RSS",
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    "keywords": "journal rss; Nature; Nature current issue"
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  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01460-5",
    "canonical_key": "doi:10.1038/d41586-026-01460-5",
    "headline": "Five highlights from lung-cancer research",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01460-5 Treatment breakthroughs, improved screening approaches and other developments from recent studies.",
    "url": "https://doi.org/10.1038/d41586-026-01460-5",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01460-5",
    "preprint_id": "",
    "authors": "Rachel Nuwer",
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    "primary_source": "Nature RSS",
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    "id": "journal-rss:nature current issue:10.1038/s41586-026-10556-x",
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    "headline": "Four ppm measurement of the antihydrogen ground-state hyperfine splitting",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10556-x A measurement of the hyperfine splitting energy of the ground state of antihydrogen at 4 ppm precision reaches a point at which this result is sensitive to the internal structure of the antiproton.",
    "url": "https://doi.org/10.1038/s41586-026-10556-x",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
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    "doi": "10.1038/s41586-026-10556-x",
    "preprint_id": "",
    "authors": "R. Akbari; L. O. de Araujo Azevedo; C. J. Baker; W. Bertsche; N. M. Bhatt; G. Bonomi; A. Capra; I. Carli; C. L. Cesar; M. Charlton; A. Cridland Mathad; A. Del Vincio",
    "assignee": "",
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    "primary_source": "Nature RSS",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01628-z",
    "canonical_key": "doi:10.1038/d41586-026-01628-z",
    "headline": "GDP and beyond: why treating nature as capital cannot save the planet",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01628-z Global risks are too great for markets alone to curb. Political considerations must come before economic ones.",
    "url": "https://doi.org/10.1038/d41586-026-01628-z",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01628-z",
    "preprint_id": "",
    "authors": "Walter J. Radermacher",
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    "primary_source": "Nature RSS",
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  {
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    "source_type": "papers",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01661-y",
    "canonical_key": "doi:10.1038/d41586-026-01661-y",
    "headline": "Gene clock predicts time to death in humans – and assesses ‘biological’ age",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01661-y Cellular-ageing clocks based on gene activity could be more sensitive than previous measures.",
    "url": "https://doi.org/10.1038/d41586-026-01661-y",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01661-y",
    "preprint_id": "",
    "authors": "Heidi Ledford",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "Nature RSS",
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    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01326-w",
    "canonical_key": "doi:10.1038/d41586-026-01326-w",
    "headline": "Gene-expression patterns can be used to estimate mortality risk and chronological age",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01326-w Massive analyses of RNA transcripts from rodents, monkeys and humans reveal hallmarks of ageing that could expedite the development of anti-ageing interventions.",
    "url": "https://doi.org/10.1038/d41586-026-01326-w",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01326-w",
    "preprint_id": "",
    "authors": "João Pedro de Magalhães",
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    "primary_source": "Nature RSS",
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    "id": "journal-rss:nature current issue:10.1038/s41586-026-10576-7",
    "canonical_key": "doi:10.1038/s41586-026-10576-7",
    "headline": "Genetic architecture of sugarcane traits in a polyploid genomics framework",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10576-7 A fully phased genome assembly of the sugarcane foundational cultivar POJ2878 reveals extensive subgenome recombination and non-homologous chromosomal rearrangements.",
    "url": "https://doi.org/10.1038/s41586-026-10576-7",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "pmid": "",
    "doi": "10.1038/s41586-026-10576-7",
    "preprint_id": "",
    "authors": "Jungang Wang; Xiaofeng Li; Yibin Wang; Jishan Lin; Shuai Chen; Hongbo Liu; Xiao Chen; Kun Chai; Aoqian Dong; Tingting Zhao; Cuilian Feng; Ruijie Wu",
    "assignee": "",
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    "primary_source": "Nature RSS",
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    "id": "pubmed:42192477",
    "canonical_key": "pmid:42192477",
    "headline": "Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.",
    "summary": "Genome medicine. Genome Med. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42192477/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Genome medicine",
    "pmid": "42192477",
    "doi": "10.1186/s13073-026-01670-6",
    "preprint_id": "",
    "authors": "Chang X; Li Z; Thai PVK; Ha DTM; Thuong NTT; Wee D; Subhan ASBM; Silcocks M; Chee CBE; Nhu NTQ; Heng CK; Teo YY; Singhal A; Oehlers SH; Yuan JM; Koh WP; Caws M; Khor CC; Dorajoo R; Dunstan SJ",
    "assignee": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
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    "source_type": "papers",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01461-4",
    "canonical_key": "doi:10.1038/d41586-026-01461-4",
    "headline": "Global lung cancer burden shifting to middle-income countries",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01461-4 High smoking rates and polluted air mean lung cancer cases are rising fastest in places such as China. Africa could soon head in the same direction.",
    "url": "https://doi.org/10.1038/d41586-026-01461-4",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01461-4",
    "preprint_id": "",
    "authors": "Ben Deighton",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "Nature RSS",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01639-w",
    "canonical_key": "doi:10.1038/d41586-026-01639-w",
    "headline": "Hailstorms are predicted to hit harder with climate change",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01639-w The global likelihood of damage from hailstorms is predicted to increase substantially by the end of the century, owing to increases in hailstone size as the climate warms.",
    "url": "https://doi.org/10.1038/d41586-026-01639-w",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01639-w",
    "preprint_id": "",
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    "primary_source": "Nature RSS",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01458-z",
    "canonical_key": "doi:10.1038/d41586-026-01458-z",
    "headline": "How the connection between lung cancer and the brain could lead to better treatments",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01458-z The discovery that small cell lung cancer has several neuronal features is yielding biological insights that could ultimately save lives.",
    "url": "https://doi.org/10.1038/d41586-026-01458-z",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01458-z",
    "preprint_id": "",
    "authors": "Liam Drew",
    "assignee": "",
    "publication_number": "",
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    "event_type": "",
    "primary_source": "Nature RSS",
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    "digest_date": "2026-05-27",
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    "id": "pubmed:42200313",
    "canonical_key": "pmid:42200313",
    "headline": "Integrated pharmacological and Omega-3 therapy modulates immunometabolic pathways and neuro-ophthalmological outcomes in relapsing-remitting multiple sclerosis.",
    "summary": "Immunotherapy. Immunotherapy. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42200313/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Immunotherapy",
    "pmid": "42200313",
    "doi": "10.1080/1750743X.2026.2676451",
    "preprint_id": "",
    "authors": "Ahmed Merza Mohammed T; Nouri Shawis T; Ahmad Merza Mohammad T; Al-Haideri M",
    "assignee": "",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01459-y",
    "canonical_key": "doi:10.1038/d41586-026-01459-y",
    "headline": "Lung cancer in women emerges as a distinct disease",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01459-y A malignancy that once mainly affected men has broadened its reach. But marked disparities in research, detection and treatment remain.",
    "url": "https://doi.org/10.1038/d41586-026-01459-y",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
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    "doi": "10.1038/d41586-026-01459-y",
    "preprint_id": "",
    "authors": "Claire Ainsworth",
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    "primary_source": "Nature RSS",
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    "id": "journal-rss:nature current issue:10.1038/s41586-026-10569-6",
    "canonical_key": "doi:10.1038/s41586-026-10569-6",
    "headline": "Mechanism of age-related accumulation of mtDNA mutations in human blood",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10569-6 Genome-wide analyses indicate that accumulation of mitochondrial DNA mutations, a hallmark of ageing, may be caused by cryptic replication errors, which act as passenger mutations that eventually become detectable with age owing to age-related somatic mosaicism, rather...",
    "url": "https://doi.org/10.1038/s41586-026-10569-6",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
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    "journal": "Nature",
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    "doi": "10.1038/s41586-026-10569-6",
    "preprint_id": "",
    "authors": "Rahul Gupta; Timothy J. Durham; Grant Chau; Masahiro Kanai; Md Mesbah Uddin; Wenhan Lu; M. Austin Argentieri; Konrad J. Karczewski; Daniel Howrigan; Pradeep Natarajan; Wei Zhou; Benjamin M. Neale",
    "assignee": "",
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    "primary_source": "Nature RSS",
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  {
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    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 47,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01622-5",
    "canonical_key": "doi:10.1038/d41586-026-01622-5",
    "headline": "Meet the biologists deciphering marine-mammal histories from baleen, whiskers and tusks",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01622-5 The nascent field of wildlife endocrinology is upending scientists’ understanding of pregnancies and stress",
    "url": "https://doi.org/10.1038/d41586-026-01622-5",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
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    "doi": "10.1038/d41586-026-01622-5",
    "preprint_id": "",
    "authors": "Virginia Gewin",
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    "primary_source": "Nature RSS",
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    "window_start": "2026-05-26T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 48,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01618-1",
    "canonical_key": "doi:10.1038/d41586-026-01618-1",
    "headline": "Memory on trial: the new science of when to trust eyewitness testimony",
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    "url": "https://doi.org/10.1038/d41586-026-01618-1",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
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    "doi": "10.1038/d41586-026-01618-1",
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    "headline": "Metamaterial-enhanced near-field radiative heat transfer",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10595-4 Near-field radiative heat transfer between silicon nitride membranes is enhanced several-fold by using metamaterials, opening opportunities for thermal energy harvesting and infrared sensing applications.",
    "url": "https://doi.org/10.1038/s41586-026-10595-4",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
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    "preprint_id": "",
    "authors": "Zexiao Wang; Renwen Yu; Hakan Salihoglu; Xiao Luo; Zhuo Li; Hyeonggyun Kim; Xiu Liu; Tianyi Huang; Yibai Zhong; Shanhui Fan; Sheng Shen",
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    "headline": "Monolithic three-dimensional integration of silicon transistors",
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    "url": "https://doi.org/10.1038/s41586-026-10496-6",
    "source": "Nature RSS",
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    "journal": "Nature",
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    "doi": "10.1038/s41586-026-10496-6",
    "preprint_id": "",
    "authors": "Bao Lam; Yung Man Yu; Hyunjun Nam; Hsu-Chih Ni; Shomik Chatterjee; Shaloo Rakheja; Jian-Min Zuo; Qing Cao",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01686-3",
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    "headline": "Move over, AlphaFold: open source model predicts shape of 1 billion proteins",
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    "url": "https://doi.org/10.1038/d41586-026-01686-3",
    "source": "Nature RSS",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01629-y",
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    "headline": "Nature is expanding Registered Reports to all the fields in which we publish",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01629-y Registered Reports improve the credibility of scientific claims by rewarding big questions, sound methods and solid analyses. They need to become a standard tool in research.",
    "url": "https://doi.org/10.1038/d41586-026-01629-y",
    "source": "Nature RSS",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01414-x",
    "canonical_key": "doi:10.1038/d41586-026-01414-x",
    "headline": "Nests in an egg cell: structures of protein-storage units in oocytes",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01414-x A fertilized egg’s first few divisions rely on proteins stored in fibrous structures. The ordered nature of these structures and clues about their function are revealed.",
    "url": "https://doi.org/10.1038/d41586-026-01414-x",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "canonical_key": "doi:10.1038/d41586-026-01457-0",
    "headline": "Never smoked? Good, but you could still get lung cancer",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01457-0 Lung cancer in people who have never smoked is now recognized as a distinct disease with its own treatments and preventative strategies.",
    "url": "https://doi.org/10.1038/d41586-026-01457-0",
    "source": "Nature RSS",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "id": "pubmed:42191947",
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    "headline": "Optimized PET/CT response assessment for prognostic stratification compared with Lugano criteria in extranodal NK/T-Cell lymphoma.",
    "summary": "European journal of nuclear medicine and molecular imaging. Eur J Nucl Med Mol Imaging. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42191947/",
    "source": "PubMed",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "European journal of nuclear medicine and molecular imaging",
    "pmid": "42191947",
    "doi": "10.1007/s00259-026-07959-3",
    "preprint_id": "",
    "authors": "Zhang X; Zhang X; Zhang Z; Huang X; Xu P; Jiang C; Miao Y; Guo R; Li B",
    "assignee": "",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01416-9",
    "canonical_key": "doi:10.1038/d41586-026-01416-9",
    "headline": "Organ formation in early human embryos captured in spatial cell atlas",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01416-9 Spatial maps of gene expression in whole human embryos across several weeks of early development offer insights into the molecular programs that drive organogenesis.",
    "url": "https://doi.org/10.1038/d41586-026-01416-9",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "authors": "Varun K. A. Sreenivasan; Malte Spielmann",
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    "headline": "Prediction of antibody non-specificity using protein language models and biophysical parameters.",
    "summary": "mAbs. MAbs. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42200306/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "mAbs",
    "pmid": "42200306",
    "doi": "10.1080/19420862.2026.2678000",
    "preprint_id": "",
    "authors": "Sakhnini LI; Beltrame L; Fulle S; Sormanni P; Henriksen A; Lorenzen N; Vendruscolo M; Granata D",
    "assignee": "",
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    "id": "journal-rss:nature current issue:10.1038/s41586-026-10536-1",
    "canonical_key": "doi:10.1038/s41586-026-10536-1",
    "headline": "Redesigning algorithms to intervene on social norm misperceptions during a national election",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10536-1 Engagement-based feeds amplify intergroup, moralized, emotional (IME) and toxic content relative to reverse-chronological feeds, and a diversified extremity algorithm reduces exposure to IME and toxic content while maintaining comparable platform enjoyment.",
    "url": "https://doi.org/10.1038/s41586-026-10536-1",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10536-1",
    "preprint_id": "",
    "authors": "William J. Brady; Meriel Doyle; Abdo Elnakouri; Eli J. Finkel; Joshua Conrad Jackson; Nour Kteily; Victoria Parker; Curtis Puryear; Trevor Spelman; Jacob Teeny; Mark Torres",
    "assignee": "",
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    "event_type": "",
    "primary_source": "Nature RSS",
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    "keywords": "journal rss; Nature; Nature current issue"
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    "digest_date": "2026-05-27",
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    "id": "journal-rss:nature current issue:10.1038/s41586-026-10543-2",
    "canonical_key": "doi:10.1038/s41586-026-10543-2",
    "headline": "Rising global hail damage potential in a warming world",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10543-2 Hailstone trajectory simulations conducted under historical and future scenarios show a shift towards larger hailstones, resulting in global hailstorm-induced damage potential increasing by around 40% by the late twenty-first century.",
    "url": "https://doi.org/10.1038/s41586-026-10543-2",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10543-2",
    "preprint_id": "",
    "authors": "Shiyi Zhang; Qinghong Zhang; John T. Allen; Xiangyu Lin",
    "assignee": "",
    "publication_number": "",
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    "event_type": "",
    "primary_source": "Nature RSS",
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    "keywords": "journal rss; Nature; Nature current issue"
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    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
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    "source_type": "papers",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01381-3",
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    "headline": "Science takes on the world’s most lethal malignancy",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01381-3 Early detection, innovative drugs and a better understanding of lung cancer is resulting in improved outcomes for people with the disease.",
    "url": "https://doi.org/10.1038/d41586-026-01381-3",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01381-3",
    "preprint_id": "",
    "authors": "Herb Brody",
    "assignee": "",
    "publication_number": "",
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    "digest_date": "2026-05-27",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01089-4",
    "canonical_key": "doi:10.1038/d41586-026-01089-4",
    "headline": "Scraping",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01089-4 Supply and demand.",
    "url": "https://doi.org/10.1038/d41586-026-01089-4",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01089-4",
    "preprint_id": "",
    "authors": "Laura O’Meara",
    "assignee": "",
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    "primary_source": "Nature RSS",
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  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
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    "source_type": "papers",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01636-z",
    "canonical_key": "doi:10.1038/d41586-026-01636-z",
    "headline": "Social‑media feeds are detoxified by a redesigned algorithm",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01636-z A large-scale experiment tested the impact of changing the Bluesky feed-ranking algorithm on political content and perceptions during the 2024 US presidential election.",
    "url": "https://doi.org/10.1038/d41586-026-01636-z",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01636-z",
    "preprint_id": "",
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    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
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    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10537-0",
    "canonical_key": "doi:10.1038/s41586-026-10537-0",
    "headline": "Sparse-to-dense coding transformation between hippocampal areas CA3 and CA1",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10537-0 The hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.",
    "url": "https://doi.org/10.1038/s41586-026-10537-0",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
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    "authors": "Shir R. Maimon; Tamir Eliav; Johnatan Aljadeff; Aviya Shalev; Yishai Gronich; Nikita M. Finger; Keegan E. Eveland; Cynthia F. Moss; Liora Las; Nachum Ulanovsky",
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    "id": "journal-rss:cell in press:10.1016/j.cell.2026.05.006",
    "canonical_key": "doi:10.1016/j.cell.2026.05.006",
    "headline": "Structural basis of Wnt signalosome extracellular complex assembly",
    "summary": "Cryo-EM structures of Wnt3a/Fzd8-CRD/LRP6-E3E4 reveal assembly and activation mechanisms of the Wnt signalosome extracellular complex.",
    "url": "https://doi.org/10.1016/j.cell.2026.05.006",
    "source": "Cell RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cell",
    "pmid": "",
    "doi": "10.1016/j.cell.2026.05.006",
    "preprint_id": "",
    "authors": "Dan Yue, Gangyu Sun, Yunlong Cao, Hongyue Li, Yufeng Yang, Zirun Pan, Lulu Xue, Lu Zhang, Zhizhi Wang, Wenqing Xu",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Cell RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Cell; Cell in-press"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 65,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10582-9",
    "canonical_key": "doi:10.1038/s41586-026-10582-9",
    "headline": "Substrate selectivity of the human RNA m 5 C methyltransferase NSUN2",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10582-9 NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.",
    "url": "https://doi.org/10.1038/s41586-026-10582-9",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10582-9",
    "preprint_id": "",
    "authors": "Jacob Canepa; Victor M. Ruiz-Arroyo; Netanya S. Schlamowitz; Yunsun Nam",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 66,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10525-4",
    "canonical_key": "doi:10.1038/s41586-026-10525-4",
    "headline": "Technology mediation in child sexual exploitation and abuse in Africa and Asia",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10525-4 Enabling parental mediation of online activities and children’s knowledge of where to seek help after sexual harassment or assault is associated with higher rates of disclosure of technology-facilitated CSEA.",
    "url": "https://doi.org/10.1038/s41586-026-10525-4",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10525-4",
    "preprint_id": "",
    "authors": "Sakshi Ghai; Matti Vuorre; Daniel Kardefelt-Winther; Amanda M. Ferguson; Sebastian Kurten; Sonia Livingstone; Andrew K. Przybylski; Amy Orben",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 67,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10607-3",
    "canonical_key": "doi:10.1038/s41586-026-10607-3",
    "headline": "Temporary carbon dioxide removal to offset short-lived climate forcers",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10607-3 Temporary carbon dioxide removal can offset short-lived non-CO2 climate forcers, providing a viable physical approach for crediting temporary carbon dioxide removal activities in industries in which non-CO2 emissions dominate and direct emission reductions are difficul...",
    "url": "https://doi.org/10.1038/s41586-026-10607-3",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10607-3",
    "preprint_id": "",
    "authors": "Yue He; Keywan Riahi; Matthew J. Gidden; Shilong Piao; Tao Wang; Thomas Gasser",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 68,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10526-3",
    "canonical_key": "doi:10.1038/s41586-026-10526-3",
    "headline": "Transcription factor codes patterning neuronal groundplans of the cerebrum",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10526-3 Researchers mapped how transcription factors define neuron lineages in fruit fly brains, revealing hierarchical genetic programs that shape and specialize circuits controlling motivated behaviours such as mating.",
    "url": "https://doi.org/10.1038/s41586-026-10526-3",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10526-3",
    "preprint_id": "",
    "authors": "Najia A. Elkahlah; Yunzhi Lin; Yijie Pan; Joseph A. Carter; Troy R. Shirangi; E. Josephine Clowney",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 69,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01413-y",
    "canonical_key": "doi:10.1038/d41586-026-01413-y",
    "headline": "Transistors on a roll: 3D circuits built from stacks of flexible membranes",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01413-y Stacks of transistors built from nanomembranes that can be rolled onto a substrate have been used to fabricate 3D circuits.",
    "url": "https://doi.org/10.1038/d41586-026-01413-y",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01413-y",
    "preprint_id": "",
    "authors": "Veeresh Deshpande",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 70,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10542-3",
    "canonical_key": "doi:10.1038/s41586-026-10542-3",
    "headline": "Universal transcriptomic hallmarks of mammalian ageing and mortality",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10542-3 Integration of gene expression data from multiple tissues across four mammalian species reveals conserved transcriptomic signatures of mammalian ageing and mortality and uncovers the modular architecture of ageing and mortality hallmarks.",
    "url": "https://doi.org/10.1038/s41586-026-10542-3",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10542-3",
    "preprint_id": "",
    "authors": "Alexander Tyshkovskiy; Daria Kholdina; Maria Davitadze; Adrian Molière; Alibek Moldakozhayev; Yoshiyasu Tongu; Tomoko Kasahara; Dmitrii Glubokov; Alec Eames; Leonid M. Kats; Anastasiya Vladimirova; Kejun Ying",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 71,
    "score": 0,
    "id": "pubmed:42192131",
    "canonical_key": "pmid:42192131",
    "headline": "Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study.",
    "summary": "Nature communications. Nat Commun. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42192131/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature communications",
    "pmid": "42192131",
    "doi": "10.1038/s41467-026-73519-w",
    "preprint_id": "",
    "authors": "Dantas E; Hootman KC; Moyer J; Tomberlin M; Curran K; Ramesh B; Price H; Kim J; McPherson AC; Hurd MA; Zhu YS; Plodkowski AJ; Nagase E; Tsomides A; Cuevas BM; Martin ML; Nguyen J; Bennetti G; Rodriguez GB; Chang K; Mezzancello M; Gardner GJ; Broach V; Mueller JJ; Sonoda Y; Zivanovic O; Leitao MM Jr; Iasonos A; Soldan K; Carthew K; Hom V; Villamater FN; Chaari RR; Gorski K; Sigouros M; Aghajanian C; Elemento O; Cantley LC; Hopkins BD; Weigelt B; Ellenson LH; Hacker K; Abu-Rustum NR; Makker V; Goncalves MD",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 72,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/d41586-026-01462-3",
    "canonical_key": "doi:10.1038/d41586-026-01462-3",
    "headline": "Why Africa’s low rate of lung cancer is an illusion",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01462-3 Failure to capture accurate data is misrepresenting the health of people of African descent around the world at home and abroad.",
    "url": "https://doi.org/10.1038/d41586-026-01462-3",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/d41586-026-01462-3",
    "preprint_id": "",
    "authors": "Elvis Obomanu",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 73,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10584-7",
    "canonical_key": "doi:10.1038/s41586-026-10584-7",
    "headline": "αKG-mediated carnitine synthesis drives DNA repair via histone acetylation",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10584-7 The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications for chemoresistant cancers.",
    "url": "https://doi.org/10.1038/s41586-026-10584-7",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10584-7",
    "preprint_id": "",
    "authors": "Apoorva Uboveja; Baixue Yang; Raquel Buj; Amandine Amalric; Hui Wang; Naveen Kumar Tangudu; Aidan R. Cole; Julie A. Disharoon; Richard S. Fang; Evan Levasseur; Miho Naruse; Zhentai Huang",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 74,
    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10539-y",
    "canonical_key": "doi:10.1038/s41586-026-10539-y",
    "headline": "β-Arrestin condensates regulate G-protein-coupled receptor function",
    "summary": "Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10539-y β-Arrestins, multifunctional adaptor proteins that regulate G-protein-coupled receptors (GPCRs), form phase-separated condensates, suggesting that β-arrestin liquid–liquid phase separation organizes and diversifies GPCR signalling functions.",
    "url": "https://doi.org/10.1038/s41586-026-10539-y",
    "source": "Nature RSS",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10539-y",
    "preprint_id": "",
    "authors": "Preston J. Anderson; Peng Xiao; Ya-Ni Zhong; Adam N. Kaakati; Juliana Alfonso-DeSouza; Alejandra Patino; Andrew Ahn; Chanpreet Jassal; Tianyao Zhang; Chao Zhang; Kexin Yu; Lei Qi",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 75,
    "score": 0,
    "id": "pubmed:42191796",
    "canonical_key": "pmid:42191796",
    "headline": "A modified HIV model with Beddington-DeAngelis incidence and cure rate.",
    "summary": "Scientific reports. Sci Rep. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42191796/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Scientific reports",
    "pmid": "42191796",
    "doi": "10.1038/s41598-026-47946-0",
    "preprint_id": "",
    "authors": "Ramadan S; Salman S; El-Sayed A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 76,
    "score": 0,
    "id": "pubmed:42192444",
    "canonical_key": "pmid:42192444",
    "headline": "A prime-and-trap vaccination strategy to evaluate minimal requirements for malaria liver stage protection in mice.",
    "summary": "Malaria journal. Malar J. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42192444/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Malaria journal",
    "pmid": "42192444",
    "doi": "10.1186/s12936-026-05940-x",
    "preprint_id": "",
    "authors": "Watson FN; Reynolds RA; Kalata AC; Shears MJ; Murphy SC",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 77,
    "score": 0,
    "id": "europepmc:PPR1239204",
    "canonical_key": "doi:10.64898/2026.05.21.726941",
    "headline": "Age-driven Dysregulation of murine Dendritic Cells is controlled by cell-intrinsic and extrinsic effects",
    "summary": "Bloecher P, Mitra S, Guet L, Kilic E, Zou Z, Sprang M, Mayer JU.",
    "url": "https://doi.org/10.64898/2026.05.21.726941",
    "source": "Europe PMC / PPR",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "",
    "pmid": "",
    "doi": "10.64898/2026.05.21.726941",
    "preprint_id": "",
    "authors": "Bloecher P;  Mitra S;  Guet L;  Kilic E;  Zou Z;  Sprang M;  Mayer JU.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PPR",
    "secondary_coverage": "",
    "keywords": "europe pmc; preprint"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 78,
    "score": 0,
    "id": "pubmed:42189917",
    "canonical_key": "pmid:42189917",
    "headline": "Agent-based modeling demonstrates how target-independent processes supplement killing by antibody-drug conjugates in cancer therapy.",
    "summary": "PLoS computational biology. PLoS Comput Biol. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42189917/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "PLoS computational biology",
    "pmid": "42189917",
    "doi": "10.1371/journal.pcbi.1013872",
    "preprint_id": "",
    "authors": "Calopiz MC; Linderman JJ; Thurber GM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-27",
    "window_start": "2026-05-26T05:15:00.000Z",
    "window_end": "2026-05-27T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 79,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.727421",
    "canonical_key": "doi:10.64898/2026.05.25.727421",
    "headline": "An ancient retrotransposon provides species-specific tuning of IL-18 inflammatory signaling",
    "summary": "Species differ markedly in how they regulate immune responses, yet the molecular basis of this variation remains incompletely understood. Here, we characterize an under-explored regulatory mechanism of the pro-inflammatory IL-18 pathway, centered on a truncated IL18R1 isoform with striking species-specific expression differences.",
    "url": "https://doi.org/10.64898/2026.05.25.727421",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727421",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727421",
    "authors": "Ordonez, A. D.; Allen, H.; Sanford, L.; Ivancevic, A.; Agyepong, A.; Chaw, M.; Bridges, J. P.; Schountz, T.; Chuong, E. B.",
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    "headline": "An in situ generated CAR-M with IFN-γ and negative dominance Sirpα isoform augments hepatocellular carcinoma immunotherapy.",
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    "headline": "An oncolytic adenovirus armed with anticancer prodrug-activating enzyme offers enhanced tumor killing and antitumor immunity.",
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    "headline": "ATOH1 and NPAS1 are immune related prognostic biomarkers in colorectal cancer.",
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    "authors": "Fang Z; Hong G; Wu G; Feng Z",
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    "headline": "B7-H4 in cancer immune evasion and immunotherapy.",
    "summary": "Clinical cancer research : an official journal of the American Association for Cancer Research. Clin Cancer Res. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42189671/",
    "source": "PubMed",
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    "doi": "10.1158/1078-0432.CCR-25-2442",
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    "authors": "Xiao R; Yu J; Yan Y; Kryczek I; Zou W",
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    "headline": "Beyond natural amino acids: Extending immunogenicity risk assessment to non-canonical peptide drugs through chemical feature encoding",
    "summary": "Cairoli M, Nielsen M, Betts C, Obrezanova O, De Maria L.",
    "url": "https://doi.org/10.64898/2026.05.22.727138",
    "source": "Europe PMC / PPR",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "preprint_id": "",
    "authors": "Cairoli M;  Nielsen M;  Betts C;  Obrezanova O;  De Maria L.",
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    "headline": "CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma",
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    "headline": "Canagliflozin Alleviates Experimental Antineutrophil Cytoplasmic Antibody-Associated Vasculitis through Suppression of Pathogenic T-Cell Responses.",
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    "source": "PubMed",
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    "headline": "Cancer immunotherapy: mechanisms, clinical applications, resistance and future directions.",
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    "authors": "Önal A; Ayaz F; Aydemir E",
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    "headline": "Cardiovascular adverse events associated with bispecific antibodies in relapsed or refractory B-cell non-Hodgkin lymphomas.",
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    "authors": "Munir M; Sayed A; Lee DH; Awan F; Ghazi S; Kim J; Addison D; Epperla N",
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    "canonical_key": "doi:10.21203/rs.3.rs-9689894/v1",
    "headline": "CD163⁺ macrophage distribution and tumor proximity: A prognostic biomarker for non-small cell lung cancer brain metastases",
    "summary": "Cai Y, Liu X, Xu J, Zhang H, Tian S, Li Z.",
    "url": "https://doi.org/10.21203/rs.3.rs-9689894/v1",
    "source": "Europe PMC / PPR",
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    "headline": "CD80 (B7-1) as a potential therapeutic target in Epstein-Barr virus‑associated B cell diseases.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42191836/",
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    "headline": "Chimeric antigen receptor T-cell therapy and cardiovascular outcomes in US Medicare beneficiaries.",
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    "headline": "Comprehensive longitudinal profiling identifies differential frequency, epitope specificity, and effector function of CD8(+) T-cells across COVID-19 disease severities.",
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    "authors": "Amaya Hernandez SP; Munk KK; Danilov K; Kadivar M; Hersby DS; Tamhane T; Stegenborg-Grathwohl SM; Pedersen AG; Gang AO; Hadrup SR; Saini SK",
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    "headline": "CSDE1 in tumour immunology: spatiotemporal translational reprogramming and immune microenvironment remodeling.",
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    "source": "PubMed",
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    "rank_index": 94,
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    "id": "biorxiv:10.64898/2026.05.25.727736",
    "canonical_key": "doi:10.64898/2026.05.25.727736",
    "headline": "Cycle-consistent deep generative modeling unifies cellular states across unpaired spatial and single-cell modalities",
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    "url": "https://doi.org/10.64898/2026.05.25.727736",
    "source": "bioRxiv",
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    "headline": "DEC-205-mediated liposomal delivery of OVA and Eucommia polysaccharides: dendritic cell targeting, adjuvant activity, and TLR-NF-κB-mediated immune enhancement.",
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    "headline": "Decoding lactylation heterogeneity in glioblastoma: machine learning identifies G6PC3 as a prognostic target.",
    "summary": "BMC cancer. BMC Cancer. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42192326/",
    "source": "PubMed",
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    "journal": "BMC cancer",
    "pmid": "42192326",
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    "authors": "Liu Y; Deng H; Song P; Qiu Q; Bu J; Zhang M",
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    "headline": "Developmental patterns of socioemotional competencies in children with and without disabilities.",
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    "source": "PubMed",
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    "journal": "Journal of experimental child psychology",
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    "authors": "Foster ME",
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    "canonical_key": "pmid:42190649",
    "headline": "Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42190649/",
    "source": "PubMed",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Immunity",
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    "doi": "10.1016/j.immuni.2026.05.001",
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    "authors": "Lobel L; Fonseca-Pereira D; Nakatsu G; Michaud M; Cao YG; Bae S; Krabak C; Oren Y; Clay SL; El Tekle G; Chun E; Kon S; Chan AT; Clardy J; Glickman JN; Ajami NJ; Day A; Damania A; Baruch EN; White MG; Diggs LP; Wargo J; Riffelmacher T; Balancio A; Kronenberg M; Huttenhower C; Garrett WS",
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    "headline": "Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction",
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    "url": "https://doi.org/10.64898/2026.05.22.727177",
    "source": "bioRxiv",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "doi": "10.64898/2026.05.22.727177",
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    "headline": "Early mycosis fungoides: Integrating clinical, histopathological and molecular insights to improve diagnosis and risk stratification.",
    "summary": "Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia. Rev Esp Patol. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42190454/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia",
    "pmid": "42190454",
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    "authors": "Rebollo-González M; Torre-Castro J; Rodríguez M; de la Pinta FJD; Manso R; Díaz-Alejo JF; Rodríguez-Pinilla SM",
    "assignee": "",
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    "id": "pubmed:42204932",
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    "headline": "Stable β2-Microglobulin-HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes.",
    "summary": "European journal of immunology. Eur J Immunol",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204932/",
    "source": "PubMed",
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    "match_reason": "TCR-antigen specificity mapping: tcr recognition | Low-specificity pMHC/TCR field anchor: tcr, hla",
    "journal": "European journal of immunology",
    "pmid": "42204932",
    "doi": "10.1002/eji.70210",
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    "authors": "Barajas Molina A; Horokhovskyi Y; Acuti N; Chong YK; Phanichkrivalkosil M; Siddons S; Afrache H; Maloney M; Soh WT; Hofland T; Hall C; Urlaub H; Kassiotis G; Liepe J; Mishto M",
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    "id": "pubmed:42205033",
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    "headline": "Cytomegalovirus reactivation associated with CD20 × CD3 bispecific T-cell engagers: a frequentist and Bayesian analysis of a large national database.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42205033/",
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    "authors": "Frey C",
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    "id": "pubmed:42204926",
    "canonical_key": "pmid:42204926",
    "headline": "STING Activation in Dendritic Cells Enhances Antigen Presentation by Live Tumor Cells.",
    "summary": "European journal of immunology. Eur J Immunol",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204926/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "Low-specificity pMHC/TCR field anchor: antigen presentation",
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    "doi": "10.1002/eji.70212",
    "preprint_id": "",
    "authors": "Loverre A; Jneid B; Genest M; van den Broek M; Manel N",
    "assignee": "",
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    "canonical_key": "pmid:42204898",
    "headline": "Discriminating Post-Transplant Rejection from Infection by Detecting TCR-CD3 Oligomerization on Extracellular Vesicles Using a Ratiometric Caliper Probe.",
    "summary": "Journal of the American Chemical Society. J Am Chem Soc. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204898/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "Low-specificity pMHC/TCR field anchor: tcr",
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    "doi": "10.1021/jacs.6c07971",
    "preprint_id": "",
    "authors": "Yin W; Chen H; Xiao S; Zheng J; Zhao X; Fan L; Lv X; Lv H; Yang Q; Yao J; Yuan X; Yang Y; Yang M",
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    "id": "europepmc:PMC13201228",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13201228",
    "headline": "Impact of KIR3DL1/3DS1 and HLA-B polymorphisms on hepatitis C virus infection: a case-control study",
    "summary": "Yin W, Zeng T, Ren C, Chen Y, Guo Y, Ma K, Zhang Y, Yu R, Wang C, Cui J, Huang P, Yue M.",
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    "source": "Europe PMC / PMC",
    "published_date": "2026-05-27",
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    "journal": "Front Cell Infect Microbiol",
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    "doi": "",
    "preprint_id": "",
    "authors": "Yin W;  Zeng T;  Ren C;  Chen Y;  Guo Y;  Ma K;  Zhang Y;  Yu R;  Wang C;  Cui J;  Huang P;  Yue M.",
    "assignee": "",
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    "id": "pubmed:42204309",
    "canonical_key": "pmid:42204309",
    "headline": "Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription.",
    "summary": "Nature chemical biology. Nat Chem Biol. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204309/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc",
    "journal": "Nature chemical biology",
    "pmid": "42204309",
    "doi": "10.1038/s41589-026-02229-7",
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    "authors": "Hu Z; Lv W; Wen T; Sun J; Ji G; Ru S; Sun X; Wang Z; Ren H; Zhang Y; Chen P; Zhou L; Wu S; Jia X; Liu S; Zhu Z; Xu J; Liu T; Feng Y; Li G; Ding Y; Wang Y; Luo Y; Liu C; Lu Z; Ren Z; Duan SZ; Xu D",
    "assignee": "",
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    "rank_index": 6,
    "score": 9,
    "id": "pubmed:42200673",
    "canonical_key": "pmid:42200673",
    "headline": "Strain-dependent differences in the capacity of peste des petits ruminants virus to infect antigen-presenting cells.",
    "summary": "Journal of virology. J Virol. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42200673/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "Low-specificity pMHC/TCR field anchor: antigen-presenting",
    "journal": "Journal of virology",
    "pmid": "42200673",
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    "preprint_id": "",
    "authors": "Bouziane A; Lasserre V; Eloiflin R-J; Chambon M; Piro-Mégy C; Guendouz S; Holzmuller P; Totté P; Bataille A",
    "assignee": "",
    "publication_number": "",
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    "id": "pubmed:42202904",
    "canonical_key": "pmid:42202904",
    "headline": "Two Patterns of Sacroiliac Joint Bone Marrow Oedema are apparent in AxSpA Determined by HLA-B27 Status, Body Mass Index or Psoriasis.",
    "summary": "Joint bone spine. Joint Bone Spine. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42202904/",
    "source": "PubMed",
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    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
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    "authors": "Abacar K; Matteo AD; Marco G; Meridor K; Weddell J; Harrison SR; Freeston J; Vandevelde C; Barr A; Gupta H; Mankia K; Marzo-Ortega H; McGonagle D",
    "assignee": "",
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    "score": 9,
    "id": "pubmed:42200918",
    "canonical_key": "pmid:42200918",
    "headline": "HLA Class II Immunogenetic Profiles Shape Psychosis Outcomes in Cannabis Users: DRB5/DRB1*16 Vulnerability and DRB4/DRB3-Linked Protection, Particularly Against Schizophrenia.",
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    "authors": "Buciuta A; Coman HG; Nemeș B; Cimpianu ME; Oroian R; Vică Matei ML; Matei HV",
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    "id": "medrxiv:10.64898/2026.05.26.26353896",
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    "headline": "A phase 1 randomized controlled trial to evaluate the safety and immunogenicity of a HIV monomeric gp120 protein B-cell lineage targeting HIV vaccine in healthy adults",
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    "url": "https://europepmc.org/article/PMC/PMC13199050",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-27",
    "match_reason": "Watchlist hits: Roche",
    "journal": "Front Neurol",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Ferrando R.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
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  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 11,
    "score": 2,
    "id": "pubmed:42205101",
    "canonical_key": "pmid:42205101",
    "headline": "The role of ERK signaling pathway in pituitary adenomas: from molecular mechanisms to targeted therapy.",
    "summary": "Growth factors (Chur, Switzerland). Growth Factors. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205101/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "Low-specificity pMHC/TCR field anchor: hla",
    "journal": "Growth factors (Chur, Switzerland)",
    "pmid": "42205101",
    "doi": "10.1080/08977194.2026.2671736",
    "preprint_id": "",
    "authors": "Ye J; Wen Y; Zhan J; Hla KWY; Li T; Xiao Z; Shu X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 12,
    "score": 0,
    "id": "europepmc:PMC13201979",
    "canonical_key": "url:https://europepmc.org/article/pmc/pmc13201979",
    "headline": "Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery",
    "summary": "Engelhard H, Balédent O, Borzage M, Andrews-Jones L, Feldsien T, Lefebvre D.",
    "url": "https://europepmc.org/article/PMC/PMC13201979",
    "source": "Europe PMC / PMC",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Drug Deliv",
    "pmid": "",
    "doi": "",
    "preprint_id": "",
    "authors": "Engelhard H;  Balédent O;  Borzage M;  Andrews-Jones L;  Feldsien T;  Lefebvre D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Europe PMC / PMC",
    "secondary_coverage": "",
    "keywords": "europe pmc; review-article; review; journal article"
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  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 13,
    "score": 0,
    "id": "pubmed:42201044",
    "canonical_key": "pmid:42201044",
    "headline": "Beyond Clinicopathological Criteria: A Practical Management Framework for Oral Lichen Planus.",
    "summary": "Medical sciences (Basel, Switzerland). Med Sci (Basel). 2026-05-13",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42201044/",
    "source": "PubMed",
    "published_date": "2026-05-13",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Medical sciences (Basel, Switzerland)",
    "pmid": "42201044",
    "doi": "10.3390/medsci14020252",
    "preprint_id": "",
    "authors": "Rotaru DI; Păstrav O; Bolboacă SD; Lazăr C; Chisnoiu RM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
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  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 14,
    "score": 0,
    "id": "pubmed:42201547",
    "canonical_key": "pmid:42201547",
    "headline": "Adoptive T-Cell Immunotherapy.",
    "summary": "Current topics in microbiology and immunology. Curr Top Microbiol Immunol. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42201547/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Current topics in microbiology and immunology",
    "pmid": "42201547",
    "doi": "10.1007/82_2026_345",
    "preprint_id": "",
    "authors": "Gottschalk S; Bollard CM; Rooney CM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 15,
    "score": 0,
    "id": "pubmed:42206428",
    "canonical_key": "pmid:42206428",
    "headline": "Allogeneic stem cell transplantation in T-cell prolymphocytic leukemia: final disappointment or a chance for cure?",
    "summary": "Haematologica. Haematologica. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206428/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Haematologica",
    "pmid": "42206428",
    "doi": "10.3324/haematol.2026.301173",
    "preprint_id": "",
    "authors": "Shumilov E; Schmitz N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 16,
    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73790-x",
    "canonical_key": "doi:10.1038/s41467-026-73790-x",
    "headline": "An artefact-resilient wide bandwidth bidirectional graphene neural interface",
    "summary": "Nature Communications, Published online: 28 May 2026; doi:10.1038/s41467-026-73790-x Recording and modulating neural activity is critical for next-generation bidirectional neural interfaces. Here the authors present a bidirectional neural interface based on graphene transistors, to artifact-resilient and full frequency bandwidth",
    "url": "https://doi.org/10.1038/s41467-026-73790-x",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73790-x",
    "preprint_id": "",
    "authors": "Michał Prokop; Martín Esparza-Iaizzo; Eduard Masvidal-Codina; Xavi Illa; Neela K. Codadu; Daman Rathore; Nicola Ria; Kostas Kostarelos; Elena del Corro; Ramon Garcia-Cortadella; Rob C. Wykes; Anton Guimerà-Brunet",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 17,
    "score": 0,
    "id": "journal-rss:communications medicine current issue:10.1038/s43856-026-01700-9",
    "canonical_key": "doi:10.1038/s43856-026-01700-9",
    "headline": "Applying a causal biopsychosocial model to guide medicine and psychiatry fifty years after Engel",
    "summary": "Communications Medicine, Published online: 28 May 2026; doi:10.1038/s43856-026-01700-9 von Känel discusses why the biopsychosocial model, originally proposed by Engel as a scientific framework for medicine, has often been reduced to a checklist.",
    "url": "https://doi.org/10.1038/s43856-026-01700-9",
    "source": "Communications Medicine RSS",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Communications Medicine",
    "pmid": "",
    "doi": "10.1038/s43856-026-01700-9",
    "preprint_id": "",
    "authors": "Roland von Känel",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Communications Medicine RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Communications Medicine; Communications Medicine current issue"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 18,
    "score": 0,
    "id": "pubmed:42203202",
    "canonical_key": "pmid:42203202",
    "headline": "Beyond Suppression: The Plasticity, Dysfunction, and Therapeutic Reprogramming of Regulatory T Cells in Inflammatory Bowel Disease.",
    "summary": "Journal of leukocyte biology. J Leukoc Biol. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42203202/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of leukocyte biology",
    "pmid": "42203202",
    "doi": "10.1093/jleuko/qiag067",
    "preprint_id": "",
    "authors": "Shao Y; Yu S; Zhang M; Huang Y; Dou Z; Tian B; Lu J",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 19,
    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73667-z",
    "canonical_key": "doi:10.1038/s41467-026-73667-z",
    "headline": "Breaking the membrane heredity paradox through de novo protocell formation",
    "summary": "Nature Communications, Published online: 28 May 2026; doi:10.1038/s41467-026-73667-z A central paradigm in biology is that cellular membranes descend from a common ancestral membrane, and it is currently unclear whether lipid membranes can arise from membrane-less precursors.",
    "url": "https://doi.org/10.1038/s41467-026-73667-z",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73667-z",
    "preprint_id": "",
    "authors": "Satyam Khanal; Alessandro Fracassi; Alexander Harjung; Michael D. Burkart; Neal K. Devaraj",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 20,
    "score": 0,
    "id": "pubmed:42204788",
    "canonical_key": "pmid:42204788",
    "headline": "Clinical Characteristics, Treatment Patterns, and Prognosis of Central Nervous System Involvement in Multiple Myeloma: A Multicenter Retrospective Study From China.",
    "summary": "Cancer medicine. Cancer Med",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204788/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer medicine",
    "pmid": "42204788",
    "doi": "10.1002/cam4.71986",
    "preprint_id": "",
    "authors": "Li W; Tian W; Ma J; Li L; Li Z; Liu J; Gao G; Xi Z; Zhang L; Zhang W; Duan L; Geng H; Meng J; Zhu H; Chen W; Gao W",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 21,
    "score": 0,
    "id": "pubmed:42204141",
    "canonical_key": "pmid:42204141",
    "headline": "Combating small extracellular vesicle-mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides.",
    "summary": "Signal transduction and targeted therapy. Signal Transduct Target Ther. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204141/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Signal transduction and targeted therapy",
    "pmid": "42204141",
    "doi": "10.1038/s41392-026-02736-y",
    "preprint_id": "",
    "authors": "Kim CH; Ko H; Lee JA; Kim SH; Park M; Lee CH; Shin S; Shin JM; Son S; Lee J; Kang H; Cho S; Chang J; Kim J; Jang WH; Kim MJ; Jackman JA; Park JH",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 22,
    "score": 0,
    "id": "biorxiv:10.1101/2024.10.29.620847",
    "canonical_key": "doi:10.1101/2024.10.29.620847",
    "headline": "Dynamic imbalances in cell-type-specific striatal ensembles reflect learned coupling between trajectory representations and locomotor dynamics",
    "summary": "Basal ganglia models commonly propose that relative imbalances between direct and indirect pathway output shapes movement, but how such imbalances are expressed during behavior remains unclear.",
    "url": "https://doi.org/10.1101/2024.10.29.620847",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2024.10.29.620847",
    "preprint_id": "biorxiv:10.1101/2024.10.29.620847",
    "authors": "Tong, Y.; Fearey, B.; Xie, Z.; Alexander, A.; Bouabid, S.; Graham, B.; Howe, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; neuroscience"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 23,
    "score": 0,
    "id": "pubmed:42204802",
    "canonical_key": "pmid:42204802",
    "headline": "Efficacy and Safety of Immune Checkpoint Inhibitors in the Treatment of Hematologic Malignancies: An Umbrella Review of Systematic Reviews and Meta-Analyses.",
    "summary": "Cancer medicine. Cancer Med",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204802/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cancer medicine",
    "pmid": "42204802",
    "doi": "10.1002/cam4.71880",
    "preprint_id": "",
    "authors": "Yu Z; Wang Z; Xie L; Xu J; Min L; Li L; Niu T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 24,
    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73168-z",
    "canonical_key": "doi:10.1038/s41467-026-73168-z",
    "headline": "Efficacy of seaweed-based carbon dioxide removal reduced by iron limitation and nutrient competition with phytoplankton",
    "summary": "Nature Communications, Published online: 28 May 2026; doi:10.1038/s41467-026-73168-z This study shows that when iron limitation is considered, there is nowhere in the ocean that is suitable for growing kelp for carbon dioxide removal.",
    "url": "https://doi.org/10.1038/s41467-026-73168-z",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73168-z",
    "preprint_id": "",
    "authors": "Manon Berger; Lester Kwiatkowski; Laurent Bopp; David T. Ho",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 25,
    "score": 0,
    "id": "biorxiv:10.1101/2025.07.16.662511",
    "canonical_key": "doi:10.1101/2025.07.16.662511",
    "headline": "Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response",
    "summary": "Cytoplasmic double-stranded RNA (dsRNA) is a hallmark of viral infection. It triggers innate immune responses after recognition by pathogen recognition receptors (PRRs) and leads to the production of interferons.",
    "url": "https://doi.org/10.1101/2025.07.16.662511",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.07.16.662511",
    "preprint_id": "biorxiv:10.1101/2025.07.16.662511",
    "authors": "Pasquier, C.; Messmer, M.; Moroge, L.; KNOL, L.; Chicher, J.; Ngondo, R. P.; Pfeffer, S.; Girardi, E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-28",
    "window_start": "2026-05-27T05:15:00.000Z",
    "window_end": "2026-05-28T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 26,
    "score": 0,
    "id": "journal-rss:nature medicine current issue:10.1038/s41591-026-04433-3",
    "canonical_key": "doi:10.1038/s41591-026-04433-3",
    "headline": "Genetic–exposome interactions and aging clocks in dementia: the ReDLat2 initiative",
    "summary": "Nature Medicine, Published online: 28 May 2026; doi:10.1038/s41591-026-04433-3 Genetic–exposome interactions and aging clocks in dementia: the ReDLat2 initiative",
    "url": "https://doi.org/10.1038/s41591-026-04433-3",
    "source": "Nature Medicine RSS",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Medicine",
    "pmid": "",
    "doi": "10.1038/s41591-026-04433-3",
    "preprint_id": "",
    "authors": "Agustin Ibáñez; Jennifer S. Yokoyama; Claudia Duran-Aniotz; Bruce L. Miller",
    "assignee": "",
    "publication_number": "",
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    "canonical_key": "doi:10.1038/s42003-026-10293-x",
    "headline": "HK2 promotes angiogenesis through H3K18 lactylation in peripheral arterial disease",
    "summary": "Communications Biology, Published online: 28 May 2026; doi:10.1038/s42003-026-10293-x HK2 regulates angiogenesis in PAD via H3K18 lactylation; SIRT2 inhibition restores H3K18la and angiogenic function, offering a potential therapy for PAD.",
    "url": "https://doi.org/10.1038/s42003-026-10293-x",
    "source": "Communications Biology RSS",
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    "headline": "Immortal genome assumption significantly underestimates replication and death rates of Mycobacterium tuberculosis in mice and monkeys",
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    "url": "https://doi.org/10.1101/2025.08.15.670581",
    "source": "bioRxiv",
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    "journal": "bioRxiv",
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    "doi": "10.1101/2025.08.15.670581",
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    "headline": "Microbiota-derived indole derivatives as anticancer agents: mechanistic insights and major perspectives.",
    "summary": "Future microbiology. Future Microbiol. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204951/",
    "source": "PubMed",
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    "journal": "Future microbiology",
    "pmid": "42204951",
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    "preprint_id": "",
    "authors": "Tomar K; Khodlan P; Malik T; Rana P; Tariq M; Mishra R; Mohan A; Fatima S; Gautam H; Kumar S; Abdin MZ; Kumar A",
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    "summary": "Nature Communications, Published online: 28 May 2026; doi:10.1038/s41467-026-73732-7 Distributions of expansive low oxygen waters during the Miocene Climatic Optimum greenhouse interval (14.7-17 million years ago) were flipped compared to today, with low oxygen waters engulfing much of the Equatorial Atlantic but contracted in the Pacifi...",
    "url": "https://doi.org/10.1038/s41467-026-73732-7",
    "source": "Nature Communications RSS",
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    "pmid": "",
    "doi": "10.1038/s41467-026-73732-7",
    "preprint_id": "",
    "authors": "Janet E. Burke; Keyi Cheng; Andy Ridgwell; Donald E. Penman; Dalton S. Hardisty",
    "assignee": "",
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    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73813-7",
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    "headline": "Multimodal deep learning model for AI-based functional prognostic risk stratification in patients undergoing radical nephrectomy",
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    "url": "https://doi.org/10.1038/s41467-026-73813-7",
    "source": "Nature Communications RSS",
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    "preprint_id": "",
    "authors": "Yunhan Luo; Yatian Wang; Xiangpeng Zou; Shiying Tang; Xin Luo; Zhaohui Zhou; Longbin Xiong; Yulu Peng; Chunsen Yang; Ning Wang; Haitian Song; Gaoyu Zou",
    "assignee": "",
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    "source_type": "papers",
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    "headline": "Myeloid Cell Function and Cytokine Profiles in Paediatric Haemophilia A: Insights From FVIII and Emicizumab Prophylaxis.",
    "summary": "Journal of cellular and molecular medicine. J Cell Mol Med",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204756/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of cellular and molecular medicine",
    "pmid": "42204756",
    "doi": "10.1111/jcmm.71216",
    "preprint_id": "",
    "authors": "Cottonaro A; Akula S; Pollio B; Ricca I; Martini T; Albiani R; Giacchello JA; Sciancalepore P; Santi R; Follenzi A; Merlin S",
    "assignee": "",
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    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73763-0",
    "canonical_key": "doi:10.1038/s41467-026-73763-0",
    "headline": "North Atlantic influence reconciling model-observation discrepancy in the tropical Pacific warming pattern",
    "summary": "Nature Communications, Published online: 28 May 2026; doi:10.1038/s41467-026-73763-0 This study shows that climate models underestimate the strengthening of the Pacific east–west temperature contrast observed in recent decades.",
    "url": "https://doi.org/10.1038/s41467-026-73763-0",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
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    "preprint_id": "",
    "authors": "Yueh-Chi Lin; Masahiro Watanabe",
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    "id": "journal-rss:nature genetics current issue:10.1038/s41588-026-02625-8",
    "canonical_key": "doi:10.1038/s41588-026-02625-8",
    "headline": "Peer Bork (1963–2026)",
    "summary": "Nature Genetics, Published online: 28 May 2026; doi:10.1038/s41588-026-02625-8 Peer Bork (1963–2026)",
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    "source": "Nature Genetics RSS",
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    "journal": "Nature Genetics",
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    "doi": "10.1038/s41588-026-02625-8",
    "preprint_id": "",
    "authors": "Francesca D. Ciccarelli; Jan O. Korbel; Christian Von Mering",
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    "id": "biorxiv:10.1101/2023.02.01.526449",
    "canonical_key": "doi:10.1101/2023.02.01.526449",
    "headline": "Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics",
    "summary": "Lysosomes are dynamic organelles regulating metabolic signaling by recruiting cytosolic molecules to protein platforms on their limiting membrane. We used proximity labeling to define interactors and vicinal proteins of LAMTOR3, a component of the Ragulator scaffold that controls mTORC1 signaling and lysosome positioning.",
    "url": "https://doi.org/10.1101/2023.02.01.526449",
    "source": "bioRxiv",
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    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2023.02.01.526449",
    "preprint_id": "biorxiv:10.1101/2023.02.01.526449",
    "authors": "Ettelt, R.; Sandru, A.-M.; Vucak, G.; Didusch, S.; Riemelmoser, B.; Ehrenreiter, K.; Hartl, M.; Huber, L.; Baccarini, M.",
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    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73701-0",
    "canonical_key": "doi:10.1038/s41467-026-73701-0",
    "headline": "Photonic-integrated quantum sensor array for microscale magnetic localisation",
    "summary": "Nature Communications, Published online: 28 May 2026; doi:10.1038/s41467-026-73701-0 Arrays of NV centres operating in parallel promise advantages in resolving spatio-temporal dynamics.",
    "url": "https://doi.org/10.1038/s41467-026-73701-0",
    "source": "Nature Communications RSS",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73701-0",
    "preprint_id": "",
    "authors": "Hao-Cheng Weng; John G. Rarity; Krishna C. Balram; Joe A. Smith",
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    "id": "journal-rss:communications medicine current issue:10.1038/s43856-026-01645-z",
    "canonical_key": "doi:10.1038/s43856-026-01645-z",
    "headline": "Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness",
    "summary": "Communications Medicine, Published online: 28 May 2026; doi:10.1038/s43856-026-01645-z Lin et al. developed and validated a polygenic risk score (PRS-KLK3int) that incorporates SNP-SNP interactions involving KLK3 to predict prostate cancer aggressiveness.",
    "url": "https://doi.org/10.1038/s43856-026-01645-z",
    "source": "Communications Medicine RSS",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Communications Medicine",
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    "preprint_id": "",
    "authors": "Hui-Yi Lin; Indrani Sarkar; Harun Mazumder; Po-Yu Huang; Kenneth R. Muir; Johanna Schleutker; Nora Pashayan; Jyotsna Batra; David E. Neal; Henrik Grönberg; Sune F. Nielsen; Børge G. Nordestgaard",
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    "headline": "Presentation and management of pediatric T-cell acute lymphoblastic leukemia with mediastinal mass and hyperleukocytosis.",
    "summary": "Haematologica. Haematologica. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206439/",
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    "journal": "Haematologica",
    "pmid": "42206439",
    "doi": "10.3324/haematol.2026.300811",
    "preprint_id": "",
    "authors": "Muller B; Su Y; Rule A; Hu Z; Holland AC; Choi JK; Klco J; Yang JJ; Mullighan C; Karol SE; Cheng C; Tang L; Jeha S; Pui CH; Inaba H",
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    "id": "journal-rss:nature aging current issue:10.1038/s43587-026-01133-y",
    "canonical_key": "doi:10.1038/s43587-026-01133-y",
    "headline": "Questions of the future in aging and longevity research at the GIMM Festival",
    "summary": "Nature Aging, Published online: 28 May 2026; doi:10.1038/s43587-026-01133-y On 4–6 September 2025, the Gulbenkian Institute for Molecular Medicine (GIMM) hosted its inaugural GIMM Festival in Lisbon, Portugal.",
    "url": "https://doi.org/10.1038/s43587-026-01133-y",
    "source": "Nature Aging RSS",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Aging",
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    "doi": "10.1038/s43587-026-01133-y",
    "preprint_id": "",
    "authors": "Laura Ward; Claudia C. Faria; Maria M. Mota; João Pedro de Magalhães; Brian K. Kennedy; Miguel Godinho Ferreira; Joana Neves; Pedro Sousa-Victor",
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    "primary_source": "Nature Aging RSS",
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    "headline": "Resolution of PML after Treatment with Virus-Specific T Cells and HCT.",
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    "url": "https://pubmed.ncbi.nlm.nih.gov/42202329/",
    "source": "PubMed",
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    "journal": "The New England journal of medicine",
    "pmid": "42202329",
    "doi": "10.1056/NEJMc2514186",
    "preprint_id": "",
    "authors": "Gonzalez CE; Fletcher A; Jenkins TL; Zahraeifard S; Peterson R; Taylor M; Jones C; Urban A; Avila D; Campillay M; Wilhelm J; Soldatos A; Kuhle J; Jain P; Corey S; Bergerson JRE; Reich DS; Highfill S; Stroncek D; Dinh A; Pittaluga S; Kong HH; Su HC; Notarangelo LD; Pai SY; Grimley M; Freeman AF; Cortese I",
    "assignee": "",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
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    "digest_date": "2026-05-28",
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    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73429-x",
    "canonical_key": "doi:10.1038/s41467-026-73429-x",
    "headline": "Retraction Note: Daylight saving time affects European mortality patterns",
    "summary": "Nature Communications, Published online: 28 May 2026; doi:10.1038/s41467-026-73429-x Retraction Note: Daylight saving time affects European mortality patterns",
    "url": "https://doi.org/10.1038/s41467-026-73429-x",
    "source": "Nature Communications RSS",
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    "authors": "Laurent Lévy; Jean-Marie Robine; Grégoire Rey; Raúl Fernando Méndez Turrubiates; Marcos Quijal-Zamorano; Hicham Achebak; Joan Ballester; Xavier Rodó; François R. Herrmann",
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    "headline": "A Presentation of Meckel’s Diverticulum With Malignancy",
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    "summary": "Chen Y, Zhu Q, Yuan N, Jin D, Zhu Z, Chen F.",
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    "journal": "Front Immunol",
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    "headline": "Advances in immune checkpoint inhibitor therapy for microsatellite instability-high (MSI-H) and mismatch repair-deficient (dMMR) colorectal cancer: Insights from the tumor immune microenvironment.",
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    "authors": "Monzón Manzano E;  Herrero Carrasco C;  Acuña P;  del Pino Molina L;  Arias-Salgado E;  Mendoza A;  Kapur R;  Porcelijn L;  Martín Salces M;  Rivas Pollmar M;  López-Granados E;  Jiménez Yuste V",
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    "authors": "Kalra R;  Tamai M;  Sarkar S;  Han Y;  Miyagi M;  Sasaki D;  Ishikawa H.",
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    "source": "Europe PMC / PMC",
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    "source": "Europe PMC / PMC",
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    "canonical_key": "pmid:42200447",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood advances",
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    "headline": "Berberine is a key active component underlying the anti-allergic actions of orengedokuto in a murine model of contact hypersensitivity.",
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    "doi": "10.1007/s11418-026-02047-0",
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    "headline": "Beyond conventional therapies: immunotherapeutic strategies targeting HPV-associated cervical cancer.",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "headline": "Beyond the Nodes: Atypical Presentations of Non-Hodgkin's Lymphoma Across Organs",
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    "source": "Europe PMC / PMC",
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    "authors": "A S;  D'Cruze L;  Archana B;  Sundaram S;  Priyathersini N.",
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    "source": "Europe PMC / PMC",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "authors": "Atanasiu D;  Saw W;  Cairns T;  Friedman H;  Cohen G.",
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    "source": "Europe PMC / PMC",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "headline": "Coconut oil/lauric acid-based nanodrug formulation: a multifunctional platform for enhancing cancer therapy and mitigating toxicity",
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    "source": "Europe PMC / PMC",
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    "authors": "Luo R;  Xu S;  Chen Y;  Liu Z;  Deng X;  Li C;  Hui K;  Chen Y;  Hong C;  Chen C;  Chen H.",
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    "doi": "10.1556/1886.2026.00025",
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    "headline": "Comprehensive Profiling of Age- and Immune Cell- Specific Signaling Activation Using Multiplex Phosphoflow",
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    "source": "Europe PMC / PMC",
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    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Front Cell Dev Biol",
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    "headline": "Cross-talk between intracellular pathogen infection and IFNγ signaling drives enhanced pro-inflammatory responses",
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    "source": "Europe PMC / PMC",
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    "authors": "Li R;  Liu Y;  Zou R;  Li M.",
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    "summary": "Yang S, Wu J, Xiang J, Wang M, Shen P, He L.",
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    "source": "Europe PMC / PMC",
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    "summary": "Chen Z, Liao Y, Yang J, Zeng X.",
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    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73789-4 Reliable sweat induction remains a challenge for wearable sweat biosensing. Here, the authors develop a skin-conformal wearable device that uses ultrasound to induce sweat under resting conditions for electrochemical biomarker tracking.",
    "url": "https://doi.org/10.1038/s41467-026-73789-4",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "Watchlist hits: Roche",
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    "preprint_id": "",
    "authors": "Litong Chen; Benxing Su; Geng Zhong; Jing Wang; Yongxiang Ji; Zhongzeng Zhou; Xuecheng He; Tailin Xu",
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    "primary_source": "Nature Communications RSS",
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    "headline": "Biofunctional 2D Graphitic Carbon Nitride-Hydrogel Heterointerfaces for Electrochemical Detection of Interleukin-6 toward Septic Cardiomyopathy Diagnostics in Clinical Biofluids",
    "summary": "Interleukin-6 (IL-6) is a key pro-inflammatory cytokine closely associated with sepsis progression and septic cardiomyopathy (SCM), a severe clinical condition characterized by acute cardiac dysfunction and high mortality in critically ill patients.",
    "url": "https://doi.org/10.64898/2026.05.25.727622",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "Watchlist hits: Roche",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727622",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727622",
    "authors": "Agarwal, P.; Yadav, A. K.; Singh, A.; Yadav, S. K.; Praneeth, N. V. S.; Bhatia, D. D.",
    "assignee": "",
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    "primary_source": "bioRxiv",
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    "digest_date": "2026-05-29",
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    "canonical_key": "doi:10.64898/2026.05.25.727605",
    "headline": "BIFO: A Biological Information Flow Ontology for Directed Propagation in Heterogeneous Biomedical Knowledge Graphs",
    "summary": "Biomedical knowledge graphs integrate heterogeneous data by connecting many entity types through many relationship types. Computational analyses that propagate signal across these graphs (random walks, diffusion, and message passing) implicitly assume that every traversable edge can carry a biological signal.",
    "url": "https://doi.org/10.64898/2026.05.25.727605",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727605",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727605",
    "authors": "Taylor, D. M.; Mohseni Ahooyi, T.; Stear, B.; Zhang, Y.; Lahiri, A. M.; Simmons, J. A.; Chinwalla, A.; Nemarich, C.; Callahan, T. J.; Silverstein, J. C.",
    "assignee": "",
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    "headline": "Intravital mid-infrared biosensing by normalized spatial probing of self-referenced optothermal signals",
    "summary": "We present a compact pump-and-probe mid-infrared Optothermal Spectrometer (OTHES) equipped with Spatial Probing and Autocorrection (SPAC) optimized for robust intravital application in humans. SPAC-OTHES facilitates alignment stability and spectral comparability across different measurement sessions involving different skin types.",
    "url": "https://doi.org/10.64898/2026.05.27.26354202",
    "source": "medRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.27.26354202",
    "preprint_id": "medrxiv:10.64898/2026.05.27.26354202",
    "authors": "Berger, C. G.; Puttfarcken, B.; Qiu, J.; Hauer, I.; Herr, S.; Juestel, D.; Pleitez, M. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; endocrinology"
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "score": 0,
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    "canonical_key": "doi:10.1101/2024.08.16.608170",
    "headline": "Oncolytic vaccinia virus expression of a defined peptide-MHCI complex as a precision cancer immunotherapy platform",
    "summary": "Oncolytic viruses are immunotherapeutic agents that selectively replicate in and kill tumour cells with the goal of promoting anti-cancer immune responses. Vaccinia virus (VACV) is a strong oncolytic virus candidate as it infects a wide range of cancer cells, is amenable to genetic tailoring and induces potent, long-lasting immunity.",
    "url": "https://doi.org/10.1101/2024.08.16.608170",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2024.08.16.608170",
    "preprint_id": "biorxiv:10.1101/2024.08.16.608170",
    "authors": "Komant, S. J.; Wang, J. L.; Favis, N.; Alex, C.; Evans, D. H.; Noyce, R. S.; Baldwin, T. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-29",
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    "id": "journal-rss:nature chemical biology current issue:10.1038/s41589-026-02233-x",
    "canonical_key": "doi:10.1038/s41589-026-02233-x",
    "headline": "A potent alternative cysteine production pathway allows reductase independence",
    "summary": "Nature Chemical Biology, Published online: 29 May 2026; doi:10.1038/s41589-026-02233-x To obtain the semi-essential amino acid cysteine, cells assimilate its oxidized form, cystine, and then reduce its disulfide bond.",
    "url": "https://doi.org/10.1038/s41589-026-02233-x",
    "source": "Nature Chemical Biology RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Chemical Biology",
    "pmid": "",
    "doi": "10.1038/s41589-026-02233-x",
    "preprint_id": "",
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    "primary_source": "Nature Chemical Biology RSS",
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    "keywords": "journal rss; Nature Chemical Biology; Nature Chemical Biology current issue"
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "score": 0,
    "id": "journal-rss:nature reviews genetics current issue:10.1038/s41576-026-00974-y",
    "canonical_key": "doi:10.1038/s41576-026-00974-y",
    "headline": "Advancing the applications of liquid biopsies in oncology",
    "summary": "Nature Reviews Genetics, Published online: 29 May 2026; doi:10.1038/s41576-026-00974-y In this Review, Valpione et al. discuss how the current applications of liquid biopsies in precision oncology might be expanded to provide a more holistic and personalized view of cancer and to improve cancer diagnosis and treatment.",
    "url": "https://doi.org/10.1038/s41576-026-00974-y",
    "source": "Nature Reviews Genetics RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Reviews Genetics",
    "pmid": "",
    "doi": "10.1038/s41576-026-00974-y",
    "preprint_id": "",
    "authors": "Sara Valpione; Alexandra Clipson; Dominic G. Rothwell; Caroline Dive; Florent Mouliere",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Reviews Genetics RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Reviews Genetics; Nature Reviews Genetics current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73839-x",
    "canonical_key": "doi:10.1038/s41467-026-73839-x",
    "headline": "Anthropogenic climate change accelerates the onset of global flood timing",
    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73839-x The study shows that climate warming alters global flood timing, producing regionally divergent shifts that affect over half of the world and challenge traditional disaster preparedness.",
    "url": "https://doi.org/10.1038/s41467-026-73839-x",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73839-x",
    "preprint_id": "",
    "authors": "Wei Qi; Yanli Liu; Xin Jiang; Junguo Liu",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
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    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
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    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "score": 0,
    "id": "journal-rss:nature current issue:10.1038/s41586-026-10605-5",
    "canonical_key": "doi:10.1038/s41586-026-10605-5",
    "headline": "Author Correction: US oil and gas system emissions from nearly one million aerial site measurements",
    "summary": "Nature, Published online: 29 May 2026; doi:10.1038/s41586-026-10605-5 Author Correction: US oil and gas system emissions from nearly one million aerial site measurements",
    "url": "https://doi.org/10.1038/s41586-026-10605-5",
    "source": "Nature RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature",
    "pmid": "",
    "doi": "10.1038/s41586-026-10605-5",
    "preprint_id": "",
    "authors": "Evan D. Sherwin; Jeffrey S. Rutherford; Zhan Zhang; Yuanlei Chen; Erin B. Wetherley; Petr V. Yakovlev; Elena S. F. Berman; Brian B. Jones; Daniel H. Cusworth; Andrew K. Thorpe; Alana K. Ayasse; Riley M. Duren",
    "assignee": "",
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    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "Nature RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature; Nature current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 17,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.26.726543",
    "canonical_key": "doi:10.64898/2026.05.26.726543",
    "headline": "Circadian misalignment underlies immune escape in breast cancer",
    "summary": "Circadian regulation shapes tissue physiology, yet how it organizes cellular and molecular dynamics within the tumor microenvironment (TME) and influences tumor immunity remains unclear.",
    "url": "https://doi.org/10.64898/2026.05.26.726543",
    "source": "bioRxiv",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.26.726543",
    "preprint_id": "biorxiv:10.64898/2026.05.26.726543",
    "authors": "Liang, C.; Liu, Z.; Xu, X.; Xu, Z.; Zhang, Q.; Zhang, T.; Mangan, R. J.; Xiu, B.; Wu, G.; Akhshi, T.; Sandusky, Z. M.; Gray, G. K.; Zhang, N.; Kuziel, G.; Traphagen, N. A.; Fass, S. B.; Grayson, A.; Ho, L.-L.; Gu, S. S.; Wang, S.; Sheng, Z. Z.; Zhang, Y.; Adib, E.; Chen, T.; Jeselsohn, R.; Kellis, M.; Brown, M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cancer biology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 18,
    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73820-8",
    "canonical_key": "doi:10.1038/s41467-026-73820-8",
    "headline": "Directed trilithiation enables entropically stabilized heavy-atom-centered triangulenes",
    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73820-8 Embedding heavy main-group elements at the core of rigid π-conjugated frameworks has long been recognized as an ideal strategy for enhanced stability yet synthetic realization has remained elusive.",
    "url": "https://doi.org/10.1038/s41467-026-73820-8",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73820-8",
    "preprint_id": "",
    "authors": "Hajime Gotoh; Soichiro Nakatsuka; Keisuke Kinoshita; Jiping Hao; Takuji Hatakeyama",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "score": 0,
    "id": "biorxiv:10.64898/2026.01.30.702929",
    "canonical_key": "doi:10.64898/2026.01.30.702929",
    "headline": "Dual roles for influenza A virus PA-X in evasion of innate and adaptive immunity in the human airway epithelium",
    "summary": "The mechanisms of immune evasion of influenza A virus are key to its success as an infectious agent. To replicate effectively, influenza A virus must suppress both early innate immune responses, like antiviral type I and III interferons, and adaptive immune responses.",
    "url": "https://doi.org/10.64898/2026.01.30.702929",
    "source": "bioRxiv",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.01.30.702929",
    "preprint_id": "biorxiv:10.64898/2026.01.30.702929",
    "authors": "Setaro, A. C.; Thomas, C. A.; Gaglia, M. M.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "id": "journal-rss:nature reviews immunology current issue:10.1038/s41577-026-01317-y",
    "canonical_key": "doi:10.1038/s41577-026-01317-y",
    "headline": "Eosinophils shape barrier immunity during reproduction",
    "summary": "Nature Reviews Immunology, Published online: 29 May 2026; doi:10.1038/s41577-026-01317-y Eosinophils remodel the maternal intestine during pregnancy and lactation, promoting goblet cell differentiation and strengthening barrier immunity.",
    "url": "https://doi.org/10.1038/s41577-026-01317-y",
    "source": "Nature Reviews Immunology RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Reviews Immunology",
    "pmid": "",
    "doi": "10.1038/s41577-026-01317-y",
    "preprint_id": "",
    "authors": "Alexandra Flemming",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Reviews Immunology RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Reviews Immunology; Nature Reviews Immunology current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 21,
    "score": 0,
    "id": "journal-rss:communications biology current issue:10.1038/s42003-026-10376-9",
    "canonical_key": "doi:10.1038/s42003-026-10376-9",
    "headline": "Extrinsic MMPs drive epithelial shape change via basal extracellular matrix disassembly in the Drosophila wing disc",
    "summary": "Communications Biology, Published online: 29 May 2026; doi:10.1038/s42003-026-10376-9 A study shows that epithelial shape changes in the Drosophila wing disc are driven by basal extracellular matrix disassembly induced by MMP activity in neighboring non-epithelial tissues.",
    "url": "https://doi.org/10.1038/s42003-026-10376-9",
    "source": "Communications Biology RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Communications Biology",
    "pmid": "",
    "doi": "10.1038/s42003-026-10376-9",
    "preprint_id": "",
    "authors": "Chigusa Hinata; Hirotatsu Nakagawa; Shigenori Nonaka; Katsuya Nozaki; Yoshikatsu Sato; Shizue Ohsawa",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "Communications Biology RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Communications Biology; Communications Biology current issue"
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 22,
    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73782-x",
    "canonical_key": "doi:10.1038/s41467-026-73782-x",
    "headline": "Grayscale projection two-photon lithography using sub-diffraction motifs for ultrafast and precise nanoscale 3D printing",
    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73782-x The ability to precisely tune light intensity within projected images can massively scale up sub-100 nm additive manufacturing. Kim and Saha show how optical diffraction can be leveraged to achieve this with a single pulse of femtosecond laser.",
    "url": "https://doi.org/10.1038/s41467-026-73782-x",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73782-x",
    "preprint_id": "",
    "authors": "Harnjoo Kim; Sourabh K. Saha",
    "assignee": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73406-4",
    "canonical_key": "doi:10.1038/s41467-026-73406-4",
    "headline": "Highly potent C-type nanoantibodies neutralize Nipah and Hendra viruses by cavity filling on fusion glycoprotein",
    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73406-4 Currently, no approved vaccines or antiviral drugs are available against Nipah virus.",
    "url": "https://doi.org/10.1038/s41467-026-73406-4",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73406-4",
    "preprint_id": "",
    "authors": "Shengdong Wang; Guibo Rao; Xinghai Zhang; Yanfeng Yao; Li Chen; Shaohong Chen; Haiwei Zhang; Hang Liu; Miaoyu Chen; Wujian Li; Sheng Cao; Sandra Chiu",
    "assignee": "",
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    "primary_source": "Nature Communications RSS",
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    "id": "journal-rss:nature current issue:10.1038/d41586-026-01393-z",
    "canonical_key": "doi:10.1038/d41586-026-01393-z",
    "headline": "How jazz boosts my creativity in physics",
    "summary": "Nature, Published online: 29 May 2026; doi:10.1038/d41586-026-01393-z Stephon Alexander says his passion for musical improvisation helps him to understand and teach complex ideas.",
    "url": "https://doi.org/10.1038/d41586-026-01393-z",
    "source": "Nature RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
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    "doi": "10.1038/d41586-026-01393-z",
    "preprint_id": "",
    "authors": "Dom Byrne",
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    "event_type": "",
    "primary_source": "Nature RSS",
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  {
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    "window_start": "2026-05-28T05:15:00.000Z",
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    "id": "journal-rss:nature immunology current issue:10.1038/s41590-026-02539-x",
    "canonical_key": "doi:10.1038/s41590-026-02539-x",
    "headline": "Immune-competent new approach methodologies for a hybrid future",
    "summary": "Nature Immunology, Published online: 29 May 2026; doi:10.1038/s41590-026-02539-x In a shifting regulatory landscape that increasingly favors organ-on-chip and human cell-based systems, embedding immune complexity is essential to advance new approach methodologies beyond reductionist models and toward a hybrid ecosystem that integrates an...",
    "url": "https://doi.org/10.1038/s41590-026-02539-x",
    "source": "Nature Immunology RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Immunology",
    "pmid": "",
    "doi": "10.1038/s41590-026-02539-x",
    "preprint_id": "",
    "authors": "Vance Soares; Victor M. Quiroz; Martin Trapecar; Deok-Ho Kim; Joshua C. Doloff",
    "assignee": "",
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    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Immunology RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Immunology; Nature Immunology current issue"
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "score": 0,
    "id": "journal-rss:nature methods current issue:10.1038/s41592-026-03116-8",
    "canonical_key": "doi:10.1038/s41592-026-03116-8",
    "headline": "iPS cells: history made and history in the making",
    "summary": "Nature Methods, Published online: 29 May 2026; doi:10.1038/s41592-026-03116-8 The method to reprogram fully differentiated cells using transcription factors retools cells — and has retooled many a scientist’s trajectory. Here, researchers comment on this ‘remodeling’ and the future they foresee.",
    "url": "https://doi.org/10.1038/s41592-026-03116-8",
    "source": "Nature Methods RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Methods",
    "pmid": "",
    "doi": "10.1038/s41592-026-03116-8",
    "preprint_id": "",
    "authors": "Vivien Marx",
    "assignee": "",
    "publication_number": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Methods RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Methods; Nature Methods current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 27,
    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73686-w",
    "canonical_key": "doi:10.1038/s41467-026-73686-w",
    "headline": "Metabolic feedbacks drive population dynamics and can lead to oscillations among leaf bacteria",
    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73686-w Plant-associated bacteria engage in complex metabolic interactions. Here authors used microfluidics and computational modeling to identify molecular drivers of these interactions and disentangle their contributions to emergent ecological dynamics.",
    "url": "https://doi.org/10.1038/s41467-026-73686-w",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73686-w",
    "preprint_id": "",
    "authors": "Alan R. Pacheco; Giovanni Stefano Ugolini; Simon H. Rüdisser; Andrea Zamuner; Miriam Bortfeld-Miller; Patrick Kiefer; Franziska Oschmann; Samuel G. V. Charlton; Michael Berger; Tommaso Redaelli; Miguel Ángel Salazar; Ilija Dukovski",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
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    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "score": 0,
    "id": "biorxiv:10.64898/2026.05.26.727850",
    "canonical_key": "doi:10.64898/2026.05.26.727850",
    "headline": "Multi omics reveals mesodermal fate bias and enables predictive cell state control in human pluripotent stem cell biomanufacturing",
    "summary": "Despite accelerating interest in using human induced pluripotent stem cell (hiPSC)-derived products for disease modeling and therapeutic development, there is substantial evidence that conventional culture approaches do not fully recapitulate natural embryonic nor lineage committed states.",
    "url": "https://doi.org/10.64898/2026.05.26.727850",
    "source": "bioRxiv",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.26.727850",
    "preprint_id": "biorxiv:10.64898/2026.05.26.727850",
    "authors": "Colter, J.; Dang, T.; Young, D.; Dufour, A.; Lewis, I.; Murari, K.; Kallos, M. S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
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  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "rank_index": 29,
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    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73693-x",
    "canonical_key": "doi:10.1038/s41467-026-73693-x",
    "headline": "Noisy quantum learning theory",
    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73693-x Expected quantum advantages in learning unknown system properties usually rely on idealized scenarios.",
    "url": "https://doi.org/10.1038/s41467-026-73693-x",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73693-x",
    "preprint_id": "",
    "authors": "Jordan Cotler; Weiyuan Gong; Ishaan Kannan",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
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    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "score": 0,
    "id": "journal-rss:nature medicine current issue:10.1038/s41591-026-04451-1",
    "canonical_key": "doi:10.1038/s41591-026-04451-1",
    "headline": "Pathogenic germline variants identify elevated cancer risk in pediatric patients referred for genetic testing",
    "summary": "Nature Medicine, Published online: 29 May 2026; doi:10.1038/s41591-026-04451-1 Through large-scale genomic analysis, we show that pathogenic germline variants in pediatric cancer-predisposition genes are associated with increased subsequent tumor risk, highlighting their value for counseling and surveillance.",
    "url": "https://doi.org/10.1038/s41591-026-04451-1",
    "source": "Nature Medicine RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Medicine",
    "pmid": "",
    "doi": "10.1038/s41591-026-04451-1",
    "preprint_id": "",
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    "event_type": "",
    "primary_source": "Nature Medicine RSS",
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    "keywords": "journal rss; Nature Medicine; Nature Medicine current issue"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 31,
    "score": 0,
    "id": "journal-rss:communications medicine current issue:10.1038/s43856-026-01695-3",
    "canonical_key": "doi:10.1038/s43856-026-01695-3",
    "headline": "Predict neuromuscular performance in human epidural electrical stimulation: phase 1 trial interim results",
    "summary": "Communications Medicine, Published online: 29 May 2026; doi:10.1038/s43856-026-01695-3 Li et al. integrate computational modeling and AI-based optimization to personalize epidural electrical stimulation for individuals with spinal cord injury.",
    "url": "https://doi.org/10.1038/s43856-026-01695-3",
    "source": "Communications Medicine RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Communications Medicine",
    "pmid": "",
    "doi": "10.1038/s43856-026-01695-3",
    "preprint_id": "",
    "authors": "Hongda Li; Yunyue Wei; Yanan Sui; Xi Zhang; Xuesong Luo; Boyang Zhang; Bozhi Ma",
    "assignee": "",
    "publication_number": "",
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    "event_type": "",
    "primary_source": "Communications Medicine RSS",
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    "keywords": "journal rss; Communications Medicine; Communications Medicine current issue"
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "score": 0,
    "id": "biorxiv:10.64898/2026.05.27.728291",
    "canonical_key": "doi:10.64898/2026.05.27.728291",
    "headline": "Single-cell analysis of Plasmodium falciparum transcripts after drug perturbation identifies feedback regulation as well as increased transmission potential",
    "summary": "Gene expression analysis in malaria parasites has been used to define transcriptional regulatory networks but has been used less frequently to characterize parasite response to drug treatment or to show how parasites may evade killing.",
    "url": "https://doi.org/10.64898/2026.05.27.728291",
    "source": "bioRxiv",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.27.728291",
    "preprint_id": "biorxiv:10.64898/2026.05.27.728291",
    "authors": "Godinez-Macias, K. P.; Calla, J.; Jepsen, K.; Winzeler, E. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "score": 0,
    "id": "journal-rss:nature communications current issue:10.1038/s41467-026-73656-2",
    "canonical_key": "doi:10.1038/s41467-026-73656-2",
    "headline": "Sterically-extended asymmetric conjugated hole-selective layer for perovskite/silicon tandem solar cells",
    "summary": "Nature Communications, Published online: 29 May 2026; doi:10.1038/s41467-026-73656-2 Carbazole-based monolayers aid perovskite–silicon tandem solar cells yet preventing aggregation while maintaining charge transport on textured silicon is challenging. Yan et al.",
    "url": "https://doi.org/10.1038/s41467-026-73656-2",
    "source": "Nature Communications RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Communications",
    "pmid": "",
    "doi": "10.1038/s41467-026-73656-2",
    "preprint_id": "",
    "authors": "Tingxia Yan; Chenxu He; Chi Li; Xinhua Ouyang",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Communications RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Communications; Nature Communications current issue"
  },
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "score": 0,
    "id": "journal-rss:nature reviews immunology current issue:10.1038/s41577-026-01315-0",
    "canonical_key": "doi:10.1038/s41577-026-01315-0",
    "headline": "Why pigs might help us develop better vaccines and drugs against influenza virus",
    "summary": "Nature Reviews Immunology, Published online: 29 May 2026; doi:10.1038/s41577-026-01315-0 Advances in genetic engineering, immunological tools, single-cell transcriptomics and in vivo imaging have strengthened the usefulness of pigs in influenza research.",
    "url": "https://doi.org/10.1038/s41577-026-01315-0",
    "source": "Nature Reviews Immunology RSS",
    "published_date": "2026-05-29",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature Reviews Immunology",
    "pmid": "",
    "doi": "10.1038/s41577-026-01315-0",
    "preprint_id": "",
    "authors": "John P. Driver; Daniela S. Rajao; Anika Singanayagam; Montserrat Torremorell; Elma Tchilian",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "Nature Reviews Immunology RSS",
    "secondary_coverage": "",
    "keywords": "journal rss; Nature Reviews Immunology; Nature Reviews Immunology current issue"
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 35,
    "score": 0,
    "id": "pubmed:42206702",
    "canonical_key": "pmid:42206702",
    "headline": "[Unveiling the mechanisms of baicalein in regulating allergic contact dermatitis: A network pharmacology approach].",
    "summary": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206702/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
    "pmid": "42206702",
    "doi": "",
    "preprint_id": "",
    "authors": "Fan H; Jing Y; Yang J; Wang S; Wei Y; Lyu Y; Zhuang R",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed crdt"
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  {
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    "score": 0,
    "id": "journal-rss:science latest articles:10.1126/science.aeb2672",
    "canonical_key": "doi:10.1126/science.aeb2672",
    "headline": "A Hormone Cell Atlas maps the human endocrine system at cellular resolution",
    "summary": "Science, Ahead of Print.",
    "url": "https://doi.org/10.1126/science.aeb2672",
    "source": "Science RSS",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Science",
    "pmid": "",
    "doi": "10.1126/science.aeb2672",
    "preprint_id": "",
    "authors": "Lijiang Fei, Isabel Huang-Doran, Katherine Lawler, Yizhou Yu, Jan Patrick Pett, Kevin M. Méndez-Acevedo, Dinesh Shah, Jaume Margalef-Rieres, Joseph S. Pohlman, Batuhan Cakir, Madelyn R. Moy, Robert G. Legg, Chuan Xu, Ken To, Duy Pham, Alexander V. Predeus, Ruth Hanssen, Tessa M. Cacciottolo, Rakesh K. Kapuge, Krzysztof Polanski, Amanda J. Oliver, Sarah A. Teichmann, I. Sadaf Farooqi",
    "assignee": "",
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    "primary_source": "Science RSS",
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    "keywords": "journal rss; Science; Science latest articles"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "score": 0,
    "id": "biorxiv:10.64898/2026.05.27.728110",
    "canonical_key": "doi:10.64898/2026.05.27.728110",
    "headline": "A neuroimmune IL-13 axis is associated with human enteric nervous system development",
    "summary": "The mechanisms governing maturation of the human enteric nervous system (ENS) during early postnatal life remain poorly defined. Here, we characterize the transcriptomic, cellular, and functional landscape of the neonatal human ileum and identify a neuro-immune axis associated with ENS expansion.",
    "url": "https://doi.org/10.64898/2026.05.27.728110",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.27.728110",
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    "authors": "Goncalves, L. E. D.; Ghirotto, B.; Pizano, A.; Rossdeutsch, L.; Thoma, O.-M.; Jacobsen, A.; Trumet, L.; Weber, M.; Rosshart, S. P.; Besendörfer, M.; Eckstein, M.; Schmidt, C.; Namipashaki, A.; Yu, H.; Hao, M. M.; Stamp, L. A.; Neurath, M.; Günther, C.; Winner, B.; Hensel, I. V.; Diez, S.",
    "assignee": "",
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    "primary_source": "bioRxiv",
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    "id": "pubmed:42017804",
    "canonical_key": "pmid:42017804",
    "headline": "A novel manganese glycerophosphate vaccine gel elicits broad and durable immunity across an aged and pox virus model.",
    "summary": "Nanoscale. Nanoscale. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42017804/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nanoscale",
    "pmid": "42017804",
    "doi": "10.1039/d5nr03936c",
    "preprint_id": "",
    "authors": "Islam MJ; Ontiveros-Padilla L; Ehrenzeller SA; Middleton DD; Roque JA 3rd; Murphy CT; Lukesh NR; Hendy DA; Pena ES; Stack RN; Polacheck WJ; Bachelder EM; Ainslie KM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 39,
    "score": 0,
    "id": "pubmed:42207301",
    "canonical_key": "pmid:42207301",
    "headline": "A rare solid tumor frequently misdiagnosed as lymphoma: primary colonic Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma.",
    "summary": "Virchows Archiv : an international journal of pathology. Virchows Arch. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207301/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Virchows Archiv : an international journal of pathology",
    "pmid": "42207301",
    "doi": "10.1007/s00428-026-04581-4",
    "preprint_id": "",
    "authors": "Xie JL; Yang HJ; Zhang ZF; Yue B; Zheng GJ; Wang LH; Zhou XG; Zhao C; Chen GY",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 40,
    "score": 0,
    "id": "pubmed:42207554",
    "canonical_key": "pmid:42207554",
    "headline": "A reassessment of anti-CAR T-cell expansion strategies.",
    "summary": "Blood. Blood. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207554/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood",
    "pmid": "42207554",
    "doi": "10.1182/blood.2026033564",
    "preprint_id": "",
    "authors": "Bollard CM; Heslop HE",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 41,
    "score": 0,
    "id": "biorxiv:10.64898/2026.01.13.699115",
    "canonical_key": "doi:10.64898/2026.01.13.699115",
    "headline": "Amplified genome editing by in vivo editor production",
    "summary": "Genome editing enzymes have vast therapeutic potential. However, achieving sufficient delivery in vivo remains a major challenge, because editing machinery is confined to the subset of transfectable cells in a tissue.",
    "url": "https://doi.org/10.64898/2026.01.13.699115",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.01.13.699115",
    "preprint_id": "biorxiv:10.64898/2026.01.13.699115",
    "authors": "Ngo, W.; Rosas-Rivera, D.; Wasko, K. M.; Qiu, L.; Kang, M. H.; Gogna, S.; Zeng, J.; Hooks, M. T.; Wu, J. L. Y.; Li, Z.; Doudna, J. A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 42,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.727443",
    "canonical_key": "doi:10.64898/2026.05.25.727443",
    "headline": "An integrated human forebrain organoid reveals microglia-mediated CD8⁺ T cell recruitment and neuroimmune dysfunction in Alzheimer's disease pathology",
    "summary": "Genetic evidence implicates immune dysfunction in Alzheimer's disease (AD), yet human-specific neuroimmune mechanisms remain poorly defined. Here, we establish a modular human forebrain organoid platform that systematically integrates iPSC-derived microglia and CD8 T cells to reconstitute multicellular AD pathology.",
    "url": "https://doi.org/10.64898/2026.05.25.727443",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727443",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727443",
    "authors": "MA, S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 43,
    "score": 0,
    "id": "pubmed:41734346",
    "canonical_key": "pmid:41734346",
    "headline": "Antigen-boosted CD4CAR T cells fail to expand or control viremia in multiple nonhuman primate models of HIV.",
    "summary": "Blood. Blood. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41734346/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood",
    "pmid": "41734346",
    "doi": "10.1182/blood.2025032142",
    "preprint_id": "",
    "authors": "Maynard LH; Starke CE; Poole NH; Rust BJ; Zhu H; Stensland L; Huang ML; Pérez-Osorio AC; Atherley JI; Einhaus T; Murray J; Pampena MB; Betts MR; Jerome KR; Riley JL; Kiem HP; Peterson CW",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 44,
    "score": 0,
    "id": "pubmed:42206678",
    "canonical_key": "pmid:42206678",
    "headline": "Astragaloside IV inhibits nasopharyngeal carcinoma progression by inhibiting SATB2/Wnt/PD-L1 pathway and enhancing the killing activity of T cells.",
    "summary": "European journal of histochemistry : EJH. Eur J Histochem. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206678/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "European journal of histochemistry : EJH",
    "pmid": "42206678",
    "doi": "10.4081/ejh.2026.4540",
    "preprint_id": "",
    "authors": "Zeng Y; Huang J; Duan T; Wang X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 45,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.27.725267",
    "canonical_key": "doi:10.64898/2026.05.27.725267",
    "headline": "CAR-Engineered Human Hematopoietic Stem Cell Macrophages Control Solid Tumors",
    "summary": "Chimeric antigen receptor (CAR) T-cells have been a groundbreaking progress in the control of hematological cancers. However, its efficacy in controlling solid tumors has been rather limited, highlighting the importance of new cell-based therapy strategies to curb the progression of solid cancers.",
    "url": "https://doi.org/10.64898/2026.05.27.725267",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.27.725267",
    "preprint_id": "biorxiv:10.64898/2026.05.27.725267",
    "authors": "Ramos, R. N.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 46,
    "score": 0,
    "id": "pubmed:42207485",
    "canonical_key": "pmid:42207485",
    "headline": "Clinical implications of minimal residual disease monitoring in multiple myeloma.",
    "summary": "International journal of hematology. Int J Hematol. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207485/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "International journal of hematology",
    "pmid": "42207485",
    "doi": "10.1007/s12185-026-04229-8",
    "preprint_id": "",
    "authors": "Yoroidaka T",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 47,
    "score": 0,
    "id": "pubmed:42207336",
    "canonical_key": "pmid:42207336",
    "headline": "Clinicopathological characteristics of a rare group of chronic active Epstein-Barr virus disease involving the gastrointestinal tract.",
    "summary": "Journal of hematopathology. J Hematop. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207336/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of hematopathology",
    "pmid": "42207336",
    "doi": "10.1007/s12308-026-00707-4",
    "preprint_id": "",
    "authors": "Zheng X; Zheng Y; Xie J; Huang X; Teng X; Zhang Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 48,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.26.26353629",
    "canonical_key": "doi:10.64898/2026.05.26.26353629",
    "headline": "Deep Learning Spatial Profiling of CD103+CD8+ T Cells and Survival in Rectal Cancer After Neoadjuvant Chemoradiotherapy",
    "summary": "Background: CD8+ tumor-infiltrating lymphocytes (TILs) are established prognostic markers in colorectal cancer, yet the clinical significance of CD103+CD8+ tissue-resident memory-like (TRM-like) T cells in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (NACRT) remains unknown.",
    "url": "https://doi.org/10.64898/2026.05.26.26353629",
    "source": "medRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.26.26353629",
    "preprint_id": "medrxiv:10.64898/2026.05.26.26353629",
    "authors": "Abe, T.; Yamashita, K.; Nagasaka, T.; Fujita, M.; Ueda, Y.; Miyake, S.; Ito, R.; Adachi, Y.; Ando, M.; Tsuneki, T.; Okazoe, Y.; Konaka, R.; Takahashi, T.; Kagiyama, H.; Tachibana, T.; Imai, M.; Yoshida, T.; Saito, M.; Mukohyama, J.; Kanayama, K.; Koma, Y.-I.; Otowa, Y.; Hasegawa, H.; Ikeda, T.; Koterazawa, Y.; Aoki, T.; Harada, H.; Urakawa, N.; Goto, H.; Kanaji, S.; Yanagimoto, H.; Matsuda, T.; Takamura, S.; Yamashita, T.; Sasaki, R.; Fukumoto, T.; Kakeji, Y.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; oncology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 49,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.727705",
    "canonical_key": "doi:10.64898/2026.05.25.727705",
    "headline": "Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction",
    "summary": "Biological aging greatly impacts the body's ability to handle glucose, and represents a major risk factor the development and progression of type 2 diabetes (T2D).",
    "url": "https://doi.org/10.64898/2026.05.25.727705",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727705",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727705",
    "authors": "Iwasaki, K.; Pan, H.; M. Dreyfuss, J.; Jackson, M.; Domanskyi, S.; Baker, D.; Carapeto, P.; Cahill, C.; Le, S.; Hela, F.; Alcoforado Diniz, J.; Naim Eryilmaz, G.; Wu, F.; Wu, P.-H.; Yu, B.; Wirtz, D.; Espinoza, S.; Pena, A.; G. Cigarroa, F.; Abrahamian, G.; Woodworth, J. L.; Adams, P. D.; Ucar, D.; Chuang, J. H.; Wu, Q.; Garovic, V. D.; Kirkland, J. L.; Tchkonia, T.; Musi, N.; Kuchel, G. A.; Robson, P.; Aguayo-Mazzucato, C.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 50,
    "score": 0,
    "id": "pubmed:42207214",
    "canonical_key": "pmid:42207214",
    "headline": "Exploratory multiomics analysis identifies WDR17 as a potential biomarker of tyrosine kinase inhibitor resistance in lung adenocarcinoma.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207214/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42207214",
    "doi": "10.1007/s12672-026-05286-5",
    "preprint_id": "",
    "authors": "Xu Y; Li L; Li Z; Yang Y; Xing H; Ma X; Zhang X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 51,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.26.26354165",
    "canonical_key": "doi:10.64898/2026.05.26.26354165",
    "headline": "Grounding Language Models in Behavioral Science to Scale Physical Activity Interventions for Hispanic/Latinx Populations",
    "summary": "Objective: Hispanic/Latinx populations in the U.S. experience higher rates of chronic disease linked to physical inactivity, yet digital health interventions remain largely inaccessible to more than 16 million Hispanic/Latinx adults with limited English proficiency.",
    "url": "https://doi.org/10.64898/2026.05.26.26354165",
    "source": "medRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.26.26354165",
    "preprint_id": "medrxiv:10.64898/2026.05.26.26354165",
    "authors": "Mantena, S. D.; Johnson, A.; Schuetz, N.; Tolas, A.; Montalvo, S.; Delgado-SanMartin, J.; Ramirez Posada, M.; Du, L.; Zhang, S.; Huynh, A. D.; Oppezzo, M.; King, A. C.; Schmiedmayer, P.; Lawrie, A.; Rodriguez, F.; Ashley, E.; Kim, D. S.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; cardiovascular medicine"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 52,
    "score": 0,
    "id": "pubmed:41592325",
    "canonical_key": "pmid:41592325",
    "headline": "High-dimensional spatiotemporal single-cell atlas and 3D imaging of the bone marrow microenvironment during CML progression.",
    "summary": "Blood. Blood. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41592325/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood",
    "pmid": "41592325",
    "doi": "10.1182/blood.2025029824",
    "preprint_id": "",
    "authors": "Li L; Rottmann I; Saeed BR; Ivison G; Wei H; Schroeder JC; Dunkel G; Greif K; Zhang Y; Makky A; Ochsenbein AF; Riether C; Goltsev Y; Nolan GP; Mayer AT; Weigelin B; Schürch CM",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 53,
    "score": 0,
    "id": "pubmed:41779733",
    "canonical_key": "pmid:41779733",
    "headline": "How I treat HLH-like toxicities after immune effector cell therapy.",
    "summary": "Blood. Blood. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41779733/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood",
    "pmid": "41779733",
    "doi": "10.1182/blood.2025032352",
    "preprint_id": "",
    "authors": "Johnson WT; McNerney KO; Frank MJ; Shah NN",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 54,
    "score": 0,
    "id": "biorxiv:10.1101/2025.09.12.675873",
    "canonical_key": "doi:10.1101/2025.09.12.675873",
    "headline": "IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice",
    "summary": "The diarrheal disease cholera remains a global threat, but there is limited knowledge of the innate immune defenses in the small intestine that protect against the causative agent, Vibrio cholerae.",
    "url": "https://doi.org/10.1101/2025.09.12.675873",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.1101/2025.09.12.675873",
    "preprint_id": "biorxiv:10.1101/2025.09.12.675873",
    "authors": "Suzuki, M.; Hasegawa, Y.; Zhang, H.; Liang, Z.; Tie, G.; Shivdasani, R.; Waldor, M. K.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; microbiology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 55,
    "score": 0,
    "id": "pubmed:42207176",
    "canonical_key": "pmid:42207176",
    "headline": "Intrathecal Allogeneic B7-H3-targeted CAR γδ T Cells for Leptomeningeal Metastasis from Solid Tumors: Safety, Efficacy, and Immunological Dynamics in a Phase 1 Trial.",
    "summary": "Clinical cancer research : an official journal of the American Association for Cancer Research. Clin Cancer Res. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207176/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
    "pmid": "42207176",
    "doi": "10.1158/1078-0432.CCR-26-0738",
    "preprint_id": "",
    "authors": "Ma P; Zhou Y; Ma W; Wang Y; Cai H; Sui Y; Zhao L; Zhang Y; Wang S; Li N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.726449",
    "canonical_key": "doi:10.64898/2026.05.25.726449",
    "headline": "Mapping Genetic Risk Associations to Cellular Contexts via Deep Learning and Biological Ontologies",
    "summary": "Translating genome-wide association studies (GWAS) signals into trait-relevant cellular contexts remains challenging due to the complexity of the genomic regulatory code and linkage disequilibrium among associated variants.",
    "url": "https://doi.org/10.64898/2026.05.25.726449",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.726449",
    "preprint_id": "biorxiv:10.64898/2026.05.25.726449",
    "authors": "Margalit, T.; Levi, H.; Shamir, R.; Elkon, R.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioinformatics"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 57,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.25.727439",
    "canonical_key": "doi:10.64898/2026.05.25.727439",
    "headline": "MicroRNA-29a enhances and preserves stem-like CD8 T cell differentiation by regulating master epigenetic circuits of exhaustion.",
    "summary": "CD8 T cells mediate protective immune responses. However, persisting antigens such as chronic viruses or tumors redirect CD8 T cell differentiation to a sub-optimal, epigenetically defined state called exhaustion. Exhausted T cells (TEX) lose their ability to persist long-term and to initiate functional memory responses.",
    "url": "https://doi.org/10.64898/2026.05.25.727439",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727439",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727439",
    "authors": "Leng, X.; Buchness, L. A.; Rafie, C. I.; Vlantis, P. I.; Ristin, S.; Gallardo, M. A.; Auwardt, S. L.; Khatwani, N. K.; Tan, Y.-D.; Ban, Y.; Sologon, C. M.; Currall, B. B.; Williams, S. L.; Van der Jeught, K.; Datta, J. L.; Villarino, A. V.; Telonis, A. G.; Stelekati, E.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; immunology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 58,
    "score": 0,
    "id": "pubmed:42206847",
    "canonical_key": "pmid:42206847",
    "headline": "Myeloid-derived suppressor cell (MDSC)-like neutrophils induced by pulmonary infection with Coccidioides posadasii exacerbate disease by suppressing CD4(+) T cell immunity.",
    "summary": "mBio. mBio. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206847/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "mBio",
    "pmid": "42206847",
    "doi": "10.1128/mbio.00772-26",
    "preprint_id": "",
    "authors": "Abdul-Baki N; Negron A; Navarro R; Campuzano A; Mendoza Barker M; Prather ND; Fidel PL Jr; Forsthuber TG; Yu J-J; Hung C-Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 59,
    "score": 0,
    "id": "pubmed:42207333",
    "canonical_key": "pmid:42207333",
    "headline": "Neuropilins in Multiple Sclerosis: Dual Roles of NRP-1 in Neuroinflammation and Neuroprotection.",
    "summary": "Neuromolecular medicine. Neuromolecular Med. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207333/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Neuromolecular medicine",
    "pmid": "42207333",
    "doi": "10.1007/s12017-026-08918-9",
    "preprint_id": "",
    "authors": "Goleij P; Babamohamadi M; Heidari MM; Khazeei Tabari MA; Abolfazli S; Mohammadi S; Majma Sanaye P; Arefnezhad R; Aschner M; Khan H; Rezaei Tavirani M; Movafagh A",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 60,
    "score": 0,
    "id": "pubmed:42206580",
    "canonical_key": "pmid:42206580",
    "headline": "No Evidence for Association Between ICOS (a T-Cell Co-Stimulatory Molecule) Gene Polymorphisms and Anti-MSP-1(19) IgG Response in Venezuelan Endemic Plasmodium vivax Malaria.",
    "summary": "Parasite immunology. Parasite Immunol",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206580/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Parasite immunology",
    "pmid": "42206580",
    "doi": "10.1111/pim.70086",
    "preprint_id": "",
    "authors": "Sevilla RD; Regalado-Gutiérrez OA; Wide A; Puche-Quiñonez R; Patarroyo MA; Noya-González O; Fernández-Mestre M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 61,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.28.728382",
    "canonical_key": "doi:10.64898/2026.05.28.728382",
    "headline": "Piezo1 links cytoskeletal remodeling to differential YAP and β-catenin signaling in response to mechanical cues",
    "summary": "Mechanical cues from the extracellular matrix regulate cancer cell behavior, but how these inputs are translated into distinct nuclear signaling responses remains incompletely understood.",
    "url": "https://doi.org/10.64898/2026.05.28.728382",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.28.728382",
    "preprint_id": "biorxiv:10.64898/2026.05.28.728382",
    "authors": "Wu, Y.; Ge, C.; Su, Z. H.; You, L.; Geng, F.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 62,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.27.728101",
    "canonical_key": "doi:10.64898/2026.05.27.728101",
    "headline": "Plasticity of genetic regulation during cellular learning",
    "summary": "Even under physiological conditions, cells are exposed to multiple, spatially and temporally complex signals and need to regularly adjust their response to survive and function. At least in some cases, identifying the appropriate response relies on the ability cells to learn from experience.",
    "url": "https://doi.org/10.64898/2026.05.27.728101",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.27.728101",
    "preprint_id": "biorxiv:10.64898/2026.05.27.728101",
    "authors": "Heistinger, L.; Parfenova, I.; Damenikan, A.; Michel, A.; Kornmann, B.; Sintsova, A.; Barral, Y.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; cell biology"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 63,
    "score": 0,
    "id": "pubmed:42207441",
    "canonical_key": "pmid:42207441",
    "headline": "RAS pathway activity subtypes identified by machine learning define prognostic and immune microenvironment characteristics in lung adenocarcinoma.",
    "summary": "Discover oncology. Discov Oncol. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207441/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Discover oncology",
    "pmid": "42207441",
    "doi": "10.1007/s12672-026-05282-9",
    "preprint_id": "",
    "authors": "Shi Y",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat; pubmed crdt"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 64,
    "score": 0,
    "id": "pubmed:41734335",
    "canonical_key": "pmid:41734335",
    "headline": "Rust BJ, Kean LS, Colonna L, Brandenstein KE, Poole NH, Obenza W, Enstrom MR, Maldini CR, Ellis GI, Fennessey CM, Huang M-L, Keele BF, Jerome KR, Riley JL, Kiem H-P, Peterson CW. Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates. Blood. 2020;136(15):1722-1734.",
    "summary": "Blood. Blood. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41734335/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood",
    "pmid": "41734335",
    "doi": "10.1182/blood.2026033814",
    "preprint_id": "",
    "authors": "",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 65,
    "score": 0,
    "id": "pubmed:42090447",
    "canonical_key": "pmid:42090447",
    "headline": "SARS-CoV-2 triggers an NF-kB-driven proliferative response in epididymal clear cells of K18-hACE2 mice.",
    "summary": "Reproduction & fertility. Reprod Fertil. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42090447/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Reproduction & fertility",
    "pmid": "42090447",
    "doi": "10.1530/RAF-25-0197",
    "preprint_id": "",
    "authors": "Da Silva AAS; Akinsomisoye OS; Battistone MA; Cerri PS; Sasso-Cerri E",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
    "secondary_coverage": "",
    "keywords": "pubmed; pubmed pdat"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 66,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.24.727572",
    "canonical_key": "doi:10.64898/2026.05.24.727572",
    "headline": "Self-regenerating opsin from reef-building coral",
    "summary": "Opsins underlie diverse physiological responses to light in animals. In the dark, most opsins bind the chromophore 11-cis retinal, which isomerizes to all-trans form upon light absorption, representing the initial key step in signaling.",
    "url": "https://doi.org/10.64898/2026.05.24.727572",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.24.727572",
    "preprint_id": "biorxiv:10.64898/2026.05.24.727572",
    "authors": "Sakai, Y.; Imamoto, Y.; Inukai, S.; Tominaga, Y.; Sugihara, T.; Yamashita, T.; Katayama, K.; Kakeyama, Y.; Oka, R.; Okuno, E.; Iwasaki, M.; Kandori, H.; Koyanagi, M.; Terakita, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
    "company_name": "",
    "drug_name": "",
    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; biophysics"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 67,
    "score": 0,
    "id": "medrxiv:10.64898/2026.05.05.26352450",
    "canonical_key": "doi:10.64898/2026.05.05.26352450",
    "headline": "Shared Genetics of Hypertension and Preeclampsia Converges on Immune Regulation",
    "summary": "Background: Hypertension and preeclampsia are clinically distinct, yet biologically related conditions characterized by vascular dysfunction and elevated cardiovascular risk.",
    "url": "https://doi.org/10.64898/2026.05.05.26352450",
    "source": "medRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "medRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.05.26352450",
    "preprint_id": "medrxiv:10.64898/2026.05.05.26352450",
    "authors": "Farahat, M. A.; Abbas, M.; Melese, M. T.; Gaye, A.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "medRxiv",
    "secondary_coverage": "",
    "keywords": "medrxiv; genetic and genomic medicine"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 68,
    "score": 0,
    "id": "biorxiv:10.64898/2026.05.27.728160",
    "canonical_key": "doi:10.64898/2026.05.27.728160",
    "headline": "STIMscope: centimeter-scale all-optical imaging and patterned optogenetic manipulation at single-cell resolution",
    "summary": "Linking observation to intervention at cellular resolution makes it possible to move from measuring network activity to testing the contribution of defined neurons or ensembles within the same preparation. All-optical probing provides this capability by combining fluorescence-based readout with targeted optogenetic manipulation.",
    "url": "https://doi.org/10.64898/2026.05.27.728160",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.27.728160",
    "preprint_id": "biorxiv:10.64898/2026.05.27.728160",
    "authors": "Chorsi, H.; Soldado-Magraner, S.; Jin, Y.; Soltanalipouryekesammak, I.; Zheng, A.; Markovic, D.; Geschwind, D. H.; Golshani, P.; Buonomano, D. V.; Aharoni, D.",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "bioRxiv",
    "secondary_coverage": "",
    "keywords": "biorxiv; bioengineering"
  },
  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 69,
    "score": 0,
    "id": "pubmed:42207200",
    "canonical_key": "pmid:42207200",
    "headline": "Structural basis of a CDR3-embedded binding mechanism in a nanobody for sensitivity enhancement toward tenuazonic acid.",
    "summary": "Analytical and bioanalytical chemistry. Anal Bioanal Chem. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207200/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Analytical and bioanalytical chemistry",
    "pmid": "42207200",
    "doi": "10.1007/s00216-026-06563-6",
    "preprint_id": "",
    "authors": "Wei XF; Fang RY; Wang CL; Liang YF; Li JD; Wang LT; Shen YD; Xu ZL; Xiao ZL; Schneider RJ; Wang H",
    "assignee": "",
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    "event_type": "",
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    "id": "biorxiv:10.64898/2026.05.25.726204",
    "canonical_key": "doi:10.64898/2026.05.25.726204",
    "headline": "Supporting-like cells constitute an alternative steroidogenic lineage conserved in amniotes",
    "summary": "In mammals, the production of sex hormones is widely considered to depend on the interstitial lineage of the gonad, which differentiates into Leydig cells in males or theca cells in females.",
    "url": "https://doi.org/10.64898/2026.05.25.726204",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.726204",
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    "authors": "Barbera-Aura, I.; Chung, W.-Y.; Dujardin, E.; Hurtado, A.; Galmiche, M.; Mayere, C.; Guy, M.; Mandon-Pepin, B.; Franke, V.; Jaszczyszyn, Y.; D. Acemel, R.; Rudaz, S.; Mckey, J.; Nef, S.; Pailhoux, E.; G. Lupianez, D.",
    "assignee": "",
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    "id": "biorxiv:10.64898/2026.05.25.727700",
    "canonical_key": "doi:10.64898/2026.05.25.727700",
    "headline": "Transient ATR inhibition following ionizing radiation enhances immune-mediated antitumor response and survival",
    "summary": "Background. ATR activation following DNA damage from cancer treatments such as radiation can mitigate anticancer efficacy, making ATR inhibitors (ATRi) an attractive therapeutic.",
    "url": "https://doi.org/10.64898/2026.05.25.727700",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727700",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727700",
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    "assignee": "",
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    "id": "pubmed:42204686",
    "canonical_key": "pmid:42204686",
    "headline": "Role of tumor microenvironment composition and metabolism in lymphoid malignancies and therapeutic strategies.",
    "summary": "Cell transplantation. Cell Transplant. 2026-05-27",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42204686/",
    "source": "PubMed",
    "published_date": "2026-05-27",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Cell transplantation",
    "pmid": "42204686",
    "doi": "10.1177/09636897261449351",
    "preprint_id": "",
    "authors": "Niu S; Liu C; Deng Q",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 73,
    "score": 0,
    "id": "pubmed:42206269",
    "canonical_key": "pmid:42206269",
    "headline": "A Spatially Constrained Fibroblast-Myeloid Program Associates With Immune Exclusion and Poor Prognosis in Lung Adenocarcinoma.",
    "summary": "Human mutation. Hum Mutat. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206269/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Human mutation",
    "pmid": "42206269",
    "doi": "10.1155/humu/8218916",
    "preprint_id": "",
    "authors": "Zhou Y; Ren X; Li R; Chen S; Wei B; Shen Y; Wang X; Xia Y; Cao S; Sun P; Ding N",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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  {
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    "source_type": "papers",
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    "score": 0,
    "id": "pubmed:42205540",
    "canonical_key": "pmid:42205540",
    "headline": "C5 inhibition restores B cell homeostasis and humoral immunity in CHAPLE disease patients.",
    "summary": "Journal of human immunity. J Hum Immun. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205540/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of human immunity",
    "pmid": "42205540",
    "doi": "10.70962/jhi.20260042",
    "preprint_id": "",
    "authors": "Tahiat A; Belbouab R; Yagoubi A; Buta Panov S; Cuollo L; Djenouhat K; Bogunovic D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 75,
    "score": 0,
    "id": "pubmed:42205539",
    "canonical_key": "pmid:42205539",
    "headline": "Rebooting immunity in congenital athymia: Factors impacting reconstitution with thymus implantation.",
    "summary": "Journal of human immunity. J Hum Immun. 2026-05-26",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205539/",
    "source": "PubMed",
    "published_date": "2026-05-26",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Journal of human immunity",
    "pmid": "42205539",
    "doi": "10.70962/jhi.20260016",
    "preprint_id": "",
    "authors": "Cresoe-Ortiz S; Venturi G; McCarthy EA; Stewart-Bates B; Heimall JR; Wu EY; Sleasman JW; Hall G",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "score": 0,
    "id": "pubmed:42206267",
    "canonical_key": "pmid:42206267",
    "headline": "PLSCR3 Deficiency Triggers mtDNA-Driven cGAS-STING Activation to Potentiate Antitumor Immunity in Colorectal Cancer.",
    "summary": "Human mutation. Hum Mutat. 2026-05-25",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206267/",
    "source": "PubMed",
    "published_date": "2026-05-25",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Human mutation",
    "pmid": "42206267",
    "doi": "10.1155/humu/8545428",
    "preprint_id": "",
    "authors": "Ling L; Wu J; Bao L; Liu Z; Deng Q; Ji X; Yu S; Yu F; Zhu A; Xiao Q; Zheng W",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 77,
    "score": 0,
    "id": "pubmed:42205992",
    "canonical_key": "pmid:42205992",
    "headline": "A Risk Model Using Refined Disease Risk Index and 1-Month NK-Cell Count for Relapse in Children and Adults with T-ALL/LBL After Myeloablative Umbilical Cord Blood Transplantation.",
    "summary": "Blood and lymphatic cancer : targets and therapy. Blood Lymphat Cancer. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205992/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Blood and lymphatic cancer : targets and therapy",
    "pmid": "42205992",
    "doi": "10.2147/BLCTT.S582933",
    "preprint_id": "",
    "authors": "Zhao N; Chi R; Song K; Wu Y; Yan B; Wang D; Tang B; Zhu X",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 78,
    "score": 0,
    "id": "pubmed:42206240",
    "canonical_key": "pmid:42206240",
    "headline": "An Exploratory in vitro Study of Cytotoxicity and Cytokine Profiling of Cytokine-Induced Killer (CIK) Cells Against HCT-15 Colorectal Cancer (CRC) Cells.",
    "summary": "ImmunoTargets and therapy. Immunotargets Ther. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206240/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "ImmunoTargets and therapy",
    "pmid": "42206240",
    "doi": "10.2147/ITT.S594441",
    "preprint_id": "",
    "authors": "Chin SP; Nor Arfuzir NN; Kong VW; Cheong SK",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "event_type": "",
    "primary_source": "PubMed",
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 79,
    "score": 0,
    "id": "pubmed:42205867",
    "canonical_key": "pmid:42205867",
    "headline": "CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis.",
    "summary": "International journal of nanomedicine. Int J Nanomedicine. 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205867/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "International journal of nanomedicine",
    "pmid": "42205867",
    "doi": "10.2147/IJN.S596277",
    "preprint_id": "",
    "authors": "Ye Y; Sun J; Zhang Y; Wang S; Meng Z",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
    "claims": "",
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    "drug_name": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 80,
    "score": 0,
    "id": "pubmed:42206198",
    "canonical_key": "pmid:42206198",
    "headline": "Paraneoplastic Papuloerythroderma of Ofuji Masquerading as Worsening Psoriasis.",
    "summary": "Psoriasis (Auckland, N.Z.). Psoriasis (Auckl). 2026-05-22",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206198/",
    "source": "PubMed",
    "published_date": "2026-05-22",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Psoriasis (Auckland, N.Z.)",
    "pmid": "42206198",
    "doi": "10.2147/PTT.S608704",
    "preprint_id": "",
    "authors": "Hauptman M; Mehta N; Wang F; Lowe L; Nakamura M",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "drug_name": "",
    "event_type": "",
    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 81,
    "score": 0,
    "id": "pubmed:42207571",
    "canonical_key": "pmid:42207571",
    "headline": "Spine structural lesions in ankylosing spondylitis: comparison between radiographic and opportunistic thoraco-abdomino-pelvic computed tomography assessment.",
    "summary": "Clinical and experimental rheumatology. Clin Exp Rheumatol. 2026-05-21",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42207571/",
    "source": "PubMed",
    "published_date": "2026-05-21",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Clinical and experimental rheumatology",
    "pmid": "42207571",
    "doi": "10.55563/clinexprheumatol/iushi3",
    "preprint_id": "",
    "authors": "Morizot C; Favre-Félix I; Mennini A; Bauer E; Chary-Valckenaere I; Loeuille D",
    "assignee": "",
    "publication_number": "",
    "jurisdiction": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 82,
    "score": 0,
    "id": "pubmed:42206145",
    "canonical_key": "pmid:42206145",
    "headline": "Immunotherapy drug target identification using machine learning and patient-derived tumour explant validation.",
    "summary": "Nature machine intelligence. Nat Mach Intell. 2026-05-18",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206145/",
    "source": "PubMed",
    "published_date": "2026-05-18",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Nature machine intelligence",
    "pmid": "42206145",
    "doi": "10.1038/s42256-026-01201-3",
    "preprint_id": "",
    "authors": "Augustine M; Nene NR; Fu H; Pinder CL; Ligammari L; Simpson AP; Sanz-Fernández I; Thakkar K; Qian D; Fitzsimons E; Simpson BS; Vendramin R; Castro A; Niederer H; Turajlic S; Quezada SA; McGranahan N; Watkins C; Swanton C; Litchfield K",
    "assignee": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
    "rank_bucket": "lower_priority",
    "rank_index": 83,
    "score": 0,
    "id": "pubmed:42206032",
    "canonical_key": "pmid:42206032",
    "headline": "Early sex-related transcriptional differences in CD8(+) T cells responding to chronic viral infection reveal a sex bias in exhaustion.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206032/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Frontiers in immunology",
    "pmid": "42206032",
    "doi": "10.3389/fimmu.2026.1783098",
    "preprint_id": "",
    "authors": "Kahia N; Robertson SM; Rodriguez M; Layug PJ; Vats H; Kannan K; Spicer V; Ozturk-Aptekmann A; Wilkins O; Arsenio J",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "window_start": "2026-05-28T05:15:00.000Z",
    "window_end": "2026-05-29T07:15:00.000Z",
    "source_type": "papers",
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    "rank_index": 84,
    "score": 0,
    "id": "pubmed:42206036",
    "canonical_key": "pmid:42206036",
    "headline": "HDAC7 controls anti-viral and anti-tumor immunity by CD8(+) T cells.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206036/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Frontiers in immunology",
    "pmid": "42206036",
    "doi": "10.3389/fimmu.2026.1816695",
    "preprint_id": "",
    "authors": "Yerinde C; Keye J; Hsiao HJ; Durlanik S; Freise I; Nowak F; Letizia M; Schlickeiser S; Obermayer B; Huck A; Friedrich M; Wu H; Kunkel D; Kühl AA; Bauer S; Thiel A; Hegazy AN; Siegmund B; Glauben R; Weidinger C",
    "assignee": "",
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    "primary_source": "PubMed",
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  {
    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "source_type": "papers",
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    "rank_index": 85,
    "score": 0,
    "id": "pubmed:42205833",
    "canonical_key": "pmid:42205833",
    "headline": "Integrase inhibitor-based antiretroviral therapy drives gut microbiota remodeling and immune recovery in HIV infection.",
    "summary": "Frontiers in medicine. Front Med (Lausanne). 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205833/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Frontiers in medicine",
    "pmid": "42205833",
    "doi": "10.3389/fmed.2026.1814926",
    "preprint_id": "",
    "authors": "Karaca B; Şener A; Kaptan F; Ece D; Örmen B; Caner A",
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    "authors": "Deng M; Lin Y; Fang C; Cai J; Chen C; Ding J",
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    "headline": "Real-world comparison of anti-CD20 therapies: efficacy, infections, and immune profiles in a German cohort.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206028/",
    "source": "PubMed",
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    "journal": "Frontiers in immunology",
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    "preprint_id": "",
    "authors": "Stögbauer J; Bewarder M; Groß L; Thurner L; Fassbender K; Urschel R; Høgestøl EA; Nygaard GO; Harbo HF; Stüve O; Pawlitzki M; Meuth SG; Sester M; Groppa S; Fousse M",
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    "headline": "Therapeutic cancer vaccines: navigating clinical translation and multimodal synergy.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206048/",
    "source": "PubMed",
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    "journal": "Frontiers in immunology",
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    "preprint_id": "",
    "authors": "Chu TH; Huynh TL; Phuong LT",
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    "headline": "Treg-derived IFN-γ supports the differentiation of Th1-Treg in tumor immunity and autoimmunity.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206029/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Frontiers in immunology",
    "pmid": "42206029",
    "doi": "10.3389/fimmu.2026.1756194",
    "preprint_id": "",
    "authors": "Kuratani A; Okamoto M; Arumsari S; Kobayashi T; Sasai M; Yamamoto M",
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    "digest_date": "2026-05-29",
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    "id": "pubmed:42206056",
    "canonical_key": "pmid:42206056",
    "headline": "Unlocking the potential: current landscape and future directions of immunotherapy in gastric cancer.",
    "summary": "Frontiers in immunology. Front Immunol. 2026-05-12",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206056/",
    "source": "PubMed",
    "published_date": "2026-05-12",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Frontiers in immunology",
    "pmid": "42206056",
    "doi": "10.3389/fimmu.2026.1742723",
    "preprint_id": "",
    "authors": "Zhou Y; Wei L; Wang L; Zhang B; Liang J",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "digest_date": "2026-05-29",
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    "canonical_key": "pmid:42205925",
    "headline": "Zigakibart Potently Inhibits A Proliferation-Inducing Ligand-Mediated IgA Production, Addressing IgAN Pathogenesis Root Causes.",
    "summary": "Kidney international reports. Kidney Int Rep. 2026-04-06",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205925/",
    "source": "PubMed",
    "published_date": "2026-04-06",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "Kidney international reports",
    "pmid": "42205925",
    "doi": "10.1016/j.ekir.2026.106516",
    "preprint_id": "",
    "authors": "Dulos J; Kreijtz J; Vink P; Cotton V; Kuo JJ; Lo J; Jansen W; Bakker J; Driessen L; Guadagnoli M; van Zandvoort P; Warncke M; Medema JP; Barratt J; van Eenennaam H; Van Elsas A",
    "assignee": "",
    "publication_number": "",
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    "primary_source": "PubMed",
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    "canonical_key": "pmid:42205417",
    "headline": "The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis.",
    "summary": "World journal of otorhinolaryngology - head and neck surgery. World J Otorhinolaryngol Head Neck Surg. 2025-08-17",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42205417/",
    "source": "PubMed",
    "published_date": "2025-08-17",
    "match_reason": "No high-specificity pMHC/TCR ranking signal detected.",
    "journal": "World journal of otorhinolaryngology - head and neck surgery",
    "pmid": "42205417",
    "doi": "10.1002/wjo2.70037",
    "preprint_id": "",
    "authors": "Li DL; Li Y; Jiang YJ; Zhang GH; Chang LH",
    "assignee": "",
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    "id": "biorxiv:10.64898/2026.05.25.727656",
    "canonical_key": "doi:10.64898/2026.05.25.727656",
    "headline": "STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.",
    "summary": "A growing body of evidence supports the contribution of the long-lasting adaptive immune system in Parkinson's disease (PD). We showed that the PD-associated protein PINK1 negatively regulates the presentation of mitochondrial antigens (MitAP) on MHC-I molecules.",
    "url": "https://doi.org/10.64898/2026.05.25.727656",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "Low-specificity pMHC/TCR field anchor: mhc | Downranked for Non-therapeutic broad immunology: inflammation",
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    "doi": "10.64898/2026.05.25.727656",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727656",
    "authors": "Fahmy, A. M.; Ahmadi, A.; Lanoix, J.; Cannon, T.; Badr Elemeery, m. N.; Hernandez Paredes, C.; Barrette, B.; Bonneil, E.; Zhong Xu, Y.; Ibrahim, M.; Arango-Duque, G.; Audemard, E. O.; Lemieux, S.; Chevet, E.; Schurr, E.; Pierre, P.; Gruenheid, S.; Thibault, P.; McBride, H. M.; Desjardins, M.",
    "assignee": "",
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    "digest_date": "2026-05-29",
    "window_start": "2026-05-28T05:15:00.000Z",
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    "id": "biorxiv:10.64898/2026.05.01.716870",
    "canonical_key": "doi:10.64898/2026.05.01.716870",
    "headline": "Tissue-adapted NK cells shape pathogenic cDC1 niches in early arthritis",
    "summary": "Chronic forms of autoimmune arthritis, including juvenile idiopathic arthritis (JIA), are characterised by persistent synovial inflammation. While adaptive mechanisms are well-studied, the innate networks driving early joint disease remain poorly defined.",
    "url": "https://doi.org/10.64898/2026.05.01.716870",
    "source": "bioRxiv",
    "published_date": "2026-05-29",
    "match_reason": "Downranked for Non-therapeutic broad immunology: autoimmune, inflammation",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.01.716870",
    "preprint_id": "biorxiv:10.64898/2026.05.01.716870",
    "authors": "Knight, O. C.; Giordano, C.; von Stuckrad, A. S. L.; Winning, C.; Bolton, C.; Mahony, C. B.; Croft, A. P.; Mashreghi, M.-F.; Kallinich, T.; Rückert, T.; Romagnani, C.",
    "assignee": "",
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    "canonical_key": "doi:10.64898/2026.05.25.727767",
    "headline": "FOXP3-engineered regulatory T cells restore intestinal barrier integrity in Crohn's disease enteroids via PDGF-AA",
    "summary": "Epithelial regeneration and barrier integrity are impaired in inflammatory bowel diseases, including Crohn's disease (CD), yet current therapies largely target immune inflammation without directly promoting mucosal repair.",
    "url": "https://doi.org/10.64898/2026.05.25.727767",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "Downranked for Non-therapeutic broad immunology: inflammation",
    "journal": "bioRxiv",
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    "doi": "10.64898/2026.05.25.727767",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727767",
    "authors": "Saini, N.; Ojo, B. A.; Bozza, N.; Ramachandran, A.; Gahlot, P.; Lopez-Rivera, J. A.; Tran, T.; Sokzini, P.; Meyer, H.; Dunn, J. C. Y.; Roncarolo, M. G.; Rosen, M. J.; Bacchetta, R.",
    "assignee": "",
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    "headline": "Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation",
    "summary": "Prenatal inflammation has been associated with an increased likelihood of the child developing neurodevelopmental conditions, such as autism spectrum disorder (ASD). Several pro-inflammatory cytokines are significantly upregulated and play critical roles during immune activation, with interleukin-6 (IL-6) being particularly prominent.",
    "url": "https://doi.org/10.64898/2026.05.26.728058",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "Downranked for Non-therapeutic broad immunology: inflammation",
    "journal": "bioRxiv",
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    "doi": "10.64898/2026.05.26.728058",
    "preprint_id": "biorxiv:10.64898/2026.05.26.728058",
    "authors": "Papetti, A. V.; Ma, Z.; NG, M.; Jin, M.; Levison, S. W.; Jiang, P.",
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    "id": "biorxiv:10.64898/2026.05.27.726087",
    "canonical_key": "doi:10.64898/2026.05.27.726087",
    "headline": "IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus",
    "summary": "Immune checkpoint inhibitor-induced lichen planus (ICI-LP) is a cutaneous immune related adverse event (irAE) that shares key clinicopathologic features with spontaneous lichen planus (LP) but differs histologically and in the sex distribution of its incidence, and may therefore reflect a distinct tissue inflammatory state.",
    "url": "https://doi.org/10.64898/2026.05.27.726087",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "Downranked for Non-therapeutic broad immunology: inflammation",
    "journal": "bioRxiv",
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    "doi": "10.64898/2026.05.27.726087",
    "preprint_id": "biorxiv:10.64898/2026.05.27.726087",
    "authors": "Hornick, N. I.; Billo, A.; Fey, R. M.; Hawkins, R. M.; Muhaj, F. F.; Richards, K. N.; Patel, A. B.; Schenkel, J. M.; Pauken, K. E.; Moran, A. E.",
    "assignee": "",
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    "primary_source": "bioRxiv",
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    "source_type": "papers",
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    "id": "pubmed:42206386",
    "canonical_key": "pmid:42206386",
    "headline": "Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis.",
    "summary": "Circulation. Circulation. 2026-05-28",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42206386/",
    "source": "PubMed",
    "published_date": "2026-05-28",
    "match_reason": "Downranked for Non-therapeutic broad immunology: autoimmune",
    "journal": "Circulation",
    "pmid": "42206386",
    "doi": "10.1161/CIRCULATIONAHA.126.079304",
    "preprint_id": "",
    "authors": "Neyazi M; Venturini G; Brown KJ; Choi Y; Gorham JM; Layton OG; Verma A; Wang AJ; Gross RT; McDonough BA; Mendiola Pla M; Viveiros A; DeLaughter DM; DePalma SR; Kim Y; Reichart D; Wakimoto H; Elledge SJ; Divakaran S; Mitchell RN; Koh J; Park JB; Bowles DE; Glass C; Oudit GY; Seidman JG; Seidman CE",
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    "digest_date": "2026-05-29",
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    "id": "biorxiv:10.64898/2026.05.25.727733",
    "canonical_key": "doi:10.64898/2026.05.25.727733",
    "headline": "Nucleic acid turnover and lipid remodeling distinguish T cell activation and exhaustion states via label-free Raman spectroscopy",
    "summary": "T cell exhaustion impairs immune control of chronic diseases including tuberculosis, HIV, malaria, and cancer. Its clinical implications are vast, predicting HIV-associated malignancy and treatment response and limiting the efficacy of cell therapies.",
    "url": "https://doi.org/10.64898/2026.05.25.727733",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "Downranked for Generic T cell biology without antigen specificity: t cell exhaustion",
    "journal": "bioRxiv",
    "pmid": "",
    "doi": "10.64898/2026.05.25.727733",
    "preprint_id": "biorxiv:10.64898/2026.05.25.727733",
    "authors": "Morales, M.; Premachandran, S.; Ravichandran, S.; Tadesse, L. F.",
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    "primary_source": "bioRxiv",
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    "digest_date": "2026-05-29",
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    "id": "biorxiv:10.64898/2026.05.28.724702",
    "canonical_key": "doi:10.64898/2026.05.28.724702",
    "headline": "Vagus nerve stimulation limits colonic inflammation through distinct neuroimmune circuitry shaped by inflammatory history",
    "summary": "Bidirectional communication between the nervous and immune systems has been demonstrated to limit or enhance immune cell function across organ systems and conditions.",
    "url": "https://doi.org/10.64898/2026.05.28.724702",
    "source": "bioRxiv",
    "published_date": "2026-05-28",
    "match_reason": "Downranked for Non-therapeutic broad immunology: inflammation",
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    "doi": "10.64898/2026.05.28.724702",
    "preprint_id": "biorxiv:10.64898/2026.05.28.724702",
    "authors": "Sanchez, K.; Park, J.; Tay, E.; Pore, G. M.; Wagner, A.; Lee, S.; Li, J.; Mirza, A.; Reardon, C.",
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]
